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21. 发明授权

US07521465B2 Diphenyl ether derivatives 有权
标题翻译：二苯醚衍生物
公开(公告)号：US07521465B2
公开(公告)日：2009-04-21
申请号：US11096718
申请日：2005-03-31
申请人： Bishwajit Nag , Abhijeet Nag , Debendranath Dey , Shiv Kumar Agarwal , Partha Neogi , Gaddam Om Reddy , Sangamesh Badiger , Gajendra Singh , Surendra Kumar Pandey , Santhanagopalan Chithra
发明人： Bishwajit Nag , Abhijeet Nag , Debendranath Dey , Shiv Kumar Agarwal , Partha Neogi , Gaddam Om Reddy , Sangamesh Badiger , Gajendra Singh , Surendra Kumar Pandey , Santhanagopalan Chithra
IPC分类号： A61K31/426 , A61K31/421
CPC分类号： C07D277/20 , A61K31/4164 , A61K31/421 , A61K31/426 , C07D277/34 , C07D277/36
摘要： Novel diphenyl ether derivatives are provided that exhibit activity useful for reducing glucose, cholesterol, and/or triglyceride levels in plasma, and for treatment of obesity, inflammation, immunological diseases, autoimmune diseases, diabetes and disorders associated with insulin resistance.
摘要翻译：提供新的二苯醚衍生物，其显示可用于降低血浆中的葡萄糖，胆固醇和/或甘油三酯水平的活性，以及用于治疗肥胖，炎症，免疫疾病，自身免疫性疾病，糖尿病和与胰岛素抵抗相关的疾病。

22. 发明授权

US07399786B2 Derivatives of amino acids for treatment of obesity and related disorders 失效
标题翻译：用于治疗肥胖症和相关疾病的氨基酸衍生物
公开(公告)号：US07399786B2
公开(公告)日：2008-07-15
申请号：US11174301
申请日：2005-06-30
申请人： Debendranath Dey , Abjiheet Nag , Bindu Pandey , Preeti Balse , Partha Neogi , Bishwajit Nag
发明人： Debendranath Dey , Abjiheet Nag , Bindu Pandey , Preeti Balse , Partha Neogi , Bishwajit Nag
IPC分类号： A61K31/19 , C07C63/00
CPC分类号： C07D295/185 , C07C237/20 , C07C259/06 , C07C311/19
摘要： Novel amino acid derivatives are provided that are useful for management of disorders such as obesity and immunological diseases. The derivatives are also useful in lowering blood glucose levels in hyperglycemic disorders and for treating related disorders such as body weight gain, elevated free fatty acid, cholesterol and triglyceride levels and other disorder exacerbated by obesity.
摘要翻译：提供了可用于治疗肥胖症和免疫疾病等疾病的新型氨基酸衍生物。该衍生物还可用于降低高血糖病症中的血糖水平和用于治疗相关疾病如体重增加，升高的游离脂肪酸，胆固醇和甘油三酯水平以及由肥胖加剧的其它疾病。

23. 发明申请

US20070004725A1 Novel derivatives of amino acids for treatment of obesity and related disorders 失效
标题翻译：用于治疗肥胖症和相关疾病的氨基酸的新型衍生物
公开(公告)号：US20070004725A1
公开(公告)日：2007-01-04
申请号：US11174301
申请日：2005-06-30
申请人： Debendranath Dey , Abjiheet Nag , Bindu Pandey , Preeti Balse , Partha Neogi , Bishwajit Nag
发明人： Debendranath Dey , Abjiheet Nag , Bindu Pandey , Preeti Balse , Partha Neogi , Bishwajit Nag
IPC分类号： A61K31/5375 , A61K31/495 , A61K31/325 , C07D241/04 , C07C271/42
CPC分类号： C07D295/185 , C07C237/20 , C07C259/06 , C07C311/19
摘要： Novel amino acid derivatives are provided that are useful for management of disorders such as obesity and immunological diseases. The derivatives are also useful in lowering blood glucose levels in hyperglycemic disorders and for treating related disorders such as body weight gain, elevated free fatty acid, cholesterol and triglyceride levels and other disorder exacerbated by obesity.
摘要翻译：提供了可用于治疗肥胖症和免疫疾病等疾病的新型氨基酸衍生物。该衍生物还可用于降低高血糖病症中的血糖水平和用于治疗相关疾病如体重增加，升高的游离脂肪酸，胆固醇和甘油三酯水平以及由肥胖加剧的其它疾病。

