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21. 发明申请

US20100137277A1 PYRIDINE COMPOUNDS AND THEIR USE AS P2Y12 ANTAGONISTS 审中-公开
标题翻译：吡啶化合物及其作为P2Y12拮抗剂使用
公开(公告)号：US20100137277A1
公开(公告)日：2010-06-03
申请号：US12522724
申请日：2008-01-11
申请人： Thomas Antonsson , Peter Bach , David Brown , Ruth Bylund , Fabrizio Giordanetto , Johan Johansson
发明人： Thomas Antonsson , Peter Bach , David Brown , Ruth Bylund , Fabrizio Giordanetto , Johan Johansson
IPC分类号： A61K31/397 , C07D401/04 , A61K31/4545 , A61P7/02 , A61K31/4439
CPC分类号： C07D401/04 , C07D413/14
摘要： The present invention relates to certain new pyridin analogues of Formula (I) to processes for preparing such compounds, to their utility as P2Y12 inhibitors and as anti-trombotic agents etc, their use as medicaments in cardiovascular diseases as well as pharmaceutical compositions containing them.
摘要翻译：本发明涉及式（I）的某些新的吡啶类似物，用于制备这些化合物的方法，其作为P2Y12抑制剂和抗血栓形成剂的用途，其作为心血管疾病中的药物的用途以及含有它们的药物组合物。

22. 发明授权

US07716398B2 Bifurcate buffer 有权
标题翻译：分叉缓冲液
公开(公告)号：US07716398B2
公开(公告)日：2010-05-11
申请号：US12004500
申请日：2007-12-20
申请人： David Brown
发明人： David Brown
IPC分类号： G06F3/00 , G11C7/10
CPC分类号： H04J3/047
摘要： A buffer includes a plurality of serial inputs, a plurality of de-serializers, each coupled to a respective input, a plurality n of buffers and a media access controller having inputs coupled to the plurality of de-serializers, data outputs coupled to the buffers, and two control outputs coupled to respective buffers for buffering input data at a clock rate one-nth that of the input data. Preferably the buffer is a bifurcate buffer. In operation, serial packets are received on a port. They must be converted to parallel data for processing by conventional CMOS logic, however there are limits serial to parallel conversion ratio. This buffer describe circumvents theses limits.
摘要翻译：缓冲器包括多个串行输入，多个解串器，每个耦合到相应的输入，多个n个缓冲器以及具有耦合到多个解串器的输入的媒体访问控制器，耦合到缓冲器的数据输出以及耦合到相应缓冲器的两个控制输出，用于以输入数据的输入数据的1/0的时钟速率缓冲输入数据。优选地，缓冲液是分叉缓冲液。在操作中，端口上接收到串行数据包。它们必须转换为并行数据，以便通过常规CMOS逻辑进行处理，但串行到并行转换比率有限制。这个缓冲区描述了这些限制。

23. 发明授权

US07714721B1 Anti-theft ring tag 失效
标题翻译：防盗环标签
公开(公告)号：US07714721B1
公开(公告)日：2010-05-11
申请号：US12014287
申请日：2008-01-15
申请人： Jeffrey Feibelman , David Brown
发明人： Jeffrey Feibelman , David Brown
IPC分类号： G08B13/14
CPC分类号： G09F3/14 , G08B13/2434 , G09F3/0329 , G09F3/0335
摘要： An anti-theft tag deterring theft of a ring is provided. The anti-theft tag includes an elongated housing for accommodating an EAS marker, a product support member that locks into the housing and which supports the ring, and a flexible, tear resistant strap for securing the ring to the support member, the strap being disposed at least partially within the housing during use. In one embodiment, the support member includes an arcuate seat portion for supporting a circular shank portion of the ring, and a locking member that locks into a corresponding cavity in the housing. In use, the tear resistant strap extends over the ring shank, and the strap ends are received within the cavity of the housing to protect the strap from unauthorized removal by a consumer.
摘要翻译：提供防盗环的防盗标签。防盗标签包括用于容纳EAS标记的细长壳体，锁定到壳体中并且支撑环的产品支撑构件以及用于将环固定到支撑构件的柔性防撕裂带，所述带被设置在使用期间至少部分地在壳体内。在一个实施例中，支撑构件包括用于支撑环的圆形柄部分的弓形座部分，以及锁定在壳体中的对应空腔中的锁定构件。在使用中，防撕裂带延伸到环形柄上，并且带端部容纳在壳体的空腔内，以保护带免遭消费者的非法移除。

