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21. 发明授权

US4619265A Interactive portable defibrillator including ECG detection circuit 失效
公开(公告)号：US4619265A
公开(公告)日：1986-10-28
申请号：US776391
申请日：1985-09-16
申请人： Carlton B. Morgan , Daniel Yerkovich , Thomas D. Lyster , Eric C. Hagen , Douglas H. Roberts
发明人： Carlton B. Morgan , Daniel Yerkovich , Thomas D. Lyster , Eric C. Hagen , Douglas H. Roberts
IPC分类号： A61N1/08 , A61N1/39 , G09B23/28 , A61N1/36 , A61B5/05
CPC分类号： A61N1/39 , A61N1/3925 , G09B23/288
摘要： A portable, interactive medical electronic device exemplified by a defibrillator. The device obtains information about a patient's condition, such as ECG and transthoracic impedance data, directly from the patient, and information pertinent to the treatment of the patient indirectly through an operator of the device, and produces a medically appropriate action such as a defibrillation shock in response. Indirect information is obtained through information processing means that includes means for prompting the operator of the device and means for receiving the operator's responses thereto. Prompts may include both questions and instructions, and in one embodiment the information processing means obtains the assent of the operator before causing the defibrillation shock. Indirect information may include information as to whether the patient is conscious, and as to whether or not cardiopulmonary resuscitation has been performed. The ECG and transthoracic impedance data may be collected through a common pair of electrodes. In one embodiment the device produces an indication that the ECG data is invalid if the transthoracic impedance data indicates excessive motion on the part of the patient. When a defibrillation shock is determined to be medically appropriate, a control signal is produced that causes the charging of an energy storage means and the subsequent discharging of such energy storage means through the patient without further operator intervention. The device also includes a tape recorder for allowing later analysis of the use of the device, and means for holding the tape recorder drive means in a disengaged position until the device is opened for use. The device also includes testing means for enabling a person to test the condition of the device without opening the case in which it is enclosed, means for producing and recording a distinctive sound when and if a defibrillation pulse is delivered, and means for allowing the electrodes to be quickly disconnected so that emergency personnel can conveniently use the electrodes with their own equipment.

22. 发明授权

US4610254A Interactive portable defibrillator 失效
公开(公告)号：US4610254A
公开(公告)日：1986-09-09
申请号：US587439
申请日：1984-03-08
申请人： Carlton B. Morgan , Daniel Yerkovich , Thomas D. Lyster , Eric C. Hagen , Douglas H. Roberts
发明人： Carlton B. Morgan , Daniel Yerkovich , Thomas D. Lyster , Eric C. Hagen , Douglas H. Roberts
IPC分类号： A61N1/08 , A61N1/39 , G09B23/28 , A61N1/36
CPC分类号： A61N1/39 , A61N1/3925 , A61N1/3937 , G09B23/288
摘要： A portable, interactive medical electronic device exemplified by a defibrillator. The device obtains information about a patient's condition, such as ECG and transthoracic impedance data, directly from the patient, and information pertinent to the treatment of the patient indirectly through an operator of the device, and produces a medically appropriate action such as a defibrillation shock in response. Indirect information is obtained through information processing means that includes means for prompting the operator of the device and means for receiving the operator's responses thereto. Prompts may include both questions and instructions, and in one embodiment the information processing means obtains the assent of the operator before causing the defibrillation shock. Indirect information may include information as to whether the patient is conscious, and as to whether or not cardiopulmonary resuscitiation has been performed. The ECG and transthroacic impedance data may be collected through a common pair of electrodes. In one embodiment the device produces an indication that the ECG data is invalid if the transthoracic impedance data indicates excessive motion on the part of the patient. When a difibrillation shock is determined to be medically appropriate, a control signal is produced that causes the charging of an energy storage means and the subsequent discharging of such energy storage means through the patient without further operator intervention. The device also includes a tape recorder for allowing later analysis of the use of the device, and means for holding the tape recorder drive means in a disengaged position until the device is opened for use. The device also includes testing means for enabling a person to test the condition of the device without opening the case in which it is enclosed, means for producing and recording a distinctive sound when and if a defibrillation pulse is delivered, and means for allowing the electrodes to be quickly disconnected so that emergency personnel can conveniently use the electrodes with their own equipment.

