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1. 发明授权

US08754086B2 Indolyl-substituted pyrazino-quinolines and their use for the treatment of cancer 有权
标题翻译：吲哚基取代的吡嗪 - 喹啉及其用于治疗癌症的用途
公开(公告)号：US08754086B2
公开(公告)日：2014-06-17
申请号：US13379497
申请日：2010-03-19
申请人： Jenny Persson , Rikard Larsson , Olov Sterner , Martin Johansson
发明人： Jenny Persson , Rikard Larsson , Olov Sterner , Martin Johansson
IPC分类号： A61K31/495
CPC分类号： A61K31/4985 , C07D471/04 , C07D471/14 , C07D491/14
摘要： The disclosure describes compounds of formula I, wherein the wedged bonds, R1, R2, R3, R4, R5, R5a, R6, R7, R8, R9, R10, R11, R12, R13, R14, X and Y have meanings given in the description, and pharmaceutically-acceptable salts thereof; and methods of using such compounds useful in the treatment of cancer and conditions affected by inhibition of angiogenesis. Also provided, are processes for the preparation of formula I, by reacting formula I with other compounds; and processes for the preparation of a pharmaceutical formulation by bringing into association, a compound of formula I, with therapeutic agents and/or a pharmaceutically-acceptable adjuvant, diluent, or carrier.
摘要翻译：本发明描述了式I化合物，其中楔形键，R1，R2，R3，R4，R5，R5a，R6，R7，R8，R9，R10，R11，R12，R13，R14，X和Y具有描述及其药学上可接受的盐; 以及使用这些化合物可用于治疗癌症和受血管生成抑制影响的病症的方法。还提供了通过使式I与其它化合物反应制备式I的方法; 以及通过将式I化合物与治疗剂和/或药学上可接受的佐剂，稀释剂或载体结合而制备药物制剂的方法。

2. 发明申请

US20120157461A1 Indolyl-Substituted Pyrazino-Quinolines and Their Use for the Treatment of Cancer 有权
标题翻译：吲哚基取代的吡嗪 - 喹啉及其用于治疗癌症的用途
公开(公告)号：US20120157461A1
公开(公告)日：2012-06-21
申请号：US13379497
申请日：2010-03-19
申请人： Jenny Persson , Rikard Larsson , Olov Sterner , Martin Johansson
发明人： Jenny Persson , Rikard Larsson , Olov Sterner , Martin Johansson
IPC分类号： A61K31/4985 , A61P35/02 , A61P35/04 , C07D491/147 , A61P35/00
CPC分类号： A61K31/4985 , C07D471/04 , C07D471/14 , C07D491/14
摘要： There is provided compounds of formula I, wherein the wedged bonds, R1, R2, R3, R4, R5, R5a, R6, R7, R8, R9, R10, R11, R12, R13, R14, X and Y have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of cancer and conditions affected by inhibition of angiogenesis.
摘要翻译：提供式I化合物，其中楔形键，R1，R2，R3，R4，R5，R5a，R6，R7，R8，R9，R10，R11，R12，R13，R14，X和Y具有其描述及其药学上可接受的盐，该化合物可用于治疗癌症和受血管生成抑制影响的病症。

3. 发明授权

US09150531B2 Tricyclic lactones for treatment of cancer 有权
标题翻译：三环内酯治疗癌症
公开(公告)号：US09150531B2
公开(公告)日：2015-10-06
申请号：US13811015
申请日：2011-07-18
申请人： Ritha Gidlöf , Martin Johansson , Olov Sterner , Eduardo Muñoz
发明人： Ritha Gidlöf , Martin Johansson , Olov Sterner , Eduardo Muñoz
IPC分类号： C07D303/40 , C07D307/93 , C07D303/38 , A61K31/336 , A61K31/365 , A61K45/06
CPC分类号： C07D307/93 , A61K31/336 , A61K31/365 , A61K45/06 , C07D303/38 , C07D303/40
摘要： The present invention discloses novel compounds useful for the inhibition of IL-6/STAT signaling and/or PI3K/NF-κB signaling in the treatment of associated diseases or conditions, e.g. cancer. A pharmaceutical composition comprising such novel compounds, its use and a method thereof, is also disclosed.
摘要翻译：本发明公开了可用于抑制IL-6 / STAT信号传导和/或PI3K / NF-κB信号传导治疗相关疾病或病症的新化合物，例如，癌症。还公开了包含这些新化合物的药物组合物及其用途及其方法。

4. 发明申请

US20130310451A1 TRICYCLIC LACTONES FOR TREATMENT OF CANCER 有权
标题翻译：治疗癌症的治疗手段
公开(公告)号：US20130310451A1
公开(公告)日：2013-11-21
申请号：US13811015
申请日：2011-07-18
申请人： Ritha Gidlöf , Martin Johansson , Olov Sterner , Eduardo Muñoz
发明人： Ritha Gidlöf , Martin Johansson , Olov Sterner , Eduardo Muñoz
IPC分类号： C07D307/93 , A61K45/06 , A61K31/336 , A61K31/365 , C07D303/40
CPC分类号： C07D307/93 , A61K31/336 , A61K31/365 , A61K45/06 , C07D303/38 , C07D303/40
摘要： The present invention discloses novel compounds useful for the inhibition of IL-6/STAT signaling and/or PI3K/NF-κB signaling in the treatment of associated diseases or conditions, e.g. cancer. A pharmaceutical composition comprising such novel compounds, its use and a method thereof, is also disclosed.
摘要翻译：本发明公开了用于抑制IL-6 / STAT信号传导和/或PI3K / NF-κB信号传导治疗相关疾病或病症的新化合物，例如，癌症。还公开了包含这些新化合物的药物组合物及其用途及其方法。

