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21. 发明授权

US4884579A Catheter guide wire 失效
标题翻译：导管导丝
公开(公告)号：US4884579A
公开(公告)日：1989-12-05
申请号：US182870
申请日：1988-04-18
申请人： Erik T. Engelson
发明人： Erik T. Engelson
IPC分类号： A61M25/01 , A61B5/02 , A61M25/00
CPC分类号： A61M25/09 , A61M2025/09175
摘要： A catheter guide wire designed for use in guiding a catheter to a target site along a tortuous vessel path. The guide wire has a relatively long, torqueable proximal wire section, a more flexible intermediate section, and a most flexible distal end section designed to be advanced across sharp-bend vessel junctions. The intermediate section has greater lubricity than the adjacent proximal and distal sections. The greater frictional coefficient in the distal end segment acts to anchor the end of the wire in a branch vessel, when the guide wire has been advanced across the sharp-bend vessel junction, and the catheter is threaded axially over the wire, while the more lubricious surface of the intermediate section gives reduced sliding friction within the catheter during such advance. The invention also includes a catheter device containing the guide wire and catheter.
摘要翻译：导管导丝，其设计用于沿着曲折的血管路径将导管引导到目标部位。引导线具有相对长的，可扭转的近侧线段，更柔性的中间段，以及最柔性的远端段，其被设计成在尖弯管容器连接处前进。中间部分具有比相邻的近端和远端部分更大的润滑性。当导丝已经穿过尖弯管容器连接处时，远端段中较大的摩擦系数用于将电线的末端锚定在分支容器中，并且导管在导线上轴向穿过，而更多中间部分的光滑表面在这样的推进期间导致导管内的滑动摩擦减小。本发明还包括含有导丝和导管的导管装置。

22. 发明授权

US4832047A Guide wire device 失效
标题翻译：导线装置
公开(公告)号：US4832047A
公开(公告)日：1989-05-23
申请号：US132924
申请日：1987-12-15
申请人： Ivan Sepetka , Erik T. Engelson
发明人： Ivan Sepetka , Erik T. Engelson
IPC分类号： A61B17/00 , A61B17/22
CPC分类号： A61M25/09033 , A61B2017/00526 , A61B2017/22001 , A61M2025/09175
摘要： A guide wire formed with a distal tapered segment and having a distal-end coil carried over a portion of the tapered segment. The strand forming the helical wrappings of the coil is reduced in thickness in the region of proximal attachment to the wire, to reduce the difference in diameter between the wire and the coil. Also disclosed is a method of producing the coil.
摘要翻译：导丝，其形成有远端锥形段，并且具有承载在锥形段的一部分上的远端线圈。形成线圈的螺旋形包装的线材在近端连接到线材的区域中的厚度减小，以减少线材和线圈之间的直径差。还公开了一种制造线圈的方法。

23. 发明授权

US07883474B1 Composite braided guidewire 失效
标题翻译：复合编织导丝
公开(公告)号：US07883474B1
公开(公告)日：2011-02-08
申请号：US08640259
申请日：1996-04-30
申请人： Gregory E. Mirigian , Harold E. Carrison , Laurent Schaller , Erik T. Engelson
发明人： Gregory E. Mirigian , Harold E. Carrison , Laurent Schaller , Erik T. Engelson
IPC分类号： A61M25/00
CPC分类号： A61M25/09 , A61M2025/09175
摘要： This is a composite guidewire for use with a catheter for accessing a targeted site in a lumen system of a patient's body. The guidewire core or guidewire section may be of a stainless steel or a high elasticity metal alloy, preferably a Ni—Ti alloy, also preferably having specified physical parameters. The composite guidewire assembly is especially useful for accessing peripheral or soft tissue targets. The invention includes multi-section guidewire assemblies having super-elastic alloy or stainless steel ribbon braided reinforcements along a least a portion of the core. A variation of the inventive guidewire includes a braid and a tie layer (and one or more lubricious polymers on the tie layer exterior) to enhance the guidewire's suitability for use within catheters and within the interior of vascular lumen.
摘要翻译：这是一种用于与用于进入患者身体的管腔系统中的目标部位的导管一起使用的复合导丝。导丝芯或导丝部分可以是不锈钢或高弹性金属合金，优选Ni-Ti合金，也优选具有特定的物理参数。复合导丝组件对于接近外周或软组织靶是特别有用的。本发明包括具有沿着芯的至少一部分的超弹性合金或不锈钢丝带编织增强件的多段导丝组件。本发明的导丝的变体包括编织物和连接层（以及在连接层外部的一种或多种润滑聚合物），以增强导丝线在导管内和血管内腔内的适用性。