23. 发明申请

US20120022611A1 METHODS AND APPARATUS FOR EFFECTUATING A LASTING CHANGE IN A NEURAL-FUNCTION OF A PATIENT 审中-公开
标题翻译：影响患者神经功能变化的方法和装置
公开(公告)号：US20120022611A1
公开(公告)日：2012-01-26
申请号：US13240053
申请日：2011-09-22
申请人： Andrew D. Firlik , Jeffrey Balzer , Bradford Evan Gliner , Alan J. Levy , Carlton B. Morgan , Katrina S. Firlik
发明人： Andrew D. Firlik , Jeffrey Balzer , Bradford Evan Gliner , Alan J. Levy , Carlton B. Morgan , Katrina S. Firlik
IPC分类号： A61N1/36
CPC分类号： A61N1/375 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36017 , A61N1/36025 , A61N1/36082 , A61N1/36103 , A61N1/3756
摘要： The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. The methods in accordance with the invention can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods in accordance with the invention can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain).
摘要翻译：以下公开内容描述了用于治疗或以其他方式实现患者神经功能变化的颅内电刺激的几种方法和装置。根据本发明的方法可用于治疗脑损伤（例如中风，创伤等），脑部疾病（例如阿尔茨海默氏症，皮克病，帕金森氏病等）和/或脑部疾病（例如癫痫，抑郁症等）。根据本发明的方法还可以用于增强正常，健康的大脑（例如学习，记忆等）的神经功能，或用于控制感觉功能（例如疼痛）。

24. 发明授权

US08065012B2 Methods and apparatus for effectuating a lasting change in a neural-function of a patient 有权
标题翻译：用于实现患者神经功能持续变化的方法和装置
公开(公告)号：US08065012B2
公开(公告)日：2011-11-22
申请号：US11834650
申请日：2007-08-06
申请人： Andrew D. Firlik , Jeffrey Balzer , Bradford Evan Gliner , Alan J. Levy , Carlton B. Morgan , Katrina S. Firlik
发明人： Andrew D. Firlik , Jeffrey Balzer , Bradford Evan Gliner , Alan J. Levy , Carlton B. Morgan , Katrina S. Firlik
IPC分类号： A61N1/05
CPC分类号： A61N1/375 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36017 , A61N1/36025 , A61N1/36082 , A61N1/36103 , A61N1/3756
摘要： Disclosed are several apparatuses and methods for applying intracranial electrical stimulation to treat or enhance the neural function of the patient. In accordance with the invention, intracranial electrical stimulation can be administered to treat brain damage, brain disease, and/or brain disorders. Additionally the intracranial electrical stimulation can be applied to a normal healthy brain to enhance neural-function or control sensory functions. The electrical stimulation site(s) of the brain are located where neuroplasticity is occurring, expected to occur, or in a region where neuroplasticity is not occurring. The intracranial stimulation is expected to produce a lasting effect on the intended neural activity by applying subthreshold stimulation to the increasing the resting membrane potential of the neurons at the stimulation site.
摘要翻译：公开了几种用于施加颅内电刺激以治疗或增强患者的神经功能的装置和方法。根据本发明，可以施用颅内电刺激来治疗脑损伤，脑疾病和/或脑疾病。此外，颅内电刺激可以应用于正常的健康大脑，以增强神经功能或控制感觉功能。大脑的电刺激部位位于发生神经可塑性，预期发生或未出现神经可塑性的区域。预期颅内刺激通过应用亚阈值刺激来增加刺激部位神经元的静息膜电位，对预期的神经活动产生持久的作用。

