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1. 发明授权

US06855865B2 Nucleic acids encoding plant defensins and methods of use thereof 有权
标题翻译：编码植物防御素的核酸及其使用方法
公开(公告)号：US06855865B2
公开(公告)日：2005-02-15
申请号：US10178449
申请日：2002-06-21
申请人： Omolayo O. Famodu , Rafael Herrmann , Albert L. Lu , Billy Fred McCutchen , Guo-Hua Miao , James K. Presnail , Zude Weng
发明人： Omolayo O. Famodu , Rafael Herrmann , Albert L. Lu , Billy Fred McCutchen , Guo-Hua Miao , James K. Presnail , Zude Weng
IPC分类号： C07K14/415 , C12N15/29 , C12N15/82 , C12N15/09 , C11N15/82 , A01H5/00 , A01H5/10
CPC分类号： C12N15/8279 , C07K14/415 , C12N15/8282 , C12N15/8285 , Y02A40/164
摘要： This invention relates to isolated nucleic acids encoding plant defensins. The invention also relates to the construction of a chimeric gene encoding all or a portion of the plant defensin, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of plant defensins in a transformed host cell.
摘要翻译：本发明涉及编码植物防御素的分离的核酸。本发明还涉及在正义或反义方向上编码全部或部分植物防御素的嵌合基因的构建，其中嵌合基因的表达导致转化宿主细胞中植物防御素水平的变化。

2. 发明授权

US07238781B2 Plant defensin polynucleotides and methods of use thereof 有权
标题翻译：植物防御素多核苷酸及其使用方法
公开(公告)号：US07238781B2
公开(公告)日：2007-07-03
申请号：US10954790
申请日：2004-09-30
申请人： Omolayo O. Famodu , Rafael Herrmann , Albert L. Lu , Billy Fred McCutchen , Guo-Hua Miao , James K. Presnail , Zude Weng
发明人： Omolayo O. Famodu , Rafael Herrmann , Albert L. Lu , Billy Fred McCutchen , Guo-Hua Miao , James K. Presnail , Zude Weng
IPC分类号： C07K1/00
CPC分类号： C12N15/8279 , C07K14/415 , C12N15/8282 , C12N15/8285 , Y02A40/164
摘要： This invention relates to plant defensin polypeptides, nucleic acids encoding them, and methods of use thereof. The invention also relates to a chimeric protein containing all or a portion of the plant defensin.
摘要翻译：本发明涉及植物防御素多肽，编码它们的核酸及其使用方法。本发明还涉及含有植物防御素全部或部分的嵌合蛋白。

3. 发明授权

US08872001B2 Compositions and methods for insecticidal control of stinkbugs 有权
标题翻译：臭椿害虫防治的组成和方法
公开(公告)号：US08872001B2
公开(公告)日：2014-10-28
申请号：US13152795
申请日：2011-06-03
申请人： Karen E. Broglie , David C. Cerf , Rafael Herrmann , Albert L. Lu , Brian McGonigle , James K. Presnail
发明人： Karen E. Broglie , David C. Cerf , Rafael Herrmann , Albert L. Lu , Brian McGonigle , James K. Presnail
IPC分类号： C12N15/113 , C12N15/05 , C12N15/14 , A01H5/00 , A01N57/16 , A01N65/00 , C12N15/82
CPC分类号： C12N15/8286 , A01N57/16 , A01N65/00 , A01N65/44 , C12N15/113 , C12N15/8218 , C12N2310/14 , C12N2310/531 , Y02A40/162
摘要： Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a Pentatomidae plant pest or a N. viridula, Acrosternum hilare, Piezodorus guildini, and/or Halymorpha halys plant pest, decrease the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides various target polynucleotides set forth in any one of SEQ ID NOS: 1-292 or 302-304 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is Pentatomidae. Plants, plant part, bacteria and other host cells comprising the silencing elements or an active variant or fragment thereof of the invention are also provided.
摘要翻译：提供了使用沉积元件的方法和组合物，当被害虫摄入时，例如五子科植物害虫或N. viridula，Acrosternum hilare，Piezodorus guildini和/或Halymorpha halys植物害虫，降低靶的表达序列在害虫中。在具体实施方案中，靶序列的表达降低控制有害生物，因此方法和组合物能够限制对植物的损害。本发明提供了SEQ ID NO：1-292或302-304中任一项所述的各种靶多核苷酸或其活性变体和片段，其中目标害虫中一个或多个序列的表达降低控制害虫（即具有杀虫活性）。进一步提供的是沉积元件，当受害虫摄入时，降低靶多肽的水平，从而控制害虫。在具体实施方案中，害虫是五角科。还提供了包含本发明的沉默元件或其活性变体或片段的植物，植物部分，细菌和其它宿主细胞。

