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21. 发明授权

US06743219B1 Delivery apparatus for a self-expanding stent 有权
标题翻译：用于自扩张支架的输送装置
公开(公告)号：US06743219B1
公开(公告)日：2004-06-01
申请号：US09631002
申请日：2000-08-02
申请人： Clifford J. Dwyer , Luis A. Davila , Frederick Feller, III , Mark L. Mathis , David J. Wilson
发明人： Clifford J. Dwyer , Luis A. Davila , Frederick Feller, III , Mark L. Mathis , David J. Wilson
IPC分类号： A61M2500
CPC分类号： A61F2/95 , A61F2/958 , A61F2/966
摘要： A delivery apparatus for self-expanding stents may be utilized to safely deliver stents to a target site. The apparatus has an outer sheath forming an elongated tubular member having distal and proximal ends and an inside and outside diameter. The apparatus also includes an inner shaft located coaxially within the outer sheath. The inner shaft has a distal end, a proximal end and a longitudinal axis extending therebetween. At least a portion of the inner shaft is made from a flexible coiled member. The shaft preferably includes a stop attached thereto, the stop being proximal to the distal end of the sheath. Lastly, the apparatus includes a self-expanding stent located within the outer sheath, wherein the stent makes frictional contact with the outer sheath and the shaft is disposed coaxially within a lumen of the stent. During deployment of the stent, the stent makes contact with the stop.
摘要翻译：用于自扩张支架的输送装置可用于将支架安全地输送到目标部位。该装置具有形成具有远端和近端以及内径和外径的细长管状构件的外护套。该装置还包括同轴地位于外护套内的内轴。内轴具有远端，近端和在其间延伸的纵向轴线。内轴的至少一部分由柔性卷绕构件制成。轴优选地包括附接到其上的止动件，止动件靠近护套的远端。最后，该装置包括位于外护套内的自扩张支架，其中支架与外护套摩擦接触，并且轴同轴地设置在支架内腔内。在展开支架期间，支架与止动器接触。

22. 发明授权

US09408695B2 Fixed anchor and pull mitral valve device and method 有权
标题翻译：固定和拉动二尖瓣装置及方法
公开(公告)号：US09408695B2
公开(公告)日：2016-08-09
申请号：US12016054
申请日：2008-01-17
申请人： Mark L. Mathis , Gregory D. Nieminen , David G. Reuter
发明人： Mark L. Mathis , Gregory D. Nieminen , David G. Reuter
IPC分类号： A61F2/24 , A61B17/00 , A61N1/05
CPC分类号： A61F2/2451 , A61B2017/00243 , A61F2/24 , A61F2/2442 , A61F2/2466 , A61F2210/0014 , A61F2220/0008 , A61F2250/0012 , A61F2310/00017 , A61F2310/00023 , A61N1/057 , A61N2001/0585
摘要： A device affects the mitral valve annulus geometry of a heart. The device includes a first anchor configured to be positioned within and anchored to the coronary sinus of the heart adjacent the mitral valve annulus within the heart and a second anchor configured to be positioned within the coronary sinus of the heart proximal to the first anchor and adjacent the mitral valve annulus within the heart. The second anchor, when deployed, anchors against distal movement and is moveable in a proximal direction. The device further includes a connecting member having a fixed length permanently attached to the first and second anchors. As a result, when the first and second anchors are within the coronary sinus with the first anchor anchored in the coronary sinus, the second anchor may be displaced proximally to affect the geometry of the mitral valve annulus and released to maintain the effect on the mitral valve geometry.
摘要翻译：一个装置影响心脏的二尖瓣环几何形状。该装置包括第一锚定构件，其构造成定位在心脏内邻近心脏二尖瓣环的心脏的冠状窦内并且锚固在心脏周围的第二锚定件上，第二锚固件构造成定位在靠近第一锚固件的心脏的冠状窦内，心脏内的二尖瓣环。当第二锚固件被展开时，锚固件抵靠远端运动并且可沿近端方向移动。该装置还包括具有固定长度的连接构件，该固定长度永久地附接到第一和第二锚固件。结果，当第一和第二锚固件位于冠状窦内时，第一锚固件锚固在冠状窦中时，第二锚固件可以向近侧位移以影响二尖瓣环的几何形状并被释放以维持对二尖瓣的作用阀几何。

