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21. 发明授权

US08908066B2 Solid state imaging device 有权
标题翻译：固态成像装置
公开(公告)号：US08908066B2
公开(公告)日：2014-12-09
申请号：US13279794
申请日：2011-10-24
申请人： Maki Sato , Kazuki Hizu , Tetsuya Amano , Katsuya Kudo , Toyoharu Igarashi
发明人： Maki Sato , Kazuki Hizu , Tetsuya Amano , Katsuya Kudo , Toyoharu Igarashi
IPC分类号： H04N5/217 , H04N5/361 , H04N5/378 , H04N5/357
CPC分类号： H04N5/357 , H04N5/3572 , H04N5/361 , H04N5/378
摘要： According to one embodiment, a solid state imaging device includes an imaging unit that outputs imaging data by performing an imaging operation, a temperature sensor that outputs a diode voltage according to a diode current, and an output circuit that shares a part of a circuit with the imaging unit and outputs temperature data based on the diode voltage outputted from the temperature sensor in the same semiconductor chip.
摘要翻译：根据一个实施例，固态成像装置包括：通过执行成像操作输出成像数据的成像单元，根据二极管电流输出二极管电压的温度传感器和共享电路的一部分的输出电路，成像单元，并且基于从同一半导体芯片中的温度传感器输出的二极管电压输出温度数据。

22. 发明申请

US20090276863A1 Protein formulations comprising s1-5 审中-公开
标题翻译：包含s1-5的蛋白质制剂
公开(公告)号：US20090276863A1
公开(公告)日：2009-11-05
申请号：US11631040
申请日：2005-07-01
申请人： Toshihiro Nakajima , Naoko Yagishita , Tetsuya Amano
发明人： Toshihiro Nakajima , Naoko Yagishita , Tetsuya Amano
IPC分类号： A61K49/00 , A01K67/027 , C12N5/10 , C12N15/09 , G01N33/567 , G01N33/00 , C07K14/00 , A61K38/16 , C07K16/00 , A61P35/00
CPC分类号： C07K14/475 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/035 , A61K38/00 , G01N33/5044
摘要： The present inventors discovered that knockout mice whose S1-5 gene function is lost develop age-related diseases or symptoms. Histological analysis in such knockout mice revealed that bone mineral content, bone mineral density, and bone strength were decreased, and the number of osteoclasts in bone tissues was increased. Analysis of osteoclast-forming ability using bone marrow cells derived from the knockout mice revealed that osteoclast-forming ability is enhanced and osteoclasts are larger in the knockout mice than in wildtype mice. When purified S1-5 protein was added to this in vitro system, osteoclast-forming ability was inhibited.
摘要翻译：本发明人发现S1-5基因功能丧失的敲除小鼠发生与年龄相关的疾病或症状。在这种敲除小鼠中的组织学分析显示，骨矿物质含量，骨矿物质密度和骨强度降低，骨组织中破骨细胞数量增加。使用衍生自敲除小鼠的骨髓细胞破骨细胞形成能力的分析显示，在野生型小鼠中，敲除小鼠的破骨细胞形成能力增强，破骨细胞较大。当纯化的S1-5蛋白加入体外时，破骨细胞形成能力受到抑制。

23. 发明申请

US20070275887A1 Method of Inhibiting Secretase Activity 审中-公开
标题翻译：抑制分泌酶活性的方法
公开(公告)号：US20070275887A1
公开(公告)日：2007-11-29
申请号：US10576281
申请日：2004-10-20
申请人： Toshihiro Nakajima , Tetsuya Amano , Lei Zhang , Rie Ikeda , Satoshi Yamasaki , Naoko Yagishita
发明人： Toshihiro Nakajima , Tetsuya Amano , Lei Zhang , Rie Ikeda , Satoshi Yamasaki , Naoko Yagishita
IPC分类号： A61K38/55 , A61P25/28
CPC分类号： C12N15/1137 , A61K31/7088 , A61K45/06 , C12N2310/14 , A61K2300/00
摘要： The present invention provides a method for inhibiting secretase activity. A method for promoting the sensitivity of a secretase inhibitor, a method for binding synoviolin to Herp (homocysteine-inducible endoplasmic reticulum stress-inducible ubiquitin-like domain member 1), or the like is employed to inhibit secretase activity.
摘要翻译：本发明提供抑制分泌酶活性的方法。用于促进分泌酶抑制剂的敏感性的方法，将滑膜蛋白与Herp结合的方法（同型半胱氨酸诱导型内质网应激诱导型泛素样结构域成员1）等用于抑制分泌酶活性。