4. 发明授权

US08847013B2 Compositions and methods for the suppression of target polynucleotides from lepidoptera 有权
标题翻译：用于抑制鳞翅目的靶多核苷酸的组合物和方法
公开(公告)号：US08847013B2
公开(公告)日：2014-09-30
申请号：US12351267
申请日：2009-01-09
申请人： Rafael Herrmann , Michael Lassner , Albert L. Lu , Mark Nelson , James K. Presnail , Janet A. Rice
发明人： Rafael Herrmann , Michael Lassner , Albert L. Lu , Mark Nelson , James K. Presnail , Janet A. Rice
IPC分类号： A01H1/00 , C12N15/82 , C07H21/04
CPC分类号： C12N15/8286 , A01N65/20 , A01N65/44 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/531 , C12N2320/32 , Y02A40/162
摘要： Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a Lepidopteran pest, decreases the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest, thereby limiting damage to a plant. The present invention provides target polynucleotides encoding polypeptides from specific protein families and various target polynucleotides as set forth, or active variants and fragments thereof, wherein a decrease in expression of one or more sequences in the target pest has insecticidal activity. Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In a specific embodiment, the pest is Spodoptera frugiperda. Plants, plant parts, bacteria and other host cells comprising the silencing elements or an active variant or fragment thereof of the invention are also provided.
摘要翻译：提供了使用沉积元件的方法和组合物，当由有害生物（例如鳞翅目害虫）摄入时，降低害虫中靶序列的表达。在具体实施方案中，靶序列的表达降低控制害虫，从而限制对植物的损害。本发明提供了编码来自特定蛋白质家族的多肽的多核苷酸和如所述的各种靶多核苷酸或其活性变体和片段，其中目标害虫中一个或多个序列的表达降低具有杀虫活性。进一步提供的是沉积元件，当受害虫摄入时，降低靶多肽的水平，从而控制害虫。在具体实施方案中，害虫是草地夜蛾（Spodoptera frugiperda）。还提供了包含本发明的沉默元件或其活性变体或片段的植物，植物部分，细菌和其它宿主细胞。

5. 发明授权

US08367895B2 Compositions and methods for the suppression of target polynucleotides from the family aphididae 有权
标题翻译：用于抑制来自家蚜科的靶多核苷酸的组合物和方法
公开(公告)号：US08367895B2
公开(公告)日：2013-02-05
申请号：US12351189
申请日：2009-01-09
申请人： Rafael Herrmann , Michael Lassner , Albert L. Lu , Mark Nelson , James K. Presnail , Janet A. Rice
发明人： Rafael Herrmann , Michael Lassner , Albert L. Lu , Mark Nelson , James K. Presnail , Janet A. Rice
IPC分类号： A01H5/00 , C12N15/82 , C07H21/04
CPC分类号： C12N15/8286 , C07K14/43563 , Y02A40/162
摘要： Methods and compositions are provided which employ a silencing element that, when ingested by a pest, are capable of decreasing the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. Target polynucleotides for specific protein classes and target polynucleotides set forth in SEQ ID NOS:1, 2, 3, 4, 5, 6, 7, 8, 9, 10 or active variants or fragments thereof are provided, wherein a decrease in expression of one or more sequences in the target pest controls the pest. Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. Plants, plant part, bacteria and host cells comprising the silencing elements or an active variant or fragment thereof are also provided.
摘要翻译：提供了使用沉积元件的方法和组合物，其在被害虫摄入时能够降低害虫中靶序列的表达。在具体实施方案中，靶序列的表达降低控制有害生物，因此方法和组合物能够限制对植物的损害。提供了SEQ ID NOS：1,2,3,4,5,6,7,8,9,10或其活性变体或片段中列出的特异性蛋白质类别和靶多核苷酸的靶多核苷酸，其中表达降低目标害虫中的一个或多个序列控制害虫。进一步提供的是沉积元件，当受害虫摄入时，降低靶多肽的水平，从而控制害虫。还提供了包含沉默元件或其活性变体或片段的植物，植物部分，细菌和宿主细胞。