25. 发明授权

US07062321B2 Method and apparatus for defibrillating patients of all ages 有权
公开(公告)号：US07062321B2
公开(公告)日：2006-06-13
申请号：US09954574
申请日：2001-09-14
申请人： Thomas D. Lyster , Thomas Solosko , Carlton B. Morgan
发明人： Thomas D. Lyster , Thomas Solosko , Carlton B. Morgan
IPC分类号： A61N1/39
CPC分类号： A61N1/046 , A61N1/0492 , A61N1/39 , A61N1/3912
摘要： A defibrillation system for patients of all ages may include an Automated External Defibrillator (AED) coupled to a set of universal electrodes. Universal electrodes may be reduced-size versions of adult electrodes, and may include an opening to lower effective impedance. The AED may include an adult/pediatric mode control or switch. Based upon the setting of the adult/pediatric switch, the AED may perform an adult defibrillation sequence or a pediatric defibrillation sequence. An adult defibrillation sequence may comprise delivery of one or more waveforms or shocks characterized by energies appropriate for adults, for example, 150 Joule biphasic waveforms. A pediatric defibrillation sequence may comprise delivery of one or more waveforms characterized by energies appropriate for children, for example, 50 Joule biphasic waveforms. Another pediatric defibrillation sequence may comprise delivery of an escalating low-energy shock sequence to a patient, such as a 25 to 50 Joule shock, followed by a 65 to 75 Joule shock as necessary, followed by one or more 100 Joule shocks as necessary.

26. 发明授权

US5749905A Electrotherapy method utilizing patient dependent electrical parameters 失效
标题翻译：使用患者依赖电参数的电疗方法
公开(公告)号：US5749905A
公开(公告)日：1998-05-12
申请号：US691755
申请日：1996-08-02
申请人： Bradford E. Gliner , Thomas D. Lyster , Clinton S. Cole , Daniel J. Powers , Carlton B. Morgan
发明人： Bradford E. Gliner , Thomas D. Lyster , Clinton S. Cole , Daniel J. Powers , Carlton B. Morgan
IPC分类号： A61N1/39
CPC分类号： A61N1/3937 , A61N1/3906 , A61N1/3912
摘要： This invention provides an external defibrillator and defibrillation method that automatically compensates for patient-to-patient impedance differences in the delivery of electrotherapeutic pulses for defibrillation and cardioversion. In a preferred embodiment, the defibrillator has an energy source that may be discharged through electrodes on the patient to provide a biphasic voltage or current pulse. In one aspect of the invention, the first and second phase duration and initial first phase amplitude are predetermined values. In a second aspect of the invention, the duration of the first phase of the pulse may be extended if the amplitude of the first phase of the pulse fails to fall to a threshold value by the end of the predetermined first phase duration, as might occur with a high impedance patient. In a third aspect of the invention, the first phase ends when the first phase amplitude drops below a threshold value or when the first phase duration reaches a threshold time value, whichever comes first, as might occur with a low to average impedance patient. This method and apparatus of altering the delivered biphasic pulse thereby compensates for patient impedance differences by changing the nature of the delivered electrotherapeutic pulse, resulting in a smaller, more efficient and less expensive defibrillator.
摘要翻译：本发明提供一种外部除颤器和除颤方法，其自动补偿用于除颤和心脏复律的电疗脉冲递送中的患者对患者的阻抗差异。在优选实施例中，除颤器具有能够通过患者身上的电极排出的能量源，以提供双相电压或电流脉冲。在本发明的一个方面，第一和第二相位持续时间和初始第一相位振幅是预定值。在本发明的第二方面中，如果脉冲的第一相位的幅度在预定的第一相位持续时间结束时不能下降到阈值，则脉冲的第一相位的持续时间可能会延长与高阻抗患者。在本发明的第三方面中，当第一相位幅度下降到低于阈值时或当第一相位持续时间达到阈值时间值（以先到者为准）时，第一相位结束，如同低平均阻抗患者可能发生的那样。改变输送的双相脉冲的这种方法和装置由此通过改变递送的电疗脉冲的性质来补偿患者的阻抗差异，导致更小，更有效和更便宜的除颤器。

