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21. 发明申请

US20080004679A1 NON-INVASIVE MODULATION OF THE AUTONOMIC NERVOUS SYSTEM 审中-公开
标题翻译：自主神经系统的非侵入性调节
公开(公告)号：US20080004679A1
公开(公告)日：2008-01-03
申请号：US11779543
申请日：2007-07-18
申请人： Morteza Naghavi , Mortaza Naghavi , Mojtaba Naghavi , Mark Johnson , Timothy O'Brien
发明人： Morteza Naghavi , Mortaza Naghavi , Mojtaba Naghavi , Mark Johnson , Timothy O'Brien
IPC分类号： A61F7/08
CPC分类号： A61N2/006 , A61B18/14 , A61F7/007 , A61N2/002 , A61N7/02
摘要： The present invention is directed to methods and apparatus for modulation of the sympathetic-parasympathetic balance by application of heat, carotid and/or ocular message to reduce sympathetic tone or increase parasympathetic tone in a target muscle system to relieve a symptom of urinary hesitancy, shy bladder syndrome, DESD, urinary retention, or laryngeal spasm, as well as to monitor the efficacy of treatments for bladder conditions and to assist in the passage of medical devices through bodily sphincters as well as to treat congestive heart failure.
摘要翻译：本发明涉及通过应用热，颈动脉和/或眼睛信息来调节交感神经副交感神经平衡的方法和装置，以减少交感神经紧张或增加目标肌肉系统中的副交感神经紧张以减轻尿犹豫症状，害羞膀胱综合征，DESD，尿潴留或喉痉挛，以及监测治疗膀胱状况的功效，并帮助医疗器械通过身体括约肌以及治疗充血性心力衰竭。

22. 发明申请

US20070257499A1 Automatic Deploying Handle 有权
标题翻译：自动部署句柄
公开(公告)号：US20070257499A1
公开(公告)日：2007-11-08
申请号：US11744474
申请日：2007-05-04
申请人： Clarence Lipke , Timothy O'Brien
发明人： Clarence Lipke , Timothy O'Brien
IPC分类号： B60J9/00
CPC分类号： B60N3/023 , B60N3/026
摘要： A trim assembly is disclosed. The trim assembly includes a vehicular trim panel and a portion mounted to the vehicular trim panel that is movable between a stowed position and a deployed position relative the vehicular trim panel. The portion is defined to include a shape-changing polymer. The assembly also includes an energy transfer device that provides energy to the shape-changing polymer to cause movement of the portion between the stowed position and the deployed position. A method is also disclosed.
摘要翻译：公开了一种装饰组件。修剪组件包括车辆装饰板和安装到车辆装饰板的部分，其可以在相对于车辆装饰板的收起位置和展开位置之间移动。该部分被定义为包括形状改变的聚合物。组件还包括能量传递装置，其向形状改变聚合物提供能量以引起部分在收起位置和展开位置之间的移动。还公开了一种方法。

23. 发明申请

US20070173727A1 Method and apparatus for isolating the vascular component in digital temerature monitoring 审中-公开
标题翻译：在数字温度监测中隔离血管成分的方法和装置
公开(公告)号：US20070173727A1
公开(公告)日：2007-07-26
申请号：US11504225
申请日：2006-08-14
申请人： Morteza Naghavi , Timothy O'Brien , Craig Jamieson , Mark Johnson
发明人： Morteza Naghavi , Timothy O'Brien , Craig Jamieson , Mark Johnson
IPC分类号： A61B5/02 , A61B5/00
CPC分类号： A61B5/6826 , A61B5/01 , A61B5/4035 , A61B5/6806 , A61B5/6838
摘要： Methods and apparatus are provided for identifying and minimizing neurovascular contributions to determinations of endothelial function, including by digital temperature monitoring such that an accurate status of vascular reactivity can be obtained. Methods are also provided for identifying individuals having increased sympathetic nervous system activity impacting peripheral vascular function as well as for determining a status of diabetic foot.
摘要翻译：提供了方法和装置，用于识别和最小化对内皮功能测定的神经血管贡献，包括通过数字温度监测，从而可以获得血管反应性的准确状态。还提供了用于鉴定具有影响外周血管功能的增加的交感神经系统活性以及用于确定糖尿病足的状态的个体的方法。