23. 发明申请

US20120172909A1 Lung Volume Reduction Devices, Methods, and Systems 有权
标题翻译：肺减容装置，方法和系统
公开(公告)号：US20120172909A1
公开(公告)日：2012-07-05
申请号：US13418534
申请日：2012-03-13
申请人： Mark L. Mathis , David Thompson , Nathan Aronson , Patrick Wu
发明人： Mark L. Mathis , David Thompson , Nathan Aronson , Patrick Wu
IPC分类号： A61M29/00
CPC分类号： A61B17/12104 , A61B1/2676 , A61B17/12022 , A61B17/12031 , A61B17/12131 , A61B17/12145 , A61B17/12172 , A61B17/122 , A61B2017/00477 , A61B2017/00809 , A61B2017/1205 , A61B2017/12054 , A61F2/04 , A61F2002/043 , A61M16/04 , A61M16/0406 , A61M16/208 , A61M2205/0266
摘要： The invention provides improved medical devices, therapeutic treatment systems, and treatment methods for treatment of the lung. A lung volume reduction system includes an implantable device having an elongate body that is sized and shaped for delivery via the airway system to a lung airway of a patient. The implant is inserted and positioned while the implant is in a delivery configuration, and is reconfigured to a deployed configuration so as to locally compress adjacent tissue of the lung, with portions of the elongate body generally moving laterally within the airway so as to laterally compress lung tissue. A plurality of such implants will often be used to treat a lung of a patient.
摘要翻译：本发明提供改进的医疗装置，治疗处理系统和用于治疗肺的治疗方法。肺容积减小系统包括可植入装置，其具有细长体，其尺寸和形状用于经由气道系统输送到患者的肺气道。植入物在植入物处于输送构型中时被插入和定位，并且被重新配置为展开构型，以便局部压缩肺的邻近组织，细长体的一部分通常在气道内侧向移动，以便横向压缩肺组织。多个这样的植入物将经常用于治疗患者的肺部。

24. 发明授权

US08182529B2 Percutaneous mitral valve annuloplasty device delivery method 有权
标题翻译：经皮二尖瓣瓣环成形术装置输送方法
公开(公告)号：US08182529B2
公开(公告)日：2012-05-22
申请号：US10945855
申请日：2004-09-20
申请人： Lucas S. Gordon , Mark L. Mathis , Gregory Nieminen , Leonard Kowalsky , Ryan Braxtan , Brian J. Doll
发明人： Lucas S. Gordon , Mark L. Mathis , Gregory Nieminen , Leonard Kowalsky , Ryan Braxtan , Brian J. Doll
IPC分类号： A61F2/24 , A61F2/06
CPC分类号： A61F2/95 , A61B17/3468 , A61B2017/1205 , A61F2002/9511
摘要： The invention is a method of delivering and deploying a tissue shaping device in a lumen within a patient, with the tissue shaping device including an anchor. In some embodiments the method includes the steps of: inserting a delivery catheter into the lumen; percutaneously delivering the device to a target site within the lumen through a delivery catheter; operating an actuator to expose an anchor; and operating the actuator to lock the anchor. In other, the method includes the steps of: inserting a delivery catheter into the lumen; moving the device from a cartridge into the delivery catheter; delivering the device to a target site within the lumen; operating an actuator to move the delivery catheter with respect to the anchor to expose the anchor; and expanding the anchor.
摘要翻译：本发明是一种在组织整形装置中包括锚固件的方式，将组织成形装置递送和展开在患者体内。在一些实施例中，该方法包括以下步骤：将输送导管插入内腔; 通过输送导管将装置经皮递送到内腔内的目标部位; 操作致动器以暴露锚; 并操作致动器以锁定锚。另外，该方法包括以下步骤：将输送导管插入内腔; 将装置从药筒移动到输送导管中; 将装置输送到管腔内的目标部位; 操作致动器以使输送导管相对于锚固件移动以暴露锚固件; 并扩大锚点。