6. 发明申请

US20090192116A1 COMPOSITIONS AND METHODS FOR THE SUPPRESSION OF TARGET POLYNUCLEOTIDES FROM THE FAMILY APHIDIDAE 有权
标题翻译：从家禽APHIDIDA中抑制目标多核苷酸的组合物和方法
公开(公告)号：US20090192116A1
公开(公告)日：2009-07-30
申请号：US12351189
申请日：2009-01-09
申请人： Rafael Herrmann , Michael Lassner , Albert L. Lu , Mark Nelson , James K. Presnail , Janet A. Rice
发明人： Rafael Herrmann , Michael Lassner , Albert L. Lu , Mark Nelson , James K. Presnail , Janet A. Rice
IPC分类号： A01N43/02 , A01H5/00 , C12N5/10 , A01P7/00
CPC分类号： C12N15/8286 , C07K14/43563 , Y02A40/162
摘要： Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pest from the Aphididae family, they are capable of decreasing the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides target polynucleotides for specific protein classes and also target polynucleotides as set forth in SEQ ID NOS:1, 2, 3, 4, 5, 6, 7, 8, 9, 10 or active variants or fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is Aphis glycines. Plants, plant part, bacteria and other host cells comprising the silencing elements or an active variant or fragment thereof of the invention are also provided.
摘要翻译：提供了使用沉积元件的方法和组合物，当沉积元件在被害虫摄入时，例如来自蚜科的害虫中，它们能够降低害虫中靶序列的表达。在具体实施方案中，靶序列的表达降低控制有害生物，因此方法和组合物能够限制对植物的损害。本发明提供了用于特异性蛋白质类别的靶多核苷酸以及如SEQ ID NO：1,2,3,4,5,6,7,8,9,10或其活性变体或片段所示的靶多核苷酸，其中a 目标害虫中一个或多个序列的表达减少对害虫的控制（即具有杀虫活性）。进一步提供的是沉积元件，当受害虫摄入时，降低靶多肽的水平，从而控制害虫。在具体实施方案中，害虫是蚜虫甘氨酸。还提供了包含本发明的沉默元件或其活性变体或片段的植物，植物部分，细菌和其它宿主细胞。

7. 发明授权

US07172901B2 Scorpion toxins 有权
标题翻译：蝎毒素
公开(公告)号：US07172901B2
公开(公告)日：2007-02-06
申请号：US10614934
申请日：2003-07-08
申请人： Rafael Herrmann , Jian-Ming Lee , Albert L. Lu , James K. Presnail , James F H Wong
发明人： Rafael Herrmann , Jian-Ming Lee , Albert L. Lu , James K. Presnail , James F H Wong
IPC分类号： C12N15/12 , C12N15/63 , C12N5/10 , C12N1/16 , C12N1/21
CPC分类号： C12N15/8286 , C07K14/43522 , Y02A40/162
摘要： This invention relates to an isolated nucleic acid fragment encoding scorpion toxins that are K-channel agonists. The invention also relates to the construction of a chimeric gene encoding all or a portion of the K-channel agonists, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the K-channel agonists in a transformed host cell.
摘要翻译：本发明涉及编码作为K-通道激动剂的蝎毒素的分离的核酸片段。本发明还涉及在正义或反义方向上构建编码全部或部分K-通道激动剂的嵌合基因，其中嵌合基因的表达导致转化的K通道激动剂水平的改变宿主细胞。

8. 发明授权

US07910807B2 Plant activation of insect toxin 有权
标题翻译：植物激活昆虫毒素
公开(公告)号：US07910807B2
公开(公告)日：2011-03-22
申请号：US11940002
申请日：2007-11-14
申请人： Andre R. Abad , Ronald D. Flannagan , Rafael Herrmann , Albert L. Lu , Billy F. McCutchen , James K. Presnail , Janet A. Rice , James F. Wong , Cao-Guo Yu
发明人： Andre R. Abad , Ronald D. Flannagan , Rafael Herrmann , Albert L. Lu , Billy F. McCutchen , James K. Presnail , Janet A. Rice , James F. Wong , Cao-Guo Yu
IPC分类号： C12N15/82 , C12N15/32 , A01H5/00 , A01H5/10
CPC分类号： C12N15/8286 , C12N9/641 , Y02A40/162
摘要： Compositions and methods for protecting a plant from an insect pest are provided. In particular, nucleic acid sequences encoding insect protoxins modified to comprise at least one proteolytic activation site that is sensitive to a plant protease or an insect gut protease are provided. Cleavage of the modified protoxin at the proteolytic activation site by a protease produces an active insect toxin. Methods of using the modified insect protoxin nucleic acid sequences and the polypeptides they encode to protect a plant from an insect pest are provided. Particular embodiments of the invention further provide modified insect protoxin compositions and formulations, expression cassettes, and transformed plants, plant cells, and seeds.
摘要翻译：提供了保护植物免受害虫害虫的组合物和方法。特别地，提供了编码昆虫原毒素的核酸序列，其被修饰为包含对植物蛋白酶或昆虫肠道蛋白酶敏感的至少一个蛋白水解活化位点。通过蛋白酶在蛋白水解活化位点切割修饰的原毒素会产生活性昆虫毒素。提供了使用修饰的昆虫原毒素核酸序列及其编码的多肽保护植物免受害虫的方法。本发明的具体实施方案还提供了改良的昆虫原毒素组合物和制剂，表达盒，以及转化的植物，植物细胞和种子。

