会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 24. 发明授权
    • Application of puerarin in the preparation of P2X3 mediated drugs for pain/nervous system diseases
    • 应用葛根素制备P2X3介导的药物用于疼痛/神经系统疾病
    • US08362070B2
    • 2013-01-29
    • US12922245
    • 2010-06-29
    • Shangdong LiangChangshui XuYun GaoGuilin LiJiari LinShuangmei LiuHan LiuJun ZhangXin Li
    • Shangdong LiangChangshui XuYun GaoGuilin LiJiari LinShuangmei LiuHan LiuJun ZhangXin Li
    • A61K31/35A61K31/70
    • A61K31/352
    • The invention relates to the new usage of puerarin in the field of pharmaceutical products, in other words, it relates to the application of puerarin in the preparation of drugs for P2X3 mediated pain/nervous system diseases. The experiment shows that puerarin can inhibit pain-related behavioral responses, subsequently immunohistochemical analysis, in situ hybridization, RT-PCR, protein blotting and other techniques were utilized to observe the inhibition of puerarin on mRNA and protein expression of P2X3 receptor in dorsal root ganglion of rats with neuropathic pain and in dorsal root ganglion and sensory nerve ending in the burn model of rats, it was found by using whole-cell patch clamp technique that puerarin can significantly reduce the electric current activated by P2X3 receptor agonist in the neuron of dorsal root ganglion of rats with neuropathic pain. The experiment proves that the mechanism for the inhibitory effects of puerarin on acute and chronic pain is to block the transmission of pain sense information that is mediated by P2X3 receptor in primary sensory neurons. The invention provides a kind of new method for the prevention and treatment on acute and chronic pain, and it also indicates that puerarin can act as a antagonist for P2X3 receptor, which will be helpful for the application of drugs in the prevention and treatment on P2X3 receptor involved nervous system diseases.
    • 本发明涉及葛根素在药物领域的新用途,换句话说,涉及葛根素在制备P2X3介导的疼痛/神经系统疾病药物中的应用。 实验表明,葛根素可以抑制疼痛相关的行为反应,随后免疫组化分析,原位杂交,RT-PCR,蛋白质印迹等技术用于观察葛根素对背根神经节P2X3受体mRNA和蛋白表达的抑制作用 的大鼠神经性疼痛和背根神经节和感觉神经结束于大鼠烧伤模型,通过使用全细胞膜片钳技术发现,葛根素可以显着降低P2X3受体激动剂在背侧神经元中活化的电流 神经性疼痛大鼠根神经节。 实验证明,葛根素对急性和慢性疼痛的抑制作用机制是阻断P2X3受体介导的疼痛感知信息在原发感觉神经元中的传播。 本发明提供了一种预防和治疗急性和慢性疼痛的新方法,也表明葛根素可以作为P2X3受体的拮抗剂,有利于药物在P2X3的预防和治疗中的应用 受体涉及神经系统疾病。
    • 28. 发明申请
    • Bottle with Multiple Openings
    • 带多个开口的瓶子
    • US20120074179A1
    • 2012-03-29
    • US12891520
    • 2010-09-27
    • Jun Zhang
    • Jun Zhang
    • A47G19/24
    • B65D47/42B65D47/2081
    • A bottle includes a reservoir comprising a top main opening, a threaded neck, and a shoulder adjacent the neck; a flexible, disc-shaped dispensing device comprising a central bottom riser; grooves extending from the riser, each groove having an outlet opening, top projecting members each having one end of the outlet opening terminated thereon, and a central recess with the projecting members therearound; an internally threaded retaining ring secured to the neck to fasten the dispensing device on the reservoir with the outlet openings being exposed; and a cap comprising a bottom post inserted into the recess when the cap is secured to the shoulder so as to flexibly deform both the recess and the riser to seal the main opening.
