专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明授权

US08097733B2 Pyrazole derivatives as 5-LO-inhibitors 失效
标题翻译：吡唑衍生物作为5-LO抑制剂
公开(公告)号：US08097733B2
公开(公告)日：2012-01-17
申请号：US12276779
申请日：2008-11-24
申请人： Edgardo Alvira , Matthew J. Graneto , Margaret Lanahan Grapperhaus , Kaliappan Iyanar , Todd Michael Maddux , Matthew William Mahoney , Mark Alan Massa , Kirby Ray Sample , Michelle Ann Schmidt , Ronald Edward Seidel , Jon Gordon Selbo , Michael Brent Tollefson , Richard Alan Vonder Embse , Grace Mary Wagner , Scott Santford Woodard
发明人： Edgardo Alvira , Matthew J. Graneto , Margaret Lanahan Grapperhaus , Kaliappan Iyanar , Todd Michael Maddux , Matthew William Mahoney , Mark Alan Massa , Kirby Ray Sample , Michelle Ann Schmidt , Ronald Edward Seidel , Jon Gordon Selbo , Michael Brent Tollefson , Richard Alan Vonder Embse , Grace Mary Wagner , Scott Santford Woodard
IPC分类号： C07D231/10
CPC分类号： C07D405/12 , C07D405/14
摘要： The invention relates to compounds of formula (I) processes for their preparation, their use as 5-lipoxygenase inhibitors and pharmaceutical compositions containing the same.
摘要翻译：本发明涉及式（I）化合物的制备方法，它们作为5-脂肪氧合酶抑制剂的用途和含有它们的药物组合物。

22. 发明申请

US20090227634A1 Pyrazole Derivatives as 5-LO-Inhibitors 失效
标题翻译：吡唑衍生物作为5-LO抑制剂
公开(公告)号：US20090227634A1
公开(公告)日：2009-09-10
申请号：US12276779
申请日：2008-11-24
申请人： Edgardo Alvira , Matthew J. Graneto , Margaret Lanahan Grapperhaus , Kaliappan Iyanar , Todd M. Maddux , Matthew W. Mahoney , Mark A. Massa , Kirby R. Sample , Michelle A. Schmidt , Ronald E. Seidel , Jon G. Selbo , Michael B. Tollefson , Richard A. Vonder Embse , Grace M. Wagner , Scott S. Woodard
发明人： Edgardo Alvira , Matthew J. Graneto , Margaret Lanahan Grapperhaus , Kaliappan Iyanar , Todd M. Maddux , Matthew W. Mahoney , Mark A. Massa , Kirby R. Sample , Michelle A. Schmidt , Ronald E. Seidel , Jon G. Selbo , Michael B. Tollefson , Richard A. Vonder Embse , Grace M. Wagner , Scott S. Woodard
IPC分类号： A61K31/4439 , A61K31/4178 , A61K31/4162 , C07D405/14 , C07D405/12
CPC分类号： C07D405/12 , C07D405/14
摘要： The invention relates to compounds of formula (I) processes for their preparation, their use as 5-lipoxygenase inhibitors and pharmaceutical compositions containing the same.
摘要翻译：本发明涉及式（I）化合物的制备方法，它们作为5-脂肪氧合酶抑制剂的用途和含有它们的药物组合物。

23. 发明授权

US06875785B2 Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors 失效
标题翻译：杂环取代的异羟肟酸衍生物作为环加氧酶-2和5-脂氧合酶抑制剂
公开(公告)号：US06875785B2
公开(公告)日：2005-04-05
申请号：US10254701
申请日：2002-09-25
申请人： John J. Talley , James A. Sikorski , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Balekudru Devadas , Hwang-Fun Lu
发明人： John J. Talley , James A. Sikorski , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Balekudru Devadas , Hwang-Fun Lu
IPC分类号： A61P29/00 , C07D231/12 , C07D263/32 , A61K31/421 , C07D413/00
CPC分类号： C07D231/12 , C07D263/32
摘要： This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
摘要翻译：本发明涉及抗炎药物领域，具体涉及用于治疗由环氧合酶-2或5-脂氧合酶如炎症介导的病症的化合物，组合物和方法。