25. 发明授权

US08157823B2 Lung volume reduction devices, methods, and systems 有权
标题翻译：肺减容装置，方法和系统
公开(公告)号：US08157823B2
公开(公告)日：2012-04-17
申请号：US12209662
申请日：2008-09-12
申请人： Nathan Aronson , Mark L. Mathis
发明人： Nathan Aronson , Mark L. Mathis
IPC分类号： A61B17/08
CPC分类号： A61M16/208 , A61B1/018 , A61B1/04 , A61B1/2676 , A61B5/06 , A61B6/032 , A61B6/12 , A61B6/485 , A61B17/00234 , A61B17/12022 , A61B17/12031 , A61B17/12104 , A61B17/12131 , A61B17/1214 , A61B17/12145 , A61B17/1215 , A61B17/12172 , A61B90/00 , A61B90/02 , A61B2017/00477 , A61B2017/00809 , A61B2017/00867 , A61B2017/12054 , A61F2/04 , A61F2002/043 , A61F2002/046 , A61M16/04 , A61M16/0406 , A61M16/0833 , A61M37/0069 , A61M2205/0266 , A61M2205/32
摘要： The invention provides improved medical devices, therapeutic treatment systems, and treatment methods for treatment of the lung. A lung volume reduction system includes an implantable device having an elongate body that is sized and shaped for delivery via the airway system to a lung airway of a patient. The implant is inserted and positioned while the implant is in a delivery configuration, and is reconfigured to a deployed configuration so as to locally compress adjacent tissue of the lung, with portions of the elongate body generally moving laterally within the airway so as to laterally compress lung tissue. A plurality of such implants will often be used to treat a lung of a patient.
摘要翻译：本发明提供改进的医疗装置，治疗处理系统和用于治疗肺的治疗方法。肺容积减小系统包括可植入装置，其具有细长体，其尺寸和形状用于经由气道系统输送到患者的肺气道。植入物在植入物处于输送构型中时被插入和定位，并且被重新配置为展开构型，以便局部压缩肺的邻近组织，细长体的一部分通常在气道内侧向移动，以便横向压缩肺组织。多个这样的植入物将经常用于治疗患者的肺部。

26. 发明授权

US07828841B2 Device and method for modifying the shape of a body organ 有权
公开(公告)号：US07828841B2
公开(公告)日：2010-11-09
申请号：US11963417
申请日：2007-12-21
申请人： Mark L. Mathis , Leonard Kowalsky , David G. Reuter , Cruz Beeson
发明人： Mark L. Mathis , Leonard Kowalsky , David G. Reuter , Cruz Beeson
IPC分类号： A61F2/06
CPC分类号： A61F2/2451 , A61F2250/001 , A61F2250/0059
摘要： An intravascular support device includes a support or reshaper wire, a proximal anchor and a distal anchor. The support wire engages a vessel wall to change the shape of tissue adjacent the vessel in which the intravascular support is placed. The anchors and support wire are designed such that the vessel in which the support is placed remains open and can be accessed by other devices if necessary. The device provides a minimal metal surface area to blood flowing within the vessel to limit the creation of thrombosis. The anchors can be locked in place to secure the support within the vessel.

27. 发明授权

US07814635B2 Method of making a tissue shaping device 有权
标题翻译：制作组织整形装置的方法
公开(公告)号：US07814635B2
公开(公告)日：2010-10-19
申请号：US11383115
申请日：2006-05-12
申请人： Lucas Gordon , Mark L. Mathis , Nathan Aronson
发明人： Lucas Gordon , Mark L. Mathis , Nathan Aronson
IPC分类号： B23P11/00 , A61F2/24
CPC分类号： A61F2/2451 , Y10T29/49609 , Y10T29/49826 , Y10T29/49947 , Y10T29/49995
摘要： A tissue shaping device adapted to be deployed in a vessel to reshape tissue adjacent to the vessel. In some embodiments the device includes first and second anchors and a connector disposed between the first and second anchors, with the connector being integral with at least a portion of the first anchor. The invention is also a method of making a tissue shaping device including the steps of removing material from a blank to form a connector and an integral anchor portion; and attaching a non-integral anchor portion to the integral anchor portion.
摘要翻译：一种组织成形装置，其适于部署在容器中以重塑邻近容器的组织。在一些实施例中，该装置包括第一和第二锚定器以及设置在第一和第二锚固件之间的连接器，其中连接器与第一锚固件的至少一部分成一体。本发明还是一种制造组织成形装置的方法，包括以下步骤：从坯料上去除材料以形成连接器和一体的锚定部分; 以及将非整体锚定部分附接到所述整体锚定部分。