24. 发明授权

US06468266B1 Fast detaching electrically isolated implant 有权
标题翻译：快速拆卸电隔离植入物
公开(公告)号：US06468266B1
公开(公告)日：2002-10-22
申请号：US09644244
申请日：2000-08-22
申请人： Mehran Bashiri , Michael P. Wallace , Pete Phong Pham , Cong Thach , Chad C. Roue , Joseph C. Eder , Erik T. Engelson
发明人： Mehran Bashiri , Michael P. Wallace , Pete Phong Pham , Cong Thach , Chad C. Roue , Joseph C. Eder , Erik T. Engelson
IPC分类号： A61F1100
CPC分类号： A61F2/95 , A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B17/12154 , A61B2017/12063 , A61F2/01 , A61F2002/011 , A61F2002/016 , A61F2002/9505 , A61F2230/0006 , A61F2230/005 , A61F2230/0069 , A61F2230/0091
摘要： This is an implant for placement in the human body and an assembly for so placing that implant. Most desirably, it is an implant for use in the vasculature of the human body and is used to occlude some space in that vasculature as a portion of a treatment regimen. The implant itself is preferably a component of a deployment device using an electrolytically severable joint. The implant is electrically isolated from the electrolytically severable joint by a highly resistive or insulative layer. Such isolation and minimization of the conductive pathway from the placement apparatus to the body's fluids appears to enhance the susceptibility of the electrolytic joint to quick erosion and detachment of the implant from the deployment media. Although the implant itself is preferably a vaso-occlusive device, it may instead be a stent, a vena cava filter, or other implant which may be installed in this manner.
摘要翻译：这是用于放置在人体中的植入物和用于使得植入物放置的组件。最理想的是，它是用于人体脉管系统的植入物，并且用于封闭该脉管系统中的一些空间作为治疗方案的一部分。植入物本身优选是使用电解可分割接头的展开装置的部件。植入物通过高电阻或绝缘层与电解可分离的接头电隔离。从放置装置到身体的流体的导电通路的这种隔离和最小化似乎增强了电解接头对植入物从展开介质的快速侵蚀和分离的敏感性。虽然植入物本身优选为血管闭塞装置，但它可以是支架，腔静脉过滤器或可以以这种方式安装的其它植入物。

