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21. 发明授权

US08774494B2 Method and system for accurate alignment and registration of array for DNA sequencing 有权
标题翻译：用于DNA测序的阵列的准确对准和配准的方法和系统
公开(公告)号：US08774494B2
公开(公告)日：2014-07-08
申请号：US13092618
申请日：2011-04-22
申请人： Bryan P. Staker
发明人： Bryan P. Staker
IPC分类号： G06K9/00
CPC分类号： C12Q1/6874 , G06K9/32 , G06K9/42 , G06K2209/07 , G06T7/0012 , G06T7/32 , G06T7/337 , G06T7/74 , G06T2207/10056 , G06T2207/30072
摘要： In a genome sequencing system and methodology, a protocol is provided to achieve precise alignment and accurate registration of an image of a planar array of nanoballs subject to optical analysis. Precise alignment correcting for fractional offsets is achieved by correcting for errors in subperiod x-y offset, scale and rotation by use of minimization techniques and Moiré averaging. In Moiré averaging, magnification is intentionally set so that the pixel period of the imaging element is a noninteger multiple of the site period. Accurate registration is achieved by providing for pre-defined pseudo-random sets of sites, herein deletion or reserved sites, where nanoballs are prevented from attachment to the substrate so that the sites of the array can be used in a pattern matching scheme as registration markers for absolute location identification. Information can be extracted with a high degree of confidence that it is correlated to a known location, while at the same time the amount of information that can be packed on a chip is maximized.
摘要翻译：在基因组测序系统和方法学中，提供了一种协议，以实现经受光学分析的纳米棒的平面阵列的图像的精确对准和精确配准。通过使用最小化技术和莫尔平均来校正子周期x-y偏移，刻度和旋转中的误差来实现分数偏移的精确对准校正。在莫尔平均中，有意地设置放大率，使得成像元件的像素周期是站点周期的非整数倍。通过提供预定义的伪随机组的位点（这里是删除或保留位点）来实现精确的注册，其中防止了纳米线附着到基底，使得阵列的位点可以以模式匹配方案用作对准标记用于绝对位置识别。可以高信度地提取信息，使其与已知位置相关联，同时可将芯片上打包的信息量最大化。

22. 发明授权

US08428454B2 Method and system for imaging high density biochemical arrays with sub-pixel alignment 有权
公开(公告)号：US08428454B2
公开(公告)日：2013-04-23
申请号：US13451678
申请日：2012-04-20
申请人： Bryan P. Staker , Craig E. Uhrich
发明人： Bryan P. Staker , Craig E. Uhrich
IPC分类号： G02B21/36
CPC分类号： G02B21/365 , G01B11/272 , G02B21/002 , G02B21/025 , G02B21/361 , H04N5/37206 , H04N7/18
摘要： A method and associated system for imaging high density biochemical arrays comprises one or more imaging channels that share a common objective lens and a corresponding one or more time delay integration-type imaging cameras with optical alignment mechanisms that permit independent inter-channel and intra-channel adjustment of each of four degrees: X, Y, rotation and scale. The imaging channels are configured to independently examine different spectra of the image of the biochemical arrays.

23. 发明申请

US20120004140A1 FLOW CELLS FOR BIOCHEMICAL ANALYSIS 审中-公开
标题翻译：流式细胞用于生物化学分析
公开(公告)号：US20120004140A1
公开(公告)日：2012-01-05
申请号：US13232858
申请日：2011-09-14
申请人： Bryan P. Staker
发明人： Bryan P. Staker
IPC分类号： C40B40/06 , G01N21/75 , C12M1/40
CPC分类号： B01L3/5027 , B01L2300/0636 , B01L2300/0816 , B01L2300/0877 , B01L2400/0487
摘要： Assay flow cells used as part of an overall system for biological assays include, in various configurations, a carrier in which an assay substrate may be provided, where a substantial portion of the assay substrate can be used for biochemical analysis, since the carrier component of the flow cell is designed to provide functionalities that in prior art systems were performed by the assay substrate itself The flow cells may be used in automated systems, are flat for imaging and various configurations of the components of the flow cells minimize evaporation, yet allow for precise control of fluid intake and evacuation.
摘要翻译：用作生物测定的整个系统的一部分的测定流动池包括在各种构型中的载体，其中可以提供测定底物，其中大部分测定底物可用于生物化学分析，因为载体组分流动池被设计成提供在现有技术系统中由测定底物本身执行的功能。流动池可以用于自动化系统中，对于成像是平坦的，并且流动池的组分的各种构型使蒸发最小化，但允许精确控制流体摄入和撤离。

