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21. 发明授权

US5232437A Mobile, self-contained blood collection system and method 失效
标题翻译：移动式，独立采血系统及方法
公开(公告)号：US5232437A
公开(公告)日：1993-08-03
申请号：US496739
申请日：1990-03-21
申请人： Michael J. Lysaght , Daniel R. Boggs , Philip L. Ritger , Robert R. Stromberg , Leonard I. Friedman
发明人： Michael J. Lysaght , Daniel R. Boggs , Philip L. Ritger , Robert R. Stromberg , Leonard I. Friedman
IPC分类号： A61M1/30 , A61M1/36 , A61M5/148
CPC分类号： A61M5/1483 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/308 , A61M5/148 , A61M1/3643 , A61M2205/8225
摘要： Methods and systems for collection of blood components, such as plasma, from donors are provided. One method includes the steps of collecting a unit of whole blood from a donor; forcing the collected blood unit through a plasma separator; accumulating the plasma in a container; and returning concentrated cells to the donor. One system includes a disposable blood collection set and a reusable fixture into which the collection set can be mounted. The fixture is operated by a self-contained energy source, requiring no exterior electrical connection or other external source of energy.
摘要翻译：提供了从供体收集血液成分（如血浆）的方法和系统。一种方法包括从供体收集全血的单元的步骤; 通过等离子体分离器迫使收集的血液单元; 将等离子体积聚在容器中; 并将浓缩的细胞返回给供体。一个系统包括一次性血液收集装置和可重复使用的固定装置，收集装置可安装在其上。夹具由独立的能源操作，不需要外部电气连接或其他外部能源。

22. 发明授权

US4410026A Port block assembly for interconnecting a fluid container with a fluid conduit 失效
标题翻译：用于将流体容器与流体导管互连的端口块组件
公开(公告)号：US4410026A
公开(公告)日：1983-10-18
申请号：US282894
申请日：1981-07-13
申请人： Daniel R. Boggs , Carl Aronson
发明人： Daniel R. Boggs , Carl Aronson
IPC分类号： A61J1/00 , A61J1/05 , B65D33/38 , B65D30/24
CPC分类号： A61J1/10 , Y10T137/1632
摘要： A port block assembly for interconnecting a fluid container with a fluid conduit includes a body which has a port and which is attachable to the container with the port in flow communication with the container interior. The assembly also includes a rigid, tubular insert which is engageable within the body port and to which the fluid conduit can be attached. A secure and rugged interconnection between the container and the conduit results. When the container and conduit are fabricated from dissimilar materials, the body of the assembly is fabricated from the same materal as the container, and the associated insert is fabricated from the same material as the conduit and adapted for an interference or friction fit within the body port. The same secure and rugged interconnection between the container and conduit is achieved, despite the presence of dissimilar materials.
摘要翻译：用于将流体容器与流体导管互连的端口块组件包括具有端口并且可附接到容器的主体，其中端口与容器内部流动连通。组件还包括刚性的管状插入件，其可接合在主体端口内并且流体导管可附接到该插入件。容器和管道之间的牢固连接牢固结合。当容器和导管由不相似的材料制成时，组件的主体由与容器相同的侧面制成，并且相关的插入件由与导管相同的材料制成，并适于在体内进行干涉或摩擦配合港口。尽管存在不同的材料，但实现了容器和导管之间相同的牢固和坚固的互连。

23. 发明授权

US4325417A Connector member for sealed conduits utilizing crystalline plastic barrier membrane 失效
标题翻译：使用结晶塑料阻隔膜的密封导管连接器构件
公开(公告)号：US4325417A
公开(公告)日：1982-04-20
申请号：US27575
申请日：1979-04-06
申请人： Daniel R. Boggs , Peter C. Kwong , Dean G. Laurin
发明人： Daniel R. Boggs , Peter C. Kwong , Dean G. Laurin
IPC分类号： A61L2/08 , A61M39/14 , B29C35/08 , B29C65/00 , B29C65/02 , B29C65/14 , B29C65/58 , F16L37/26 , F16L55/10 , B65B3/04
CPC分类号： B29C65/58 , A61L2/08 , A61M39/143 , B29C65/1435 , B29C65/148 , B29C65/7473 , B29C66/137 , B29C66/5221 , B29C66/5223 , B29C66/52298 , B29C66/534 , B29C66/54 , B29C66/73362 , B29C66/73776 , B29C66/73921 , B29C66/857 , F16L37/26 , F16L55/10 , A61M2039/1027 , B29C2035/0822 , B29C2793/0045 , B29C65/1406 , B29C65/1409 , B29C65/1412 , B29C65/16 , B29C66/71 , B29C66/73366 , B29K2023/00 , B29K2027/12 , B29K2067/006 , B29K2069/00 , B29K2077/00 , B29K2995/0025 , B29K2995/0027 , B29L2031/753 , Y10S604/905
摘要： A connector member for a fluid flow path is provided which comprises a transparent housing enclosing an opaque barrier membrane or wall portion blocking flow through the flow path. The barrier membrane is adapted to be openable by exposure to radiant energy from the exterior through the transparent housing. In accordance with this invention, the barrier membrane is made of a predominantly crystalline plastic material, and, accordingly, exhibits a relatively sharp melting point for improved opening characteristics upon exposure to the radiant energy.
摘要翻译：提供了一种用于流体流动路径的连接器构件，其包括封闭不透明阻挡膜的透明壳体或阻挡流过所述流动路径的壁的壁部分。阻挡膜适于通过从外部通过透明壳体暴露于辐射能而可打开。根据本发明，阻挡膜由主要为结晶的塑料材料制成，因此，在暴露于辐射能时，显示出相当尖的熔点以改善开口特性。