27. 发明授权

US5749904A Electrotherapy method utilizing patient dependent electrical parameters 失效
标题翻译：使用患者依赖电参数的电疗方法
公开(公告)号：US5749904A
公开(公告)日：1998-05-12
申请号：US690529
申请日：1996-07-31
申请人： Bradford E. Gliner , Thomas D. Lyster , Clinton S. Cole , Daniel J. Powers , Carlton B. Morgan
发明人： Bradford E. Gliner , Thomas D. Lyster , Clinton S. Cole , Daniel J. Powers , Carlton B. Morgan
IPC分类号： A61N1/39
CPC分类号： A61N1/3937 , A61N1/3906 , A61N1/3912
摘要： The invention provides a method for delivering electrotherapy to a patient through electrodes connected to a plurality of capacitors, including the steps of discharging at least one of the capacitors across the electrodes to deliver electrical energy to the patient, monitoring a patient-dependent electrical parameter (such as voltage, current or charge) during the discharging step, and adjusting energy delivered to the patient based on a value of the electrical parameter. The adjusting step may include selecting a serial or parallel arrangement for the capacitors based on a value of the electrical parameter. In another embodiment, the invention provides a method for delivering electrotherapy to a patient through electrodes connectable to a plurality of capacitors including the steps of discharging at least one of the capacitors across the electrodes to deliver electrical energy to the patient in a waveform having at least a first phase and a second phase, monitoring a patient-dependent electrical parameter (such as voltage, current or charge) during the discharging step, and modifying second phase initial voltage based on a value of the electrical parameter. The adjusting step may include selecting a serial or a parallel arrangement for the capacitors based on a value of the electrical parameter.
摘要翻译：本发明提供了一种通过连接到多个电容器的电极向患者传送电疗的方法，包括以下步骤：将电极中的至少一个放电到电极以将电能传递给患者，监测患者依赖的电参数（例如电压，电流或电荷），以及基于电参数的值来调节递送给患者的能量。调整步骤可以包括基于电参数的值来选择用于电容器的串行或并行布置。在另一个实施例中，本发明提供了一种通过可连接到多个电容器的电极向患者传送电疗的方法，包括以下步骤：跨过电极放电电容器中的至少一个电容器，以至少具有至少一个波形的电波第一阶段和第二阶段，在放电步骤期间监测与患者相关的电参数（例如电压，电流或电荷），以及基于电参数的值修改第二相初始电压。调整步骤可以包括基于电参数的值来选择用于电容器的串行或并行布置。

28. 发明授权

US5620470A Electrotherapy method 失效
公开(公告)号：US5620470A
公开(公告)日：1997-04-15
申请号：US653386
申请日：1996-05-24
申请人： Bradford E. Gliner , Thomas D. Lyster , Clinton S. Cole , Daniel J. Powers , Carlton B. Morgan
发明人： Bradford E. Gliner , Thomas D. Lyster , Clinton S. Cole , Daniel J. Powers , Carlton B. Morgan
IPC分类号： A61N1/39
CPC分类号： A61N1/3937 , A61N1/3906 , A61N1/3912
摘要： This invention provides an external defibrillator and defibrillation method that automatically compensates for patient-to-patient impedance differences in the delivery of electrotherapeutic pulses for defibrillation and cardioversion. In a preferred embodiment, the defibrillator has an energy source that may be discharged through electrodes on the patient to provide a biphasic voltage or current pulse. In one aspect of the invention, the first and second phase duration and initial first phase amplitude are predetermined values. In a second aspect of the invention, the duration of the first phase of the pulse may be extended if the amplitude of the first phase of the pulse fails to fall to a threshold value by the end of the predetermined first phase duration, as might occur with a high impedance patient. In a third aspect of the invention, the first phase ends when the first phase amplitude drops below a threshold value or when the first phase duration reaches a threshold time value, whichever comes first, as might occur with a low to average impedance patient. This method and apparatus of altering the delivered biphasic pulse thereby compensates for patient impedance differences by changing the nature of the delivered electrotherapeutic pulse, resulting in a smaller, more efficient and less expensive defibrillator.

