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21. 发明授权

US06777592B2 Arthropod defensins of Scolopendra canidens, Vaejovis carolinianus, and Argiope spp. 失效
标题翻译：节肢动物防御素Scolopendra canidens，Vaejovis carolinianus和Argiope spp。
公开(公告)号：US06777592B2
公开(公告)日：2004-08-17
申请号：US09829481
申请日：2001-04-10
申请人： James K. Presnail , Zude Weng , James F. Wong
发明人： James K. Presnail , Zude Weng , James F. Wong
IPC分类号： A01H500
CPC分类号： C07K14/4723 , C07K14/43504
摘要： This invention relates to an isolated nucleic acid fragment encoding a defensin which shares a high degree of sequence identity with the disclosed sequences from Scolopendra canidens, Vaejovis carolinianus, and Argiope spp. The invention also relates to the construction of a chimeric gene encoding all or a portion of the defensin, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the defensin in a transformed host cell.
摘要翻译：本发明涉及编码防御素的分离的核酸片段，其与Scolopendra canidens，Vaejovis carolinianus和Argiope spp的公开序列具有高度的序列同一性。本发明还涉及在正义或反义方向上编码全部或部分防御素的嵌合基因的构建，其中嵌合基因的表达导致转化宿主细胞中防御素水平的改变。

22. 发明申请

US20110054007A1 COMPOSITIONS AND METHODS TO CONTROL INSECT PESTS 审中-公开
标题翻译：组合物及其控制方法
公开(公告)号：US20110054007A1
公开(公告)日：2011-03-03
申请号：US12868994
申请日：2010-08-26
申请人： Karen E. Broglie , Kevin Kriss , Albert Laurence Lu , Mani Muthalagi , James K. Presnail
发明人： Karen E. Broglie , Kevin Kriss , Albert Laurence Lu , Mani Muthalagi , James K. Presnail
IPC分类号： A01N57/16 , C07H21/04 , C07H21/02 , A01H5/00 , A01H5/10 , A01P7/04 , C12N5/10 , C12N15/63
CPC分类号： A01N57/16 , A01N63/00 , A01N65/20 , A01N65/44 , C12N15/113 , C12N15/8218 , C12N15/8286 , C12N2310/11 , C12N2310/531 , Y02A40/162
摘要： Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a Coleopteran plant pest or a Diabrotica plant pest, decrease the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides various target polynucleotides set forth in any one of SEQ ID NOS: 1-236 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is D. virgifera virgifera, D. barberi, D. speciosa, or D. undecimpunctata howardi. Plants, plant part, bacteria and other host cells comprising the silencing elements or an active variant or fragment thereof of the invention are also provided.
摘要翻译：提供了使用沉积元件的方法和组合物，当由有害生物摄取的诸如鞘翅目植物病虫害（Diaprotica plant pest）的害虫时，会降低害虫中靶序列的表达。在具体实施方案中，靶序列的表达降低控制有害生物，因此方法和组合物能够限制对植物的损害。本发明提供了SEQ ID NO：1-236中任一项所述的各种靶多核苷酸或其活性变体及其片段，其中目标害虫中一个或多个序列的表达降低控制害虫（即具有杀虫活性活动）。进一步提供的是沉积元件，当受害虫摄入时，降低靶多肽的水平，从而控制害虫。在具体实施方案中，害虫是D. virgifera virgifera，D.barberi，D. speciosa或D. undecimpunctata howardi。还提供了包含本发明的沉默元件或其活性变体或片段的植物，植物部分，细菌和其它宿主细胞。

