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21. 发明申请

US20060293514A1 Nucleotide lipid ester derivatives 失效
标题翻译：核苷酸脂质酯衍生物
公开(公告)号：US20060293514A1
公开(公告)日：2006-12-28
申请号：US10549799
申请日：2004-03-18
申请人： Dieter Herrmann , Brigitte Heckl-Oestreicher , Christoph Mueller , Christian Lutz , Robert Voigt , William Bauta
发明人： Dieter Herrmann , Brigitte Heckl-Oestreicher , Christoph Mueller , Christian Lutz , Robert Voigt , William Bauta
IPC分类号： C07H19/20 , C07H19/04
CPC分类号： A61K31/7076 , C07H19/04 , C07H19/20
摘要： The subject of the present invention are specific lipidesters of halogenated-adenine nucleotides and the use of such lipidesters in the treatment of tumors.
摘要翻译：本发明的主题是卤代腺嘌呤核苷酸的特异性脂质体以及这些脂质体在治疗肿瘤中的用途。

22. 发明授权

US06955608B1 Double joint for steering axles in automobiles 失效
标题翻译：汽车转向轴双关节
公开(公告)号：US06955608B1
公开(公告)日：2005-10-18
申请号：US09600593
申请日：1999-01-13
申请人： Christian Lutz
发明人： Christian Lutz
IPC分类号： F16D3/33 , F16D3/36
CPC分类号： F16D3/33 , Y10T403/32737 , Y10T403/32762
摘要： A steering shaft universal joint assembly for motor vehicles as provided. Shaft ends are fastened against rotation in the joint, the ends being held in a housing joint adjoining the two joints with interposition of a ball joint so that the ball of the ball joint is mounted for rotation about its center point in a socket of one shaft end and is slidingly movable in a direction of the shaft axis of the other shaft end. The ball is resiliently mounted in the socket and the socket receives a slide bushing.
摘要翻译：提供的用于机动车辆的转向轴万向节组件。轴端部被紧固在接头中以防止旋转，端部被保持在与两个接头相邻的壳体接头中，插入球接头，使得球窝接头的球被安装成围绕其中心点在一个轴的插座中旋转并且能够在另一轴端的轴线的方向上滑动移动。球弹性地安装在插座中，并且插座接收滑动衬套。

23. 发明授权

US06896290B2 Steering gear shaft for a steering column of a motor vehicle 有权
标题翻译：用于汽车转向柱的转向齿轮轴
公开(公告)号：US06896290B2
公开(公告)日：2005-05-24
申请号：US10388010
申请日：2003-03-13
申请人： Christian Lutz
发明人： Christian Lutz
IPC分类号： B21C37/15 , B21C37/20 , B21D15/06 , B62D1/19 , B60D1/19
CPC分类号： B62D1/192 , B21C37/154 , B21C37/205 , B21D15/06
摘要： A steering gear shaft for a steering column of a motor vehicle has at least one crash-deformable section formed as a corrugated tube at least a portion of a longitudinal extent of which that contains at least one of corrugation crests of the corrugated tube, is formed of several layers, with a wall thickness of at least one layer in the at least one of the at least one of the corrugation crests and a respective corrugation trough diminishing over a region of the at least one of the corrugation crests and the respective corrugation trough between a side of the corrugation tube adjacent to which a universal joint is provided, and a side of the corrugation tube remote from the universal joint.
摘要翻译：用于机动车辆的转向柱的转向齿轮轴具有形成为波纹管的至少一个可变形部分，其中至少一部分纵向延伸部分包含波纹管的波纹波峰中的至少一个，形成其中至少一个波纹顶部中的至少一个中的至少一个壁的壁厚和相应的波纹槽在波纹波峰和相应的波纹槽中的至少一个的区域上减小，在相邻于其的万向节的波纹管的一侧和远离万向接头的波纹管的一侧之间。