25. 发明授权

US6152912A Optimized high performance spiral-wound vascular catheter 失效
标题翻译：优化的高性能螺旋缠绕血管导管
公开(公告)号：US6152912A
公开(公告)日：2000-11-28
申请号：US872215
申请日：1997-06-10
申请人： Lex P. Jansen , Peter Kyone Park , Gene Samson , Henry Nita , Erik T. Engelson
发明人： Lex P. Jansen , Peter Kyone Park , Gene Samson , Henry Nita , Erik T. Engelson
IPC分类号： A61M25/00
CPC分类号： A61M25/0053
摘要： This is a catheter suitable for accessing a tissue target within the body, typically a target which is accessible through the vascular system. Central to the concept of the catheter is the use of a reinforcing member wound within the catheter body in such a way to create a catheter having an exceptionally thin wall, excellent kink-resistance, and controlled stiffness. The catheter assembly desirably is constructed of: (a) an inner, polymeric, lubricious liner, (b) a first, helically wound coil over at least the more distal portions of the inner liner, (c) a second, helically wound coil exterior to the first coil located at least on the more proximal portion of the assembly, and (d) one or more outer polymeric coverings exterior to the second coil. Further polymeric layers may also be placed between the outer polymeric covering and the helically wound coils. The outer polymeric covering may be composed of a series of different polymeric compositions to provide suitably differing flexibilities to the assembly. The catheter assembly is quite easy to produce. The helically wound coils are desirably bound to the assembly via the use of radio-opaque bands or coils and preferably are continuously wound from a single member. The distal-most portion of the catheter assembly is very flexible but highly kink resistant.
摘要翻译：这是适于进入体内的组织靶的导管，通常是可通过血管系统接近的靶。导管概念的中心是使用缠绕在导管体内的加强构件以这种方式产生具有特别薄壁的导管，优异的耐扭结性和可控刚度。导管组件理想地由以下构成：（a）内部，聚合物，润滑衬垫，（b）在内衬层的至少较远的远端部分上的第一螺旋卷绕的线圈，（c）第二螺旋卷绕的线圈外部至少位于组件的较近端部分上的第一线圈，和（d）在第二线圈外部的一个或多个外部聚合物覆盖物。另外的聚合物层也可以放置在外部聚合物覆盖物和螺旋卷绕的线圈之间。外部聚合物覆盖物可以由一系列不同的聚合物组合物组成，以向该组件提供适当不同的柔性。导管组件很容易生产。螺旋卷绕的线圈期望地通过使用不透射线的带或线圈与组件接合，并且优选地从单个构件连续缠绕。导管组件的最远端部分是非常柔性的，但是高度扭结。

26. 发明授权

US5951539A Optimized high performance multiple coil spiral-wound vascular catheter 失效
公开(公告)号：US5951539A
公开(公告)日：1999-09-14
申请号：US995088
申请日：1997-12-19
申请人： Henry Nita , Lex P. Jansen , Peter Kyone Park , Gene Samson , Erik T. Engelson , Jeffrey A. Sarge
发明人： Henry Nita , Lex P. Jansen , Peter Kyone Park , Gene Samson , Erik T. Engelson , Jeffrey A. Sarge
IPC分类号： A61M25/00
CPC分类号： A61M25/0053 , A61M25/005
摘要： This invention is a surgical device. In particular, it is a catheter suitable for accessing a tissue target within the body, typically a target which is accessible through the vascular system. Central to the invention is the use of at least pair of wound or counterwound reinforcing members situated within the wall of the catheter body in such a way to achieve a catheter having an exceptionally thin wall, excellent kink-resistance, and controlled stiffness. The catheter assembly desirably is constructed of: (a) an inner, polymeric, lubricious liner, (b) a first, helically wound coil extending over at least the more distal portions of the inner liner but preferably for most of the length of the catheter, (c) a second, helically wound coil exterior to the first coil, located at least on the more proximal portion of the assembly but preferably for most of the length of the catheter, preferably wound in a direction opposite to the first coil, (d) optionally, one or more helically wound coils placed on the proximal and mid-section of the assembly, and (e) one or more polymeric layers variously exterior to the second coil and interior to the first coil. Preferably, the coils are wound from metallic ribbons or wireshaving a relatively constant pitch of from 10.degree.-15.degree. of the central catheter axis. Further polymeric layers may also be placed between the outer polymeric covering and various and the helically wound coils. The outer polymeric covering may be composed of a series of different polymeric compositions to provide suitably differing flexibilities along the length of the assembly. The catheter assembly is quite easy to produce. The helically wound coils may be bound to the assembly via the use of radio-opaque bands or coils and may be continuously wound from a single member. The distal-most portion of the catheter assembly is very flexible but highly kink resistant. Optionally, the invention includes a catheter in which only the more distal catheter section incorporates multiple coil stiffener members.