5. 发明授权

US06423823B1 Organic chemical compounds and method for producing the same 失效
标题翻译：有机化合物及其制备方法
公开(公告)号：US06423823B1
公开(公告)日：2002-07-23
申请号：US09555922
申请日：2000-11-28
申请人： Ulrike Martini-Marr neé Martini , Anke Mayer-Bartschmid neé Mayer , Heidrun Anke , Olov Sterner , Michael Kilian , Ulrike Wachendorff-Neumann , Achim Harder , Peter Jeschke
发明人： Ulrike Martini-Marr neé Martini , Anke Mayer-Bartschmid neé Mayer , Heidrun Anke , Olov Sterner , Michael Kilian , Ulrike Wachendorff-Neumann , Achim Harder , Peter Jeschke
IPC分类号： A61K3812
CPC分类号： C07K7/64 , A01N43/90 , A61K38/00 , C12P21/02
摘要： The present invention relates to novel organochemical compounds, referred to as omphalotins for short, a process for their preparation by an essentially microbiological route and their use as pesticides, preferably for controlling animal pests.
摘要翻译：本发明涉及新的有机化合物，简称为奥马卫，，它们通过基本上微生物学途径制备的方法及其作为农药的用途，优选用于控制动物害虫。

6. 发明授权

US08425894B2 Use of oligomers of lactic acid in the treatment of gynaecological disorders 有权
标题翻译：使用乳酸低聚物治疗妇科疾病
公开(公告)号：US08425894B2
公开(公告)日：2013-04-23
申请号：US12594147
申请日：2008-03-28
申请人： Greg Batcheller , Thomas Hedner , Joergen Johnsson , Werner Schubert , Christer Sjoegren , Olov Sterner , Malgorzat Sznitowska
发明人： Greg Batcheller , Thomas Hedner , Joergen Johnsson , Werner Schubert , Christer Sjoegren , Olov Sterner , Malgorzat Sznitowska
IPC分类号： A61K31/765 , A61K31/225 , A61P31/00 , A61P15/02
CPC分类号： C07C69/34 , A61K9/0034 , A61K9/0036 , A61K9/02 , A61K9/06 , A61K9/19 , A61K31/19 , A61K31/74 , A61K31/765 , A61K45/06 , A61K47/10 , A61K47/38 , A61K2300/00
摘要： Use of the one or more oligomers of lactic acid with the following formula (I) wherein n is an integer from 2 to 25 such as, e.g., from 2 to 20, from 3 to 25, from 3 to 20, from 2 to 15, from 3 to 15, from 2 to 10, from 3 to 10, from 4 to 10, or from 4 to 9 or a lactic acid oligomeric product for the prophylaxis and/or treatment of a disease or condition that benefit of an acidic environment especially a gynaecological infection such as a bacterial infection, such as bacterial vaginosis, unspecific colpitis, senile colpitis, cervicitis, and urethritis, a fungal infection, such as candidosis (Candida albicans), cryptococcosis, actinomycosis, or a viral infection, such as Human Immunodefiency Virus (HIV), Herpes Simplex Virus (HSV), Human Papilloma Virus (HPV).
摘要翻译：使用一种或多种具有下式（I）的乳酸低聚物，其中n是2至25的整数，例如2至20,3至25，3至20，2至15 ，3至15，2至10，3至10，4至10，或4至9或用于预防和/或治疗有利于酸性环境的疾病或病症的乳酸低聚产物特别是诸如细菌性阴道炎，非特异性阴道炎，老年性阴道炎，宫颈炎和尿道炎等细菌感染的妇科感染，真菌感染如念珠菌（白念珠菌），隐球菌病，放线菌病或病毒感染，如人免疫缺陷病毒（HIV），单纯疱疹病毒（HSV），人乳头瘤病毒（HPV）。

7. 发明申请

US20080249164A1 Antimicrobial and Antinflammatory Composition 审中-公开
标题翻译：抗菌和抗炎组合物
公开(公告)号：US20080249164A1
公开(公告)日：2008-10-09
申请号：US11994252
申请日：2006-06-30
申请人： Jan Faergemann , Thomas Hedner , Olov Sterner , Lars Bjork
发明人： Jan Faergemann , Thomas Hedner , Olov Sterner , Lars Bjork
IPC分类号： A61K31/35 , A61P29/00 , A61P31/00
CPC分类号： A61K31/352 , A61K8/0208 , A61K8/11 , A61K8/4973 , A61K8/498 , A61K8/97 , A61K31/047 , A61K31/341 , A61K31/343 , A61K36/28 , A61K36/282 , A61Q5/006 , A61Q5/02 , A61Q17/005 , A61Q19/00 , A61Q19/10 , A61K2300/00
摘要： The invention relates to the use of at least davanone and 1,8-cineol for the manufacture of an antimicrobial and/or antiinflammatory composition as well as a method of producing said composition.
摘要翻译：本发明涉及至少使用大分子酮和1,8-桉树脑来制造抗微生物剂和/或抗炎组合物以及生产所述组合物的方法。

