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21. 发明申请

US20130310908A1 PLASMONIC NANOPARTICLE-DOPED SILK MATERIALS 有权
公开(公告)号：US20130310908A1
公开(公告)日：2013-11-21
申请号：US13819419
申请日：2011-09-03
申请人： Fiorenzo Omenetto , David L. Kaplan , Hu Tao
发明人： Fiorenzo Omenetto , David L. Kaplan , Hu Tao
IPC分类号： A61N5/06 , H01L35/30
CPC分类号： A61N5/0625 , A61F7/03 , A61L31/005 , A61L31/125 , A61L31/14 , A61L2400/12 , A61N5/062 , H01L35/30 , Y10T428/268 , Y10T428/2927
摘要： Provided herein are silk fibroin-based photothermal elements and uses thereof. The silk fibroin-based photothermal elements comprise a plurality of plasmonic nanoparticle distributed in a silk fibroin matrix, and can generate heat when the plasmonic nanoparticles are exposed to electromagnetic radiation. The silk fibroin-based photothermal elements can be adapted to be conformable and biodegradable, and can further be integrated with various electronic components, such as a thermo-electric device for conversion of heat into electricity. The invention is useful for various in vivo applications, such as photothermal therapy, controlled drug-delivery devices or wireless powering of implanted micro-devices.
摘要翻译：本文提供的是丝素蛋白基光热元件及其用途。基于丝素蛋白的光热元件包括分布在丝素蛋白基质中的多个等离子体激元纳米颗粒，当等离子体激元纳米粒子暴露于电磁辐射时可产生热量。丝素蛋白的光热元件可以适应和可生物降解，并且可以进一步与各种电子部件集成，例如用于将热量转换成电的热电装置。本发明可用于各种体内应用，例如光热治疗，受控药物递送装置或植入的微器件的无线供电。

22. 发明申请

US20120188640A1 ALL-PROTEIN IMPLANTABLE, RESORBABLE REFLECTORS 有权
标题翻译：全蛋白可植入，可折叠的反射器
公开(公告)号：US20120188640A1
公开(公告)日：2012-07-26
申请号：US13386388
申请日：2010-07-20
申请人： Fiorenzo Omenetto , David L. Kaplan
发明人： Fiorenzo Omenetto , David L. Kaplan
IPC分类号： G02B5/124 , B05D5/06 , G02B5/04 , B05D3/00
CPC分类号： A61B5/0059 , A61K49/0004 , A61L27/227
摘要： The invention provides for compositions and process for fabricating an optical reflector constructed from biocompatible and bioresorbable silk fibroin proteins. For example, the silk retroreflectors may be built based on millimeter size microprism arrays to rotate the image plane of imaged cortical layers, thus enhancing the amount of photons that are detectable in the reflected direction when inserted in a sample to be analyzed, and ultimately increasing in contrast ratio in multiphoton microscopy. Such device can be used as a label-free, biocompatible, bioresorbable, implantable device for various applications ranging from medical imaging/diagnostics, drug/therapeutic delivery, to food chain safety and environmental monitoring.
摘要翻译：本发明提供了用于制造由生物相容性和生物可再吸收的丝素蛋白构成的光反射体的组合物和方法。例如，丝绸后向反射器可以基于毫米尺寸的微棱镜阵列构建，以旋转成像的皮质层的图像平面，从而增加当插入待分析的样品中时在反射方向上可检测的光子的量，并且最终增加在多光子显微镜中的对比度。这种装置可用作用于各种应用的无标签，生物相容性，生物可再吸收的可植入装置，从医学成像/诊断，药物/治疗递送，食品链安全和环境监测。