24. 发明授权

US06696477B2 Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors 失效
标题翻译：杂环取代的异羟肟酸衍生物作为环加氧酶-2和5-脂氧合酶抑制剂
公开(公告)号：US06696477B2
公开(公告)日：2004-02-24
申请号：US09997633
申请日：2001-11-29
申请人： John J. Talley , James A. Sikorski , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Balekudru Devadas
发明人： John J. Talley , James A. Sikorski , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Balekudru Devadas
IPC分类号： C07D23110
CPC分类号： C07D231/12 , B60G17/018 , B60G2400/102 , B60G2400/206 , B60G2400/25 , B60G2400/60 , B60G2400/91 , B64C27/001 , B64C2027/004 , C07D263/32
摘要： This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation. Compounds of particular interest are defined by Formula I wherein A, Y, R1, R2, R3, R4 and R5 are as defined in the specification.
摘要翻译：本发明涉及抗炎药物领域，具体涉及用于治疗由环氧合酶-2或5-脂氧合酶如炎症介导的病症的化合物，组合物和方法。特别感兴趣的化合物由式I定义，其中A，Y，R 1，R 2，R 3，R 4和R 5如说明书中所定义。

25. 发明授权

US06677364B2 Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors 失效
标题翻译：取代的磺酰基苯基杂环作为环加氧酶-2和5-脂氧合酶抑制剂
公开(公告)号：US06677364B2
公开(公告)日：2004-01-13
申请号：US10004960
申请日：2001-12-04
申请人： John J. Talley , James A. Sikorski , Balekudru Devadas , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Roland S. Rogers , Hwang-Fun Lu , David L. Brown
发明人： John J. Talley , James A. Sikorski , Balekudru Devadas , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Roland S. Rogers , Hwang-Fun Lu , David L. Brown
IPC分类号： A61K314178
CPC分类号： A61K31/44 , A61K31/15 , A61K31/277 , A61K31/4015
摘要： This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
摘要翻译：本发明涉及抗炎药物领域，具体涉及用于治疗由环氧合酶-2或5-脂氧合酶如炎症介导的病症的化合物，组合物和方法。

26. 发明授权

US06673818B2 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation 失效
标题翻译：用于治疗炎症的氟取代苯磺酰基化合物
公开(公告)号：US06673818B2
公开(公告)日：2004-01-06
申请号：US10124209
申请日：2002-04-16
申请人： David L. Brown , Matthew J. Graneto , Cindy L. Ludwig , John M. Molyneaux , John J. Talley
发明人： David L. Brown , Matthew J. Graneto , Cindy L. Ludwig , John M. Molyneaux , John J. Talley
IPC分类号： C07D40102
CPC分类号： C07D231/12 , C07D261/08 , C07D307/32
摘要： Methods of treating cyclooxygenase-2 mediated disorders comprising administering to a subject a therapeutically effective amount of one or more fluoro-substituted benzenesulfonyl compounds corresponding to Formula I: wherein A, X, n, R1, R2, and R3 are as described in the specification, and novel fluoro-substituted benzenesulfonyl compounds within Formula I.
摘要翻译：治疗环氧合酶-2介导的病症的方法包括向受试者施用治疗有效量的一种或多种对应于式I的氟取代的苯磺酰基化合物：其中A，X，n，R 1，R 2和R 在说明书中描述的<3>和式I中的新的氟取代的苯磺酰基化合物。