24. 发明申请

US20060247285A1 Novel heterocyclic diphenyl ethers 有权
标题翻译：新型杂环二苯醚
公开(公告)号：US20060247285A1
公开(公告)日：2006-11-02
申请号：US11359657
申请日：2006-02-21
申请人： Partha Neogi , Bishwajit Nag , Debendranath Dey , Abhijeet Nag , Birendra Bhattacharya , Vinod Singh , Surendradoss Jayakumar
发明人： Partha Neogi , Bishwajit Nag , Debendranath Dey , Abhijeet Nag , Birendra Bhattacharya , Vinod Singh , Surendradoss Jayakumar
IPC分类号： A61K31/426 , C07D277/24
CPC分类号： C07D277/34 , C07D209/34 , C07D277/36 , C07D401/12 , C07D417/12
摘要： The present invention relates to novel heterocyclic diphenyl ether and diphenyl amine compounds, derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and pharmaceutically acceptable solvates thereof and pharmaceutically acceptable compositions containing these singly or in combination. The compounds of the present invention are effective in lowering blood glucose, serum insulin, free fatty acids, cholesterol and triglyceride levels and are useful in the treatment and/or prophylaxis of diabetes. The compounds of the present invention are effective in treatment of obesity, inflammation, autoimmune diseases such as multiple sclerosis and rheumatoid arthritis and immunological diseases, including the treatment of cancer. Furthermore, the compounds are useful for the treatment of disorders associated with insulin resistance.
摘要翻译：本发明涉及新颖的杂环二苯醚和二苯胺化合物，衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂化物，药学上可接受的盐和药学上可接受的溶剂合物以及含有这些单独或组合的药学上可接受的组合物。本发明的化合物可有效降低血糖，血清胰岛素，游离脂肪酸，胆固醇和甘油三酯水平，并且可用于治疗和/或预防糖尿病。本发明的化合物可有效治疗肥胖，炎症，自身免疫性疾病如多发性硬化和类风湿性关节炎以及免疫疾病，包括治疗癌症。此外，这些化合物可用于治疗与胰岛素抵抗相关的疾病。

25. 发明申请

US20050288341A1 Novel diphenyl ether derivatives 有权
标题翻译：新型二苯醚衍生物
公开(公告)号：US20050288341A1
公开(公告)日：2005-12-29
申请号：US11096718
申请日：2005-03-31
申请人： Bishwajit Nag , Abhijeet Nag , Debendranath Dey , Shiv Agarwal , Partha Neogi , Gaddam Reddy , Sangamesh Badiger , Gajendra Singh , Surendra Pandey , Santhanagopalan Chithra
发明人： Bishwajit Nag , Abhijeet Nag , Debendranath Dey , Shiv Agarwal , Partha Neogi , Gaddam Reddy , Sangamesh Badiger , Gajendra Singh , Surendra Pandey , Santhanagopalan Chithra
IPC分类号： A61K31/4164 , A61K31/421 , A61K31/426
CPC分类号： C07D277/20 , A61K31/4164 , A61K31/421 , A61K31/426 , C07D277/34 , C07D277/36
摘要： Novel diphenyl ether derivatives are provided that exhibit activity useful for reducing glucose, cholesterol, and/or triglyceride levels in plasma, and for treatment of obesity, inflammation, immunological diseases, autoimmune diseases, diabetes and disorders associated with insulin resistance.
摘要翻译：提供新的二苯醚衍生物，其显示可用于降低血浆中的葡萄糖，胆固醇和/或甘油三酯水平的活性，以及用于治疗肥胖，炎症，免疫疾病，自身免疫性疾病，糖尿病和与胰岛素抵抗相关的疾病。