23. 发明申请

US20090192116A1 COMPOSITIONS AND METHODS FOR THE SUPPRESSION OF TARGET POLYNUCLEOTIDES FROM THE FAMILY APHIDIDAE 有权
标题翻译：从家禽APHIDIDA中抑制目标多核苷酸的组合物和方法
公开(公告)号：US20090192116A1
公开(公告)日：2009-07-30
申请号：US12351189
申请日：2009-01-09
申请人： Rafael Herrmann , Michael Lassner , Albert L. Lu , Mark Nelson , James K. Presnail , Janet A. Rice
发明人： Rafael Herrmann , Michael Lassner , Albert L. Lu , Mark Nelson , James K. Presnail , Janet A. Rice
IPC分类号： A01N43/02 , A01H5/00 , C12N5/10 , A01P7/00
CPC分类号： C12N15/8286 , C07K14/43563 , Y02A40/162
摘要： Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pest from the Aphididae family, they are capable of decreasing the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides target polynucleotides for specific protein classes and also target polynucleotides as set forth in SEQ ID NOS:1, 2, 3, 4, 5, 6, 7, 8, 9, 10 or active variants or fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is Aphis glycines. Plants, plant part, bacteria and other host cells comprising the silencing elements or an active variant or fragment thereof of the invention are also provided.
摘要翻译：提供了使用沉积元件的方法和组合物，当沉积元件在被害虫摄入时，例如来自蚜科的害虫中，它们能够降低害虫中靶序列的表达。在具体实施方案中，靶序列的表达降低控制有害生物，因此方法和组合物能够限制对植物的损害。本发明提供了用于特异性蛋白质类别的靶多核苷酸以及如SEQ ID NO：1,2,3,4,5,6,7,8,9,10或其活性变体或片段所示的靶多核苷酸，其中a 目标害虫中一个或多个序列的表达减少对害虫的控制（即具有杀虫活性）。进一步提供的是沉积元件，当受害虫摄入时，降低靶多肽的水平，从而控制害虫。在具体实施方案中，害虫是蚜虫甘氨酸。还提供了包含本发明的沉默元件或其活性变体或片段的植物，植物部分，细菌和其它宿主细胞。

24. 发明授权

US07172901B2 Scorpion toxins 有权
标题翻译：蝎毒素
公开(公告)号：US07172901B2
公开(公告)日：2007-02-06
申请号：US10614934
申请日：2003-07-08
申请人： Rafael Herrmann , Jian-Ming Lee , Albert L. Lu , James K. Presnail , James F H Wong
发明人： Rafael Herrmann , Jian-Ming Lee , Albert L. Lu , James K. Presnail , James F H Wong
IPC分类号： C12N15/12 , C12N15/63 , C12N5/10 , C12N1/16 , C12N1/21
CPC分类号： C12N15/8286 , C07K14/43522 , Y02A40/162
摘要： This invention relates to an isolated nucleic acid fragment encoding scorpion toxins that are K-channel agonists. The invention also relates to the construction of a chimeric gene encoding all or a portion of the K-channel agonists, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the K-channel agonists in a transformed host cell.
摘要翻译：本发明涉及编码作为K-通道激动剂的蝎毒素的分离的核酸片段。本发明还涉及在正义或反义方向上构建编码全部或部分K-通道激动剂的嵌合基因，其中嵌合基因的表达导致转化的K通道激动剂水平的改变宿主细胞。

25. 发明授权

US06855865B2 Nucleic acids encoding plant defensins and methods of use thereof 有权
标题翻译：编码植物防御素的核酸及其使用方法
公开(公告)号：US06855865B2
公开(公告)日：2005-02-15
申请号：US10178449
申请日：2002-06-21
申请人： Omolayo O. Famodu , Rafael Herrmann , Albert L. Lu , Billy Fred McCutchen , Guo-Hua Miao , James K. Presnail , Zude Weng
发明人： Omolayo O. Famodu , Rafael Herrmann , Albert L. Lu , Billy Fred McCutchen , Guo-Hua Miao , James K. Presnail , Zude Weng
IPC分类号： C07K14/415 , C12N15/29 , C12N15/82 , C12N15/09 , C11N15/82 , A01H5/00 , A01H5/10
CPC分类号： C12N15/8279 , C07K14/415 , C12N15/8282 , C12N15/8285 , Y02A40/164
摘要： This invention relates to isolated nucleic acids encoding plant defensins. The invention also relates to the construction of a chimeric gene encoding all or a portion of the plant defensin, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of plant defensins in a transformed host cell.
摘要翻译：本发明涉及编码植物防御素的分离的核酸。本发明还涉及在正义或反义方向上编码全部或部分植物防御素的嵌合基因的构建，其中嵌合基因的表达导致转化宿主细胞中植物防御素水平的变化。