27. 发明授权

US5547975A Benzopyranopyrazolyl derivatives for the treatment of inflammation 失效
标题翻译：苯并吡喃并吡唑衍生物用于治疗炎症
公开(公告)号：US5547975A
公开(公告)日：1996-08-20
申请号：US309291
申请日：1994-09-20
申请人： John J. Talley , Stephen R. Bertenshaw , Matthew J. Graneto , Donald J. Rogier
发明人： John J. Talley , Stephen R. Bertenshaw , Matthew J. Graneto , Donald J. Rogier
IPC分类号： C07D491/04 , C07D491/044 , C07D491/048 , C07D491/052 , C07D495/04 , A61K31/415 , A61K31/63
CPC分类号： C07D491/04 , C07D495/04
摘要： A class of benzopyranopyrazolyl derivatives is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I ##STR1## wherein A is --(CH.sub.2).sub.m --X--(CH.sub.2).sub.n --; wherein X is S(O).sub.p or O; wherein m is 0 or 1; wherein n is 0 or 1; wherein p is 0 or 1; wherein B is selected from phenyl and five and six membered heteroaryl; wherein R.sup.1 is selected from lower haloalkyl, cyano, formyl, lower alkoxycarbonyl, lower alkoxy, lower N-alkylaminocarbonyl, N-phenylaminocarbonyl, lower N,N-dialkylaminocarbonyl and lower N-alkyl-N-phenylaminocarbonyl; wherein R.sup.2 is phenyl substituted at a substitutable position with a radical selected from lower alkylsulfonyl and sulfamyl; and wherein R.sup.4 is one or more radicals selected from hydrido, halo, lower alkylthio, lower alkylsulfinyl, lower alkyl, cyano, carboxyl, lower alkoxycarbonyl, aminocarbonyl, lower haloalkyl, hydroxyl, lower alkoxy, amino, lower N-alkylamino, lower N,N-dialkylamino, lower hydroxyalkyl and lower haloalkoxy; or a pharmaceutically-acceptable salt thereof.
摘要翻译：描述了一类苯并吡喃并吡唑基衍生物用于治疗炎症和炎症相关疾病。特别感兴趣的化合物由式I（I）定义，其中A是 - （CH 2）m -X-（CH 2）n - ; 其中X是S（O）p或O; 其中m为0或1; 其中n为0或1; 其中p为0或1; 其中B选自苯基和五元和六元杂芳基; 其中R 1选自低级卤代烷基，氰基，甲酰基，低级烷氧基羰基，低级烷氧基，低级N-烷基氨基羰基，N-苯基氨基羰基，低级N，N-二烷基氨基羰基和低级N-烷基-N-苯基氨基羰基。其中R2是在可取代的位置被选自低级烷基磺酰基和氨磺酰基的基团取代的苯基; 氰基，羧基，低级烷氧基羰基，氨基羰基，低级卤代烷基，羟基，低级烷氧基，氨基，低级N-烷基氨基，低级N，低级烷基氨基，低级烷基氨基，低级烷基氨基， N-二烷基氨基，低级羟烷基和低级卤代烷氧基; 或其药学上可接受的盐。

28. 发明授权

US5093347A 3-difluoromethylpyrazolecarboxamide fungicides, compositions and use 失效
标题翻译： 3-二氟甲基吡唑酰胺类杀真菌剂，组合物及用途
公开(公告)号：US5093347A
公开(公告)日：1992-03-03
申请号：US725151
申请日：1991-07-03
申请人： Matthew J. Graneto , Wendell G. Phillips
发明人： Matthew J. Graneto , Wendell G. Phillips
IPC分类号： A01N43/56 , C07D231/14
CPC分类号： A01N43/56 , C07D231/14
摘要： Novel 3-difluoromethyl-1-methyl-N-(substituted-indane-4-yl)pyrazole-4-carboxamides useful as fungicides, particularly effective in alleviating infections in diseased plants.
摘要翻译：用作杀真菌剂的新型3-二氟甲基-1-甲基-N-（取代 - 茚满-4-基）吡唑-4-甲酰胺，特别有效地减轻病害植物的感染。

