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21. 发明授权

US4852736A Metal case for housing an IC and a manufacturing method therefor 失效
标题翻译：用于容纳IC的金属外壳及其制造方法
公开(公告)号：US4852736A
公开(公告)日：1989-08-01
申请号：US257866
申请日：1988-10-14
申请人： Masayasu Kojima , Chihiro Hayashi
发明人： Masayasu Kojima , Chihiro Hayashi
IPC分类号： G06K19/077
CPC分类号： G06K19/07728 , G06K19/077 , Y10T29/49002 , Y10T29/49126
摘要： A metal case for housing electronic parts including an IC and a manufacturing method therefor are disclosed. The case comprises a shallow vessel having a wall on its periphery which is formed from metal sheet having the same thickness as the bottom of said depression and a rectangular metal ring which has a contour such that it can fit into the wall of said shallow vessel, said rectangular metal ring being fit into said shallow vessel and connected thereto so as to form a single body.

22. 发明授权

US08524871B2 Modified gherlin peptides 有权
标题翻译：修饰的更小的蛋白肽
公开(公告)号：US08524871B2
公开(公告)日：2013-09-03
申请号：US13076844
申请日：2011-03-31
申请人： Kenji Kangawa , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
发明人： Kenji Kangawa , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
IPC分类号： C07K16/00 , C07K1/00 , C07K14/00 , C07K17/00
CPC分类号： C07K14/575 , A01K2217/05 , A61K9/0019 , A61K38/00 , A61K47/42 , A61K48/00 , C07K14/461 , C07K14/463 , C07K14/465 , C07K14/47 , C07K14/4702
摘要： The present invention provides a peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供诱导生长激素分泌的肽型化合物，其具有增加细胞内钙离子浓度的活性，其中至少一个氨基酸被修饰的氨基酸和/或非氨基酸化合物代替，或其药学上可接受的盐。

23. 发明授权

US07943580B2 Polypeptide and the use thereof 有权
标题翻译：多肽及其用途
公开(公告)号：US07943580B2
公开(公告)日：2011-05-17
申请号：US11793760
申请日：2005-12-22
申请人： Kenji Kangawa , Kenji Mori , Mikiya Miyazato , Masayasu Kojima
发明人： Kenji Kangawa , Kenji Mori , Mikiya Miyazato , Masayasu Kojima
IPC分类号： A61K38/16 , A61K51/08
CPC分类号： G01N33/9406 , A01K2217/05 , A01K2227/10 , A61K38/17 , C07K14/47 , G01N33/6893 , G01N2500/00 , G01N2800/046 , G01N2800/306 , G01N2800/362 , G01N2800/367
摘要： The present invention provides a variety of useful polypeptides. In particular, a polypeptide comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3, its amide, or a salt thereof can be used as an agent for preventing/treating hypotension; an agent for preventing/treating obesity, hyperphagia, etc.; an agent for preventing/treating lethargy, time-zone change syndrome (jet lag), etc.; an agent for preventing/treating sterility, etc. A compound or its salt that promotes the activity of a polypeptide comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by any of SEQ ID NOS: 7 to 12 and 37 to 42, its partial peptide, or a salt thereof is useful as an agent for preventing/treating, e.g., menopausal symptoms or hyperthyroidism. A compound or its salt that inhibits the activity of said polypeptide is useful as an agent for preventing/treating, e.g., sterility or hypothyroidism.
摘要翻译：本发明提供了多种有用的多肽。特别地，可以使用包含与SEQ ID NO：1，SEQ ID NO：2或SEQ ID NO：3所示的氨基酸序列相同或基本上相同的氨基酸序列的多肽，其酰胺或其盐作为预防/治疗低血压的药剂; 用于预防/治疗肥胖症，食欲过多等的药剂; 预防/治疗嗜睡，时区变化综合征（时差）等的药剂; 用于预防/治疗不育症的药剂等。一种促进包含与SEQ ID NO：7至12和37中任一项所示的氨基酸序列相同或基本上相同的氨基酸序列的多肽的活性的化合物或其盐至42，其部分肽或其盐可用作预防/治疗例如绝经症状或甲状腺功能亢进的药剂。抑制所述多肽的活性的化合物或其盐可用作预防/治疗例如不育或甲状腺功能减退的药剂。

24. 发明申请

US20090170763A1 Modified gherlin peptides 有权
标题翻译：修饰的更小的蛋白肽
公开(公告)号：US20090170763A1
公开(公告)日：2009-07-02
申请号：US12010838
申请日：2008-01-30
申请人： Kenji Kangawa , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
发明人： Kenji Kangawa , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
IPC分类号： A61K38/16 , C12P21/02 , C12N1/21 , C12N15/00 , G01N33/566 , A61K38/08 , A61K38/07 , A61K31/711 , C07K14/00 , C07K7/00 , C07K16/18 , C12N15/11
CPC分类号： C07K14/575 , A01K2217/05 , A61K9/0019 , A61K38/00 , A61K47/42 , A61K48/00 , C07K14/461 , C07K14/463 , C07K14/465 , C07K14/47 , C07K14/4702
摘要： The present invention provides a novel peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供了诱导生长激素分泌的新型肽型化合物，其具有增加细胞内钙离子浓度的活性，其中至少一个氨基酸被修饰的氨基酸和/或非氨基酸替代化合物或其药学上可接受的盐。