26. 发明授权

US5702932A Microinjection methods to transform arthropods with exogenous DNA 失效
标题翻译：用外源DNA转化节肢动物的显微注射方法
公开(公告)号：US5702932A
公开(公告)日：1997-12-30
申请号：US479485
申请日：1995-06-07
申请人： Marjorie A. Hoy , James K. Presnail
发明人： Marjorie A. Hoy , James K. Presnail
IPC分类号： A01K67/033 , C12N15/00 , C12N5/00
CPC分类号： A01K67/0337 , A01K67/033
摘要： This invention relates to methods for transforming arthropods with exogenous DNA. The methods are useful for arthropods that have not previously been amenable to DNA-mediated transformation, and also provide a simpler and more efficient means of transforming arthropods than have previously been described. The method involves microinjecting a nucleic acid sequence encoding a desired trait into the reproductive tract of a female arthropod before oviposition.
摘要翻译：本发明涉及用外源DNA转化节肢动物的方法。这些方法对于以前从未适应于DNA介导的转化的节肢动物是有用的，并且还提供了比先前描述的更简单和更有效的转化节肢动物的方法。该方法包括在产卵前将编码期望性状的核酸序列显微注射到雌性节肢动物的生殖道中。

27. 发明申请

US20110301223A1 COMPOSITIONS AND METHODS FOR INSECTICIDAL CONTROL OF STINKBUGS 有权
标题翻译： STINKBUGS的杀虫剂控制组合物和方法
公开(公告)号：US20110301223A1
公开(公告)日：2011-12-08
申请号：US13152795
申请日：2011-06-03
申请人： Karen E. Broglie , David C. Cerf , Rafael Herrmann , Albert L. Lu , Brian McGonigle , James K. Presnail
发明人： Karen E. Broglie , David C. Cerf , Rafael Herrmann , Albert L. Lu , Brian McGonigle , James K. Presnail
IPC分类号： A01N57/16 , A01P7/04 , C12N5/10 , C12N15/113 , C12N15/63
CPC分类号： C12N15/8286 , A01N57/16 , A01N65/00 , A01N65/44 , C12N15/113 , C12N15/8218 , C12N2310/14 , C12N2310/531 , Y02A40/162
摘要： Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a Pentatomidae plant pest or a N. viridula, Acrosternum hilare, Piezodorus guildini, and/or Halymorpha halys plant pest, decrease the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides various target polynucleotides set forth in any one of SEQ ID NOS: 1-292 or 302-304 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is Pentatomidae. Plants, plant part, bacteria and other host cells comprising the silencing elements or an active variant or fragment thereof of the invention are also provided.
摘要翻译：提供了使用沉积元件的方法和组合物，当被害虫摄入时，例如五子科植物害虫或N. viridula，Acrosternum hilare，Piezodorus guildini和/或Halymorpha halys植物害虫，降低靶的表达序列在害虫中。在具体实施方案中，靶序列的表达降低控制有害生物，因此方法和组合物能够限制对植物的损害。本发明提供了SEQ ID NO：1-292或302-304中任一项所述的各种靶多核苷酸或其活性变体和片段，其中目标害虫中一个或多个序列的表达降低控制害虫（即具有杀虫活性）。进一步提供的是沉积元件，当受害虫摄入时，降低靶多肽的水平，从而控制害虫。在具体实施方案中，害虫是五角科。还提供了包含本发明的沉默元件或其活性变体或片段的植物，植物部分，细菌和其它宿主细胞。