8. 发明申请

US20060040919A1 Bronchorelaxing compounds 审中-公开
标题翻译：支气管放生化合物
公开(公告)号：US20060040919A1
公开(公告)日：2006-02-23
申请号：US11186841
申请日：2005-07-22
申请人： Staffan Skogvall , Henrik Bjork , Per Berglund , Maria Dalence Guzman , Olov Sterner
发明人： Staffan Skogvall , Henrik Bjork , Per Berglund , Maria Dalence Guzman , Olov Sterner
IPC分类号： A61K31/55 , C07D223/16
CPC分类号： C07D223/16 , C07D217/06
摘要： A compound of the general formula (I) including its pharmaceutically acceptable acid addition salts wherein A is CHR9, wherein R9 is H, C1-C6 alkyl; n is 1-3; B is CHR10, wherein R10 is H, C1-C6 alkyl; m is 1 or 2; D is O or S; E is CR11R12 or NR13, wherein R11 and R12 are, independent of each other, H or C1-C6 alkyl, R13 is H or C1-C6 alkyl; F is C1-C18 alkyl or R4-R7 cycloalkyl, which may be mono- or di-unsaturated and/or substituted, is useful in treating and preventing pulmonary disease characterized by bronchoconstriction; also disclosed is a pharmaceutical composition comprising the compound of formula (I), a pharmaceutical carrier and, optionally, an anti-asthmatic, a method for its manufacture, and a method for treating or preventing such disease.
摘要翻译：包括其药学上可接受的酸加成盐的通式（I）的化合物，其中A是CHR 9，其中R 9是H，C 1 H 12 -C 6 -C 6烷基; n为1-3; B是CHR 10 N，其中R 10是H，C 1 -C 6烷基; m为1或2; D为O或S; E是CR 11 R 12或NR 13，其中R 11和R 12是/或 >彼此独立地为H或C 1 -C 6烷基，R 13为H或C 1〜 C 1 -C 6烷基; F是C 1 -C 18烷基或R 4 -R 7 R 7环烷基，其可以是单 - 或二 - 二不饱和和/或取代的，可用于治疗和预防以支气管收缩为特征的肺部疾病; 还公开了包含式（I）化合物，药物载体和任选的抗哮喘，其制备方法，以及治疗或预防这种疾病的方法的药物组合物。

9. 发明授权

US06384186B2 Cyclic dodecapeptide and process for the preparation thereof 失效
标题翻译：环十二肽及其制备方法
公开(公告)号：US06384186B2
公开(公告)日：2002-05-07
申请号：US09077489
申请日：1998-05-29
申请人： Heidrun Anke , Winfried Etzel , Wolfgang Gau , Rüdiger Hain , Michael Kilian , Anke Mayer , Olov Sterner
发明人： Heidrun Anke , Winfried Etzel , Wolfgang Gau , Rüdiger Hain , Michael Kilian , Anke Mayer , Olov Sterner
IPC分类号： C07K708
CPC分类号： C07K7/64 , A61K38/00
摘要： The present invention relates to a novel organochemical compound, referred to as omphalotin for short, a process for its preparation by an essentially microbiological route and its use as microbicide and pesticide, preferably for controlling animal pests, harmful fungi and bacteria.
摘要翻译：本发明涉及一种新的有机化合物，简称为奥马林，其通过基本上微生物学途径制备的方法及其作为杀微生物剂和农药的用途，优选用于防治动物害虫，有害真菌和细菌。

10. 发明申请

US20110092525A1 GABAA RECEPTOR MODULATORS 有权
标题翻译： GABAA受体调节剂
公开(公告)号：US20110092525A1
公开(公告)日：2011-04-21
申请号：US12936050
申请日：2009-04-02
申请人： Mogens Nielsen , Tommy Liljefors , Jakob Nilsson , Olov Sterner
发明人： Mogens Nielsen , Tommy Liljefors , Jakob Nilsson , Olov Sterner
IPC分类号： A61K31/519 , C07D471/04 , A61P25/22 , A61P25/08 , A61P25/20 , A61P21/02
CPC分类号： C07D487/04 , A61K31/519
摘要： The resent invention relates to novel compounds of the general formula (I) having anxiolytic, anticonvulsant, sedative-hypnotic and myorelaxant conditions as well as anxiogenic, somnolytic and convulsant conditions in mammals, including humans, as GABAA receptor modulator.
摘要翻译：本发明涉及具有抗焦虑药，抗惊厥药，镇静催眠药和嗜酸性症状的通式（I）的新化合物以及作为GABA A受体调节剂的哺乳动物（包括人）中的焦虑症，嗜酸性和惊厥症状。

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