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1. 发明申请

US20070260883A1 PERSONAL DIGITAL KEY DIFFERENTIATION FOR SECURE TRANSACTIONS 有权
标题翻译：个人数字关键安全交易的主要差异
公开(公告)号：US20070260883A1
公开(公告)日：2007-11-08
申请号：US11744833
申请日：2007-05-05
申请人： John Giobbi , David Brown , Fred Hirt
发明人： John Giobbi , David Brown , Fred Hirt
IPC分类号： H04L9/00 , H04K1/00
CPC分类号： G06Q20/341 , G06Q20/40145 , G07C9/00087 , G07C2209/12 , G07F7/1008
摘要： A system and method provide efficient, secure, and highly reliable authentication for transaction processing and/or access control applications. A Personal Digital Key is a portable device carried by an individual that stores one or more profiles (e.g., a biometric profile) in a tamper-proof memory. When multiple PDKs are present at the point of the transaction, the system automatically determines which PDK to associate with the authentication and transaction processes. The differentiation decision is based on one or more differentiation metrics including distance information, location information, and detection duration information associated with each of the PDKs within range. Profile samples comprising subsets of the profile information are received to provide a quick correlation between a PDK an input sample (e.g., a subset of a biometric input). After determining which PDK should be associated with the transaction, a full authentication process is executed.
摘要翻译：系统和方法为交易处理和/或访问控制应用提供高效，安全和高度可靠的认证。个人数字密钥是由个人承载的便携式设备，其在防篡改存储器中存储一个或多个简档（例如，生物特征）。当交易点存在多个PDK时，系统会自动确定哪个PDK与认证和事务处理相关联。差分决定基于包括距离信息，位置信息和与范围内的每个PDK相关联的检测持续时间信息的一个或多个差异度量。接收包含简档信息子集的简档样本以提供PDK输入样本（例如生物特征输入的子集）之间的快速相关性。在确定哪个PDK应该与事务相关联之后，执行完整的认证过程。

2. 发明申请

US20070245158A1 SINGLE STEP TRANSACTION AUTHENTICATION USING PROXIMITY AND BIOMETRIC INPUT 有权
标题翻译：使用接近和生物量输入的单步交易验证
公开(公告)号：US20070245158A1
公开(公告)日：2007-10-18
申请号：US11745249
申请日：2007-05-07
申请人： John Giobbi , David Brown , Fred Hirt
发明人： John Giobbi , David Brown , Fred Hirt
IPC分类号： H04L9/32
CPC分类号： H04L63/0861 , G06F21/31 , G06F21/32 , G06F21/34 , G06F2221/2115 , H04W12/06
摘要： A system and method provide efficient, secure and highly reliable authentication for transaction processing and/or access control applications in which only biometric input is required from the user. A Personal Digital Key stores a biometric profile that comprises a representation of physical or behavioral characteristics that are uniquely associated with an individual that owns and carries the PDK. The PDK wirelessly transmits the biometric profile over a secure wireless transaction to a Reader for use in a biometric authentication process. The Reader compares the received biometric profile to a biometric input acquired at the point of transaction in order to determine if the transaction should be authorized.
摘要翻译：一种系统和方法为事务处理和/或访问控制应用提供了有效，安全和高度可靠的认证，其中仅需要用户的生物特征输入。个人数字密钥存储生物特征，其包括与拥有并携带PDK的个体唯一相关联的物理或行为特征的表示。 PDK通过安全无线事务无线地将生物特征分发到读取器以用于生物特征认证过程。读者将接收到的生物特征图与在交易点获取的生物特征输入进行比较，以确定交易是否应被授权。