24. 发明授权

US07424821B1 Characterization of porous media 有权
标题翻译：多孔介质的表征
公开(公告)号：US07424821B1
公开(公告)日：2008-09-16
申请号：US11158771
申请日：2005-06-22
申请人： Grant S. Benjamin , Daniel R. Boggs , Rosa H. Yeh
发明人： Grant S. Benjamin , Daniel R. Boggs , Rosa H. Yeh
IPC分类号： G01N5/02
CPC分类号： B01D69/02 , A61M1/262 , A61M1/3633 , B01D65/10 , B01D2325/36
摘要： Porous filter media and methods for characterizing, selecting and using such media based on their dynamic wettability are disclosed. The dynamic wettability of a medium is a measure of how quickly a given liquid is absorbed by the medium.
摘要翻译：公开了多孔过滤介质以及基于它们的动态润湿性来表征，选择和使用这种介质的方法。介质的动态润湿性是指定液体被介质吸收的速度的量度。

25. 发明授权

US06908553B1 Composite membrane with particulate matter substantially immobilized therein 失效
标题翻译：复合膜，其中颗粒物质基本上固定在其中
公开(公告)号：US06908553B1
公开(公告)日：2005-06-21
申请号：US09111915
申请日：1998-07-08
申请人： Daniel R. Boggs , Shmuel Sternberg , Robin G. Pauley , Donna L. McLarty
发明人： Daniel R. Boggs , Shmuel Sternberg , Robin G. Pauley , Donna L. McLarty
IPC分类号： B01D69/12 , A61M1/36 , B01D69/14 , B01D71/20 , B01D71/30 , B01D71/38 , B01D71/54 , B01J20/28 , B01D39/00
CPC分类号： B01J20/28033 , A61M1/3686 , B01D69/141 , B01J20/28004 , B01J20/28026 , B01J20/28035
摘要： Membranes and methods for making membranes are disclosed. The membranes include a polymeric matrix and a particulate material immobilized within the matrix. The membranes may find particular application in methods and apparatus for removing organic compounds from a biological fluid as part of a pathogen inactivation treatment.
摘要翻译：公开了膜和膜的制造方法。膜包括聚合物基质和固定在基质内的颗粒物质。作为病原体灭活处理的一部分，膜可以特别适用于从生物液体中除去有机化合物的方法和装置。

26. 发明授权

US4111356A Centrifugal apparatus with flexible sheath 失效
标题翻译：离心装置与柔性护理
公开(公告)号：US4111356A
公开(公告)日：1978-09-05
申请号：US815095
申请日：1977-07-13
申请人： Daniel R. Boggs , Richard I. Brown
发明人： Daniel R. Boggs , Richard I. Brown
IPC分类号： B04B5/04 , B04B9/08
CPC分类号： B04B5/0442 , B04B9/08 , B04B2005/0492
摘要： Centrifugal processing apparatus in which a processing chamber is rotatably mounted with respect to a stationary base. An umbilical cable segment is fixed at one end substantially along the axis of the processing chamber at one side thereof, with the other end of the cable segment being attached substantially on the axis in rotationally locked engagement to the processing chamber. Frictional heating and drag of the umbilical cable segment during rotation thereof is alleviated by providing a flexible sheath having a variable radius which defines an outer surface contour conforming to the inner wall surface of a curved support to thereby provide non-slipping rotary motion of the umbilical cable segment.

