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1. 发明授权

US07335770B2 Triazine compounds and their analogs, compositions, and methods 失效
标题翻译：三嗪化合物及其类似物，组合物和方法
公开(公告)号：US07335770B2
公开(公告)日：2008-02-26
申请号：US10808210
申请日：2004-03-24
申请人： Richard T. Timmer , Christopher W. Alexander , Sivaram Pillarisetti , Uday Saxena , Sesha Sridevi Alluri , Velagala Venkata Rama Murali Krishna Reddy , Manojit Pal , Jangalgar Tirupathy Reddy , Koteswar Rao Yeleswarapu , Gaddam Om Reddy , Potlapally Rajender Kumar
发明人： Richard T. Timmer , Christopher W. Alexander , Sivaram Pillarisetti , Uday Saxena , Sesha Sridevi Alluri , Velagala Venkata Rama Murali Krishna Reddy , Manojit Pal , Jangalgar Tirupathy Reddy , Koteswar Rao Yeleswarapu , Gaddam Om Reddy , Potlapally Rajender Kumar
IPC分类号： C07D251/54 , C07D251/48 , C07D251/18 , C07D251/42 , A61K31/53 , A61P35/00
CPC分类号： C07D251/46
摘要： The present invention relates to triazine compounds and their analogs and derivatives, and methods and compositions comprising these compounds. The compounds and compositions of this invention are useful for, among other things, treating pathophysiological conditions arising from inflammatory responses, inhibiting or blocking glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells, inhibiting smooth muscle proliferation, treating vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis, and the like.
摘要翻译：本发明涉及三嗪化合物及其类似物和衍生物，以及包含这些化合物的方法和组合物。本发明的化合物和组合物尤其可用于治疗由炎症反应引起的病理生理学病症，抑制或阻断糖基化蛋白产生内皮细胞中信号传导相关炎症反应的诱导，抑制平滑肌增生，治疗血管闭塞症状其特征在于平滑肌增生如再狭窄和动脉粥样硬化等。

2. 发明申请

US20070167413A1 Novel heterocycles 审中-公开
标题翻译：新的杂环
公开(公告)号：US20070167413A1
公开(公告)日：2007-07-19
申请号：US11633053
申请日：2006-12-04
申请人： Akella Satya Surya Visweswara Srinivas , Ravikumar Tadiparthi , Ganapavarapu Veera Raghava Sharma , Sappanimuthu Thirunavukkarasu , Durairaj Peter Bhakiaraj , Virendra Kachhadia , Kilambi Narsimhan , Sathya Narayana Thara , Sriram Rajagopal , Gaddam Om Reddy , Sukunath Narayanan , Venkatesan Parameswaran , Venkatesan Janarthanam
发明人： Akella Satya Surya Visweswara Srinivas , Ravikumar Tadiparthi , Ganapavarapu Veera Raghava Sharma , Sappanimuthu Thirunavukkarasu , Durairaj Peter Bhakiaraj , Virendra Kachhadia , Kilambi Narsimhan , Sathya Narayana Thara , Sriram Rajagopal , Gaddam Om Reddy , Sukunath Narayanan , Venkatesan Parameswaran , Venkatesan Janarthanam
IPC分类号： A61K31/655 , A61K31/506 , C07D403/04
CPC分类号： C07D239/42 , C07D213/30 , C07D239/32 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/04 , C07D417/12 , C07D417/14
摘要： The present invention relates to novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof. The present invention more particularly provides novel hetereocycles of the general formula (I). Also included is a method of treatment of immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; ischemic heart disease; atherosclerosis; cancer; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; adult respiratory distress syndrome (ARDS); psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; cachexia; asthma; bone resorption diseases; ischemia reperfusion injury; brain trauma; multiple sclerosis; sepsis; septic shock; toxic shock syndrome; fever, and myalgias due to infection in a mammal comprising administering an effective amount of a compound of formula (I) as described above.
摘要翻译：本发明涉及通式（I）的新型杂环化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂化物，药学上可接受的盐和组合物，其代谢物和前药。本发明更具体地提供了通式（I）的新颖的杂环。还包括治疗免疫疾病，炎症，疼痛障碍，类风湿性关节炎的方法; 骨质疏松症多发性骨髓瘤葡萄膜炎急性和慢性粒细胞白血病; 缺血性心脏病; 动脉粥样硬化癌症; 缺血诱导的细胞损伤; 胰腺β细胞破坏; 骨关节炎类风湿性脊柱炎; 痛风性关节炎炎症性肠病; 成人呼吸窘迫综合征（ARDS）; 银屑病; 克罗恩病; 过敏性鼻炎; 溃疡性结肠炎过敏反应接触性皮炎; 肌肉退化; 恶病质哮喘; 骨吸收疾病; 缺血再灌注损伤; 脑外伤; 多发性硬化症脓毒症败血性休克中毒性休克综合征; 发热和由于哺乳动物感染引起的肌痛，包括给予有效量的如上所述的式（I）化合物。