3. 发明申请

US20070260888A1 PERSONAL DIGITAL KEY INITIALIZATION AND REGISTRATION FOR SECURE TRANSACTIONS 有权
标题翻译：个人数字关键初始化和安全交易登记
公开(公告)号：US20070260888A1
公开(公告)日：2007-11-08
申请号：US11744832
申请日：2007-05-05
申请人： John Giobbi , David Brown , Fred Hirt
发明人： John Giobbi , David Brown , Fred Hirt
IPC分类号： H04L9/00
CPC分类号： G06F21/31 , G06F21/32 , G06F21/34 , G07C9/00087 , H04L9/3231 , H04L63/0861 , H04L2209/56 , H04L2209/80
摘要： A system and method provide efficient, secure, and highly reliable authentication for transaction processing and/or access control applications. A personal digital key (PDK) is programmed using a trusted programming device to initialize and/or register the PDK for use. In one embodiment, the initialization and registration processes are administered by a specialized trusted Notary to ensure the processes follow defined security procedures. In a biometric initialization, the programming device acquires a biometric input from a user and writes the biometric data to a tamperproof memory in the PDK. In registration, the Programmer communicates to one or more remote registries to create or update entries associated with the user PDK. Once initialized and registered, the PDK can be used for various levels of secure authentication processes.
摘要翻译：系统和方法为交易处理和/或访问控制应用提供高效，安全和高度可靠的认证。使用可信编程设备对个人数字键（PDK）进行编程，以初始化和/或注册PDK以供使用。在一个实施例中，初始化和注册过程由专门的可信公证人管理，以确保过程遵循定义的安全程序。在生物识别初始化中，编程设备从用户获取生物特征输入，并将生物特征数据写入PDK中的防篡改存储器。在注册中，程序员与一个或多个远程注册表通信以创建或更新与用户PDK相关联的条目。一旦初始化和注册，PDK可以用于各种级别的安全认证过程。

4. 发明申请

US20070245157A1 Two-Level Authentication For Secure Transactions 有权
标题翻译：用于安全事务的两级认证
公开(公告)号：US20070245157A1
公开(公告)日：2007-10-18
申请号：US11744831
申请日：2007-05-05
申请人： John Giobbi , David Brown , Fred Hirt
发明人： John Giobbi , David Brown , Fred Hirt
IPC分类号： H04L9/00
CPC分类号： G06Q20/40145 , G06F21/31 , G06F21/32 , G06F21/34 , G06Q20/341 , G06Q20/4014 , G07C9/00087 , G07C2009/00095 , G07F7/1008 , H04L63/0861 , H04W12/06
摘要： A system and method provide efficient, secure, and highly reliable authentication for transaction processing and/or access control applications. A Personal Digital Key stores one or more profiles (e.g., a biometric profile) in a tamper-proof memory that is acquired in a secure trusted process. Biometric profiles comprise a representation of physical or behavioral characteristics that are uniquely associated with an individual that owns and carries the PDK. The PDK wirelessly transmits the biometric profile over a secure wireless transaction to a Reader for use in a biometric authentication process. The Reader compares the received biometric profile to a biometric input acquired at the point of transaction in order to determine if the transaction should be authorized.
摘要翻译：系统和方法为交易处理和/或访问控制应用提供高效，安全和高度可靠的认证。个人数字密钥将一个或多个简档（例如，生物特征简档）存储在在安全可信过程中获取的防篡改存储器中。生物特征描述包括与拥有和携带PDK的个人唯一相关联的物理或行为特征的表示。 PDK通过安全无线事务无线地将生物特征分发到读取器以用于生物特征认证过程。读者将接收到的生物特征图与在交易点获取的生物特征输入进行比较，以确定交易是否应被授权。

5. 发明申请

US20070159301A1 DYNAMIC CELL SIZE VARIATION VIA WIRELESS LINK PARAMETER ADJUSTMENT 有权
标题翻译：动态细胞尺寸变化通过无线链路参数调整
公开(公告)号：US20070159301A1
公开(公告)日：2007-07-12
申请号：US11620600
申请日：2007-01-05
申请人： Fred Hirt , David Brown
发明人： Fred Hirt , David Brown
IPC分类号： H04Q5/22
CPC分类号： H04W72/0446 , H04W4/06 , H04W8/005 , H04W12/02 , H04W12/06 , H04W12/08 , H04W24/00 , H04W48/08 , H04W52/0216 , H04W52/50 , H04W56/00 , Y02D70/144 , Y02D70/22 , Y02D70/26
摘要： In a wireless network, a cell's transmission power and reception sensitivity may be dynamically adjusted along with those of a client device detected in the cell. Thus, in other words, when a client device is in proximity of a particular reader device, the transmission power levels and reception sensitivities of the reader device and the client device may be adjusted in an effort to require the client device to be “drawn in” towards the reader device to conduct a data transaction between the reader device and the client device.
摘要翻译：在无线网络中，小区的发射功率和接收灵敏度可以与在小区中检测到的客户端设备的发射功率和接收灵敏度一起动态调整。因此，换句话说，当客户端设备处于特定的读取器设备附近时，可以调整读取器设备和客户端设备的发送功率电平和接收灵敏度，以便要求客户端设备被“ “朝向读取器设备在读取器设备和客户端设备之间进行数据交易。

