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21. 发明授权

US07585881B2 Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists 失效
标题翻译：额外的杂多环化合物及其作为代谢型谷氨酸受体拮抗剂的用途
公开(公告)号：US07585881B2
公开(公告)日：2009-09-08
申请号：US11053752
申请日：2005-02-09
申请人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tau Xin , Jalaj Arora
发明人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tau Xin , Jalaj Arora
IPC分类号： A61K31/4439 , C07D401/14 , C07D413/04
CPC分类号： C07D487/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要： The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
摘要翻译：本发明涉及新的式I化合物，含有该化合物的药物制剂，以及该化合物在预防和/或治疗mGluR5受体介导的病症中的用途。

22. 发明申请

US20080045571A1 ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS 审中-公开
标题翻译：其他杂环化合物及其作为代谢谷氨酸受体拮抗剂的使用
公开(公告)号：US20080045571A1
公开(公告)日：2008-02-21
申请号：US11840953
申请日：2007-08-18
申请人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
发明人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
IPC分类号： A61K31/4439 , A61K31/4196 , A61K31/4245 , A61P19/06 , A61P25/18 , A61P25/30 , A61P29/00 , A61P9/00 , C07D413/14 , C12N5/00 , C07D271/06 , A61P35/00 , A61P27/02 , A61P25/28 , A61P25/08 , A61P19/02 , A61K31/443
CPC分类号： C07D487/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要： The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
摘要翻译：本发明涉及新的式I化合物，含有该化合物的药物制剂，以及该化合物在预防和/或治疗mGluR5受体介导的病症中的用途。

23. 发明申请

US20070179188A1 Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists 审中-公开
标题翻译：额外的杂多环化合物及其作为代谢型谷氨酸受体拮抗剂的用途
公开(公告)号：US20070179188A1
公开(公告)日：2007-08-02
申请号：US10588702
申请日：2005-02-15
申请人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald Mcleod , Alexander Minidis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
发明人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald Mcleod , Alexander Minidis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
IPC分类号： A61K31/4439 , A61K31/4245 , C07D413/14 , C07D413/02
CPC分类号： C07D487/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要： The present invention relates to new compounds of formula (I), to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
摘要翻译：本发明涉及新的式（I）化合物，含有该化合物的药物制剂，以及该化合物在预防和/或治疗mGluR5受体介导的病症中的用途。

24. 发明申请

US20060122397A1 Compounds 失效
标题翻译：化合物
公开(公告)号：US20060122397A1
公开(公告)日：2006-06-08
申请号：US11274611
申请日：2005-11-14
申请人： Jalaj Arora , Louise Edwards , Methvin Isaac , Donald McLeod , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Helena Gyback , Martin Johansson , Annika Kers , John Malmberg , Alexander Minidis , Karin Oscarsson , Mangus Waldman , Ulrika Yngve , Christoffer Osterwall
发明人： Jalaj Arora , Louise Edwards , Methvin Isaac , Donald McLeod , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Helena Gyback , Martin Johansson , Annika Kers , John Malmberg , Alexander Minidis , Karin Oscarsson , Mangus Waldman , Ulrika Yngve , Christoffer Osterwall
IPC分类号： A61K31/4439 , A61K31/4245 , C07D417/14 , C07D413/14 , C07D409/14
CPC分类号： C07D413/14 , C07D413/12 , C07D417/14
摘要： The present invention relates to new compounds of formula I, a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.
摘要翻译：本发明涉及新的式I化合物，其制备方法和其中制备的新中间体，含有所述化合物的药物制剂和所述化合物在治疗中的用途。

25. 发明申请

US20060009443A1 Fused heterocyclic compounds and their use as metabotropic glutamate receptor antagonists 失效
标题翻译：稠合杂环化合物及其作为代谢型谷氨酸受体拮抗剂的用途
公开(公告)号：US20060009443A1
公开(公告)日：2006-01-12
申请号：US11060560
申请日：2005-02-18
申请人： David Wensbo , Martin Johansson , Alexander Minidis , Karin Staaf , Annika Kers , Louise Edwards , Methvin Isaac , Tom Stefanac , Abdelmalik Slassi , Don McLeod , Tao Xin
发明人： David Wensbo , Martin Johansson , Alexander Minidis , Karin Staaf , Annika Kers , Louise Edwards , Methvin Isaac , Tom Stefanac , Abdelmalik Slassi , Don McLeod , Tao Xin
IPC分类号： A61K31/407
CPC分类号： C07D211/22 , C07D223/08 , C07D241/18 , C07D273/02 , C07D403/12 , C07D409/12 , C07D413/12 , C07D471/04
摘要： The present invention is directed to compounds of formula I: wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, R1, R2, R3, R4, and n are as defined for formula I in the description. The invention also relates to processes for the preparation of the compounds and to new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and to the use of the compounds in therapy.
摘要翻译：本发明涉及式I化合物：其中X 1，X 2，X 3，X 4， >，X 5，X 6，X 7，X 8，X 9， >，X <10>，R 1，R 2，R 3，R 4， >，n如在说明书中对式I所定义。本发明还涉及制备化合物的方法和用于制备中的新中间体，含有该化合物的药物组合物，以及该化合物在治疗中的用途。