27. 发明授权

US06596230B1 Device and method for pathogen inactivation of therapeutic fluids with sterilizing radiation 有权
标题翻译：用灭菌辐射使病原体灭活治疗液的装置和方法
公开(公告)号：US06596230B1
公开(公告)日：2003-07-22
申请号：US09494338
申请日：2000-01-28
申请人： Lecon Woo , Daniel R. Boggs , Shmuel Sternberg , Craig Sandford , Atul Khare , Julian Breillatt
发明人： Lecon Woo , Daniel R. Boggs , Shmuel Sternberg , Craig Sandford , Atul Khare , Julian Breillatt
IPC分类号： A61L208
CPC分类号： A61M1/3681 , A61L2/0011 , A61L2/10 , A61M1/0281 , A61M2202/0415 , A61M2205/053
摘要： A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous thin fluid flow arrangement that exhibits radiation dose uniformity for fluids having high optical densities. Radiation dose uniformity is achieved in part through a “carrying” mechanism that moves or carries the fluid, thereby eliminating a channel flow velocity profile where flow volumes near the channel walls run the risk of overexposure to the radiation due to very large residence times within the channel. The device comprises a relatively flat belt chamber (22) connected to a fluid flow through an inlet (24) and an outlet (26) on the belt chamber (22). The belt chamber (22) has a top surface (28) and a bottom surface (30). A radiation permeable plate (32) is disposed adjacent the top surface (28) of the belt chamber (22) and is in contact with the belt chamber (22). A radiation source (42) is provided adjacent to the plate (32) adjacent to a side opposite the belt chamber (22). A belt (34) having a plurality of flexible vanes (36) is disposed adjacent the bottom surface (30) of the belt chamber (22) such that the vanes (36) make contact with the belt chamber (22). The belt is driven by a roller mechanism (38) in the direction of the fluid flow. As the fluid flows through the belt chamber (22), the flexible vanes (36) provide a squeegee-like mechanism to move the fluid through the belt chamber (22) in discrete packets (40) defined by a pair of vanes (36). As the packets of fluid move through the belt chamber, they are exposed to sterilizing radiation passing through the plate (32).
摘要翻译：一种在具有对具有高光密度的流体显示辐射剂量均匀性的连续薄流体流动布置中灭菌治疗性流体中的灭菌辐射的装置和方法。辐射剂量均匀性部分地通过移动或携带流体的“携带”机构实现，从而消除了通道流速分布，其中通道壁附近的流量具有过度暴露于辐射的风险，这是由于内部的非常大的停留时间渠道。该装置包括连接到通过入口（24）的流体流和带室（22）上的出口（26）的相对平坦的带室（22）。带室（22）具有顶表面（28）和底表面（30）。辐射透射板（32）邻近带室（22）的顶表面（28）设置并与带室（22）接触。辐射源（42）邻近于与带室（22）相对的一侧邻近板（32）设置。具有多个柔性叶片（36）的带（34）邻近带室（22）的底表面（30）设置，使得叶片（36）与带室（22）接触。皮带由辊机构（38）沿着流体流动的方向驱动。当流体流过皮带室（22）时，柔性叶片（36）提供刮板状机构，以使流体通过一对叶片（36）限定的离散的分组（40）移动通过皮带室（22）。当流体包装移动通过皮带室时，它们暴露于穿过板（32）的灭菌辐射。

