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1. 发明申请

US20120070519A1 METHOD FOR EXTRACTION OF FRACTIONS CONTAINING PHARMACOLOGICALLY ACTIVE INGREDIENTS WITH LESS CYTOTOXICITY FROM ONE OR MORE PLANTS 有权
标题翻译：一种或多种植物提取含有较少细胞毒性的药物活性成分的物质的方法
公开(公告)号：US20120070519A1
公开(公告)日：2012-03-22
申请号：US13322147
申请日：2010-05-21
申请人： Deepa Chitre , Debendranath Dey
发明人： Deepa Chitre , Debendranath Dey
IPC分类号： A61K36/00 , A61P17/06 , A61P35/00 , A61P25/00 , A61P25/28 , A61P9/10 , A61K31/365 , A61P19/02
CPC分类号： A61K36/53 , A61K36/19 , A61K36/81
摘要： A method of obtaining one or more fractions from one or more plants is disclosed. The method includes subjecting one or more parts of the one or more plants to hydro-alcoholic extraction in presence of a water-insoluble solvent to obtain one or more extracts. The method further includes subjecting the one or more extracts to one or more of de-pigmentation, de-fatting and detoxification process to obtain the one or more fractions. The one or more fractions thus obtained contain a desired pharmacologically active ingredient in concentration greater than concentrations of other pharmacologically active ingredients present in the at least one fraction. Further, the one or more fractions are less toxic as compared with corresponding one or more fractions obtained by conventional methods. In addition, the one or more fractions are therapeutically more effective in various diseases as compared to one or more fractions obtained by conventional methods.
摘要翻译：公开了从一种或多种植物获得一种或多种级分的方法。该方法包括使一种或多种植物的一个或多个部分在水不溶性溶剂存在下进行水 - 醇提取以获得一种或多种提取物。所述方法进一步包括使一种或多种提取物经历一种或多种脱色素，去脂肪和解毒过程以获得一种或多种级分。由此获得的一种或多种级分含有浓度大于存在于至少一个级分中的其它药理活性成分的浓度的所需药理活性成分。此外，与通过常规方法获得的相应的一种或多种级分相比，一种或多种级分的毒性较小。此外，与通过常规方法获得的一种或多种级分相比，一种或多种级分在各种疾病中治疗上更有效。

2. 发明申请

US20100150865A1 NOVEL FORMULATIONS TO INHIBIT CYCLOOXYGENASE AND PRO-INFLAMMATORY CYTOKINE MEDIATED DISEASES 审中-公开
标题翻译：抑制环孢菌素和促炎细胞因子介导性疾病的新型制剂
公开(公告)号：US20100150865A1
公开(公告)日：2010-06-17
申请号：US12632824
申请日：2009-12-08
申请人： Deepa Chitre , Debendranath Dey
发明人： Deepa Chitre , Debendranath Dey
IPC分类号： A61K36/00 , A61K38/20 , A61K36/324 , A61K36/9066 , A61K36/906 , A61P29/00
CPC分类号： A61K31/573 , A61K31/415 , A61K31/4402 , A61K36/324 , A61K36/81 , A61K36/9066 , A61K36/9068 , A61K2300/00
摘要： The invention provides method and composition for alleviating one or more symptoms associated with a medical condition mediated by one or more of a cyclooxygenase, a pro-inflammatory cytokine, and a pro-inflammatory enzyme. The method includes administering an effective amount of a composition to a person suffering from the medical condition. The composition essentially includes a set of plant extracts. The set of plant extracts include an extract of Withania somnifera, an extract of Boswellia serrata, an extract of Curcuma longa, and an extract of Zingiber officinale. Wherein, one or more extracts of the set of plant extracts includes one or more desired active ingredient in an amount greater than an amount of other active ingredients present in the one or more extracts. The composition can also be used as combination therapy with any other known anti-inflammatory agents.
摘要翻译：本发明提供了用于减轻与一种或多种环加氧酶，促炎细胞因子和促炎症酶介导的医学病症相关的一种或多种症状的方法和组合物。该方法包括向患有该疾病的患者施用有效量的组合物。组合物基本上包括一组植物提取物。一组植物提取物包括檀香皂提取物，芥子油提取物，姜黄提取物和姜黄提取物。其中，所述一组植物提取物中的一种或多种提取物包含大于所述一种或多种提取物中存在的其它活性成分的量的一种或多种所需活性成分。组合物也可以与任何其它已知的抗炎剂组合使用。

3. 发明申请

US20170119835A1 METHOD OF MAKING AN ADJUNCT TO POTENTIATE BLOCKING OF RIBOSOMAL FUNCTIONS IN TUMOR CELLS AND PREVENT BODY WEIGHT LOSS DURING CYCLOPHOSPHAMIDE CANCER THERAPY 审中-公开
公开(公告)号：US20170119835A1
公开(公告)日：2017-05-04
申请号：US15257912
申请日：2016-09-07
申请人： Deepa Chitre , Debendranath Dey , Sunetra Chaskar
发明人： Deepa Chitre , Debendranath Dey , Sunetra Chaskar
IPC分类号： A61K36/81 , A61K9/00 , A61K31/58
CPC分类号： A61K36/81 , A61K31/585 , A61K31/675 , A61K2236/333 , A61K2300/00
摘要： A method of obtaining one or more fractions from a plant material of Withania somnifera (WS) is disclosed. The method includes subjecting the plant material to hydro-alcoholic extraction in presence of a water-insoluble solvent to obtain at least one extract. The method further includes subjecting the at least one extract obtained from the hydro-alcoholic extraction to at least one of de-pigmentation, de-fatting and detoxification process to obtain the one or more fractions. The one or more fractions thus obtained contain Withaferin A in a concentration greater than concentrations of other pharmacologically active ingredients present in the one or more fractions. The one or more fraction thus obtained and one or more compositions containing the one or more fractions are effective in inhibiting proliferation of mammalian cancerous cells.