28. 发明授权

US07758639B2 Mitral valve device using conditioned shape memory alloy 有权
标题翻译：二尖瓣装置采用条状形状记忆合金
公开(公告)号：US07758639B2
公开(公告)日：2010-07-20
申请号：US11655710
申请日：2007-01-18
申请人： Mark L. Mathis
发明人： Mark L. Mathis
IPC分类号： A61F2/24
CPC分类号： A61F2/2451 , A61F2210/0023
摘要： A mitral valve annulus reshaping device includes at least a portion that is formed of a biocompatible shape memory alloy SMA having a characteristic temperature, Af, that is preferably below body temperature. The device is constrained in an unstable martensite (UM) state while being introduced through a catheter that passes through the venous system and into the coronary sinus of the heart. The reshaping device is deployed adjacent to the mitral valve annulus of the heart as it is forced from the catheter. When released from the constraint of the catheter, the SMA of the device at least partially converts from the UM state to an austenitic state and attempts to change to a programmed shape that exerts a force on the adjacent tissue and modifies the shape of the annulus. The strain of the SMA can be varied when the device is within the coronary sinus.
摘要翻译：二尖瓣环重塑装置至少包括由具有特征温度Af的生物相容性形状记忆合金SMA形成的部分，其优选低于体温。该装置被限制在不稳定的马氏体（UM）状态，同时通过导管穿过静脉系统并进入心脏的冠状窦。当从导管被迫时，整形装置邻近心脏的二尖瓣环部署。当从导管的约束释放时，该装置的SMA至少部分地从UM状态转变为奥氏体状态，并尝试改变为在相邻组织上施加力并且修改环形的形状的编程形状。当器件在冠状窦内时，SMA的应变可以变化。

29. 发明授权

US07608102B2 Focused compression mitral valve device and method 有权
标题翻译：聚焦压缩二尖瓣装置及方法
公开(公告)号：US07608102B2
公开(公告)日：2009-10-27
申请号：US10813354
申请日：2004-03-29
申请人： John M. Adams , David G. Reuter , Mark L. Mathis , Scott J. Wolf
发明人： John M. Adams , David G. Reuter , Mark L. Mathis , Scott J. Wolf
IPC分类号： A61F2/24
CPC分类号： A61F2/2451 , A61M25/1006
摘要： A mitral valve therapy device and method treats dilated cardiomyopathy. The device is configured to be placed in the coronary sinus of a heart adjacent to the mitral valve annulus. The device includes a force distributor that distributes an applied force along a pericardial wall of the coronary sinus, and a force applier that applies the applied force to one or more discrete portions of a wall of the coronary sinus adjacent to the mitral valve annulus to reshape the mitral valve annulus in a localized manner.
摘要翻译：二尖瓣治疗装置和方法治疗扩张型心肌病。该装置被配置成放置在与二尖瓣环相邻的心脏的冠状窦中。该装置包括力分配器，其沿着冠状窦的心包壁分布施加的力，以及施加力施加器，其将所施加的力施加到邻近二尖瓣环的冠状窦的壁的一个或多个离散部分，以重塑二尖瓣环以局部方式。

30. 发明授权

US06964683B2 System and method to effect the mitral valve annulus of a heart 有权
标题翻译：影响心脏二尖瓣环的系统和方法
公开(公告)号：US06964683B2
公开(公告)日：2005-11-15
申请号：US10798728
申请日：2004-03-10
申请人： Leonard Kowalsky , Gregory D. Nieminen , Ryan H. Braxtan , Mark L. Mathis
发明人： Leonard Kowalsky , Gregory D. Nieminen , Ryan H. Braxtan , Mark L. Mathis
IPC分类号： A61F2/24
CPC分类号： A61F2/2451
摘要： An assembly for effecting the condition of a mitral valve annulus includes a mitral valve therapy device, a coupling structure carried by the device, a catheter, a second coupling structure, and a locking member. To implant the device, the device is first releasably locked to a pushing member by the coupling structures and the locking member. When the device is positioned within the coronary sinus adjacent the mitral valve annulus and deployed, the coupling structures may be released from each other by the release of the locking member.
摘要翻译：用于实现二尖瓣环的状态的组件包括二尖瓣治疗装置，由装置承载的联接结构，导管，第二联接结构和锁定构件。为了植入装置，装置首先通过联接结构和锁定构件可释放地锁定到推动构件。当装置定位在邻近二尖瓣环并展开的冠状窦内时，联接结构可以通过释放锁定构件而相互释放。

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