26. 发明授权

US09295738B2 Contrast agent for imagining myocardial perfusion 有权
标题翻译：用于想象心肌灌注的对比剂
公开(公告)号：US09295738B2
公开(公告)日：2016-03-29
申请号：US14367520
申请日：2012-12-18
申请人： Martin Johansson
发明人： Martin Johansson
IPC分类号： A61K51/04 , A61K49/00 , C07D471/04 , C07B59/00
CPC分类号： A61K49/00 , A61K51/0455 , C07B59/002 , C07D471/04
摘要： Compounds and a method for imaging myocardial perfusion, including administering to a patient a compound linked to an imaging moiety, wherein the compound binds MC-1, and scanning the patient using diagnostic imaging. Kits including the compound or precursor compounds linked or not linked to an imaging moiety are also described.
摘要翻译：化合物和用于成像心肌灌注的方法，包括向患者施用与成像部分连接的化合物，其中所述化合物结合MC-1，并使用诊断成像扫描患者。还描述了包括与成像部分连接或未连接的化合物或前体化合物的试剂盒。

27. 发明授权

US09107764B2 Medical closure device 有权
标题翻译：医疗闭合装置
公开(公告)号：US09107764B2
公开(公告)日：2015-08-18
申请号：US13499621
申请日：2010-10-01
申请人： Christer Jacobsson , Martin Johansson , Jimmy Gido Schon , Jens Nygarden Brandstorm , Janame Wetterheim , Erik Elwing
发明人： Christer Jacobsson , Martin Johansson , Jimmy Gido Schon , Jens Nygarden Brandstorm , Janame Wetterheim , Erik Elwing
IPC分类号： A61F5/44 , A61F5/445 , A61F5/448
CPC分类号： A61F5/445 , A61F2005/4455 , A61F2005/4486
摘要： A medical closure device serves for coupling to a discharge opening of a device protruding from a mammalian body. The medical closure device includes a coupling part for engaging a part of the device protruding from the mammalian body. The coupling part is a circumferential flexible member delimiting a coupling opening configurable between a relaxed configuration where the coupling opening cannot pass over the medical device and a stressed configuration where the coupling opening of the coupling part can pass over the medical device. The coupling part has a securing member for securing the coupling part to a closure part, such as a cap, an ostomy bag, a catheter, or an irrigation device, for subsequent closure of a discharge opening.
摘要翻译：医疗闭合装置用于联接到从哺乳动物身体突出的装置的排出口。医疗闭合装置包括用于接合从哺乳动物身体突出的装置的一部分的联接部分。连接部分是周向柔性部件，其限定联接开口，其可配置在联接开口不能通过医疗装置的松弛构型和联接部件的联接开口可以越过医疗装置的应力配置。联接部件具有固定构件，用于将联接部件固定到封闭部件，例如帽，造口袋，导管或冲洗装置，用于随后关闭排放口。