6. 发明申请

US20070207750A1 Integrated Power Management of a Client Device Via System Time Slot Assignment 有权
标题翻译：通过系统时隙分配对客户端设备进行集成电源管理
公开(公告)号：US20070207750A1
公开(公告)日：2007-09-06
申请号：US11620603
申请日：2007-01-05
申请人： David Brown , Fred Hirt
发明人： David Brown , Fred Hirt
IPC分类号： H01Q11/12
CPC分类号： H04W72/0446 , H04W4/06 , H04W8/005 , H04W12/02 , H04W12/06 , H04W12/08 , H04W24/00 , H04W48/08 , H04W52/0216 , H04W52/50 , H04W56/00 , Y02D70/144 , Y02D70/22 , Y02D70/26
摘要： In a wireless network, time slots may be configured in a manner such that the network directs portable wireless client devices to listen and respond within specific time slots. Because the time slots can be predicted or are known, one of the client devices may be configured to set a timer, enter a sleep mode, and then later awaken when a specific, time-slotted data interaction is required of the client device. Accordingly, battery power that would otherwise be consumed if the client device were active outside of the time slot may be saved.
摘要翻译：在无线网络中，可以以这样的方式配置时隙，使得网络指示便携式无线客户端设备在特定时隙内收听和响应。由于可以预测或已知时隙，所以客户端设备之一可以被配置为设置定时器，进入休眠模式，然后在客户端设备需要特定的时隙数据交互时随后唤醒。因此，如果客户端设备在时隙之外活动，否则将消耗电池电量。

7. 发明申请

US20070174809A1 Dynamic Real-Time Tiered Client Access 有权
标题翻译：动态实时分层客户端访问
公开(公告)号：US20070174809A1
公开(公告)日：2007-07-26
申请号：US11620577
申请日：2007-01-05
申请人： David Brown , Fred Hirt
发明人： David Brown , Fred Hirt
IPC分类号： G06F9/44
CPC分类号： H04W72/0446 , H04W4/06 , H04W8/005 , H04W12/02 , H04W12/06 , H04W12/08 , H04W24/00 , H04W48/08 , H04W52/0216 , H04W52/50 , H04W56/00 , Y02D70/144 , Y02D70/22 , Y02D70/26
摘要： Wireless client devices within a wireless network exchange data with other wireless devices during particular time slots determined by the network. More particularly, the system generates and wirelessly broadcasts synchronization information to the client devices, where the synchronization information contains individual masks to be applied to bit fields of individual client devices, where said time slots are determined in accordance with the masked bit fields. In such a manner, client devices can be coordinated to communicate with the system in a dynamic real-time tiered manner.
摘要翻译：在由网络确定的特定时隙期间，无线网络内的无线客户端设备与其他无线设备交换数据。更具体地，系统生成并向客户端设备无线地广播同步信息，其中同步信息包含要应用于单个客户端设备的位域的单独掩码，其中根据掩码比特字段来确定所述时隙。以这种方式，可以协调客户端设备以动态实时分层方式与系统通信。