9. 发明申请

US20090265818A1 COMPOSITIONS AND METHODS FOR THE SUPPRESSION OF TARGET POLYNUCLEOTIDES FROM LEPIDOPTERA 有权
标题翻译：用于抑制来自LEPIDOPTERA的目标多核苷酸的组合物和方法
公开(公告)号：US20090265818A1
公开(公告)日：2009-10-22
申请号：US12351267
申请日：2009-01-09
申请人： Rafael Herrmann , Michael Lassner , Albert L. Lu , Mark Nelson , James K. Presnail , Janet A. Rice
发明人： Rafael Herrmann , Michael Lassner , Albert L. Lu , Mark Nelson , James K. Presnail , Janet A. Rice
IPC分类号： A01H5/00 , C12N5/04 , A01N43/04 , A01P7/04
CPC分类号： C12N15/8286 , A01N65/20 , A01N65/44 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/531 , C12N2320/32 , Y02A40/162
摘要： Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pest from the Lepidoptera order, they are capable of decreasing the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides target polynucleotides encoding polypeptides from specific protein families and various target polynucleotides set forth in SEQ ID NOS: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, or 50 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is Spodoptera frugiperda. Plants, plant part, bacteria and other host cells comprising the silencing elements or an active variant or fragment thereof of the invention are also provided.
摘要翻译：提供了使用沉积元件的方法和组合物，当沉积元件在被害虫如来自鳞翅目序列的害虫中摄取时，它们能够降低害虫中靶序列的表达。在具体实施方案中，靶序列的表达降低控制有害生物，因此方法和组合物能够限制对植物的损害。本发明提供编码来自特定蛋白质家族的多肽的多核苷酸和SEQ ID NO：1,2,3,4,5,6,7,8,9,10,11,12,13,14中所示的各种靶多核苷酸的靶多核苷酸，15，16，17，18，19，20，21，22，23，24，25，26，27，28，29，30，31，32，33，34，35，36，37，38，39 ，40,41,42,43,44,45,46,47,48,49或50个或其活性变体和片段，其中目标害虫中一个或多个序列的表达降低控制害虫（即，具有杀虫活性）。进一步提供的是沉积元件，当受害虫摄入时，降低靶多肽的水平，从而控制害虫。在具体实施方案中，害虫是草地夜蛾（Spodoptera frugiperda）。还提供了包含本发明的沉默元件或其活性变体或片段的植物，植物部分，细菌和其它宿主细胞。

10. 发明申请

US20090192117A1 COMPOSITIONS AND METHODS FOR THE SUPPRESSION OF TARGET POLYNUCLEOTIDES FROM LYGUS 有权
标题翻译：用于抑制来自LYGUS的目标多核苷酸的组合物和方法
公开(公告)号：US20090192117A1
公开(公告)日：2009-07-30
申请号：US12351379
申请日：2009-01-09
申请人： Rafael Herrmann , Michael Lassner , Albert L. Lu , Mark E. Nelson , James K. Presnail , Janet A. Rice
发明人： Rafael Herrmann , Michael Lassner , Albert L. Lu , Mark E. Nelson , James K. Presnail , Janet A. Rice
IPC分类号： A61K31/7088 , C12N5/10 , A01H5/00
CPC分类号： C12N15/8286 , A01N57/16 , C12N15/113 , C12N15/8218 , C12N2310/141 , C12N2310/531 , Y02A40/162
摘要： Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pest from the Lygus genus, they are capable of decreasing the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides various target polynucleotides from specific polypeptide families as disclosed herein, and further provides target polynucleotides set forth in SEQ ID NOS:1-21 or active variants thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is Lygus Hesperus. Plants, plant part, bacteria and other host cells comprising the silencing elements or an active variant or fragment thereof of the invention are also provided.
摘要翻译：提供了使用沉积元件的方法和组合物，当沉积元件被害虫摄取时，例如来自莱古氏属属的害虫时，它们能够降低害虫中靶序列的表达。在具体实施方案中，靶序列的表达降低控制有害生物，因此方法和组合物能够限制对植物的损害。本发明提供了本文公开的来自特定多肽家族的多种靶多核苷酸，并进一步提供了SEQ ID NO：1-21所示的靶多核苷酸或其活性变体，其中目标害虫中一个或多个序列的表达降低控制害虫（即具有杀虫活性）。进一步提供的是沉积元件，当受害虫摄入时，降低靶多肽的水平，从而控制害虫。在具体实施方案中，有害生物是黄瓜（Lygus Hesperus）。还提供了包含本发明的沉默元件或其活性变体或片段的植物，植物部分，细菌和其它宿主细胞。

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