26. 发明授权

US06794401B2 Amino acid phenoxy ethers 有权
标题翻译：氨基酸苯氧基醚
公开(公告)号：US06794401B2
公开(公告)日：2004-09-21
申请号：US10356113
申请日：2003-01-31
申请人： Bishwajit Nag , Abhijeet Nag , Debendranath Dey , Shiv Kumar Agarwal
发明人： Bishwajit Nag , Abhijeet Nag , Debendranath Dey , Shiv Kumar Agarwal
IPC分类号： A61K31425
CPC分类号： C07D263/44 , A61K31/421 , A61K31/422 , A61K31/426 , A61K31/427 , C07D277/34
摘要： Novel amino acid phenyl ethers are provided which exhibit activity for the treatment of immunological diseases, inflammation, obesity, hyperlipidemia, hypertension, neurological diseases and diabetes.
摘要翻译：提供了新的氨基酸苯基醚，其表现出用于治疗免疫疾病，炎症，肥胖症，高脂血症，高血压，神经疾病和糖尿病的活性。

27. 发明申请

US20050096366A1 Amino acid phenoxy ethers 审中-公开
标题翻译：氨基酸苯氧基醚
公开(公告)号：US20050096366A1
公开(公告)日：2005-05-05
申请号：US10947047
申请日：2004-09-21
申请人： Bishwajit Nag , Abhijeet Nag , Debendranath Dey , Shiv Agarwal
发明人： Bishwajit Nag , Abhijeet Nag , Debendranath Dey , Shiv Agarwal
IPC分类号： C07D263/44 , C07D277/34 , A61K31/426 , A61K31/421 , C07D277/14 , C07D413/02 , C07D417/02
CPC分类号： C07D263/44 , A61K31/421 , A61K31/422 , A61K31/426 , A61K31/427 , C07D277/34
摘要： Novel amino acid phenyl ethers are provided which exhibit activity for the treatment of immunological diseases, inflammation, obesity, hyperlipidemia, hypertension, neurological diseases and diabetes.
摘要翻译：提供新的氨基酸苯基醚，其表现出用于治疗免疫疾病，炎症，肥胖症，高脂血症，高血压，神经疾病和糖尿病的活性。

28. 发明申请

US20090069313A1 Novel MAO-A inhibitors 审中-公开
标题翻译：新型MAO-A抑制剂
公开(公告)号：US20090069313A1
公开(公告)日：2009-03-12
申请号：US11896902
申请日：2007-09-06
申请人： Debendranath Dey , Gajendra Singh , Partha Neogi , Uma Ramachandran , Chithra Santhanagopalan
发明人： Debendranath Dey , Gajendra Singh , Partha Neogi , Uma Ramachandran , Chithra Santhanagopalan
IPC分类号： A61K31/5377 , C07D277/16 , A61K31/426 , C07D209/34 , A61P25/24 , A61P25/32 , A61P25/08 , A61P25/00 , A61P25/34 , A61P25/28 , A61K31/404 , C07D413/12 , A61K31/422
CPC分类号： C07D277/36 , C07D209/34 , C07D277/34 , C07D413/12 , C07D417/12
摘要： The present invention provides a new medical use for the compounds of the formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof, as MAO-A inhibitors. Also included is a method for prophylaxis and treatment of mental disorders such as depression, in a mammal, comprising administering an effective amount of a compound of formula (I). These compounds are also effective in treating a disease, condition or disorder such as weight loss, obesity, bulimia, depression, bipolar disorders, psychoses, schizophrenia, behaviors, alcoholism, tobacco abuse, memory loss, Alzheimer's disease, dementia of aging, seizure disorders, epilepsy, attention deficit disorder, and Parkinson's disease, which is modulated by a cannabinoid receptor antagonist.
摘要翻译：本发明提供了作为MAO-A抑制剂的式（I）化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物，药学上可接受的盐和组合物，其代谢物和前药的新医学用途。还包括在哺乳动物中预防和治疗精神障碍如抑郁症的方法，包括施用有效量的式（I）化合物。这些化合物在治疗疾病，病症或病症如体重减轻，肥胖，贪食症，抑郁症，双相性精神障碍，精神病，精神分裂症，行为，酒精中毒，吸烟，记忆丧失，阿尔茨海默病，老年痴呆，癫痫发作障碍，癫痫，注意力缺陷障碍和由大麻素受体拮抗剂调节的帕金森病。