23. 发明授权

US09517357B2 Plasmonic nanoparticle-doped silk materials 有权
标题翻译：掺杂等离子体纳米粒子的丝材料
公开(公告)号：US09517357B2
公开(公告)日：2016-12-13
申请号：US13819419
申请日：2011-09-03
申请人： Fiorenzo Omenetto , David L. Kaplan , Hu Tao
发明人： Fiorenzo Omenetto , David L. Kaplan , Hu Tao
IPC分类号： A61N5/00 , A61N5/06 , A61F7/03 , A61L31/00 , A61L31/12 , A61L31/14 , H01L35/30
CPC分类号： A61N5/0625 , A61F7/03 , A61L31/005 , A61L31/125 , A61L31/14 , A61L2400/12 , A61N5/062 , H01L35/30 , Y10T428/268 , Y10T428/2927
摘要： Provided herein are silk fibroin-based photothermal elements and uses thereof. The silk fibroin-based photothermal elements comprise a plurality of plasmonic nanoparticle distributed in a silk fibroin matrix, and can generate heat when the plasmonic nanoparticles are exposed to electromagnetic radiation. The silk fibroin-based photothermal elements can be adapted to be conformable and biodegradable, and can further be integrated with various electronic components, such as a thermo-electric device for conversion of heat into electricity. The invention is useful for various in vivo applications, such as photothermal therapy, controlled drug-delivery devices or wireless powering of implanted micro-devices.
摘要翻译：本文提供的是丝素蛋白基光热元件及其用途。基于丝素蛋白的光热元件包括分布在丝素蛋白基质中的多个等离子体激元纳米颗粒，当等离子体激元纳米粒子暴露于电磁辐射时可产生热量。丝素蛋白的光热元件可以适应和可生物降解，并且可以进一步与各种电子部件集成，例如用于将热量转换成电的热电装置。本发明可用于各种体内应用，例如光热治疗，受控药物递送装置或植入的微器件的无线供电。

24. 发明申请

US20140154788A1 ELECTRONIC COMPONENTS ON PAPER-BASED SUBSTRATES 审中-公开
标题翻译：基于纸张基板的电子元件
公开(公告)号：US20140154788A1
公开(公告)日：2014-06-05
申请号：US13977233
申请日：2012-01-04
申请人： Fiorenzo Omenetto , David L. Kaplan , Hu Tao
发明人： Fiorenzo Omenetto , David L. Kaplan , Hu Tao
IPC分类号： B01L3/00 , C12Q1/54 , G01N22/00 , G01J1/02 , G01J5/02
CPC分类号： B01L3/502707 , C12Q1/54 , G01J1/02 , G01J5/02 , G01N21/3563 , G01N21/3581 , G01N22/00
摘要： The present disclosure relates to paper-based substrates and apparatus comprising such substrates. The apparatus may include a patterned conductive structure coupled to the paper-based substrate, wherein the patterned conductive structure responds to electromagnetic radiation.
摘要翻译：本公开涉及基于纸的基板和包括这种基板的装置。该装置可以包括耦合到纸基基板的图案化导电结构，其中图案化导电结构响应于电磁辐射。

25. 发明申请

US20120034291A1 NANOIMPRINTING OF SILK FIBROIN STRUCTURES FOR BIOMEDICAL AND BIOPHOTONIC APPLICATIONS 有权
标题翻译：用于生物医学和生物医学应用的丝素纤维结构的纳米生物
公开(公告)号：US20120034291A1
公开(公告)日：2012-02-09
申请号：US13201380
申请日：2010-02-12
申请人： Jason J. Amsden , David L. Kaplan , Fiorenzo Omenetto
发明人： Jason J. Amsden , David L. Kaplan , Fiorenzo Omenetto
IPC分类号： A61K9/70 , A61K35/00 , A61K38/43 , A61K31/7088 , B29D11/00 , B32B3/10 , A61K39/395 , A61K38/00 , B82Y5/00 , B82Y40/00
CPC分类号： A61K9/7007 , A61K9/70 , A61K41/00 , A61K47/42 , B82Y10/00 , B82Y20/00 , B82Y30/00 , B82Y40/00 , G01N21/4788 , G01N21/774 , G01N2021/7776 , G02B5/1809 , G02B5/1847 , G02B6/02061 , G02B6/1225 , G02B6/262 , G03F7/0002 , Y10T428/24479
摘要： The present invention provides for photonic nanoimprinted silk fibroin-based materials and methods for making same, comprising embossing silk fibroin-based films with photonic nanometer scale patterns. In addition, the invention provides for processes by which the silk fibroin-based films can be nanoimprinted at room temperature, by locally decreasing the glass sition temperature of the silk film Such nanoimprinting process increases high throughput and improves potential for incorporation of silk-based photonics into biomedical and other optical devices.
摘要翻译：本发明提供了基于光子纳米压印的丝素蛋白的材料及其制备方法，其包括用丝光纳米尺度图案压花丝素蛋白基膜。此外，本发明提供了通过局部降低丝膜的玻璃化温度，可以在室温下将丝素蛋白基膜纳米压印的方法。这种纳米压印方法增加了高通量并提高了掺入丝基光子学的潜力进入生物医学和其他光学器件。