24. 发明授权

US06581965B2 Device for height and longitudinal adjustment of a steering column of a motor vehicle 有权
公开(公告)号：US06581965B2
公开(公告)日：2003-06-24
申请号：US09894673
申请日：2001-06-28
申请人： Christian Lutz
发明人： Christian Lutz
IPC分类号： B62D1187
CPC分类号： B62D1/184
摘要： A device for effecting height and longitudinal adjustment of a steering column of a vehicle and including first and second adjustment devices for adjusting, respectively, height and length of the steering column, with the first adjusting devices including a lamella stack formed of alternating large and small lamellas through which a locking bolt extends, with the large lamellas being arranged in or on the bracket with a possibility of changing of spacing therebetween but without a possibility of displacement in a direction of the height adjustment of the steering column, the large lamellas having each an inner recess for enabling displacement of the locking bolt relative to the bracket in the open position of the first adjusting device to enable the height adjustment of the steering column, and with the small lamellas being arranged for displacement in an axial direction of the locking bolt but without a possibility of displacement relative to the locking bolt in the direction of the height adjustment of the steering column.

25. 发明授权

US06296647B1 Instrument for the positioning of an implant in the human spine 有权
标题翻译：用于在人类脊柱中定位植入物的仪器
公开(公告)号：US06296647B1
公开(公告)日：2001-10-02
申请号：US09369477
申请日：1999-08-06
申请人： Bernd Robioneck , Christian Lutz , Reinhard Windhager , Rainer Kotz , Richard Vlasak , Paul Wuisman
发明人： Bernd Robioneck , Christian Lutz , Reinhard Windhager , Rainer Kotz , Richard Vlasak , Paul Wuisman
IPC分类号： A61F246
CPC分类号： A61F2/4611 , A61B17/025 , A61B17/70 , A61B17/7059 , A61B17/809 , A61B17/86 , A61F2/44 , A61F2002/30125 , A61F2002/30131 , A61F2002/30228 , A61F2002/30235 , A61F2002/30238 , A61F2002/30329 , A61F2002/30383 , A61F2002/30387 , A61F2002/30428 , A61F2002/30494 , A61F2002/30507 , A61F2002/30512 , A61F2002/30517 , A61F2002/3055 , A61F2002/30553 , A61F2002/30578 , A61F2002/30599 , A61F2002/30601 , A61F2002/30604 , A61F2002/30774 , A61F2002/30777 , A61F2002/30785 , A61F2002/30787 , A61F2002/30841 , A61F2002/30975 , A61F2002/4475 , A61F2220/0025 , A61F2230/0008 , A61F2230/0013 , A61F2230/0069 , A61F2250/0008 , A61F2250/0063
摘要： An instrument for the positioning of an implant into the human spine, as a replacement for one or more diseased vertebra bodies has vertebra body plates attachable to the healthy vertebra bodies. Distraction rods are provided which at one end are attachable to a vertebra body plate. Two U-shaped parts having limbs which telescopically cooperate and form a tubular housing around the attached distraction rods. The U-shaped parts comprise inner sections which are supported on the distraction rods. A distraction instrument which is connectable to the other ends of the distraction rods is used for exerting a force onto the rods transversely to their longitudinal direction.
摘要翻译：用于将植入物定位到人脊柱中的仪器作为一个或多个患病椎骨体的替代物，具有可固定到健康椎骨体的椎骨体板。提供牵引杆，其一端可附接到椎骨体板。两个U形部件具有可伸缩配合的四肢并围绕附接的牵引杆形成管状壳体。 U形部件包括支撑在牵引杆上的内部部分。可以连接到牵引杆的另一端的牵引装置用于在横向于其纵向方向上向杆施加力。