24. 发明申请

US20100071446A1 SOLUTE CONCENTRATION MEASUREMENT DEVICE AND RELATED METHODS 有权
标题翻译：溶解浓度测量装置及相关方法
公开(公告)号：US20100071446A1
公开(公告)日：2010-03-25
申请号：US12563046
申请日：2009-09-18
申请人： David Brown
发明人： David Brown
IPC分类号： G01N13/04 , G01N1/10
CPC分类号： G01N13/04 , G01N1/4055 , G01N2001/4061
摘要： A solute concentration measurement device is disclosed. The device may comprise a filter membrane, an exchange chamber, a sensing chamber, a separator, and a sensor. The device may be configured to be placed in fluid communication with a sample solution containing a solute and a solvent. The filter membrane may provide selective fluid communication between the solution and the exchange chamber. The separator may separate the exchange chamber from the sensing chamber and cause a change in a condition of the sensing chamber corresponding to a change of a condition of the exchange chamber. The sensor may sense the condition pertaining to the sensing chamber and calculate the concentration of the sample solution corresponding to this change.
摘要翻译：公开了一种溶质浓度测定装置。该装置可以包括过滤膜，交换室，感测室，分离器和传感器。该装置可以被配置为与含有溶质和溶剂的样品溶液流体连通。过滤膜可以在溶液和交换室之间提供选择性的流体连通。分离器可以将交换室与感测室分开，并且使得感应室的状态改变对应于交换室的状态的改变。传感器可以感测与感测室相关的状态，并计算与该变化相对应的样品溶液的浓度。

25. 发明申请

US20080026951A1 Methods and Compositions Involving microRNA 有权
标题翻译：涉及微小RNA的方法和组成
公开(公告)号：US20080026951A1
公开(公告)日：2008-01-31
申请号：US11837495
申请日：2007-08-11
申请人： David Brown , Rick Conrad , Eric Devroe , Marianna Goldrick , Kerri Keiger , Emmanuel Labourier , Ivonne Moon , Patricia Powers , Jeffrey Shelton , Jaclyn Shingara
发明人： David Brown , Rick Conrad , Eric Devroe , Marianna Goldrick , Kerri Keiger , Emmanuel Labourier , Ivonne Moon , Patricia Powers , Jeffrey Shelton , Jaclyn Shingara
IPC分类号： C40B30/04
CPC分类号： C12Q1/6806 , C12N15/111 , C12N2310/14 , C12N2310/3517 , C12N2310/3519 , C12N2320/10 , C12P19/34 , C12Q1/6809 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178 , C12Q2565/501 , C12Q2525/207
摘要： The present invention concerns methods and compositions for isolating, enriching, and/or labeling miRNA molecules and for preparing and using arrays or other detection techniques for miRNA analysis. Moreover, the present invention concerns methods and compositions for generating miRNA profiles and employing such profiles for therapeutic, diagnostic, and prognostic applications.
摘要翻译：本发明涉及用于分离，富集和/或标记miRNA分子以及制备和使用阵列或其他用于miRNA分析的检测技术的方法和组合物。此外，本发明涉及用于产生miRNA谱并用于治疗，诊断和预后应用的这种分布的方法和组合物。