25. 发明申请

US20080124335A1 Novel Polypeptide and the Use Thereof 有权
标题翻译：新型多肽及其用途
公开(公告)号：US20080124335A1
公开(公告)日：2008-05-29
申请号：US11793760
申请日：2005-12-22
申请人： Kenji Kangawa , Kenji Mori , Mikiya Miyazato , Masayasu Kojima
发明人： Kenji Kangawa , Kenji Mori , Mikiya Miyazato , Masayasu Kojima
IPC分类号： A61K39/395 , C07K14/00 , C12N15/11 , C12N15/00 , C12N5/06 , C07H21/00 , A61P1/00 , A01K67/00 , G01N33/00 , A61K38/00 , A61K31/70 , C07K16/18
CPC分类号： G01N33/9406 , A01K2217/05 , A01K2227/10 , A61K38/17 , C07K14/47 , G01N33/6893 , G01N2500/00 , G01N2800/046 , G01N2800/306 , G01N2800/362 , G01N2800/367
摘要： The present invention provides a variety of useful polypeptides. In particular, a polypeptide comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3, its amide, or a salt thereof can be used as an agent for preventing/treating hypotension; an agent for preventing/treating obesity, hyperphagia, etc.; an agent for preventing/treating lethargy, time-zone change syndrome (jet lag), etc.; an agent for preventing/treating sterility, etc. A compound or its salt that promotes the activity of a polypeptide comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by any of SEQ ID NOS: 7 to 12 and 37 to 42, its partial peptide, or a salt thereof is useful as an agent for preventing/treating, e.g., menopausal symptoms or hyperthyroidism. A compound or its salt that inhibits the activity of said polypeptide is useful as an agent for preventing/treating, e.g., sterility or hypothyroidism.
摘要翻译：本发明提供了多种有用的多肽。特别地，可以使用包含与SEQ ID NO：1，SEQ ID NO：2或SEQ ID NO：3所示的氨基酸序列相同或基本上相同的氨基酸序列的多肽，其酰胺或其盐作为预防/治疗低血压的药剂; 用于预防/治疗肥胖症，食欲过多等的药剂; 预防/治疗嗜睡，时区变化综合征（时差）等的药剂; 用于预防/治疗不育症的药剂等。一种促进包含与SEQ ID NO：7至12和37中任一项所示的氨基酸序列相同或基本上相同的氨基酸序列的多肽的活性的化合物或其盐至42，其部分肽或其盐可用作预防/治疗例如绝经症状或甲状腺功能亢进的药剂。抑制所述多肽的活性的化合物或其盐可用作预防/治疗例如不育或甲状腺功能减退的药剂。

26. 发明授权

US06237382B1 Method and apparatus for hydroforming metallic tube 有权
标题翻译：液压金属管的方法和装置
公开(公告)号：US06237382B1
公开(公告)日：2001-05-29
申请号：US09542292
申请日：2000-04-04
申请人： Masayasu Kojima , Saburo Inoue
发明人： Masayasu Kojima , Saburo Inoue
IPC分类号： B21D3908
CPC分类号： B21D22/025 , B21D26/033 , B21D26/047 , Y10T29/49805
摘要： A method for hydroforming a metallic tube comprising primary hydroforming and secondary hydroforming, wherein in the primary hydroforming step, the metallic tube is formed such that a circumferential length of an expanded portion of the primary-hydroformed tube as measured at a wall center region of the expanded portion becomes substantially equal to or slightly shorter than a circumferential length of an expanded portion of a product as measured at a wall center region of the expanded portion, and in the secondary hydroforming step, movable forming plates incorporated in the dies press the expanded portion formed through primary hydroforming so as to finish the cross-sectional profile of the expanded portion into that of the expanded portion of the product, and said primary hydroforming and secondary hydroforming are continuously performed within the dies. Also disclosed is an apparatus for performing the hydroformation method. According to the method of the present invention, high liquid pressure is not required, and reduction in wall thickness and shape defects can be prevented.
摘要翻译：一种用于液压成形金属管的方法，所述金属管包括主液压成形和二次液压成形，其中在所述主液压成形步骤中，所述金属管形成为使得在所述主液压成形步骤的壁中心区域处测量的所述主液压成型管的扩展部分的周长膨胀部分变得基本上等于或稍短于在膨胀部分的壁中心区域测量的产品的膨胀部分的周向长度，并且在次级液压成形步骤中，结合到模具中的可移动成形板将膨胀部分通过主液压成型形成，以便将膨胀部分的横截面轮廓完成到产品的膨胀部分的横截面轮廓，并且在模具内连续执行所述主液压成形和二次液压成形。还公开了一种用于执行加氢信息方法的装置。根据本发明的方法，不需要高液压，可以防止壁厚和形状缺陷的减少。

27. 发明授权

US5455382A IC package heat sink fin 失效
标题翻译： IC封装散热片
公开(公告)号：US5455382A
公开(公告)日：1995-10-03
申请号：US335952
申请日：1994-11-03
申请人： Masayasu Kojima , Chihiro Hayashi
发明人： Masayasu Kojima , Chihiro Hayashi
IPC分类号： H01L21/48 , H01L23/367 , H01L23/373
CPC分类号： H01L21/4878 , H01L23/3677 , H01L2224/48091 , H01L2224/48247 , H01L2924/16152
摘要： A fin assembly for use as a heat sink and production thereof are disclosed. The fin assembly comprises a plurality of heat dissipating plates formed by means of a multi-wire saw, and the heat dissipating plates each has a thickness t of no more than 1 mm and being spaced apart by a gap g of no more than 1.5 mm the heat dissipating plates or pins having a height h, wherein the ratio h/t is not less than 20 and the ratio h/g is not less than 15 in one embodiment and 19 in another embodiment of the invention.
摘要翻译：公开了一种用作散热器的翅片组件及其制造方法。翅片组件包括通过多线锯形成的多个散热板，并且散热板各自具有不大于1mm的厚度t并且间隔开不大于1.5mm的间隙g 具有高度h的散热板或销，其中在一个实施例中，比率h / t不小于20，比率h / g不小于15，在本发明的另一个实施例中为19。

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