24. 发明申请

US20060154279A1 Extracellular serine protease 有权
公开(公告)号：US20060154279A1
公开(公告)日：2006-07-13
申请号：US11295040
申请日：2005-12-05
申请人： Lowell Underwood , Timothy O'Brien
发明人： Lowell Underwood , Timothy O'Brien
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12N9/6424 , Y10T436/25
摘要： The present invention provides a DNA encoding a TADG-14 protein selected from the group consisting of: (a) isolated DNA which encodes a TADG-14 protein; (b) isolated DNA which hybridizes to isolated DNA of (a) above and which encodes a TADG-14 protein; and (c) isolated DNA differing from the isolated DNAs of (a) and (b) above in codon sequence due to the degeneracy of the genetic code, and which encodes a TADG-14 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression of the DNA in the cell.

25. 发明申请

US20060068483A1 Extracellular serine protease 失效
公开(公告)号：US20060068483A1
公开(公告)日：2006-03-30
申请号：US11251455
申请日：2005-10-14
申请人： Lowell Underwood , Timothy O'Brien
发明人： Lowell Underwood , Timothy O'Brien
IPC分类号： C07H21/04 , C12P21/06 , C12N9/64
CPC分类号： C12N9/6424
摘要： The present invention provides a DNA encoding a TADG-14 protein selected from the group consisting of: (a) isolated DNA which encodes a TADG-14 protein; (b) isolated DNA which hybridizes to isolated DNA of (a) above and which encodes a TADG-14 protein; and (c) isolated DNA differing from the isolated DNAs of (a) and (b) above in codon sequence due to the degeneracy of the genetic code, and which encodes a TADG-14 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression of the DNA in the cell.

26. 发明授权

US5977474A Continuously variable circuit for producing an output signal having a continuously variable amount of clean and distorted signals 失效
标题翻译：用于产生具有连续可变量的清洁和失真信号的输出信号的连续可变电路
公开(公告)号：US5977474A
公开(公告)日：1999-11-02
申请号：US5336
申请日：1998-01-09
申请人： Timothy O'Brien
发明人： Timothy O'Brien
IPC分类号： G10H1/16 , G10H3/18 , G10H1/055 , G10H1/08 , G10H1/46
CPC分类号： H03F3/28 , G10H1/16 , G10H3/187 , G10H2210/281 , G10H2210/311 , Y10S84/26
摘要： An amplifier circuit for providing a combined clean and dirty output signal from an electric guitar. The circuit comprises a panning pedal that has two potentiometers attached thereto so that movement of the panning pedal results in two continuously varying ranges of resistances being produced by the potentiometers. The output signal of the guitar is provided to the panning pedal and the resistance values of the potentiometers determine the proportion of the guitar output signal that is to be provided to a clean pre-amp stage and the proportion that is to be provided to a dirty pre-amp stage. The clean pre-amp stage amplifies the output signal substantially without distortion and the dirty pre-amp stage amplifies the signal so as to produce a saturated output signal. The output of the clean pre-amp stage and the dirty pre-amp stage are then combined to produce a single output signal. By changing the position of the panning pedal, the proportion between the dirty and clean signals in the single output signal can be continuously varied of a range of proportions.
摘要翻译：放大器电路，用于提供来自电吉他的组合清洁和脏的输出信号。该电路包括一个平板踏板，该踏板具有两个连接到其上的电位计，使得摇摄踏板的移动导致由电位计产生的两个连续变化的电阻范围。吉他的输出信号提供给平移踏板，电位器的电阻值决定要提供给干净的前置放大器级的吉他输出信号的比例以及要提供给脏的比例前期舞台。干净的前置放大器基本上没有失真地放大输出信号，并且脏的前置放大器放大信号以便产生饱和输出信号。然后将干净的前置放大器级和脏前置放大级的输出组合以产生单个输出信号。通过改变摇摄踏板的位置，单个输出信号中脏污和干净信号之间的比例可以连续变化一定比例。

