专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06753344B2 Thiophene substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors 失效
标题翻译：噻吩取代的异羟肟酸衍生物作为环加氧酶-2和5-脂氧合酶抑制剂
公开(公告)号：US06753344B2
公开(公告)日：2004-06-22
申请号：US10317751
申请日：2002-12-12
申请人： John J. Talley , James A. Sikorski , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Balekudru Devadas , Hwang-Fun Lu
发明人： John J. Talley , James A. Sikorski , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Balekudru Devadas , Hwang-Fun Lu
IPC分类号： A61K3138
CPC分类号： C07D231/12 , C07D263/32
摘要： This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
摘要翻译：本发明涉及抗炎药物领域，具体涉及用于治疗由环氧合酶-2或5-脂氧合酶如炎症介导的病症的化合物，组合物和方法。

2. 发明授权

US06875785B2 Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors 失效
标题翻译：杂环取代的异羟肟酸衍生物作为环加氧酶-2和5-脂氧合酶抑制剂
公开(公告)号：US06875785B2
公开(公告)日：2005-04-05
申请号：US10254701
申请日：2002-09-25
申请人： John J. Talley , James A. Sikorski , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Balekudru Devadas , Hwang-Fun Lu
发明人： John J. Talley , James A. Sikorski , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Balekudru Devadas , Hwang-Fun Lu
IPC分类号： A61P29/00 , C07D231/12 , C07D263/32 , A61K31/421 , C07D413/00
CPC分类号： C07D231/12 , C07D263/32
摘要： This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
摘要翻译：本发明涉及抗炎药物领域，具体涉及用于治疗由环氧合酶-2或5-脂氧合酶如炎症介导的病症的化合物，组合物和方法。

3. 发明授权

US06677364B2 Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors 失效
标题翻译：取代的磺酰基苯基杂环作为环加氧酶-2和5-脂氧合酶抑制剂
公开(公告)号：US06677364B2
公开(公告)日：2004-01-13
申请号：US10004960
申请日：2001-12-04
申请人： John J. Talley , James A. Sikorski , Balekudru Devadas , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Roland S. Rogers , Hwang-Fun Lu , David L. Brown
发明人： John J. Talley , James A. Sikorski , Balekudru Devadas , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Roland S. Rogers , Hwang-Fun Lu , David L. Brown
IPC分类号： A61K314178
CPC分类号： A61K31/44 , A61K31/15 , A61K31/277 , A61K31/4015
摘要： This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
摘要翻译：本发明涉及抗炎药物领域，具体涉及用于治疗由环氧合酶-2或5-脂氧合酶如炎症介导的病症的化合物，组合物和方法。

4. 发明授权

US5643933A Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors 失效
标题翻译：取代的磺酰基苯基杂环作为环加氧酶-2和5-脂氧合酶抑制剂
公开(公告)号：US5643933A
公开(公告)日：1997-07-01
申请号：US460324
申请日：1995-06-02
申请人： John J. Talley , James A. Sikorski , Bryan H. Norman , Roland S. Rogers, deceased , Balekudru Devadas , Matthew J. Graneto , Jeffery S. Carter
发明人： John J. Talley , James A. Sikorski , Bryan H. Norman , Roland S. Rogers, deceased , Balekudru Devadas , Matthew J. Graneto , Jeffery S. Carter
IPC分类号： A61P29/00 , C07D231/12 , C07D405/12 , C07D413/10 , C07D413/12 , A61K31/44 , A61K31/42 , A61K31/425 , C07D413/06 , C07D417/02 , C09D263/32
CPC分类号： C07D231/12 , C07D405/12 , C07D413/10 , C07D413/12
摘要： This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
摘要翻译：本发明涉及抗炎药物领域，具体涉及用于治疗由环氧合酶-2或5-脂氧合酶如炎症介导的病症的化合物，组合物和方法。

5. 发明授权

US06696477B2 Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors 失效
标题翻译：杂环取代的异羟肟酸衍生物作为环加氧酶-2和5-脂氧合酶抑制剂
公开(公告)号：US06696477B2
公开(公告)日：2004-02-24
申请号：US09997633
申请日：2001-11-29
申请人： John J. Talley , James A. Sikorski , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Balekudru Devadas
发明人： John J. Talley , James A. Sikorski , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Balekudru Devadas
IPC分类号： C07D23110
CPC分类号： C07D231/12 , B60G17/018 , B60G2400/102 , B60G2400/206 , B60G2400/25 , B60G2400/60 , B60G2400/91 , B64C27/001 , B64C2027/004 , C07D263/32
摘要： This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation. Compounds of particular interest are defined by Formula I wherein A, Y, R1, R2, R3, R4 and R5 are as defined in the specification.
摘要翻译：本发明涉及抗炎药物领域，具体涉及用于治疗由环氧合酶-2或5-脂氧合酶如炎症介导的病症的化合物，组合物和方法。特别感兴趣的化合物由式I定义，其中A，Y，R 1，R 2，R 3，R 4和R 5如说明书中所定义。