28. 发明授权

US08754086B2 Indolyl-substituted pyrazino-quinolines and their use for the treatment of cancer 有权
标题翻译：吲哚基取代的吡嗪 - 喹啉及其用于治疗癌症的用途
公开(公告)号：US08754086B2
公开(公告)日：2014-06-17
申请号：US13379497
申请日：2010-03-19
申请人： Jenny Persson , Rikard Larsson , Olov Sterner , Martin Johansson
发明人： Jenny Persson , Rikard Larsson , Olov Sterner , Martin Johansson
IPC分类号： A61K31/495
CPC分类号： A61K31/4985 , C07D471/04 , C07D471/14 , C07D491/14
摘要： The disclosure describes compounds of formula I, wherein the wedged bonds, R1, R2, R3, R4, R5, R5a, R6, R7, R8, R9, R10, R11, R12, R13, R14, X and Y have meanings given in the description, and pharmaceutically-acceptable salts thereof; and methods of using such compounds useful in the treatment of cancer and conditions affected by inhibition of angiogenesis. Also provided, are processes for the preparation of formula I, by reacting formula I with other compounds; and processes for the preparation of a pharmaceutical formulation by bringing into association, a compound of formula I, with therapeutic agents and/or a pharmaceutically-acceptable adjuvant, diluent, or carrier.
摘要翻译：本发明描述了式I化合物，其中楔形键，R1，R2，R3，R4，R5，R5a，R6，R7，R8，R9，R10，R11，R12，R13，R14，X和Y具有描述及其药学上可接受的盐; 以及使用这些化合物可用于治疗癌症和受血管生成抑制影响的病症的方法。还提供了通过使式I与其它化合物反应制备式I的方法; 以及通过将式I化合物与治疗剂和/或药学上可接受的佐剂，稀释剂或载体结合而制备药物制剂的方法。

29. 发明申请

US20140052085A1 PERCUTANEOUS IMPLANT AND OSTOMY METHOD 有权
标题翻译： PERCUTANEOUS IMPLANT和OSTOMY方法
公开(公告)号：US20140052085A1
公开(公告)日：2014-02-20
申请号：US14006647
申请日：2012-03-26
申请人： Martin Johansson , Robert Axelsson , Jan Erik Axelsson
发明人： Martin Johansson , Robert Axelsson , Jan Erik Axelsson
IPC分类号： A61F5/445
CPC分类号： A61F5/445 , A61F2005/4455
摘要： A percutaneous ostomy implant for implantation into the abdominal wall of a patient is provided, which includes a connecting member for mounting an external detachable device thereto; a first tubular ingrowth member depending from the connecting member; and a second tubular ingrowth member depending from the connecting member and being radially outwardly spaced from the first tubular ingrowth member. The first tubular ingrowth member is configured and dimensioned to receive a bowel segment within it to allow the stoma and serosal tissue of that bowel segment to infiltrate the first tubular ingrowth member. The second tubular member is configured and dimensioned to abut dermal tissue to allow the dermal tissue to infiltrate the second tubular ingrowth member, thereby securing and sealing the ostomy implant to the dermis.
摘要翻译：提供一种用于植入患者腹壁的经皮造口植入物，其包括用于将外部可拆卸装置安装到其上的连接构件; 第一管状向内生长构件，其从所述连接构件悬垂; 以及第二管状向内生长构件，其从连接构件悬垂并且与第一管状向内生长构件径向向外间隔开。第一管状向内生长构件的构造和尺寸被设计成在其内容纳肠段以允许该肠段的造口和浆膜组织渗透第一管状向内生长构件。第二管状构件的构造和尺寸被设计成邻接真皮组织以允许真皮组织渗透第二管状向内生长构件，从而将造口植入物固定并密封到真皮层。

30. 发明授权

US08647304B2 Implant and method for its manufacture 有权
标题翻译：种植体及其制造方法
公开(公告)号：US08647304B2
公开(公告)日：2014-02-11
申请号：US12280610
申请日：2007-02-28
申请人： Robert Axelsson , Martin Johansson , Anette Johnsson , Bjørn Edwin , Erik Fosse
发明人： Robert Axelsson , Martin Johansson , Anette Johnsson , Bjørn Edwin , Erik Fosse
IPC分类号： A61M5/178
CPC分类号： A61F5/445 , A61F2005/4455 , A61M39/0247 , A61M2039/0261
摘要： An implant for percutaneous implantation through the abdominal wall for encircling and engaging an externalized length of a body duct of a human or animal patient. The implant has an exterior ring section protruding outwardly from the abdominal wall with a free end which serves for mounting of a detachable device, and an interior section extending through the abdominal wall and inside the patient for internal fixation of the implant. The exterior ring section and interior section have a common axis. The internal circumference of at least a part of the exterior ring section above the interior section is arranged with a biocompatible, integrated ingrowth means for the exterior surface of the body duct wall.
摘要翻译：用于通过腹壁进行经皮植入的植入物，用于环绕和接合人或动物患者的身体导管的外部长度。植入物具有从腹壁向外突出的外环部分，其具有用于安装可拆卸装置的自由端，以及延伸穿过腹壁和患者内部的内部部分，用于植入物的内部固定。外环部分和内部部分具有共同的轴线。在内部部分上方的外环部分的至少一部分的内圆周布置有用于体管道壁的外表面的生物相容的，整合的向内生长装置。

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