    • 瓶子包括一个储存器,包括顶部主开口,螺纹颈部和与颈部相邻的肩部; 柔性的盘形分配装置,包括中央底部提升器; 从所述立管延伸的凹槽,每个凹槽具有出口开口,每个所述出口开口的一端终止于其上的顶部突出构件以及具有突出构件的中心凹部; 固定到颈部的内螺纹固定环将出口开口露出时将分配装置紧固在储存器上; 以及盖,其包括当所述盖被固定到所述肩部上时插入到所述凹部中的底部柱,以便使所述凹部和所述提升管两者柔性地变形以密封所述主开口。
    • 29. 发明申请
    • DOUBLE STRENGTH LOPPERS
    • 双重强力鞋
    • US20110154668A1
    • 2011-06-30
    • US12965498
    • 2010-12-10
    • Hongbin LiuJun ZhangMaocai Huang
    • Hongbin LiuJun ZhangMaocai Huang
    • A01G3/08
    • A01G3/0251
    • Double strength loppers employ double leverage effects and have two crossed pivoting blades, a main blade and an auxiliary blade, an upper handle and a lower handle correspondingly matching with the two blades, an upper gear at the end of the upper handle and a lower gear at the end of the lower handle. The lower gear matches with the blade driving gear and the blade driving gear matches with the auxiliary blade. When swinging the upper handle and/or the lower handle, a first leverage effect is created from a first fulcrum that is the contact point between the upper gear and the lower gear, while a second leverage effect is created from a second fulcrum that is the contact point between the lower gear and the blade driving gear. Such double levers and double strength effects significantly reduce the force applied upon the handles, therefore reducing the required labor.
    • 双强度修剪器采用双重杠杆效应,并具有两个交叉的枢转叶片,主叶片和辅助叶片,上手柄和下手柄,其对应地与两个叶片匹配,上手柄端部的上齿轮和下齿轮 在下手柄的末端。 下齿轮与刀片驱动齿轮匹配,刀片驱动齿轮与辅助刀片匹配。 当摆动上部手柄和/或下部手柄时,从作为上部齿轮和下部齿轮之间的接触点的第一支点产生第一杠杆效应,而从第二支点产生第二杠杆效应,第二支点为 下齿轮与叶片驱动齿轮之间的接触点。 这种双重杠杆和双重强度效应显着降低了施加在手柄上的力,从而减少了所需的劳动。
    • 30. 发明申请
    • PLANT AND PROCESS FOR RECOVERING CARBON DIOXIDE
    • 回收二氧化碳的工厂和工艺
    • US20110005389A1
    • 2011-01-13
    • US12746972
    • 2008-12-12
    • Paul Anthony WebleyJun Zhang
    • Paul Anthony WebleyJun Zhang
    • B01D53/047
    • B01D53/0476B01D53/229B01D2253/102B01D2253/104B01D2253/106B01D2253/108B01D2256/22B01D2259/40043B01D2259/40064B01D2259/402Y02C10/04Y02C10/08
    • The present invention relates to a process and plant for the recovery of carbon dioxide from a gas stream by means of pressure swing adsorption using an adsorbent, such as X or Y type Zeolite adsorbents. The gas feed stream suitably has a moderate concentration of carbon dioxide, such as gas emitted from the filling bowl of the carbonated drinks bottling plant and is recovered without rinsing or purging the adsorbent with a high purity carbon dioxide gas stream. The process therefore provides the advantage of being capturing carbon dioxide from the effluent that would otherwise be emitted to the atmosphere and captures the carbon dioxide in a manner that minimises operational and capital expenditure. The present invention also relates to a process for utilizing one dry stream from a gas separation unit (adsorption or membrane process) to conduct evaporative cooling of water, which is used as the water in a liquid ring vacuum pump thereby decreasing the vacuum level and improving the performance.
    • 本发明涉及使用吸附剂如X或Y型沸石吸附剂通过变压吸附从气流中回收二氧化碳的方法和设备。 气体进料流适当地具有中等浓度的二氧化碳,例如从碳酸饮料装瓶厂的填充碗排出的气体,并且在不用高纯度二氧化碳气流冲洗或清洗吸附剂的情况下回收。 因此,该方法提供了从流出物中捕获二氧化碳的优点,否则这些二氧化碳将被排放到大气中并以最小化操作和资本支出的方式捕获二氧化碳。 本发明还涉及利用来自气体分离单元(吸附或膜过程)的一个干燥流进行水的蒸发冷却的方法,该水用作液环真空泵中的水,从而降低真空度并提高 的表现。