24. 发明申请

US20070134720A1 Method of detecting effect of controlling synoviolin activity 审中-公开
标题翻译：检测滑膜炎活性影响的方法
公开(公告)号：US20070134720A1
公开(公告)日：2007-06-14
申请号：US10568913
申请日：2004-08-20
申请人： Toshihiro Nakajima , Tetsuya Amano , Lei Zhang , Rie Ikeda , Satoshi Yamasaki , Naoko Yagishita , Hiromitsu Yokohama , Motoji Kogushi
发明人： Toshihiro Nakajima , Tetsuya Amano , Lei Zhang , Rie Ikeda , Satoshi Yamasaki , Naoko Yagishita , Hiromitsu Yokohama , Motoji Kogushi
IPC分类号： A61K38/48 , G01N33/53 , C12Q1/37
CPC分类号： A61K38/16 , A61K38/005 , C12Q1/25 , C12Q1/26 , G01N2333/90245 , G01N2500/00
摘要： The present invention provides methods for evaluating the regulation on prolyl 4-hydroxylase activity. The present invention also provides screening methods using the evaluation methods. Furthermore, the present invention provides methods of screening for compounds that are useful for treating or preventing fibrosis or rheumatoid arthritis. The present invention relates to methods for detecting regulatory activity on the synoviolin ubiquitination of prolyl 4-hydroxylase α subunit (P4HA1). It also relates to methods of screening for compounds with regulatory effect on the ubiquitination activity of synoviolin on P4HA1 based on these methods. Compounds discovered in the screening are useful for treating and/or preventing diseases caused by abnormalities in the prolyl 4-hydroxylase activity, such as fibrosis and rheumatoid arthritis.
摘要翻译：本发明提供了评估脯氨酰4-羟化酶活性调节的方法。本发明还提供了使用评价方法的筛选方法。此外，本发明提供筛选可用于治疗或预防纤维化或类风湿性关节炎的化合物的方法。本发明涉及检测脯氨酰4-羟化酶α亚基（P4HA1）的滑膜蛋白泛素化的调节活性的方法。它还涉及基于这些方法筛选对P4HA1上滑膜素泛素化活性具有调节作用的化合物的方法。在筛选中发现的化合物可用于治疗和/或预防由脯氨酰4-羟化酶活性异常引起的疾病，例如纤维化和类风湿性关节炎。

25. 发明授权

US5426086A Reversible thermosensitive recording medium 失效
标题翻译：可逆热敏记录介质
公开(公告)号：US5426086A
公开(公告)日：1995-06-20
申请号：US300033
申请日：1994-09-02
申请人： Yoshihiko Hotta , Makoto Kawaguchi , Tetsuya Amano
发明人： Yoshihiko Hotta , Makoto Kawaguchi , Tetsuya Amano
IPC分类号： B41M5/36 , B41M5/26
CPC分类号： B41M5/363
摘要： A reversible thermosensitive recording medium includes a reversible thermosensitive recording layer which is composed of a matrix resin and an organic low-molecular material which is dispersed in the matrix resin, the transparency of the reversible thermosensitive recording layer being reversibly changeable depending upon the temperature of the reversible thermosensitive recording layer, wherein the reversible thermosensitive recording layer has a softening initiation temperature T.sub.A, the organic low-molecular-weight material has a higher crystallization temperature T.sub.B1 which is 80.degree. C. or more and a lower crystallization temperature T.sub.B2, the softening initiation temperature T.sub.A is between the higher crystallization temperature T.sub.B1 and the lower crystallization temperature T.sub.B2, and the higher crystallization temperature T.sub.B1 and the lower crystallization temperature T.sub.B2 satisfies the relationship of T.sub.B1 -T.sub.B2 .gtoreq.40.degree. C.
摘要翻译：可逆热敏记录介质包括由矩阵树脂和分散在基质树脂中的有机低分子材料组成的可逆热敏记录层，可逆热敏记录层的透明度可根据可逆热敏记录层，其中可逆热敏记录层具有软化初始温度TA，有机低分子量材料具有较高的结晶温度TB1，其结晶温度为80℃或更高，结晶温度TB2较低，软化引发温度TA在较高的结晶温度TB1和较低的结晶温度TB2之间，较高的结晶温度TB1和较低的结晶温度TB2满足TB1-TB2> / = 40℃的关系。