24. 发明申请

US20120004139A1 FLOW CELLS FOR BIOCHEMICAL ANALYSIS 审中-公开
公开(公告)号：US20120004139A1
公开(公告)日：2012-01-05
申请号：US13232822
申请日：2011-09-14
申请人： Bryan P. Staker
发明人： Bryan P. Staker
IPC分类号： C12M1/40 , B01L3/00 , C40B40/06
CPC分类号： B01L3/5027 , B01L2300/0636 , B01L2300/0816 , B01L2300/0877 , B01L2400/0487
摘要： Assay flow cells used as part of an overall system for biological assays include, in various configurations, a carrier in which an assay substrate may be provided, where a substantial portion of the assay substrate can be used for biochemical analysis, since the carrier component of the flow cell is designed to provide functionalities that in prior art systems were performed by the assay substrate itself The flow cells may be used in automated systems, are flat for imaging and various configurations of the components of the flow cells minimize evaporation, yet allow for precise control of fluid intake and evacuation.

25. 发明授权

US07049670B2 Electro ceramic components 有权
公开(公告)号：US07049670B2
公开(公告)日：2006-05-23
申请号：US09919038
申请日：2001-07-30
申请人： Bryan P. Staker , Douglas L. Teeter , Eric L. Bogatin
发明人： Bryan P. Staker , Douglas L. Teeter , Eric L. Bogatin
IPC分类号： H01L27/14
CPC分类号： B81B7/0006 , G02B6/3518 , G02B6/357 , G02B6/3582 , G02B6/3584 , G02B2006/12104
摘要： An array apparatus has a micromachined SOI structure, such as a MEMS array, mounted directly on a class of insulative substrate, such as low temperature co-fired ceramic or a thermal-coefficient of expansion matched glass, in which is embedded electrostatic electrodes disposed in alignment with the individual MEMS elements, where the electrostatic electrodes are configured for substantial fanout. In a specific embodiment in order to compensate for differences in thermal-expansion characteristics between SOI and ceramic, a flexible mounting is effected by means of posts, bridges and/or mechanical elements which allow uneven expansion in x and y while maintaining z-axis stability. Methods according to the invention include fabrication steps wherein electrodes are fabricated to a post-fired ceramic substrate and coupled via traces through the ceramic substrate to driver modules.

26. 发明授权

US06935759B1 Folded longitudinal torsional hinge for gimbaled MEMS mirror 有权
标题翻译：万向平面MEMS镜的折叠纵向扭转铰链
公开(公告)号：US06935759B1
公开(公告)日：2005-08-30
申请号：US10080064
申请日：2002-02-19
申请人： Bryan P. Staker , William C. Banyai
发明人： Bryan P. Staker , William C. Banyai
IPC分类号： B81B3/00 , G02B26/08 , G02B26/10 , G02B7/182
CPC分类号： G02B26/0841 , B81B3/0062 , G02B26/0833 , G02B26/105
摘要： In a gimbaled micromachined micromirror array optimized for parallel-plate electrostatic operation, longitudinal-type gimbal hinge elements are provided in which a plurality of torsional longitudinal hinge elements are arranged in an array parallel to the axis of rotation and which are linked together by rigid lateral brace sections. In primary embodiment the hinge elements are arranged in a double gimbal configuration. Specific embodiments of the hinge elements are simple longitudinal, compound longitudinal, stacked simple longitudinal, and stacked compound longitudinal. The longitudinal hinges may be used with various types of mirrors including circular or rectilinear, recessed or nonrecessed, where the hinges are connected in either a symmetric or asymmetric configuration relative to one another, as hereinafter illustrated by way of a subset of examples. A preferred embodiment of a mirror structure suitable for an array structure according to the invention is a nonstacked compound longitudinal hinge symmetrically connected to a circular nonrecessed electrostatically-actuatable parallel plate mirror within a substantially circular ring hinged in substantially the same way to form a double gimbaled structure.
摘要翻译：在平行板静电操作优化的万向平面微加工微镜阵列中，提供了纵向型万向铰链元件，其中多个扭转纵向铰链元件以与旋转轴线平行的阵列布置，并且通过刚性侧向大括号。在主要实施例中，铰链元件被布置成双重万向架配置。铰链元件的具体实施例是简单的纵向，复合纵向，堆叠简单的纵向和堆叠的复合纵向。纵向铰链可以与各种类型的反射镜一起使用，包括圆形或直线，凹进或不加工，其中铰链以相对于彼此的对称或非对称构造连接，如下文通过示例子集所示。适用于根据本发明的阵列结构的反射镜结构的优选实施例是一种非堆叠化合物纵向铰链，其对称地连接到基本上相同方式铰链的基本上相同方式上的环形未加工的可静电驱动的平行板反射镜，以形成双平衡结构体。