26. 发明申请

US20070299263A1 Hydroxy Alkyl Amines 审中-公开
标题翻译：羟基烷基胺
公开(公告)号：US20070299263A1
公开(公告)日：2007-12-27
申请号：US11567616
申请日：2006-12-06
申请人： John Freskos , David Brown , Yvette Fobian , Larry Fang , Arthur Romero , Varghese John
发明人： John Freskos , David Brown , Yvette Fobian , Larry Fang , Arthur Romero , Varghese John
IPC分类号： C07D233/22 , C07C215/00 , C07C229/28 , C07D319/06 , C07C235/02 , C07D211/80
CPC分类号： C07D207/26 , C07C317/46 , C07C317/48 , C07C317/50 , C07C323/60 , C07C327/32 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D207/12 , C07D207/28 , C07D209/08 , C07D211/46 , C07D211/96 , C07D213/30 , C07D213/81 , C07D213/82 , C07D231/12 , C07D231/14 , C07D233/56 , C07D233/64 , C07D233/74 , C07D233/90 , C07D237/04 , C07D241/24 , C07D249/08 , C07D261/18 , C07D277/36 , C07D277/56 , C07D295/185 , C07D307/20 , C07D309/12 , C07D317/30 , C07D319/06 , C07D333/32 , C07D333/34 , C07D333/48
摘要： Disclosed are compounds of formula X, which are useful in treating Alzheimer's disease and other similar diseases. Pharmaceutical compositions comprising compounds of formula X and methods of preparing the compounds of formula X are also disclosed.
摘要翻译：公开了式X的化合物，其可用于治疗阿尔茨海默病和其他类似疾病。还公开了包含式X化合物的药物组合物和制备式X化合物的方法。

27. 发明授权

US07287002B1 System for placing product delivery orders through the internet 有权
标题翻译：通过互联网放置产品交货订单的系统
公开(公告)号：US07287002B1
公开(公告)日：2007-10-23
申请号：US09507578
申请日：2000-02-18
申请人： Marc Asher , David Brown
发明人： Marc Asher , David Brown
IPC分类号： G06Q30/00
CPC分类号： G06Q10/08 , G06Q30/06 , G06Q30/0633
摘要： A method is disclosed by which a customer places an order for the provision of a service with one of one or more vendors that utilize electronic ordering terminals to process service orders, by transmitting information between the customer's computer and a server. The disclosed method comprising the steps of associating with each vendor a plurality of coordinate points defining the vertices of a polygonal geographic region within which region the vendor provides service, receiving information from a customer indicating the location to which service is to be provided; converting the received information into a coordinate point indicating the point to which service is to be provided; selecting each of the defined polygonal geographic regions that encompass the customer coordinate point; identifying the vendors associated with the selected polygonal geographic regions; choosing the vendor with which the order is to be placed, and placing an order with the chosen vendor.
摘要翻译：公开了一种方法，通过该方法，客户通过在客户的计算机和服务器之间传送信息，向使用电子订购终端的一个或多个供应商之一提供服务的订单进行处理服务订单。所公开的方法包括以下步骤：与每个供应商相关联地定义供应商提供服务的区域内的多边形地理区域的顶点的多个坐标点;从客户接收指示要提供服务的位置的信息; 将接收到的信息转换成指示要提供服务的点的坐标点; 选择包含客户坐标点的定义的多边形地理区域中的每一个; 识别与所选择的多边形地理区域相关联的供应商; 选择要放置订单的供应商，并与选定的供应商下订单。