27. 发明授权

US5853418A Stretch resistant vaso-occlusive coils (II) 失效
标题翻译：抗拉性血管闭塞线圈（II）
公开(公告)号：US5853418A
公开(公告)日：1998-12-29
申请号：US779451
申请日：1997-01-07
申请人： Christopher G.M. Ken , Son M. Gia , Erik T. Engelson , Joseph C. Eder , Clifford Teoh
发明人： Christopher G.M. Ken , Son M. Gia , Erik T. Engelson , Joseph C. Eder , Clifford Teoh
IPC分类号： A61B17/00 , A61B17/12 , A61B19/00 , A61F2/00 , A61M29/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B17/12154 , A61B2017/00867 , A61B2017/12063 , A61B2090/3937 , A61F2002/30093 , A61F2210/0019
摘要： This is an implantable vaso-occlusive device. It is typically a vaso-occlusive coil comprising a primary helically wound coil which may then be wound into a secondary shape. Central to the invention is the use of a stretch-resisting member extending through the lumen formed, which stretch-resisting member is fixedly attached, directly or indirectly, to the coil in at least two locations. The stretch resisting member is preferably somewhat loose within the interior of the lumen so to prevent the coil from collapsing, binding, and therefore stiffening during passage of turns through the human body. The coil should bend easily. In some variations of the invention, the stretch-resisting member may be formed into coil tips at the ends of the coil using simple equipment such as soldering irons or the like. The tips are typically of the same diameter as is the coil body itself. This stretch-resisting member is for the primary purpose of preventing stretching of the coil during movement of that coil, e.g., by retrieval or repositioning after deployment. The device may have a self-forming secondary shape made from a pre-formed primary linear helically wound coil, although it need not have the secondary form. Desirably, the coil is extremely flexible and is controllaby released using a severable or mechanical joint such as an electrolytically detachable joint. External fibers may be attached to the device and affixed to the pre-formed linear member to increase thrombogenicity. The extremely flexible variation of the invention may be hydraulically delivered through the lumen of a catheter and is so flexible that it may be retrievably delivered therethrough a flow-directed catheter. The vaso-occlusive member may be also be covered with a fibrous braid. The device is typically introduced into the body through a catheter. The device is passed axially through the catheter sheath and assumes its secondary form upon exiting the catheter.
摘要翻译：这是一种植入式血管闭塞装置。它通常是包括初级螺旋缠绕线圈的血管闭塞线圈，然后可以将其缠绕成次级形状。本发明的中心在于在至少两个位置上使用延伸穿过形成的内腔的拉伸抵抗构件，该拉伸抵抗构件直接地或间接地固定到线圈上。拉伸阻力构件优选地在内腔的内部稍微松动，从而防止线圈在匝穿过人体期间塌陷，结合并因此加强。线圈应弯曲容易。在本发明的一些变型中，可以使用诸如烙铁等的简单设备在线圈的端部处形成线圈尖端。尖端通常具有与线圈体本身相同的直径。该抗拉伸构件的主要目的是防止在线圈移动过程中线圈的拉伸，例如通过在展开后的取回或重新定位。该装置可以具有由预先形成的初级线性螺旋缠绕线圈制成的自成形次级形状，尽管它不需要具有二次形式。理想地，线圈非常柔软，并且使用可分离或机械接头（例如电解可拆卸接头）进行控制释放。外部纤维可以附着到装置上并固定到预先形成的线性构件上以增加血栓形成。本发明的极其灵活的变化可以通过导管的内腔液压输送，并且是如此柔性的，使得其可被可逆地递送通过其中的导向导管。血管闭塞性构件也可以用纤维编织物覆盖。该装置通常通过导管引入身体。该装置轴向穿过导管护套，并在离开导管时呈现其次级形式。