29. 再颁专利

USRE36562E Fungicides for the control of take-all disease of plants 失效
标题翻译：用于控制植物全部病害的杀真菌剂
公开(公告)号：USRE36562E
公开(公告)日：2000-02-08
申请号：US41113
申请日：1998-03-11
申请人： Dennis P. Phillion , Diane S. Braccolino , Matthew J. Graneto , Wendell G. Phillips , Karey A. Van Sant , Daniel M. Walker , Sai C. Wong
发明人： Dennis P. Phillion , Diane S. Braccolino , Matthew J. Graneto , Wendell G. Phillips , Karey A. Van Sant , Daniel M. Walker , Sai C. Wong
IPC分类号： A01N37/18 , A01N37/26 , A01N37/40 , A01N37/44 , A01N41/10 , A01N43/10 , A01N43/36 , A01N43/40 , A01N55/00 , A01N55/02 , A01N55/04 , A01N55/10 , A61K31/165 , A61K31/38 , A61K31/405 , A61K31/41 , A61K31/415 , A61K31/47 , A61K31/555 , A61K31/695 , C07C233/00 , C07C233/65 , C07C233/66 , C07C233/69 , C07C235/60 , C07C237/30 , C07C317/44 , C07C323/60 , C07D209/02 , C07D215/38 , C07D249/08 , C07D409/04 , C07F7/04 , C07F7/08 , C07F7/22 , C07F7/30 , C07F15/02 , A01N43/12 , C07D333/56 , C07D333/58 , C07D333/62
CPC分类号： C07C317/44 , A01N37/18 , A01N37/26 , A01N37/40 , A01N37/44 , A01N41/10 , A01N55/00 , A01N55/02 , A01N55/04 , C07C233/65 , C07C233/66 , C07C233/69 , C07C235/60 , C07C237/30 , C07C323/60 , C07F15/025 , C07F7/0812 , C07F7/0814 , C07F7/0818 , C07F7/2212 , C07F7/30 , C07C2101/04 , C07C2101/08
摘要： A method of controlling Take-All disease of plants by applying a fungicide of the formula ##STR1## wherein Z.sub.1 and Z.sub.2 are C and are part of an aromatic ring which is .[.benzothiophene.]..Iadd.thiophene.Iaddend.; andA is .[.selected from.]. --C(X)-amine .[.wherein the amine is an unsubstituted, monosubstituted or disubstituted amino radical.]..Iadd.wherein the amine is a monosubstituted or a disubstituted amine, wherein one of the substituents has a cyclic moiety, said cyclic moiety which is chosen from the group consisting of thienyl, furanyl, and a non-heterocyclic substituent, wherein when the amine is disubstituted, the second substituent is a non-cyclic substituent.Iaddend., --C(O)--SR.sub.3, --NH--C(X)R.sub.4, .[.and.]. .Iadd.or .Iaddend.--C(.dbd.NR.sub.3)--XR.sub.7 ;B is --W.sub.m --Q(R.sub.2).sub.3 or selected from .[.O-tolyl.]..Iadd.o-tolyl.Iaddend., 1-naphthyl, 2-naphthyl, and 9-phenanthryl, each optionally substituted with halogen or R.sub.4 ;Q is C, Si, Ge, or Sn;W is --C(R.sub.3).sub.p H.sub.(2-p) --; or when Q is C, W is selected from .[.--C(R.sub.3).sub.p H.sub.(2-p),.[..Iadd.--C(R.sub.3).sub.p H.sub.(2-p) --.Iaddend., --N(R.sub.3).sub.m H.sub.(1-m) --, .[.--S(O)p--,.]. .Iadd.--S(O).sub.p --, .Iaddend.and --O--,X is .[.0.]. .Iadd.O .Iaddend.or S;n is .[.0, 1, 2, or 3.]..Iadd.2.Iaddend.;m is 0 or 1;p is 0, 1, or 2;.Iadd.wherein the two R groups are combined with the thiophene ring to form a fused ring which is benzothiophene.Iaddend.; each R and R.sub.2 is independently defined herein;R.sub.3 is C.sub.1 -C.sub.4 alkyl;R.sub.4 is C.sub.1 -C.sub.4 alkyl, haloalkyl, alkoxy, alkylthio, alkylamino, or dialkylamino; andR.sub.7 is C.sub.1 -C.sub.4 alkyl, haloalkyl, or phenyl, optionally substituted with halo, nitro, or R.sub.4 ;or an agronomic salt thereof.
摘要翻译：通过应用下式的杀真菌剂其中Z1和Z2是C并且是作为[苯并噻吩]噻吩的芳环的一部分的方法来控制植物的全病害的方法; 并且A是[选自] -C（X） - 胺[其中胺是未取代的单取代或二取代的氨基]，其中胺是单取代或二取代的胺，其中一个取代基具有环状部分，所述环状部分，其选自噻吩基，呋喃基和非杂环取代基，其中当胺被二取代时，第二取代基是非环状取代基-C（O）-SR 3，-NH-C （X）R4，[和]或-C（= NR3）-XR7; B是-Wm-Q（R2）3或选自[O-甲苯基]邻甲苯基，1-萘基，2-萘基和9-菲基，各自任选被卤素或R 4取代; Q是C，Si，Ge或Sn; W是-C（R3）pH（2-p） - ; 或当Q为C时，W选自[-C（R3）pH（2-p），[-C（R3）pH（2-p） - ， - N（R3）mH（1-m） [-S（O）p-，] -S（O）对 - 和-O-，X是[0] O或S; n是[0，1，2或3] 2; m为0或1; p为0,1或2; 其中两个R基团与噻吩环结合形成苯环噻吩的稠环; 每个R和R 2在本文中独立定义; R3是C1-C4烷基; R4是C1-C4烷基，卤代烷基，烷氧基，烷硫基，烷基氨基或二烷基氨基; 并且R 7是任选被卤素，硝基或R 4取代的C 1 -C 4烷基，卤代烷基或苯基; 或其农艺盐。

