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21. 发明申请

US20050269522A1 Low Thermal Mass Fluorometer 有权
标题翻译：低热质量荧光计
公开(公告)号：US20050269522A1
公开(公告)日：2005-12-08
申请号：US10908994
申请日：2005-06-03
申请人： Andrew Farmer , David Fries , Bill Flanery
发明人： Andrew Farmer , David Fries , Bill Flanery
IPC分类号： G01J1/58 , G01N21/03 , G01N21/64
CPC分类号： G01N21/645 , G01N21/0332 , G01N2201/0221
摘要： The present invention provides core technologies necessary for a portable, low cost, thermal-regulating LED-based handheld fluorometer. The regulated fluorometer is based on a low thermal mass infrared heater, and an orthogonal geometry LED based filter fluorometer. Power is supplied through an external power supply and data is collected in real-time through standard serial interfaces of personal computers or personal digital assistants. Thermal regulation is automatically maintained using temperature sensor feedback control. Optical excitation relies on LED light source(s) and optical detection is through an adjustable integrating photodetector. Such a handheld system can allow applications requiring temperature sensitive photometric measurements for real time analyte detection to be performed in the field.
摘要翻译：本发明提供了便携式，低成本，基于热调节的基于LED的手持式荧光计所需的核心技术。调节荧光计是基于低热量红外加热器和基于正交几何LED的滤光片。通过外部电源提供电源，并通过个人电脑或个人数字助理的标准串行接口实时收集数据。使用温度传感器反馈控制自动保持热调节。光学激发依赖于LED光源，光学检测是通过可调整的积分光电检测器。这样的手持系统可以允许在现场执行需要温度敏感测光测量的实时实时分析物检测的应用。

22. 发明授权

US11877563B2 Biomimetic sentinel reef structures for optical sensing and communications 有权
公开(公告)号：US11877563B2
公开(公告)日：2024-01-23
申请号：US17134759
申请日：2020-12-28
申请人： David Fries , Tim Hutcheson , David Millie , Connor Tate , Noam Josef
发明人： David Fries , Tim Hutcheson , David Millie , Connor Tate , Noam Josef
IPC分类号： E02B17/00 , A01K61/73 , A01K61/78
CPC分类号： A01K61/73 , A01K61/78
摘要： An artificial reef structure including thin tensile members as part of the structure. These tensile members readily accumulate marine life to create a more organic structure. The reef structure can accommodate a wide variety of ocean sensing and communication systems. Embedded lighting and electronic elements can be used to attract and monitor marine life.

23. 发明申请

US20210112786A1 Biomimetic Sentinel Reef Structures for Optical Sensing and Communications 有权
公开(公告)号：US20210112786A1
公开(公告)日：2021-04-22
申请号：US17134759
申请日：2020-12-28
申请人： David Fries , Tim Hutcheson , David Millie , Connor Tate , Noam Josef
发明人： David Fries , Tim Hutcheson , David Millie , Connor Tate , Noam Josef
IPC分类号： A01K61/73 , A01K61/78
摘要： An artificial reef structure including thin tensile members as part of the structure. These tensile members readily accumulate marine life to create a more organic structure. The reef structure can accommodate a wide variety of ocean sensing and communication systems. Embedded lighting and electronic elements can be used to attract and monitor marine life.

24. 发明申请

US20170022540A1 BIOINK FOR THREE-DIMENSIONAL BIOMATERIAL PRINTING 审中-公开
标题翻译： BIOINK三维生物纸印刷
公开(公告)号：US20170022540A1
公开(公告)日：2017-01-26
申请号：US15218199
申请日：2016-07-25
申请人： David Fries
发明人： David Fries
IPC分类号： C12Q1/68 , C12N9/96 , C09D201/00 , C09D11/02 , C09D189/00 , C12N5/00 , C09D11/04
CPC分类号： C09D201/00 , C09D11/04 , C09D11/14 , C09D189/00 , C12N9/96
摘要： A method of creating “bioink” has been proposed, which increases the shelf-life and transportability of biological materials for use in bioprinting applications. The current invention also contemplates a composition of biomaterials admixed with trehalose to dehydrate the biomaterials for preservation and transportation. The dehydrated biomaterials can then be rehydrated for use in bioprinting.
摘要翻译：已经提出了一种创建“bioink”的方法，其增加了用于生物印刷应用的生物材料的保质期和可运输性。本发明还考虑了与海藻糖混合的生物材料的组合物以使生物材料脱水以进行保存和运输。然后可以将脱水的生物材料再水合用于生物印刷。