3. 发明授权

US07169785B2 Methods and compositions of novel triazine compounds 失效
公开(公告)号：US07169785B2
公开(公告)日：2007-01-30
申请号：US10400169
申请日：2003-03-26
申请人： Richard T. Timmer , Christopher W. Alexander , Sivaram Pillarisetti , Uday Saxena , Koteswar Rao Yeleswarapu , Manojit Pal , Jangalgar Tirupathy Reddy , Velagala Venkata Rama Murali Krishma Reddy , Sesha Sridevi Alluri , Potlapally Rajender Kumar , Gaddam Om Reddy
发明人： Richard T. Timmer , Christopher W. Alexander , Sivaram Pillarisetti , Uday Saxena , Koteswar Rao Yeleswarapu , Manojit Pal , Jangalgar Tirupathy Reddy , Velagala Venkata Rama Murali Krishma Reddy , Sesha Sridevi Alluri , Potlapally Rajender Kumar , Gaddam Om Reddy
IPC分类号： C07D251/42 , C07D251/48 , C07D251/54 , C07D239/24 , C07D213/02 , A61K31/53 , A61K31/506 , A61K35/00 , A61K31/424 , A61K31/427 , A61K31/4427
CPC分类号： A61K31/53 , C04B35/632 , C07D251/30 , C07D251/44 , C07D251/46 , C07D251/48 , C07D251/50 , C07D251/52 , C07D251/54 , C07D251/66 , C07D251/70 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D453/02 , C07D471/04 , C07D487/04 , C07F9/6521 , C07F9/65583
摘要： The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.

4. 发明授权

US07132423B2 Methods and compositions of novel triazine compounds 失效
公开(公告)号：US07132423B2
公开(公告)日：2006-11-07
申请号：US10400140
申请日：2003-03-26
申请人： Richard T. Timmer , Christopher W. Alexander , Sivaram Pillarisetti , Uday Saxena , Koteswar Rao Yeleswarapu , Manojit Pal , Jangalgar Tirupathy Reddy , Velagala Venkata Rama Murali Krishna Reddy , Sesha Sridevi Alluri , Potlapally Rajender Kumar , Gaddam Om Reddy
发明人： Richard T. Timmer , Christopher W. Alexander , Sivaram Pillarisetti , Uday Saxena , Koteswar Rao Yeleswarapu , Manojit Pal , Jangalgar Tirupathy Reddy , Velagala Venkata Rama Murali Krishna Reddy , Sesha Sridevi Alluri , Potlapally Rajender Kumar , Gaddam Om Reddy
IPC分类号： C07D251/70 , C07D251/48 , A61K31/53 , A61P35/00
CPC分类号： A61K31/53 , C07D251/30 , C07D251/44 , C07D251/46 , C07D251/48 , C07D251/50 , C07D251/52 , C07D251/66 , C07D251/70 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D453/02 , C07D487/04 , C07F9/6521 , C07F9/65583
摘要： The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.

5. 发明授权

US06559335B2 Process for the preparation of 3-aryl-2-hydroxy propanoic acid 失效
标题翻译： 3-芳基-2-羟基丙酸的制备方法
公开(公告)号：US06559335B2
公开(公告)日：2003-05-06
申请号：US09836559
申请日：2001-04-17
申请人： Potlapally Rajender Kumar , Siripragada Mahender Rao , Kotra Narasimha Murthy , Sirisilla Raju , Mamillapalli Ramabhadra Sarma , Gaddam Om Reddy
发明人： Potlapally Rajender Kumar , Siripragada Mahender Rao , Kotra Narasimha Murthy , Sirisilla Raju , Mamillapalli Ramabhadra Sarma , Gaddam Om Reddy
IPC分类号： C07C6976
CPC分类号： C07C67/10 , C07C67/00 , C07C67/11 , C07C69/734
摘要： The present invention relates to an improved process for the preparation of 3-aryl-2-hydroxy propanoic acid derivatives of the formula (1) useful as an intermediate for the preparation of many pharmaceutically active compounds.
摘要翻译：本发明涉及一种制备式（1）的3-芳基-2-羟基丙酸衍生物的改进方法，其用作制备许多药物活性化合物的中间体。