27. 发明申请

US20140242142A1 CELL SECRETED PROTEINS FOR THE TREATMENT OF MYOCARDIAL INFARCTION 有权
标题翻译：细胞分泌蛋白治疗心肌梗塞
公开(公告)号：US20140242142A1
公开(公告)日：2014-08-28
申请号：US14127991
申请日：2012-06-25
申请人： Timothy O'Brien , Frank Barry , Claire Kavanagh
发明人： Timothy O'Brien , Frank Barry , Claire Kavanagh
IPC分类号： A61K35/54 , A61K35/28 , A61L27/28 , A61K35/44 , A61L15/44 , A61K38/21 , A61L27/54 , A61L27/38 , A61L29/16 , A61K38/36 , A61K38/39 , A61K38/19 , A61K38/17 , A61L29/08
CPC分类号： A61K35/545 , A61K35/28 , A61K35/44 , A61K38/1709 , A61K38/1735 , A61K38/177 , A61K38/179 , A61K38/1891 , A61K38/19 , A61K38/195 , A61K38/217 , A61K38/363 , A61K38/39 , A61L15/44 , A61L27/28 , A61L27/3804 , A61L27/54 , A61L29/08 , A61L29/16
摘要： The present invention relates to the use of secreted proteins from mesenchymal stem cells and other cells for the treatment of myocardial infarction. In particular, the invention provides compositions and methods based on secreted proteins from mesenchymal stem cells and the genes encoding them.
摘要翻译：本发明涉及来自间充质干细胞和其他细胞的分泌蛋白质用于治疗心肌梗死的用途。特别地，本发明提供了基于来自间充质干细胞的分泌蛋白质的组合物和方法以及编码它们的基因。

28. 发明申请

US20100331536A1 CA125 gene and its use for diagnostic and therapeutic interventions 有权
标题翻译： CA125基因及其在诊断和治疗干预中的应用
公开(公告)号：US20100331536A1
公开(公告)日：2010-12-30
申请号：US12455366
申请日：2009-06-01
申请人： Timothy O'Brien , John Beard , Lowell Underwood
发明人： Timothy O'Brien , John Beard , Lowell Underwood
IPC分类号： C07H21/04
CPC分类号： C07K14/47 , A61K38/00 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： The CA125 gene has been cloned and multiple repeat sequences as well as the carboxy terminus have been identified. The CA125 molecule comprises three major domains: an extracellular amino terminal domain (Domain 1); a large multiple repeat domain (Domain 2); and a carboxy terminal domain (Domain 3) which includes a transmembrane anchor with a short cytoplasmic domain. The amino terminal domain is dominated by its capacity for O-glycosylation and its resultant richness in serine and threonine residues. An amino terminal extension is presented, which comprises four genomic exons. The molecular structure is dominated by a repeat domain comprising 156 amino acid repeat units, which encompass the epitope binding sites. More than 60 repeat units have been identified, sequenced, and contiguously placed in the CA125 domain structure. More specifically, this invention is directed to a CA125 cDNA sequence which can be introduced into animal or human cells to achieve transcription or expression of the cDNA.
摘要翻译：已经克隆了CA125基因，并且已经鉴定了多个重复序列以及羧基末端。 CA125分子包含三个主要的结构域：细胞外氨基末端结构域（Domain 1）; 一个大的多重重复域（域2）; 和包含具有短细胞质结构域的跨膜锚的羧基末端结构域（结构域3）。氨基末端结构域以其O-糖基化的能力为主，其结果是丝氨酸和苏氨酸残基的丰富度。提供氨基末端延伸，其包含四个基因组外显子。分子结构由包含156个氨基酸重复单元的重复结构域所支配，其包含表位结合位点。已经确定，排序和连续地排列在CA125领域结构中的60多个重复单位。更具体地，本发明涉及可以引入动物或人类细胞以实现cDNA转录或表达的CA125 cDNA序列。