25. 发明授权

US07923072B2 Silver crystals through Tollen's reaction 有权
标题翻译：银晶体通过Tollen的反应
公开(公告)号：US07923072B2
公开(公告)日：2011-04-12
申请号：US10905658
申请日：2005-01-14
申请人： Xiaoling Ding , David Fries
发明人： Xiaoling Ding , David Fries
IPC分类号： B05D3/02
CPC分类号： C30B29/10 , B22F9/24 , B22F2001/0037 , C22B11/04 , C23C26/00 , C30B7/00
摘要： A method for the formation of regular-shaped silver crystals through a wet chemical reaction (Tollen's reaction) is presented. The growth of the Ag crystals (size, morphology and aggregation) can be controlled via adjusting reaction conditions such as temperature and reducing agent concentrations before and during the reactions. The smaller Ag crystals (50-200 nm) were generated under the condition of limited reductive reagent (glucose), and the larger sliver crystals (˜5 μm) were the aggregated silver nano-particles (100-200 nm) produced at higher reducing agent concentrations. Most of the larger crystals were in the shape of cube or rectangular cube, and rarely, they were in clusters. The smaller crystals (aggregation of Ag atoms) were shaped in cube or/and cone, and both single crystals and clusters were formed. The presence of impurity (TiO2 nano-particles, 25-50 nm) as crystal seeds enables the 3-D growth of large, irregular-shaped Ag clusters (˜5 μm).
摘要翻译：提出了通过湿化学反应（Tollen's反应）形成规则形状的银晶的方法。 Ag晶体的生长（尺寸，形态和聚集）可以通过在反应之前和期间调节反应条件如温度和还原剂浓度来控制。在有限的还原剂（葡萄糖）的条件下产生较小的Ag晶体（50-200nm），较大的银晶体（〜5μm）是较高还原时产生的聚集的银纳米颗粒（100-200nm）药剂浓度。大多数较大的晶体呈立方体或矩形立方体的形状，很少是簇状。较小的晶体（Ag原子的聚集）以立方体或/或锥形成形，并且形成单晶和簇。作为晶体种子的杂质（TiO 2纳米颗粒，25-50nm）的存在使得能够形成大的不规则形状的Ag簇（〜5μm）的3-D生长。

26. 发明申请

US20070098596A1 Handheld microarray reader 审中-公开
标题翻译：手持式微阵列阅读器
公开(公告)号：US20070098596A1
公开(公告)日：2007-05-03
申请号：US11549431
申请日：2006-10-13
申请人： David Fries , Matthew Smith
发明人： David Fries , Matthew Smith
IPC分类号： G01N21/00
CPC分类号： G01N21/6452 , G01N21/6428 , G01N21/76 , G01N2201/0221
摘要： A portable, handheld micro-chip array reader capable of responding to selected test species in a field environment. The device incorporates the use of luminescence and/or chemical species in the environment. The solution to the problem of field analysis of trace species is a handheld macro- or micro-array chip-based reader device, which can detect and image small amounts of fluorescence or luminescence emitted from the array chips. The device utilizes night vision technology to effect trace detection of light emanating from array chips (nucleotide or protein. The chips may consist of immobilized capture molecules (oligonucleotides or proteins) which facilitate the binding of a target analyte, or, by using individual, spatially separated wells that enable spatially separated amplification or hybridization to occur in any combination of immobilized or aqueous reaction. The night vision technology is able to detect interaction of the target analyte with the capture molecule via the use of a light emitting (fluorescent or luminescent) label or by photon emitting chemical reaction. Both qualitative and quantitative analyses are within the scope of the invention.
摘要翻译：便携式手持式微芯片阵列读取器，能够在现场环境中对选定的测试物种进行响应。该装置在环境中使用发光和/或化学物质。对于微量物质的现场分析问题的解决方案是基于手持式的基于微阵列的芯片读取器装置，可以检测和成像从阵列芯片发射的少量荧光或发光。该设备利用夜视技术来实现从阵列芯片（核苷酸或蛋白质）发出的光的痕量检测。芯片可以由有助于靶分析物结合的固定化捕获分子（寡核苷酸或蛋白质）组成，或者通过使用个体在空间上分离的孔能够在空间上分离的扩增或杂交发生在固定化或含水反应的任何组合中。夜视技术能够通过使用发光（荧光或发光）标记来检测目标分析物与捕获分子的相互作用或通过光子发射化学反应，定性和定量分析都在本发明的范围内。