30. 发明授权

US5670532A Pyrazolyl derivatives for the treatment of inflammation 失效
标题翻译：吡唑基衍生物用于治疗炎症
公开(公告)号：US5670532A
公开(公告)日：1997-09-23
申请号：US719501
申请日：1996-09-25
申请人： John J. Talley , Stephen R. Bertenshaw , Matthew J. Graneto , Donald J. Rogier
发明人： John J. Talley , Stephen R. Bertenshaw , Matthew J. Graneto , Donald J. Rogier
IPC分类号： C07D491/04 , C07D491/044 , C07D491/048 , C07D491/052 , C07D495/04 , A61K31/415 , A61K31/435 , C07D487/04
CPC分类号： C07D491/04 , C07D495/04
摘要： A class of benzopyranopyrazolyl derivatives is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I ##STR1## wherein A is --(CH.sub.2).sub.m --X--(CH.sub.2).sub.n --; wherein X is S(O).sub.p or O; wherein m is 0 or 1; wherein n is 0 or 1; wherein p is 0 or 1; wherein B is selected from phenyl and five and six membered heteroaryl; wherein R.sup.1 is selected from lower haloalkyl, cyano, formyl, lower alkoxycarbonyl, lower alkoxy, lower N-alkylaminocarbonyl, N-phenylaminocarbonyl, lower N,N-dialkylaminocarbonyl and lower N-alkyl-N-phenylaminocarbonyl; wherein R.sup.2 is phenyl substituted at a substitutable position with a radical selected from lower alkylsulfonyl and sulfamyl; and wherein R.sup.4 is one or more radicals selected from hydrido, halo, lower alkylthio, lower alkylsulfinyl, lower alkyl, cyano, carboxyl, lower alkoxycarbonyl, aminocarbonyl, lower haloalkyl, hydroxyl, lower alkoxy, amino, lower N-alkylamino, lower N,N-dialkylamino, lower hydroxyalkyl and lower haloalkoxy; or a pharmaceutically-acceptable salt thereof.
摘要翻译：描述了一类苯并吡喃并吡唑基衍生物用于治疗炎症和炎症相关疾病。特别感兴趣的化合物由式I（I）定义，其中A是 - （CH 2）m -X-（CH 2）n - ; 其中X是S（O）p或O; 其中m为0或1; 其中n为0或1; 其中p为0或1; 其中B选自苯基和五元和六元杂芳基; 其中R 1选自低级卤代烷基，氰基，甲酰基，低级烷氧基羰基，低级烷氧基，低级N-烷基氨基羰基，N-苯基氨基羰基，低级N，N-二烷基氨基羰基和低级N-烷基-N-苯基氨基羰基。其中R2是在可取代的位置被选自低级烷基磺酰基和氨磺酰基的基团取代的苯基; 氰基，羧基，低级烷氧基羰基，氨基羰基，低级卤代烷基，羟基，低级烷氧基，氨基，低级N-烷基氨基，低级N，低级烷基氨基，低级烷基氨基，低级烷基氨基， N-二烷基氨基，低级羟烷基和低级卤代烷氧基; 或其药学上可接受的盐。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式