27. 发明授权

US06907155B2 Three-dimensional optical switch with annular input-output ports 有权
标题翻译：具有环形输入输出端口的三维光开关
公开(公告)号：US06907155B2
公开(公告)日：2005-06-14
申请号：US10271668
申请日：2002-10-15
申请人： Bryan P. Staker , Eugene W. Campbell , Paul H. Pax
发明人： Bryan P. Staker , Eugene W. Campbell , Paul H. Pax
IPC分类号： G02B6/35 , G02B6/28
CPC分类号： G02B6/356 , G02B6/3556 , G02B6/357
摘要： In a folded three-dimensional free-space optical switch including a set of fibers and an optical system for producing collimated beamlets aligned to intersect an array of dual axis micromirrors of coplanar input and output mirror elements, and a folding mirror, the input and output micromirrors are arranged in a pattern wherein either the input or output mirror set is disposed along an annulus and wherein the complementary output or input mirror set is disposed within the annulus in order to globally minimize maximum tilt angles for a two-dimensional locus of tilt angles of the micromirror set. The beamlets are routed from assigned input fibers to corresponding input moveable mirrors to assigned output fibers via the static folding mirror and corresponding output moveable mirrors.
摘要翻译：在包括一组光纤的折叠的三维自由空间光学开关和用于产生准直的子束的光学系统的光学系统中，所述准直子束被对齐以与共面输入和输出反射镜元件的双轴微镜阵列和折叠镜相交，所述输入和输出微镜以其中输入或输出反射镜组沿着环形布置的图案布置，并且其中互补输出或输入反射镜组设置在环形空间内，以便全局地最小化倾斜角度的二维轨迹的最大倾斜角度的微镜组。子束从分配的输入光纤路由到相应的输入可移动反射镜，经由静态折叠镜和相应的输出可移动反射镜分配给输出光纤。

28. 发明授权

US06791742B2 MEMS structure with raised electrodes 有权
公开(公告)号：US06791742B2
公开(公告)日：2004-09-14
申请号：US10700734
申请日：2003-11-03
申请人： Bryan P. Staker , Lawrence P. Muray , Andres Fernandez
发明人： Bryan P. Staker , Lawrence P. Muray , Andres Fernandez
IPC分类号： G02B2600
CPC分类号： G02B26/0841 , B81B3/0086 , B81B2201/042
摘要： In an electrostatically controlled deflection apparatus, such as a MEMS array having cavities formed around electrodes and which is mounted directly on a dielectric or controllably resistive substrate in which are embedded electrostatic actuation electrodes disposed in alignment with the individual MEMS elements, a mechanism is provided to mitigate the effects of uncontrolled dielectric surface potentials between the MEMS elements and the electrostatic actuation electrodes, the mechanism being raised electrodes relative to the dielectric or controllably resistive surface of the substrate. The aspect ratio of the gaps between elements (element height to element separation ratio) is at least 0.1 and preferably at least 0.5 and preferably between 0.75 and 2.0 with a typical choice of about 1.0, assuming a surface fill factor of 50% or greater. Higher aspect ratios at these fill factors are believed not to provide more than marginal improvement.

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