28. 发明授权

US5599492A Method for making a guidewire with a flexible distal tip 失效
标题翻译：用于制造具有柔性远端尖端的导丝的方法
公开(公告)号：US5599492A
公开(公告)日：1997-02-04
申请号：US357975
申请日：1994-12-16
申请人： Erik T. Engelson
发明人： Erik T. Engelson
IPC分类号： A61M25/01 , A61B5/00 , B29C47/02 , B29C47/18
CPC分类号： A61M25/09 , A61M2025/0098 , A61M2025/09083 , A61M2025/09108 , A61M2025/09175
摘要： A method for producing catheter guidewire composed of a wire core whose distal end section is encased in a polymer sleeve, to increase the column strength of the core. Axially spaced grooves formed in the sleeve increase the flexibility of the core end section. The guidewire is advantageous for use with a small-diameter catheter in accessing body sites along a tortuous vessel pathway.
摘要翻译：一种用于制造导管导丝的方法，该导丝导线由其前端部分包封在聚合物套筒中的线芯构成，以增加芯的柱强度。形成在套筒中的轴向隔开的槽增加了芯部端部的柔性。该引导线有利于与小直径导管一起沿着曲折血管通路进入身体部位。

29. 发明授权

US5308342A Variable stiffness catheter 失效
标题翻译：可变刚度导管
公开(公告)号：US5308342A
公开(公告)日：1994-05-03
申请号：US741775
申请日：1991-08-07
申请人： Ivan Sepetka , Phong Pham , Erik T. Engelson
发明人： Ivan Sepetka , Phong Pham , Erik T. Engelson
IPC分类号： A61M25/00
CPC分类号： A61M25/0054
摘要： A catheter composed of an outer coaxial tube or relatively high flexibility and three tandemly disposed inner coaxial tube segments that vary in stiffness with the stiffest being located at the proximal end of the catheter and the least stiff ending proximal of the proximal end of the catheter. The catheter thus has four regions of different stiffness/flexibility.
摘要翻译：由外同轴管或相对高柔性组成的导管和三个串列布置的内同轴管段，其刚度变化，最刚性位于导管的近端处，并且导管的近端近端的最不僵硬的终端。因此导管具有不同刚度/柔性的四个区域。

30. 发明授权

US5304195A Detachable pusher-vasoocclusive coil assembly with interlocking coupling 失效
标题翻译：具有互锁联轴器的可拆卸式推动器 - 血管闭塞线圈组件
公开(公告)号：US5304195A
公开(公告)日：1994-04-19
申请号：US007375
申请日：1993-01-21
申请人： Robert H. Twyford, Jr. , Erik T. Engelson , Uriel H. Chee , Michael J. Mariant
发明人： Robert H. Twyford, Jr. , Erik T. Engelson , Uriel H. Chee , Michael J. Mariant
IPC分类号： A61F2/82 , A61B17/12 , A61F2/01
CPC分类号： A61F2/01 , A61B17/12022 , A61B17/1214 , A61B2017/1205 , A61F2002/016 , A61F2230/0006 , A61F2230/0091
摘要： A pusher-vasoocclusive coil assembly that is advanced through a catheter to a site within a vessel and is manipulated to detach the coil from the assembly. The coil has an affixed, proximally-extending wire that carries a ball on its proximal end and the pusher has an affixed, distally-extending wire that carries a ball on its distal end. The pusher and coil are coupled by placing the wires and balls in an overlapping interlocked position and enclosing the coupled assembly with a coaxial sleeve. The coil-pusher-sleeve assembly is positioned at the site and the sleeve is retracted to allow the balls to move radially relative to one another to disengage and uncouple the pusher and coil.
摘要翻译：推进器 - 血管收缩线圈组件，其通过导管前进到血管内的部位，并被操纵以将线圈从组件分离。线圈具有固定的近端延伸的线，其在其近端处承载球，并且推动器具有固定的远端延伸的线，其在其远端上承载球。推动器和线圈通过将电线和球放置在重叠的互锁位置并且用同轴套筒包围联接的组件而联接。线圈推动器 - 套筒组件定位在现场并且套筒缩回以允许球相对于彼此径向移动以使推动器和线圈脱离和分离。

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