28. 发明授权

US6060640A Multiple-layer, formed-in-place immunoisolation membrane structures for implantation of cells in host tissue 失效
标题翻译：用于在宿主组织中植入细胞的多层形成的免疫隔离膜结构
公开(公告)号：US6060640A
公开(公告)日：2000-05-09
申请号：US446210
申请日：1995-05-19
申请人： Robin G. Pauley , Donna L. McLarty , Atul R. Khare , Shmuel Sternberg , Daniel R. Boggs , Steven Neuenfeldt , Mark Jones , James H. Brauker , Laura A. Martinson
发明人： Robin G. Pauley , Donna L. McLarty , Atul R. Khare , Shmuel Sternberg , Daniel R. Boggs , Steven Neuenfeldt , Mark Jones , James H. Brauker , Laura A. Martinson
IPC分类号： A61F2/02 , A61K9/00 , A61L27/38 , C12N5/08 , A61D7/00 , A61M31/00
CPC分类号： A61K9/0024 , A61F2/022 , A61L27/38
摘要： A permeable structure forms a chamber to hold living cells. The structure includes a first permeable region surrounding at least a portion of the chamber having a conformation that, when implanted in host tissue, substantially blocks penetration of host cells into the chamber while permitting solute transport. The structure also includes a second permeable region overlying the first permeable region having a conformation that, when implanted in host tissue, forms a permeable interface with host tissue that permits solute transport. A third permeable region is located between the first and second permeable regions. The third region comprises a solution of polymer material formed in place between the first and second permeable regions. The third permeable region bonds the first and second permeable regions together. The third permeable region also has a conformation that, when implanted in host tissue, permits solute transport between the first and second permeable regions. The third, formed-in-place region bonds the first and second permeable regions together, providing a robust, laminated structure that resists delamination during implantation caused by cellular infiltration into discontinuous spaces between the first and second regions. The third, formed-in-place region can also have a conformation providing an immunoisolation effect. Furthermore, the permeability of the third, formed-in-place membrane is sufficient high that it does not adversely effect the permeability value desired for the overall multiple layer membrane structure.
摘要翻译：可渗透结构形成容纳活细胞的室。所述结构包括围绕所述腔室的至少一部分的第一可渗透区域，其具有当植入宿主组织时基本上阻挡宿主细胞渗入所述腔室同时允许溶质运输的构象。该结构还包括覆盖第一可渗透区域的第二可渗透区域，其具有当植入宿主组织中时形成允许溶质运输的宿主组织的可渗透界面的构象。第三可渗透区域位于第一和第二可渗透区域之间。第三区域包括在第一和第二可渗透区域之间形成的聚合物材料溶液。第三可渗透区域将第一和第二可渗透区域结合在一起。第三可渗透区域还具有当植入宿主组织时允许溶质在第一和第二可渗透区域之间传输的构象。第三个就地区域将第一和第二可渗透区域结合在一起，提供坚固的层压结构，其抵抗由于细胞浸润到第一和第二区域之间的不连续空间而在植入过程中的分层。第三个就地区域也可以具有提供免疫隔离作用的构象。此外，第三成形膜的渗透性足够高，使得其不会对整个多层膜结构所期望的渗透性值产生不利影响。

29. 发明授权

US5073265A Methods of manufacturing nucleophilic material modified for improved biocompatibility 失效
标题翻译：制造改良生物相容性亲核物质的方法
公开(公告)号：US5073265A
公开(公告)日：1991-12-17
申请号：US347845
申请日：1989-05-04
申请人： Richard J. Johnson , Dennis E. Chenoweth , Daniel R. Boggs , Michael J. Lysaght
发明人： Richard J. Johnson , Dennis E. Chenoweth , Daniel R. Boggs , Michael J. Lysaght
IPC分类号： A61M1/36 , B01D67/00 , B01D69/08
CPC分类号： B01D67/0093 , A61M1/3679 , A61M1/3687 , B01D69/08 , A61M2202/0421
摘要： A material is formed into hollow fiber form, and the surface characteristics of the interior bore is selectively modified in a predetermined fashion by a reactive lumen fluid. Nucleophilic materials, such as regenerated cellulose, can be formed into hollow fibers and simultaneously modified to improve their biocompatibility in accordance with the invention.
摘要翻译：材料形成为中空纤维形式，并且内部孔的表面特性通过反应性流体流体以预定方式选择性地修改。亲核材料，例如再生纤维素，可以形成中空纤维，并且根据本发明同时进行改性以提高其生物相容性。

30. 发明授权

US4964976A Optimized filter and method 失效
标题翻译：优化过滤器和方法
公开(公告)号：US4964976A
公开(公告)日：1990-10-23
申请号：US473142
申请日：1990-02-01
申请人： Michael J. Lysaght , Daniel R. Boggs , Philip L. Ritger
发明人： Michael J. Lysaght , Daniel R. Boggs , Philip L. Ritger
IPC分类号： A61M1/34 , B01D61/14 , B01D61/22 , B01D63/02
CPC分类号： B01D61/147 , A61M1/3496 , B01D61/22 , B01D63/02 , B01D63/021 , B01D2313/90
摘要： A method and apparatus for optimizing parameters of a hollow membrane filter results in a relatively small filter when a predetermined, substantially constant, driving pressure drop is applied between the inlet and the outlet of the filter. The method includes simultaneous solution of a set of equations to specify fiber length, number and internal diameter. A system including a computer can make optimized filters in response to the determined parameters.
摘要翻译：当在过滤器的入口和出口之间施加预定的，基本恒定的驱动压降时，用于优化中空膜过滤器的参数的方法和装置导致相对较小的过滤器。该方法包括同时求解一组方程式以指定纤维长度，数量和内径。包括计算机的系统可以响应于确定的参数来制作优化的滤波器。

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