29. 发明申请

US20100237013A1 AUTONOMOUS FILTER ELEMENT 审中-公开
标题翻译：自动过滤器元件
公开(公告)号：US20100237013A1
公开(公告)日：2010-09-23
申请号：US12699996
申请日：2010-02-04
申请人： Aaron Burke , Anthony DiLeo , Timothy O'Brien
发明人： Aaron Burke , Anthony DiLeo , Timothy O'Brien
IPC分类号： B01D61/22 , B01D35/18 , B01D35/14 , B01D35/143
CPC分类号： B01D53/22 , B01D61/22 , B01D63/08 , B01D65/02 , B01D65/08 , B01D2311/103 , B01D2311/16 , B01D2313/22 , B01D2321/40 , G01F1/6888 , G01F1/69 , G01F15/125
摘要： An autonomous filter device and a method for improving the filter life and performance is disclosed. The filter element is equipped with one or more sensors, adapted to measure one or more characteristics or parameters of the fluid, such as temperature, pressure, or flow rate. In response to the measured characteristic or parameter, the control logic within the filter element is able to determine an appropriate response. For example, the control logic may determine that a sudden, but temporary, blockage has occurred in the filter membrane. In response to this, the control logic may initiate a specific response designed to alleviate the blockage. This response may be a temperature change, a vibration, a change in fluid flow path, or some other action. The control logic will then determine the success of the response, based monitoring any change in the fluid characteristics. Based thereon, the control logic may alert the operator that the filter element must be replaced. Alternatively, if the response was successful in correcting the blockage, the control logic need not notify the operator, as the filter element is back to normal operating operation.
摘要翻译：公开了一种自主的过滤装置和用于提高过滤器寿命和性能的方法。过滤元件配备有一个或多个传感器，适于测量流体的一个或多个特性或参数，例如温度，压力或流速。响应于测量的特性或参数，滤波器元件内的控制逻辑能够确定适当的响应。例如，控制逻辑可以确定在过滤膜中已经发生突然而暂时的堵塞。响应于此，控制逻辑可以发起旨在减轻阻塞的特定响应。该响应可能是温度变化，振动，流体流动路径的变化或某些其他动作。然后，控制逻辑将确定响应的成功，基于监测流体特性的任何变化。基于此，控制逻辑可以警告操作者必须更换过滤元件。或者，如果响应成功地纠正堵塞，则控制逻辑不需要通知操作者，因为过滤器元件已经回到正常的操作操作。

30. 发明申请

US20100062038A1 Markers, Antibodies and Recombinant scFvs for Mesenchymal Stem Cell Sub-populations and Osteoclasts 审中-公开
标题翻译：标记，抗体和重组scFv用于间充质干细胞亚群和破骨细胞
公开(公告)号：US20100062038A1
公开(公告)日：2010-03-11
申请号：US12529789
申请日：2008-03-12
申请人： Tyrone Villalard Bowes , Udo Greiser , William James Johnathan Finlay , Timothy O'Brien , Frank Barry
发明人： Tyrone Villalard Bowes , Udo Greiser , William James Johnathan Finlay , Timothy O'Brien , Frank Barry
IPC分类号： A61F2/00 , C07K7/06 , C07H21/04 , C07K16/00 , C12N15/63 , G01N33/566 , C12N5/00 , A61K35/12
CPC分类号： C07K14/705 , A61K38/00
摘要： Abstract Markers, antibodies and recombinant scFvs for Mesenchymal Stem Cell sub-populations and osteoclasts. The present invention relates to specific epitopes of surface membrane bound glycoproteins expressed by mesenchymal stem cells and pre-osteoclasts and relates to antibodies such as monoclonal antibodies and recombinant scFv or fragments thereof, raised to the particular epitope and their use in identifying, isolating, and characterization of mesenchymal stem cell sub-populations such as that termed “Stromal Progenitor Cells” (SPCs) in bone marrow and identifying, isolating, and characterization of pre-osteoclasts in peripheral blood. By binding to a specific epitope on the cell surface, limbin/EVC-2 detection and separation by conventional cell sorting methodologies are facilitated.
摘要翻译：摘要标记，抗体和重组scFvs用于间充质干细胞亚群和破骨细胞。本发明涉及由间充质干细胞和破骨细胞表达的表面膜结合的糖蛋白的特异性表位，涉及产生特定表位的抗体如单克隆抗体和重组scFv或其片段，以及它们在鉴定，分离和间质干细胞亚群的表征，如骨髓中称为“间质祖细胞”（SPCs），并鉴定，分离和表征外周血中破骨细胞。通过结合细胞表面上的特异性表位，促进了常规细胞分选方法的limbin / EVC-2检测和分离。

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