6. 发明授权

US08263044B2 Stilbene like compounds as novel HDAC inhibitors 失效
标题翻译：二苯乙烯类化合物作为新型HDAC抑制剂
公开(公告)号：US08263044B2
公开(公告)日：2012-09-11
申请号：US12084430
申请日：2006-11-06
申请人： Akella Satya Surya Visweswara Srinivas , Urkalan Kaveri Balan , Narayana Swamy Punthalir , Rama Swamy Velmurugan , Sriram Rajagopal , Gaddam Om Reddy , Virendra Kachhadia
发明人： Akella Satya Surya Visweswara Srinivas , Urkalan Kaveri Balan , Narayana Swamy Punthalir , Rama Swamy Velmurugan , Sriram Rajagopal , Gaddam Om Reddy , Virendra Kachhadia
IPC分类号： A61K9/12 , A61K31/427 , A61K31/4409 , C07D417/04 , C07D213/56 , A61P35/00
CPC分类号： C07C259/06 , C07C237/22 , C07C323/62 , C07D213/56 , C07D277/30 , C07D277/46 , C07D277/58 , C07D277/82 , C07D307/56 , C07D333/24 , C07D333/28 , C07D417/06
摘要： The present invention relates to novel stilbene like compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof. The present invention more particularly provides novel stilbene like compounds of the general formula (I). Also included is a method for treatment of cancer, psoriasis, proliferative conditions and conditions mediated by HDAC, in a mammal comprising administering an effective amount of a novel compound of formula (I) as described above.
摘要翻译：本发明涉及通式（I）的新颖的二苯乙烯类化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物，药学上可接受的盐和组合物，其代谢物和前药。本发明更具体地提供了通式（I）的新颖的二苯乙烯类化合物。还包括在哺乳动物中治疗癌症，牛皮癣，增殖性病症和由HDAC介导的病症的方法，包括给予有效量的如上所述的新的式（I）化合物。

7. 发明申请

US20100152188A1 Novel Heterocyclic Compounds 审中-公开
标题翻译：新型杂环化合物
公开(公告)号：US20100152188A1
公开(公告)日：2010-06-17
申请号：US11989712
申请日：2006-08-04
申请人： Akella Satya Surya Visweswara Srinivas , Kasinathan Mathiyazhagan , Duddu Savaraiah Sharada , Thanasekaran Ponpandian , Kulasekharan Revathy , Gaddam Om Reddy , Mani Kamarai , Sriram Raiagopal
发明人： Akella Satya Surya Visweswara Srinivas , Kasinathan Mathiyazhagan , Duddu Savaraiah Sharada , Thanasekaran Ponpandian , Kulasekharan Revathy , Gaddam Om Reddy , Mani Kamarai , Sriram Raiagopal
IPC分类号： A61K31/5377 , C07D417/12 , A61K31/4439 , C12N5/00 , C07D277/20 , A61K31/427 , C07D277/62 , A61K31/428 , C07D413/14 , C07D401/02 , A61K31/4545 , C07D401/14 , C07D333/22 , A61K31/381 , C07C271/02 , A61K31/27 , C07D235/04 , A61K31/4184 , C07D249/18 , A61K31/4192 , C07D215/38 , A61K31/47 , C07D405/02 , A61K31/496 , C07D403/02 , A61P35/00 , A61P17/06
CPC分类号： C07D333/16 , C07C271/22 , C07D249/18 , C07D277/24 , C07D277/48 , C07D319/20 , C07D409/12 , C07D417/12
摘要： The present invention relates to novel compounds of the general formula (I), their derivatives, their analogs, their stereoisomers, their pharmaceutically acceptable salts and compositions. The present invention more particularly provides novel heterocyclic compounds of the general formula (I).
摘要翻译：本发明涉及通式（I）的新化合物，其衍生物，其类似物，其立体异构体，其药学上可接受的盐和组合物。本发明更具体地提供了通式（I）的新型杂环化合物。

8. 发明授权

US07268134B2 Medical devices employing triazine compounds and compositions thereof 失效
公开(公告)号：US07268134B2
公开(公告)日：2007-09-11
申请号：US10951305
申请日：2004-09-27
申请人： Richard T. Timmer , Christopher W. Alexander , Sivaram Pillarisetti , Uday Saxena , Koteswar Rao Yeleswarapu , Manojit Pal , Jangalgar Tirupathy Reddy , Velagala Venkata Rama Murali Krishna Reddy , Sesha Sridevi Alluri , Potlapally Rajender Kumar , Gaddam Om Reddy
发明人： Richard T. Timmer , Christopher W. Alexander , Sivaram Pillarisetti , Uday Saxena , Koteswar Rao Yeleswarapu , Manojit Pal , Jangalgar Tirupathy Reddy , Velagala Venkata Rama Murali Krishna Reddy , Sesha Sridevi Alluri , Potlapally Rajender Kumar , Gaddam Om Reddy
IPC分类号： A61M31/00 , A61F2/86 , C07D251/70 , C07D251/52 , C07D251/30 , A61K31/53 , A61P35/00
CPC分类号： A61K31/53 , C04B35/632 , C07D251/30 , C07D251/44 , C07D251/46 , C07D251/48 , C07D251/50 , C07D251/52 , C07D251/66 , C07D251/70 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D453/02 , C07D487/04 , C07F9/6521 , C07F9/65583
摘要： The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.