29. 发明授权

US5370664A Pulse forming circuits 失效
标题翻译：脉冲形成电路
公开(公告)号：US5370664A
公开(公告)日：1994-12-06
申请号：US104441
申请日：1993-08-10
申请人： Carlton B. Morgan , Daniel Yerkovich , Donald C. Maier
发明人： Carlton B. Morgan , Daniel Yerkovich , Donald C. Maier
IPC分类号： A61N1/362 , A61N1/39 , G01K1/18 , H03K3/53 , A61N1/00
CPC分类号： A61N1/39 , A61N1/3912 , G01K1/18 , A61N1/3906
摘要： Circuits for controlling the current flow of an energy pulse as a function of the temperature of a resistive element in the circuit so that the current flow varies over time in accordance with a predetermined waveform. The circuits include at least one negative temperature coefficient thermistor connected between an energy storage device and connectors for delivering energy stored in the storage source to an external load. In one embodiment of the invention the circuit includes a second thermistor for shunting a residual portion of the current delivered by an energy pulse away from the external load. In another embodiment of the circuit, a small inductive device is used for adjusting the shape of the predetermined waveform. In yet another embodiment of the device, a plurality of thermistors arranged in a bridge-like configuration are used to control the current of the energy pulse so that its waveform is biphasic. Heat sinks may be attached to the thermistors for cooling the latter so as to increase the rate at which energy pulses may be delivered by the circuits.
摘要翻译：用于控制作为电路中的电阻元件的温度的函数的能量脉冲的电流流动的电路，使得电流根据预定波形随时间变化。电路包括连接在能量存储装置和连接器之间的至少一个负温度系数热敏电阻器，用于将存储在存储源中的能量传送到外部负载。在本发明的一个实施例中，电路包括第二热敏电阻，用于分流由能量脉冲输送的电流的剩余部分远离外部负载。在电路的另一个实施例中，使用小的电感器件来调节预定波形的形状。在器件的又一个实施例中，以桥状结构布置的多个热敏电阻用于控制能量脉冲的电流，使得其波形是双相的。散热器可以附接到热敏电阻器以冷却热敏电阻器，以便增加电路可能输送能量脉冲的速率。

30. 发明授权

US5275157A Pulse forming circuits 失效
公开(公告)号：US5275157A
公开(公告)日：1994-01-04
申请号：US685132
申请日：1991-04-12
申请人： Carlton B. Morgan , Daniel Yerkovich , Donald C. Maier
发明人： Carlton B. Morgan , Daniel Yerkovich , Donald C. Maier
IPC分类号： A61N1/362 , A61N1/39 , G01K1/18 , H03K3/53 , A61N1/00
CPC分类号： A61N1/39 , A61N1/3912 , G01K1/18 , A61N1/3906
摘要： Circuits for controlling the current flow of an energy pulse as a function of the temperature of a resistive element in the circuit so that the current flow varies over time in accordance with a predetermined waveform. The circuits include at least one negative temperature coefficient thermistor connected between an energy storage device and connectors for delivering energy stored in the storage source to an external load. In one embodiment of the invention the circuit includes a second thermistor for shunting a residual portion of the current delivered by an energy pulse away from the external load. In another embodiment of the circuit, a small inductive device is used for adjusting the shape of the predetermined waveform. In yet another embodiment of the device, a plurality of thermistors arranged in a bridge-like configuration are used to control the current of the energy pulse so that its waveform is biphasic. Heat sinks may be attached to the thermistors for cooling the latter so as to increase the rate at which energy pulses may be delivered by the circuits.

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