26. 发明授权

US09952148B2 Non-invasive optical characterization of biomaterial mineralization 有权
公开(公告)号：US09952148B2
公开(公告)日：2018-04-24
申请号：US12867383
申请日：2009-02-19
申请人： Irene Georgakoudi , Sharad Gupta , Martin Hunter , David L. Kaplan
发明人： Irene Georgakoudi , Sharad Gupta , Martin Hunter , David L. Kaplan
IPC分类号： G01N21/47 , G01N21/21
CPC分类号： G01N21/47 , G01N21/21 , G01N2021/4792
摘要： In one aspect, the present invention generally provides methods for characterizing mineralization of a material, e.g., a biomaterial, by illuminating the material with radiation and analyzing radiation scattered from the material in response to the illumination. For example, in some embodiments, a material can be illuminated with polarized radiation at a plurality of wavelengths and the elastically scattered radiation corresponding to two or more of those wavelengths can be collected at two polarizations: one parallel and the other perpendicular to the illumination polarization. A differential intensity of the scattered radiation at the two polarizations can be analyzed as a function of wavelength to obtain information regarding the morphology of mineral deposits in the sample. Further, the total scattered radiation can be analyzed to derive information regarding the level of mineralization.

27. 发明申请

US20110109910A1 NON-INVASIVE OPTICAL CHARACTERIZATION OF BIOMATERIAL MINERALIZATION 有权
标题翻译：生物矿物矿物非侵入性光学特征
公开(公告)号：US20110109910A1
公开(公告)日：2011-05-12
申请号：US12867383
申请日：2009-02-19
申请人： Irene Georgakoudi , Sharad Gupta , Martin Hunter , David L. Kaplan
发明人： Irene Georgakoudi , Sharad Gupta , Martin Hunter , David L. Kaplan
IPC分类号： G01N21/47
CPC分类号： G01N21/47 , G01N21/21 , G01N2021/4792
摘要： In one aspect, the present invention generally provides methods for characterizing mineralization of a material, e.g., a biomaterial, by illuminating the material with radiation and analyzing radiation scattered from the material in response to the illumination. For example, in some embodiments, a material can be illuminated with polarized radiation at a plurality of wavelengths and the elastically scattered radiation corresponding to two or more of those wavelengths can be collected at two polarizations: one parallel and the other perpendicular to the illumination polarization. A differential intensity of the scattered radiation at the two polarizations can be analyzed as a function of wavelength to obtain information regarding the morphology of mineral deposits in the sample. Further, the total scattered radiation can be analyzed to derive information regarding the level of mineralization.
摘要翻译：在一个方面，本发明通常提供用于通过用辐射照射材料来表征材料（例如生物材料）的矿化的方法，并且响应于照明分析从材料散射的辐射。例如，在一些实施例中，可以以多个波长的偏振辐射照射材料，并且对应于这些波长中的两个或更多个的弹性散射辐射可以以两个极化收集：一个平行且另一个垂直于照明偏振。可以分析两个极化处的散射辐射的差分强度作为波长的函数，以获得关于样品中矿物沉积物形态的信息。此外，可以分析总散射辐射以得到关于矿化水平的信息。