29. 发明申请

US20100305174A1 Novel Heterocyclic Derivatives 审中-公开
标题翻译：新型杂环衍生物
公开(公告)号：US20100305174A1
公开(公告)日：2010-12-02
申请号：US11918235
申请日：2006-04-12
申请人： Surendrakumar Satyanarayan Pandey , Gadam Om Reddy , Shiv Kumar Agarwal , Gajendra Singh , Santhanagopalan Chithra , Debendranath Dey , Abhijeet Nag , Kadnur Venkatachalapathi Sanjay
发明人： Surendrakumar Satyanarayan Pandey , Gadam Om Reddy , Shiv Kumar Agarwal , Gajendra Singh , Santhanagopalan Chithra , Debendranath Dey , Abhijeet Nag , Kadnur Venkatachalapathi Sanjay
IPC分类号： A61K31/427 , C07D417/12 , C07D413/12 , A61K31/422 , A61P3/10 , A61P3/06 , A61P3/04 , A61P37/00 , A61P29/00 , A61P35/00
CPC分类号： C07D413/12 , C07D417/12
摘要： The present invention relates to novel heterocyclic derivatives of formula (I) and their pharmaceutically acceptable salts, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmaceutically acceptable salts, their pharmaceutical compositions, and their prodrugs thereof. The present invention more particularly provides novel compounds of the general formula (1).
摘要翻译：本发明涉及式（I）的新型杂环衍生物及其药学上可接受的盐，其衍生物，其类似物，其互变异构形式，其立体异构体，它们的多晶型物，它们的水合物，它们的溶剂合物，其药学上可接受的盐，其药物组合物，及其前药。本发明更具体地提供了通式（1）的新型化合物。

30. 发明申请

US20120070519A1 METHOD FOR EXTRACTION OF FRACTIONS CONTAINING PHARMACOLOGICALLY ACTIVE INGREDIENTS WITH LESS CYTOTOXICITY FROM ONE OR MORE PLANTS 有权
标题翻译：一种或多种植物提取含有较少细胞毒性的药物活性成分的物质的方法
公开(公告)号：US20120070519A1
公开(公告)日：2012-03-22
申请号：US13322147
申请日：2010-05-21
申请人： Deepa Chitre , Debendranath Dey
发明人： Deepa Chitre , Debendranath Dey
IPC分类号： A61K36/00 , A61P17/06 , A61P35/00 , A61P25/00 , A61P25/28 , A61P9/10 , A61K31/365 , A61P19/02
CPC分类号： A61K36/53 , A61K36/19 , A61K36/81
摘要： A method of obtaining one or more fractions from one or more plants is disclosed. The method includes subjecting one or more parts of the one or more plants to hydro-alcoholic extraction in presence of a water-insoluble solvent to obtain one or more extracts. The method further includes subjecting the one or more extracts to one or more of de-pigmentation, de-fatting and detoxification process to obtain the one or more fractions. The one or more fractions thus obtained contain a desired pharmacologically active ingredient in concentration greater than concentrations of other pharmacologically active ingredients present in the at least one fraction. Further, the one or more fractions are less toxic as compared with corresponding one or more fractions obtained by conventional methods. In addition, the one or more fractions are therapeutically more effective in various diseases as compared to one or more fractions obtained by conventional methods.
摘要翻译：公开了从一种或多种植物获得一种或多种级分的方法。该方法包括使一种或多种植物的一个或多个部分在水不溶性溶剂存在下进行水 - 醇提取以获得一种或多种提取物。所述方法进一步包括使一种或多种提取物经历一种或多种脱色素，去脂肪和解毒过程以获得一种或多种级分。由此获得的一种或多种级分含有浓度大于存在于至少一个级分中的其它药理活性成分的浓度的所需药理活性成分。此外，与通过常规方法获得的相应的一种或多种级分相比，一种或多种级分的毒性较小。此外，与通过常规方法获得的一种或多种级分相比，一种或多种级分在各种疾病中治疗上更有效。

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