28. 发明申请

US20070245158A1 SINGLE STEP TRANSACTION AUTHENTICATION USING PROXIMITY AND BIOMETRIC INPUT 有权
标题翻译：使用接近和生物量输入的单步交易验证
公开(公告)号：US20070245158A1
公开(公告)日：2007-10-18
申请号：US11745249
申请日：2007-05-07
申请人： John Giobbi , David Brown , Fred Hirt
发明人： John Giobbi , David Brown , Fred Hirt
IPC分类号： H04L9/32
CPC分类号： H04L63/0861 , G06F21/31 , G06F21/32 , G06F21/34 , G06F2221/2115 , H04W12/06
摘要： A system and method provide efficient, secure and highly reliable authentication for transaction processing and/or access control applications in which only biometric input is required from the user. A Personal Digital Key stores a biometric profile that comprises a representation of physical or behavioral characteristics that are uniquely associated with an individual that owns and carries the PDK. The PDK wirelessly transmits the biometric profile over a secure wireless transaction to a Reader for use in a biometric authentication process. The Reader compares the received biometric profile to a biometric input acquired at the point of transaction in order to determine if the transaction should be authorized.
摘要翻译：一种系统和方法为事务处理和/或访问控制应用提供了有效，安全和高度可靠的认证，其中仅需要用户的生物特征输入。个人数字密钥存储生物特征，其包括与拥有并携带PDK的个体唯一相关联的物理或行为特征的表示。 PDK通过安全无线事务无线地将生物特征分发到读取器以用于生物特征认证过程。读者将接收到的生物特征图与在交易点获取的生物特征输入进行比较，以确定交易是否应被授权。

29. 发明申请

US20070223095A1 Optical device, system and method 审中-公开
标题翻译：光学装置，系统及方法
公开(公告)号：US20070223095A1
公开(公告)日：2007-09-27
申请号：US11305325
申请日：2005-12-19
申请人： David Brown
发明人： David Brown
IPC分类号： G02B27/46
CPC分类号： G02B27/0927 , G02B5/00 , G02B5/045 , G02B27/09 , G02B27/0961 , G02B27/0972 , Y10S359/90
摘要： Methods and systems are disclosed related to optical elements. An apparatus for making an optical device can be configured to divide an angular pattern into a plurality of sub-angular regions. Then, micro-wedge configurations can be determined for directing light to the sub-angular regions. Subsequently, an array of micro-wedges can be generated according to the micro-wedge configurations, such that adjacent micro-wedges in the array have different configurations.
摘要翻译：公开了与光学元件有关的方法和系统。用于制造光学装置的装置可以被配置为将角度图案分成多个子角区域。然后，可以确定微楔形结构以将光引导到亚角度区域。随后，可以根据微楔形构造产生微楔形阵列，使得阵列中的相邻微楔形件具有不同的构造。

30. 发明申请

US20070177215A1 Text rendering contrast 审中-公开
标题翻译：文字呈现对比
公开(公告)号：US20070177215A1
公开(公告)日：2007-08-02
申请号：US11345016
申请日：2006-02-01
申请人： Mikhail Lyapunov , Christopher Han , David Brown , Jason Hartman , Michael Duggan , Mikhail Leonov
发明人： Mikhail Lyapunov , Christopher Han , David Brown , Jason Hartman , Michael Duggan , Mikhail Leonov
IPC分类号： G06F15/00
CPC分类号： G09G5/227
摘要： Various technologies and techniques are disclosed that improve text rendering contrast. The shape of one or more characters is converted from an original format, such as a vector format received from a font, to an overscaled bitmap format. The width of the shape of the character is adjusted based on a text contrast setting. For example, the width of the shape can be adjusted by extending a right or other edge of the shape by the number of pixels corresponding to the numerical value of the text contrast setting. The shape is made wider or thinner based on the text contrast setting. A filtering procedure is used to determine density values for how the shape corresponds to a set of screen pixels. The density values are blended with color values related to the display device to form a modified shape ready for output. The modified shape is then displayed.
摘要翻译：公开了改善文本呈现对比度的各种技术和技术。一个或多个字符的形状从原始格式（例如从字体接收的向量格式）转换为过大的位图格式。基于文本对比度设置调整字符的形状宽度。例如，可以通过将形状的右边缘或其他边缘延伸与对应于文本对比度设置的数值的像素数量来调节形状的宽度。基于文本对比度设置，形状变得更宽或更薄。滤波过程用于确定形状对应于一组屏幕像素的密度值。将浓度值与与显示装置相关的颜色值混合以形成准备输出的修改形状。然后显示修改后的形状。

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