26. 发明授权

US5308283A Joint for cardan shafts 失效
标题翻译：万向轴接头
公开(公告)号：US5308283A
公开(公告)日：1994-05-03
申请号：US820093
申请日：1992-01-13
申请人： Christian Lutz
发明人： Christian Lutz
IPC分类号： F16D3/26 , B60K17/24 , F16D3/38 , F16D3/40 , F16D3/41 , B62D1/16
CPC分类号： B60K17/24 , F16D3/41
摘要： A joint is provided for cardan shafts, as are for instance, utilized in steering columns of motor vehicles and includes a trunnion cross provided as a coupling member, the axis length of the one pair of trunnions of this trunnion cross being larger than the axis length of the other trunnion pair, the trunnion pair having the greater axis length being supported in the end of one shaft configured as a bell-shaped joint part, while the trunnion pair having the smaller axis length on the hand is received by the arms of a fork, forming the end of the other shaft. The ratio of the lengths of the lever arms, on which the computation of the arising forces and moments is based, is only slightly greater than one, and the outer side of the bell or tulip shaped joint part is set off in a step like manner for receiving and/or abutting a bearing or a bearing ring. The center point of the joint lies in or closely to the central plane of the bearing or bearing ring received by the bell-shaped joint part.
摘要翻译：为万向轴提供接头，例如用于机动车辆的转向柱中，并且包括作为联接构件提供的耳轴十字轴，该耳轴十字形的一对耳轴的轴线长度大于轴长度的另一个耳轴对，具有较大轴长的耳轴对支撑在构成钟形接头部分的一个轴的端部，而具有较小轴线长度的耳轴对由手臂接收叉，形成另一轴的端部。所产生的力和力矩的计算所依据的杠杆臂的长度的比率仅略大于1，并且钟形或郁金香形状的接合部分的外侧以类似步骤的方式被排出用于接收和/或抵靠轴承或轴承环。接头的中心点位于或靠近由钟形接头部分接收的轴承或轴承环的中心平面。

27. 发明申请

US20180185509A1 AMATOXIN-CONJUGATES WITH IMPROVED LINKAGES 审中-公开
公开(公告)号：US20180185509A1
公开(公告)日：2018-07-05
申请号：US15728170
申请日：2017-10-09
申请人： Werner Simon , Christian Lutz , Christoph Müller , Jan Anderl
发明人： Werner Simon , Christian Lutz , Christoph Müller , Jan Anderl
IPC分类号： A61K47/68 , A61K38/12 , A61K47/64 , A61K47/61 , A61K47/66
CPC分类号： A61K47/6813 , A61K38/12 , A61K47/61 , A61K47/64 , A61K47/66 , A61K47/6831 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6891
摘要： The present disclosure relates to tumour therapy. In one aspect, the present disclosure relates to conjugates of an amatoxin and a target-binding moiety, e.g. an antibody, connected by certain linkages, which are useful in the treatment of cancer. In a further aspect the invention relates to pharmaceutical compositions comprising such conjugates.

28. 发明授权

US08603091B2 Pelvic and scapular bone plate and method for implantation 有权
标题翻译：骨盆和肩胛骨板及植入方法
公开(公告)号：US08603091B2
公开(公告)日：2013-12-10
申请号：US13040722
申请日：2011-03-04
申请人： Christian Lutz , Jakob Kemper
发明人： Christian Lutz , Jakob Kemper
IPC分类号： A61B17/80 , A61B17/88
CPC分类号： A61B17/8085 , A61B17/8066 , A61B17/809
摘要： The invention relates to a pelvic or scapular bone plate implant having a planar or curved outer frame portion. The frame has a surface which can be aligned with a surface of a bone to which the bone plate is to be implanted. The plate has a flap portion, the outer frame portion at least partially surrounds the flap portion such that the bone contacting surface the flap portion is located within the outer boundary of the frame portion. The flap portion is connected with the outer frame portion via a material interconnection which allows the flap to be bent with respect to the frame. A method for implanting such a bone plate implant is also taught.
摘要翻译：本发明涉及具有平面或弯曲的外框部分的骨盆或肩胛骨骨板植入物。框架具有可以与待植入骨板的骨的表面对准的表面。板具有翼片部分，外框架部分至少部分地围绕翼片部分，使得翼片部分的骨接触表面位于框架部分的外边界内。翼片部分经由允许翼片相对于框架弯曲的材料互连件与外框架部分连接。还教导了一种用于植入这种骨板植入物的方法。