26. 发明授权

US4827489A Decoding device for digital signals 失效
标题翻译：数字信号解码装置
公开(公告)号：US4827489A
公开(公告)日：1989-05-02
申请号：US44489
申请日：1987-05-01
申请人： Nobukazu Doi , Hideki Imai , Morishi Izumita , Seiichi Mita , Akira Saito , Hiroto Yamauchi , Mamoru Kaneko , Tetsuya Amano
发明人： Nobukazu Doi , Hideki Imai , Morishi Izumita , Seiichi Mita , Akira Saito , Hiroto Yamauchi , Mamoru Kaneko , Tetsuya Amano
IPC分类号： H03M13/00 , G11B20/18 , H03M13/45 , H04L1/00 , H04L25/04 , H04L27/06
CPC分类号： H04L1/00 , H03M13/45
摘要： A device for decoding coded digital signals for every symbol consisting of a plurality of binary signals comprises first circuit for generating a first reliability for every binary signal; hard decided from the received or reproduced signal, in the symbol and second circuit for generating a second reliability for every symbol consisting of n binary signals on the basis of the first reliability, whereby decoding processing e.g. soft decision decoding is effected for every signal, depending on the second reliability.
摘要翻译：用于对由多个二进制信号组成的每个符号对编码数字信号进行解码的装置包括用于为每个二进制信号产生第一可靠性的第一电路; 在符号和第二电路中根据所接收的或再现的信号硬判决，用于基于第一可靠性为由n个二进制信号组成的每个符号产生第二可靠性，从而解码处理例如。根据第二可靠性，对每个信号进行软判决解码。

27. 发明授权

US07830736B2 Semiconductor integrated circuit device and redundancy method thereof 失效
标题翻译：半导体集成电路器件及其冗余方法
公开(公告)号：US07830736B2
公开(公告)日：2010-11-09
申请号：US12165720
申请日：2008-07-01
申请人： Takehiko Hojo , Tomohiro Kobayashi , Tetsuya Amano
发明人： Takehiko Hojo , Tomohiro Kobayashi , Tetsuya Amano
IPC分类号： G11C29/00
CPC分类号： G11C17/18 , G11C17/16 , G11C17/165 , G11C29/027 , G11C29/785 , G11C29/802
摘要： A semiconductor integrated circuit device includes a first fuse circuit, a second fuse circuit, and a control signal generating circuit which sends a first control signal and executes program such that the resistance value of the first fuse circuit becomes greater than the resistance value of the second fuse circuit, and sends a second control signal and executes reprogram such that the resistance value of the second fuse circuit becomes greater than the resistance value of the first fuse circuit.
摘要翻译：半导体集成电路器件包括第一熔丝电路，第二熔丝电路和控制信号发生电路，其发送第一控制信号并执行程序，使得第一熔丝电路的电阻值变得大于第二熔丝电路的电阻值熔丝电路，并发送第二控制信号并执行重新编程，使得第二熔丝电路的电阻值变得大于第一熔丝电路的电阻值。

28. 发明申请

US20090029929A1 Decoy Nucleic Acid to Synoviolin Gene Promoter 审中-公开
标题翻译：诱饵核酸对滑膜蛋白基因启动子
公开(公告)号：US20090029929A1
公开(公告)日：2009-01-29
申请号：US10594146
申请日：2005-03-28
申请人： Toshihiro Nakajima , Kaneyuki Tsuchimochi , Naoko Yagishita , Satoshi Yamasaki , Yukihiro Kato , Tetsuya Amano , Kaori Tamitsu
发明人： Toshihiro Nakajima , Kaneyuki Tsuchimochi , Naoko Yagishita , Satoshi Yamasaki , Yukihiro Kato , Tetsuya Amano , Kaori Tamitsu
IPC分类号： A61K31/711 , A61K48/00 , A61P19/02 , A61P21/00 , A61P25/00 , A61P25/16 , A61P25/28 , A61P29/00 , A61P35/00 , C12N15/12 , C12N5/10
CPC分类号： C12N15/113 , A61K31/7088 , A61K48/00 , C12N2310/13
摘要： The present invention provides a decoy nucleic acid for the Synoviolin gene promoter. Also provided is the decoy nucleic acid can inhibit the promoter activity by binding to the transcription factor of the Synoviolin gene promoter. It also provides a decoy nucleic acid as expressed in (a) a decoy nucleic acid consisting of a nucleotide sequence as shown in SEQ ID NO: 11 or 12; and it also provides (b) a decoy nucleic acid consisting of a nucleotide sequence as shown in SEQ ID NO: 11 or 12 having deletion, substitution or addition of one or several nucleotides and has the function of inhibiting Synoviolin gene promoter activity.
摘要翻译：本发明提供了用于滑膜炎基因启动子的诱饵核酸。还提供了诱饵核酸可以通过与滑膜素基因启动子的转录因子结合来抑制启动子活性。它还提供如（a）由如SEQ ID NO：11或12所示的核苷酸序列组成的诱饵核酸所表达的诱饵核酸; 并且还提供（b）由SEQ ID NO：11或12所示的具有缺失，取代或添加一个或几个核苷酸的核苷酸序列组成的具有抑制滑膜素基因启动子活性的功能的诱饵核酸。