9. 发明授权

US07163943B2 Methods and compositions of novel triazine compounds 失效
标题翻译：新型三嗪化合物的方法和组成
公开(公告)号：US07163943B2
公开(公告)日：2007-01-16
申请号：US10397968
申请日：2003-03-26
申请人： Richard T. Timmer , Christopher W. Alexander , Sivaram Pillarisetti , Uday Saxena , Koteswar Rao Yeleswarapu , Manojit Pal , Jangalgar Tirupathy Reddy , Velagala Venkata Rama Murali Krishna Reddy , Bhatlapenumarthy Sesha Sridevi , Potlapally Rajender Kumar , Gaddam Om Reddy
发明人： Richard T. Timmer , Christopher W. Alexander , Sivaram Pillarisetti , Uday Saxena , Koteswar Rao Yeleswarapu , Manojit Pal , Jangalgar Tirupathy Reddy , Velagala Venkata Rama Murali Krishna Reddy , Bhatlapenumarthy Sesha Sridevi , Potlapally Rajender Kumar , Gaddam Om Reddy
IPC分类号： C07D251/30 , C07D251/46 , C07D251/52 , C07D251/54 , A61K31/53
CPC分类号： A61K31/53 , C04B35/632 , C07D251/30 , C07D251/44 , C07D251/46 , C07D251/48 , C07D251/50 , C07D251/52 , C07D251/66 , C07D251/70 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D453/02 , C07D487/04 , C07F9/6521 , C07F9/65583
摘要： The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.
摘要翻译：本发明涉及包含治疗由炎性反应引起的病理生理状况的化合物的方法和组合物。特别地，本发明涉及抑制或阻断糖基化蛋白质产生内皮细胞中信号传导相关炎症反应诱导的化合物。本发明涉及抑制平滑肌增殖的化合物。特别地，本发明涉及通过调节HSPG例如Perlecan抑制平滑肌细胞增殖的化合物。本发明还涉及化合物用于治疗以平滑肌增生为特征的血管闭塞症状，例如再狭窄和动脉粥样硬化。

10. 发明授权

US07759350B2 Pyrimidine carboxamides 失效
标题翻译：嘧啶甲酰胺
公开(公告)号：US07759350B2
公开(公告)日：2010-07-20
申请号：US11516549
申请日：2006-09-07
申请人： Ravikumar Tadipartiii , Venkatesan Parameswaran , Rajib Barik , Gaddam Om Reddy , Pawan Aggarwal , Sappanimuthu Thirunavukkarasu , Sriram Rajagopal
发明人： Ravikumar Tadipartiii , Venkatesan Parameswaran , Rajib Barik , Gaddam Om Reddy , Pawan Aggarwal , Sappanimuthu Thirunavukkarasu , Sriram Rajagopal
IPC分类号： C07D239/28 , A61K31/505
CPC分类号： C07D239/38 , C07D239/46 , C07D239/47 , C07D239/48 , C07D401/04
摘要： The present invention relates to novel compounds of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmaceutically acceptable salts and compositions, their metabolites and prodrugs thereof. The present invention more particularly relates to novel pyrimidine carboxamides of the general formula (I). Also included is a method of prophylaxis or treatment of a pain disorder, immunological diseases, inflammation, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; ischemic heart disease; atherosclerosis; cancer; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; adult respiratory distress syndrome (ARDS); psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; cachexia; asthma; bone resorption diseases; ischemia reperfusion injury; brain trauma; multiple sclerosis; sepsis; septic shock; toxic shock syndrome; fever, and myalgias due to infection in a mammal comprising administering an effective amount of a compound of formula (I) as described above.
摘要翻译：本发明涉及通式（I）的新化合物，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，它们的水合物，它们的溶剂化物，其药学上可接受的盐和组合物，其代谢物和前药。本发明更具体地涉及通式（I）的新型嘧啶甲酰胺。还包括预防或治疗疼痛障碍，免疫疾病，炎症，类风湿性关节炎的方法; 骨质疏松症多发性骨髓瘤葡萄膜炎急性和慢性粒细胞白血病; 缺血性心脏病; 动脉粥样硬化癌症; 缺血诱导的细胞损伤; 胰腺β细胞破坏; 骨关节炎类风湿性脊柱炎; 痛风性关节炎炎症性肠病; 成人呼吸窘迫综合征（ARDS）; 银屑病; 克罗恩病; 过敏性鼻炎; 溃疡性结肠炎过敏反应接触性皮炎; 肌肉退化; 恶病质哮喘; 骨吸收疾病; 缺血再灌注损伤; 脑外伤; 多发性硬化症败血症败血性休克中毒性休克综合征; 发热和由于哺乳动物感染引起的肌痛，包括给予有效量的如上所述的式（I）化合物。

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