8. 发明申请

US20070159994A1 Wireless Network Synchronization Of Cells And Client Devices On A Network 有权
标题翻译：网络上的单元和客户端设备的无线网络同步
公开(公告)号：US20070159994A1
公开(公告)日：2007-07-12
申请号：US11620581
申请日：2007-01-05
申请人： David Brown , Fred Hirt
发明人： David Brown , Fred Hirt
IPC分类号： H04B7/212
CPC分类号： H04W72/0446 , H04W4/06 , H04W8/005 , H04W12/02 , H04W12/06 , H04W12/08 , H04W24/00 , H04W48/08 , H04W52/0216 , H04W52/50 , H04W56/00 , Y02D70/144 , Y02D70/22 , Y02D70/26
摘要： A wireless synchronization device is used to coordinate the timing and activities of individual, possibly physically separated, wireless service providers with defined coverage area. Further, the synchronization information is used to coordinate the timing and activities of portable wireless client devices in an autonomous, wireless proximity sensing and data transfer network. Moreover, one or more of the wireless service providers can be arranged to simultaneously monitor broadcasts from the wireless synchronization device and communicate with one or more of the portable wireless client devices.
摘要翻译：无线同步设备用于协调具有定义的覆盖区域的个体的，可能物理上分离的无线服务提供商的定时和活动。此外，同步信息用于协调自主，无线接近感测和数据传输网络中的便携式无线客户端设备的定时和活动。此外，一个或多个无线服务提供商可以被布置为同时监视来自无线同步设备的广播并与一个或多个便携式无线客户端设备进行通信。

9. 发明申请

US20070249615A1 Pyridine [3,4-b] Pyrazinones 有权
标题翻译：吡啶[3,4-b]吡嗪酮
公开(公告)号：US20070249615A1
公开(公告)日：2007-10-25
申请号：US11737966
申请日：2007-04-20
申请人： Robert Hughes , Andrew Bell , David Brown , Dafydd Owen , Michael Palmer , Christopher Phillips , David Brown , Yvette Fobian , John Freskos , Steven Heasley , E. Jacobsen , Todd Maddux , Brent Mischke , John Molyneaux , Joseph Moon , D. Rogier , Michael Tollefson , John Walker
发明人： Robert Hughes , Andrew Bell , David Brown , Dafydd Owen , Michael Palmer , Christopher Phillips , David Brown , Yvette Fobian , John Freskos , Steven Heasley , E. Jacobsen , Todd Maddux , Brent Mischke , John Molyneaux , Joseph Moon , D. Rogier , Michael Tollefson , John Walker
IPC分类号： A61K31/498 , C07D487/02
CPC分类号： C07D471/04
摘要： Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: wherein R2, R6A, R6B and R8 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, synthetic methods, and intermediates are also disclosed.
摘要翻译：公开了化合物的化合物和药学上可接受的盐，其中所述化合物具有式I的结构：其中R 2，R 6A，R 6B， >和R＆gt; 8如说明书中所定义。还公开了相应的药物组合物，治疗方法，合成方法和中间体。

10. 发明公开

US20240026317A1 PAN-RAS mRNA CANCER VACCINES 审中-公开
公开(公告)号：US20240026317A1
公开(公告)日：2024-01-25
申请号：US18249023
申请日：2021-10-13
申请人： Dong SHEN , David BROWN , Renxiang CHEN , RNAimmune, Inc
发明人： Dong Shen , David Brown , Renxiang Chen
IPC分类号： C12N9/14 , C12P19/30 , A61K39/00 , A61K9/127 , A61K47/69 , A61P35/00 , A61K47/54
CPC分类号： C12N9/14 , C12Y306/05002 , C12P19/30 , A61K39/001164 , A61K9/1273 , A61K47/6911 , A61P35/00 , A61K47/54 , A61K2039/53 , A61K2039/585 , A61K2039/55555
摘要： Compositions and methods are provided for potent mRNA vaccines for treatment of cancers with a mutation in the ras gene family. The compositions include a pharmaceutical composition comprising, or consisting essentially of, or yet further comprising mRNA molecules encoding at least one of multiple peptides of a group of somatic mutants and a pharmaceutically acceptable carrier. Methods for stimulating system immune responses and treatment are provided, including intratumoral, intravenous, intramuscular, intradermal, or subcutaneous injection of the composition as disclosed herein.

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