28. 发明申请

US20090298139A1 Method for Polymer Synthesis Using Microfluidic Enzymatic Cascade 审中-公开
标题翻译：使用微流控酶级联的聚合物合成方法
公开(公告)号：US20090298139A1
公开(公告)日：2009-12-03
申请号：US12224149
申请日：2007-02-27
申请人： Jin Zou , David L. Kaplan , Jin Zou , Peter Y. Wong , David L. Kaplan
发明人： Jin Zou , David L. Kaplan , Jin Zou , Peter Y. Wong , David L. Kaplan
IPC分类号： C12P17/16 , B01J19/00
CPC分类号： C12P17/04
摘要： The present invention discloses a method for producing polymers in a microscale device. The system utilizes a symmetrically branched system of microchannels interconnecting a plurality of loading decks and re-action chambers. The fluid flow is manipulated by the placement of capillary check valves, mixing areas, and microcomb filters. The system provides for cascading enzymatic biosynthesis pathways wherein any variety of enzymes and reactants can be introduced into the system to produce a final product.
摘要翻译：本发明公开了一种在微型装置中制备聚合物的方法。该系统利用互连多个装载甲板和再作用室的对称分支的微通道系统。通过放置毛细管止回阀，混合区域和微孔过滤器来操纵流体流动。该系统提供级联的酶生物合成途径，其中可以将任何多种酶和反应物引入系统以产生最终产物。

29. 发明授权

US08986380B2 Multilayered silk scaffolds for meniscus tissue engineering 有权
标题翻译：用于半月板组织工程的多层丝绸支架
公开(公告)号：US08986380B2
公开(公告)日：2015-03-24
申请号：US13702606
申请日：2011-06-09
申请人： David L. Kaplan , Biman B. Mandal
发明人： David L. Kaplan , Biman B. Mandal
IPC分类号： A61F2/30 , A61L27/36 , A61L27/38 , A61L27/54 , A61L27/56 , C12N5/00 , C12N5/077
CPC分类号： A61F2/30756 , A61L27/3604 , A61L27/3654 , A61L27/3834 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/30 , A61L2300/414 , C12N5/0068 , C12N5/0655 , C12N2533/50 , C12N2533/90
摘要： Provided herein is a biocompatible implant for meniscus tissue engineering. Particularly, the biocompatible implant comprises a multi-layered crescent-shaped silk fibroin scaffold, in which each layer comprises distinct pore size and/or pore orientation, e.g., to mimic native meniscus complex architecture. Accordingly, the biocompatible implant can be used for repairing any meniscal defect or promoting meniscal regeneration in a subject.
摘要翻译：本文提供了用于弯液面组织工程的生物相容性植入物。特别地，生物相容性植入物包括多层新月形丝素蛋白支架，其中每个层包含不同的孔径和/或孔取向，例如模拟天然半月板复合体系结构。因此，生物相容性植入物可用于修复受试者中的任何半月板缺损或促进半月板再生。

30. 发明授权

US08906444B2 Diazonium salt modification of silk polymer 有权
标题翻译：丝绸聚合物的重氮盐改性
公开(公告)号：US08906444B2
公开(公告)日：2014-12-09
申请号：US13479709
申请日：2012-05-24
申请人： David L. Kaplan , Amanda Murphy
发明人： David L. Kaplan , Amanda Murphy
IPC分类号： B05D3/00 , C12N5/02 , A61K38/17 , C08L89/00 , C08H1/00
CPC分类号： C09D189/00 , C08H1/00 , C08L89/00
摘要： A method for modifying silk polymer by coupling a chemical moiety to a tyrosine residue of a silk polymer is described herein for the purpose of altering the physical properties of the silk protein. Thus, silk proteins with desired physical properties can be produced by the methods described herein. These methods are particularly useful when the introduction of cells to a mammal is desired, since modifications to the silk protein affect the physical properties and thus the adhesion, metabolic activity and cell morphology of the desired cells. The silk protein can be modified to produce, or modify, a structure that provides an optimal environment for the desired cells.
摘要翻译：本文描述了通过将化学部分偶联到丝聚合物的酪氨酸残基来修饰丝聚合物的方法，用于改变丝蛋白的物理性质。因此，可以通过本文所述的方法制备具有所需物理性质的丝蛋白。当需要向哺乳动物引入细胞时，这些方法特别有用，因为对丝蛋白的修饰会影响所需细胞的物理性质，因此影响粘附，代谢活性和细胞形态。可以修饰丝蛋白以产生或修饰为所需细胞提供最佳环境的结构。

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