29. 发明授权

US08523923B2 Clamping and articulation element 有权
标题翻译：夹紧和铰接元件
公开(公告)号：US08523923B2
公开(公告)日：2013-09-03
申请号：US11641600
申请日：2006-12-19
申请人： Roland Thomke , Christian Lutz , Vinzenz Burgherr , Damian Fankhauser
发明人： Roland Thomke , Christian Lutz , Vinzenz Burgherr , Damian Fankhauser
IPC分类号： A61B17/60
CPC分类号： A61B17/6466 , A61B17/60 , A61B17/645 , F16B7/0493 , Y10T24/3439 , Y10T24/44034 , Y10T403/7105
摘要： A two-piece clamping element comprises two separate, i.e., non-integral, opposing first and second clamping jaws forming a laterally open cavity to receive a pin or rod-shaped element. Each clamping jaw has a bore aligned with one another to receive a screw, wherein a pivot bearing is arranged opposite said cavity allowing the two opposing clamping jaws to come in contact to one another. The pivot bearing comprises at least one set of complementary part-cylindrical bearing surface portions. An anti-rotation pin extends between the two jaw members.
摘要翻译：两件式夹紧元件包括两个单独的，即非整体的相对的第一和第二夹爪，形成横向敞开的腔以容纳销或棒状元件。每个夹爪具有彼此对准的孔以容纳螺钉，其中枢转轴承布置成与所述腔相对，允许两个相对的夹爪彼此接触。枢转轴承包括至少一组互补的部分圆柱形支承表面部分。防旋转销在两个钳口构件之间延伸。

30. 发明授权

US07686837B2 Polyaxial locking implantable orthopedic fixation device 有权
标题翻译：多轴锁定植入式矫形固定装置
公开(公告)号：US07686837B2
公开(公告)日：2010-03-30
申请号：US10544323
申请日：2003-12-31
申请人： André Gasser , Christian Lutz , Thomas Baumgartner , Andreas Bernhard
发明人： André Gasser , Christian Lutz , Thomas Baumgartner , Andreas Bernhard
IPC分类号： A61B17/58
CPC分类号： A61B17/8047 , A61B17/863
摘要： The invention relates to an implantable orthopaedic device comprising a load-bearing element, such as a bone plate, for fixing elements, such as bone screws, that can be oriented polyaxially. The load-bearing element is equipped with at least one opening for the passage of the fixing elements. A two part insert is provided in the opening, the insert having an external form that complements the internal form of the receiving opening and permits the polyaxial rotation of the insert in the opening. The insert is equipped with a central bore for receiving the body of the fixing element. The first insert element part has a central inner hollow chamber, into which the second insert element part can be introduced. The first insert element is flexible or has at least one slit, in such a way that when the two insert elements are displaced axially in relation to one another, the first insert element in the plate can be expanded at least partially in order to block the position and alignment of the fixing element in the device in a polyaxial manner.
摘要翻译：本发明涉及一种可植入矫形装置，其包括用于诸如骨螺钉的固定元件（例如骨板）的承载元件，其可以被多轴定向。承载元件配备有用于固定元件通过的至少一个开口。两个部分的插入件设置在开口中，插入件具有补充接收开口的内部形式的外部形式并且允许插入件在开口中的多轴旋转。插入件配备有用于接收固定元件的主体的中心孔。第一插入元件部分具有中心内部中空室，可以将第二插入元件部分引入该中空室。第一插入元件是柔性的或具有至少一个狭缝，以这样的方式，当两个插入元件相对于彼此轴向移位时，板中的第一插入元件可以至少部分地膨胀以阻止固定元件以多轴方式在装置中的位置和对准。

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