4. 发明授权

US08808769B2 Method for extraction of fractions containing pharmacologically active ingredients with less cytotoxicity from one or more plants 有权
$Method for extraction of fractions containing pharmacologically active ingredients with less cytotoxicity from one or more plants$
标题翻译：提取含有一种或多种植物细胞毒性较小的药理活性成分的级分的方法
公开(公告)号：US08808769B2
公开(公告)日：2014-08-19
申请号：US13322147
申请日：2010-05-21
申请人： Deepa Chitre , Debendranath Dey
发明人： Deepa Chitre , Debendranath Dey
IPC分类号： A61K36/906
CPC分类号： A61K36/53 , A61K36/19 , A61K36/81
摘要： A method of obtaining one or more fractions from one or more plants is disclosed. The method includes subjecting one or more parts of the one or more plants to hydro-alcoholic extraction in presence of a water-insoluble solvent to obtain one or more extracts. The method further includes subjecting the one or more extracts to one or more of de-pigmentation, de-fatting and detoxification process to obtain the one or more fractions. The one or more fractions thus obtained contain a desired pharmacologically active ingredient in concentration greater than concentrations of other pharmacologically active ingredients present in the at least one fraction. Further, the one or more fractions are less toxic as compared with corresponding one or more fractions obtained by conventional methods. In addition, the one or more fractions are therapeutically more effective in various diseases as compared to one or more fractions obtained by conventional methods.
摘要翻译：公开了从一种或多种植物获得一种或多种级分的方法。该方法包括使一种或多种植物的一个或多个部分在水不溶性溶剂存在下进行水 - 醇提取以获得一种或多种提取物。所述方法进一步包括使一种或多种提取物经历一种或多种脱色素，去脂肪和解毒过程以获得一种或多种级分。由此获得的一种或多种级分含有浓度大于存在于至少一个级分中的其它药理活性成分的浓度的所需药理活性成分。此外，与通过常规方法获得的相应的一种或多种级分相比，一种或多种级分的毒性较小。此外，与通过常规方法获得的一种或多种级分相比，一种或多种级分在各种疾病中治疗上更有效。

5. 发明申请

US20120070521A1 METHOD OF EXTRACTION FROM WITHANIA SOMNIFERA AND ONE OR MORE FRACTIONS CONTAINING PHARMACOLOGICALLY ACTIVE INGREDIENTS OBTAINED THEREFROM 审中-公开
标题翻译：从异烟肼中提取的方法和包含其中获得的药物活性成分的一个或多个部分
公开(公告)号：US20120070521A1
公开(公告)日：2012-03-22
申请号：US13322150
申请日：2010-05-21
申请人： Deepa Chitre , Debendranath Dey , Sunetra Chaskar , Sachin Chaturvedi
发明人： Deepa Chitre , Debendranath Dey , Sunetra Chaskar , Sachin Chaturvedi
IPC分类号： A61K36/81 , A61P19/08 , A61P9/10 , A61P35/00 , A61P25/28 , A61P25/00 , A61P17/06 , A61P19/02 , A61P29/00
CPC分类号： A61K36/81
摘要： A method of obtaining one or more fractions from a plant material of Withania somnifera (WS) is disclosed. The method includes subjecting the plant material to hydro-alcoholic extraction in presence of a water-insoluble solvent to obtain at least one extract. The method further includes subjecting the at least one extract obtained from the hydro-alcoholic extraction to at least one of de-pigmentation, de-fatting and detoxification process to obtain the one or more fractions. The one or more fractions thus obtained contain Withaferin A in a concentration greater than concentrations of other pharmacologically active ingredients present in the one or more fractions. The one or more fraction thus obtained and one or more compositions containing the one or more fractions are effective in inhibiting proliferation of mammalian cancerous cells.
摘要翻译：公开了一种从无花果（WS）的植物材料获得一种或多种级分的方法。该方法包括在水不溶性溶剂的存在下对植物材料进行水 - 醇提取以获得至少一种提取物。所述方法还包括将所述至少一种从所述醇提取物获得的提取物经脱色，脱脂和解毒过程中的至少一种进行处理以获得所述一种或多种级分。由此获得的一种或多种级分含有浓度大于一种或多种级分中存在的其它药理学活性成分的浓度的嗜咖啡因A. 由此获得的一种或多种级分和含有一种或多种级分的一种或多种组合物可有效抑制哺乳动物癌细胞的增殖。

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