28. 发明授权

US08071736B2 Nucleic acid molecules encodng a cathepsin L-like cysteine protease 有权
标题翻译：核酸分子编码组织蛋白酶L样半胱氨酸蛋白酶
公开(公告)号：US08071736B2
公开(公告)日：2011-12-06
申请号：US12512425
申请日：2009-07-30
申请人： Andre R. Abad , Ronald D. Flannagan , Rafael Herrmann , Albert L. Lu , Billy F. McCutchen , James K. Presnail , Janet A. Rice , James F. Wong , Cao-Guo Yu
发明人： Andre R. Abad , Ronald D. Flannagan , Rafael Herrmann , Albert L. Lu , Billy F. McCutchen , James K. Presnail , Janet A. Rice , James F. Wong , Cao-Guo Yu
IPC分类号： C07H21/04 , C12N1/20 , C12N15/63 , C12P21/00
CPC分类号： C12N15/8286 , C12N9/641 , Y02A40/162
摘要： Compositions and methods for protecting a plant from an insect pest are provided. In particular, nucleic acid sequences encoding insect protoxins modified to comprise at least one proteolytic activation site that is sensitive to a plant protease or an insect gut protease are provided. Cleavage of the modified protoxin at the proteolytic activation site by a protease produces an active insect toxin. Methods of using the modified insect protoxin nucleic acid sequences and the polypeptides they encode to protect a plant from an insect pest are provided. Particular embodiments of the invention further provide modified insect protoxin compositions and formulations, expression cassettes, and transformed plants, plant cells, and seeds.
摘要翻译：提供了保护植物免受害虫害虫的组合物和方法。特别地，提供了编码昆虫原毒素的核酸序列，其被修饰为包含对植物蛋白酶或昆虫肠道蛋白酶敏感的至少一个蛋白水解活化位点。通过蛋白酶在蛋白水解活化位点切割修饰的原毒素会产生活性昆虫毒素。提供了使用修饰的昆虫原毒素核酸序列及其编码的多肽保护植物免受害虫的方法。本发明的具体实施方案还提供了改良的昆虫原毒素组合物和制剂，表达盒，以及转化的植物，植物细胞和种子。

29. 发明授权

US07601810B2 Insecticidal plant cyclotide with activity against homopteran insects 失效
标题翻译：具有抗同翅目昆虫活性的杀虫植物环磷酰胺
公开(公告)号：US07601810B2
公开(公告)日：2009-10-13
申请号：US11677632
申请日：2007-02-22
申请人： Rafael Herrmann , Albert L. Lu , Billy F. McCutchen , James K. Presnail , Janet A. Rice , Clement W. K. Waine
发明人： Rafael Herrmann , Albert L. Lu , Billy F. McCutchen , James K. Presnail , Janet A. Rice , Clement W. K. Waine
IPC分类号： C07K14/00 , A61K38/00
CPC分类号： C07K14/415 , C12N15/8286 , Y02A40/162
摘要： The present invention relates to isolated nucleic acids encoding plant cyclotides. The invention also relates to the construction of a chimeric gene encoding all or a portion of the plant cyclotides, in sense or antisense orientation, wherein expression of the chimeric gene results in the production of altered levels of plant cyclotides in a transformed host cell.
摘要翻译：本发明涉及编码植物环肽的分离的核酸。本发明还涉及在正义或反义方向上构建编码全部或部分植物环肽的嵌合基因，其中嵌合基因的表达导致在转化的宿主细胞中产生改变水平的植物环磷酰胺。

30. 发明授权

US07589177B2 Nucleic acid molecules encoding cyclotide polypeptides and methods of use 失效
标题翻译：编码环肽多肽的核酸分子及其使用方法
公开(公告)号：US07589177B2
公开(公告)日：2009-09-15
申请号：US11736633
申请日：2007-04-18
申请人： Rafael Herrmann , Albert L. Lu , Billy F. McCutchen , James K. Presnail , Clement W. K. Waine
发明人： Rafael Herrmann , Albert L. Lu , Billy F. McCutchen , James K. Presnail , Clement W. K. Waine
IPC分类号： A61K35/78
CPC分类号： C12N15/8285 , C07K14/415 , C12N15/8282 , Y02A40/164
摘要： The present invention relates to isolated nucleic acids encoding plant cyclotides. The invention also relates to the construction of a chimeric gene encoding all or a portion of the plant cyclotides, in sense or antisense orientation, wherein expression of the chimeric gene results in the production of altered levels of plant cyclotides in a transformed host cell.
摘要翻译：本发明涉及编码植物环肽的分离的核酸。本发明还涉及在正义或反义方向上构建编码全部或部分植物环肽的嵌合基因，其中嵌合基因的表达导致在转化的宿主细胞中产生改变水平的植物环磷酰胺。

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