29. 发明申请

US20090010085A1 SEMICONDUCTOR INTEGRATED CIRCUIT DEVICE AND REDUNDANCY METHOD THEREOF 失效
标题翻译：半导体集成电路设备及其冗余方法
公开(公告)号：US20090010085A1
公开(公告)日：2009-01-08
申请号：US12165720
申请日：2008-07-01
申请人： Takehiko Hojo , Tomohiro Kobayashi , Tetsuya Amano
发明人： Takehiko Hojo , Tomohiro Kobayashi , Tetsuya Amano
IPC分类号： G11C29/00 , G11C17/16
CPC分类号： G11C17/18 , G11C17/16 , G11C17/165 , G11C29/027 , G11C29/785 , G11C29/802
摘要： A semiconductor integrated circuit device includes a first fuse circuit, a second fuse circuit, and a control signal generating circuit which sends a first control signal and executes program such that the resistance value of the first fuse circuit becomes greater than the resistance value of the second fuse circuit, and sends a second control signal and executes reprogram such that the resistance value of the second fuse circuit becomes greater than the resistance value of the first fuse circuit.
摘要翻译：半导体集成电路器件包括第一熔丝电路，第二熔丝电路和控制信号发生电路，其发送第一控制信号并执行程序，使得第一熔丝电路的电阻值变得大于第二熔丝电路的电阻值熔丝电路，并发送第二控制信号并执行重新编程，使得第二熔丝电路的电阻值变得大于第一熔丝电路的电阻值。

30. 发明申请

US20080305102A1 Therapeutic Agent for Cancer Comprising Substance Capable of Inhibiting Expression or Function of Synoviolin as Active Ingredient and Screening Method for the Therapeutic Agent for Cancer 审中-公开
标题翻译：包含抑制作为活性成分的滑膜蛋白的表达或功能的物质的癌症治疗剂和癌症治疗剂的筛选方法
公开(公告)号：US20080305102A1
公开(公告)日：2008-12-11
申请号：US11993774
申请日：2006-06-23
申请人： Toshihiro Nakajima , Yukihiro Kato , Tadayuki Yamadera , Tetsuya Amano
发明人： Toshihiro Nakajima , Yukihiro Kato , Tadayuki Yamadera , Tetsuya Amano
IPC分类号： A61K39/395 , C07H21/00 , C07K16/18 , C07K2/00 , C12Q1/68 , G01N33/50 , A61K31/53 , C07D403/04 , C07D251/54 , A61P35/00 , A61K38/00 , A61K48/00
CPC分类号： G01N33/5011 , A01K2267/0325 , A61K31/53 , A61K31/7088 , A61K38/1709 , A61K38/53 , C12N9/93 , C12N15/1135 , C12N2310/11 , C12N2310/14 , G01N2500/00 , G01N2800/102
摘要： Inhibition of synoviolin function was found to activate the cancer-suppressing protein p53. Substances inhibiting the function of synoviolin are useful as cancer therapeutic agents. The inhibition of synoviolin function was also found to lead to the inhibition of p53 ubiquitination, increased activity of p53 phosphorylation proteins, and the like. Based on these findings, the present invention provides methods capable of efficiently screening for cancer therapeutic agents. Further, it was also found that regulation of the autoubiquitination of synoviolin protein suppresses the proliferation of rheumatoid arthritis synovial cells. Substances regulating the autoubiquitination of synoviolin protein are useful as anti-rheumatic agents. Moreover, the present invention provides methods of efficiently screening for anti-rheumatic agents.
摘要翻译：发现滑膜蛋白功能的抑制活化了癌症抑制蛋白p53。抑制滑膜素功能的物质可用作癌症治疗剂。还发现滑膜蛋白功能的抑制导致p53泛素化的抑制，p53磷酸化蛋白的活性增加等。基于这些发现，本发明提供能够有效筛选癌症治疗剂的方法。此外，还发现调节滑膜蛋白自身泛素化抑制类风湿性关节炎滑膜细胞的增殖。调节滑膜蛋白自身泛素化的物质可用作抗风湿药。此外，本发明提供了有效筛选抗风湿剂的方法。

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