27. 发明申请

US20070052962A1 Variable Exposure Rotary Spectrometer and Method of Use 有权
标题翻译：可变曝光旋转光谱仪及其使用方法
公开(公告)号：US20070052962A1
公开(公告)日：2007-03-08
申请号：US11555417
申请日：2006-11-01
申请人： Eric Kaltenbacher , Robert Byrne , David Fries
发明人： Eric Kaltenbacher , Robert Byrne , David Fries
IPC分类号： G01N21/51
CPC分类号： G01J3/51 , G01J3/0235 , G01J3/32
摘要： The present invention relates to instruments used to analyze materials with light-absorbing properties and their methods of use. More specifically, the invention relates to the use of adjustable optical filters whereby light-absorption can be measured in more detail and with greater variables than what is currently known in the art.
摘要翻译：本发明涉及用于分析具有光吸收特性的材料及其使用方法的仪器。更具体地说，本发明涉及可调式光学滤光器的使用，其中光吸收可以比现有技术中已知的更详细和更大的变量来测量。

28. 发明申请

US20070018652A1 Micro sensor system for liquid conductivity, temperature and depth 失效
公开(公告)号：US20070018652A1
公开(公告)日：2007-01-25
申请号：US11358430
申请日：2006-02-21
申请人： Heather Broadbent , David Fries , George Steimle , Stanislav Ivanov
发明人： Heather Broadbent , David Fries , George Steimle , Stanislav Ivanov
IPC分类号： G01N27/02
CPC分类号： G01N27/12
摘要： In accordance with the present invention is a miniature planar oceanographic conductivity, temperature pressure (CTD) system based on a thin film material fabricated on a Liquid Crystalline Polymer (LCP). The micro-CTD system in accordance with the present invention analyzes water for salinity by measuring conductivity, temperature and depth.

29. 发明申请

US20060216654A1 Method for Etching Microchannel Networks within Liquid Crystal Polymer Substrates 有权
标题翻译：在液晶聚合物基板中蚀刻微通道网络的方法
公开(公告)号：US20060216654A1
公开(公告)日：2006-09-28
申请号：US11160613
申请日：2005-06-30
申请人： David Fries , George Steimle , Heather Broadbent
发明人： David Fries , George Steimle , Heather Broadbent
IPC分类号： G03F7/20
CPC分类号： B81B1/00 , B01L3/5027 , B81B2203/0323 , B81C1/00071 , G02B6/136 , H05K3/002 , H05K3/107 , H05K2201/0141 , H05K2201/09036 , H05K2203/0554
摘要： The present invention provides for a method for the fabrication of microchannels, and more particularly to the fabrication of microchannels for use in Microelectromechanical (MEMS) devices and MEMS related devices. In accordance with an embodiment of the present invention, microchannels are formed by a microfabrication method utilizing electronic imaging techniques in combination with chemical etching and subsequent metallization. The method of the present invention is effective in producing networks of channels in liquid crystal polymer (LCP) polymeric substrates which are highly defined in terms of their patterns, and thus are able to encompass a wide variety of end uses.
摘要翻译：本发明提供了用于制造微通道的方法，更具体地说，涉及用于微机电（MEMS）器件和MEMS相关器件的微通道的制造。根据本发明的实施例，通过利用电子成像技术与化学蚀刻和随后的金属化组合的微细加工方法形成微通道。本发明的方法在生产液晶聚合物（LCP）聚合物基质中的通道网络方面是有效的，其在其图案方面被高度限定，因此能够涵盖各种各样的最终用途。

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