6. 发明授权

US5719163A Substituted oxazolyl compounds for the treatment of inflammation 失效
标题翻译：用于治疗炎症的取代的恶唑基化合物
公开(公告)号：US5719163A
公开(公告)日：1998-02-17
申请号：US535227
申请日：1995-10-27
申请人： Bryan H. Norman , Len F. Lee , Jaime L. Masferrer , John J. Talley
发明人： Bryan H. Norman , Len F. Lee , Jaime L. Masferrer , John J. Talley
IPC分类号： C07D263/10 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/44 , A61P29/00 , A61P43/00 , C07D263/14 , C07D263/32 , C07D413/12 , C07D413/06 , A61K31/47
CPC分类号： C07D413/12 , C07D263/32
摘要： A class of substituted oxazolyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: ##STR1## wherein R is selected from alkyl, hydroxyalkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl optionally substituted at a substitutable position by carboxy, alkyl, alkoxy and halo, aralkyl optionally substituted at a substitutable position on the aryl radical by carboxy, alkyl, alkoxy and halo, aryloxyalkyl optionally substituted at a substitutable position on the aryl radical with halo, carboxy, alkyl and alkoxy, aralkoxyalkyl optionally substituted at a substitutable position by alkyl, carboxy, alkoxy and halo, heteroaryloxyalkyl optionally substituted at a substitutable position with halo, carboxy, alkyl and alkoxy, alkoxycarbonylalkyl, carboxyalkyl and aminocarbonylalkyl; wherein R.sup.1 is selected from cycloalkyl, cycloalkenyl, heteroaryl and aryl optionally substituted at a substitutable position by alkyl, alkoxy and halo, and wherein R.sup.2 is alkyl; or a pharmaceutically-acceptable salt thereof; provided R.sup.1 is not phenyl when R.sup.2 is methyl and R is isopropyl or tert-butyl.
摘要翻译： PCT No.PCT / US94 / 05395 Sec。 371 1995年10月27日第 102（e）日期1995年10月27日PCT提交1994年5月19日PCT公布。 WO94 / 27980 PCT公开 1994年12月8日的日期描述了一类用于治疗炎症和炎症相关疾病的取代的恶唑基化合物。特别感兴趣的化合物由式I定义：其中R选自烷基，羟基烷基，卤代烷基，环烷基，环烷基烷基，在可取代的位置被羧基，烷基，烷氧基和卤素取代的芳基，任选在羧基，烷基，烷氧基和卤素在芳基上的可取代位置，在芳基上的可取代位置上被卤素，羧基，烷基和烷氧基任选取代的芳氧基烷基，任选在可取代位置被烷基，羧基，烷氧基和卤素取代的芳烷氧基烷基任选在可取代的位置被卤素，羧基，烷基和烷氧基取代的杂芳氧基烷基，烷氧基羰基烷基，羧基烷基和氨基羰基烷基; 其中R1选自环烷基，环烯基，杂芳基和芳基，其任选在可取代的位置被烷基，烷氧基和卤素取代，并且其中R2是烷基; 或其药学上可接受的盐; 当R 2是甲基且R是异丙基或叔丁基时，R 1不是苯基。

7. 发明授权

US5380738A 2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents 失效
标题翻译：进一步被4-氟苯基和4-甲基磺酰基苯基取代的2-取代的恶唑作为抗炎剂
公开(公告)号：US5380738A
公开(公告)日：1995-01-10
申请号：US65730
申请日：1993-05-21
申请人： Bryan H. Norman , Len F. Lee , Jaime L. Masferrer , John J. Talley
发明人： Bryan H. Norman , Len F. Lee , Jaime L. Masferrer , John J. Talley
IPC分类号： C07D263/10 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/44 , A61P29/00 , A61P43/00 , C07D263/14 , C07D263/32 , C07D413/12
CPC分类号： C07D413/12 , C07D263/32
摘要： 2-Substituted-4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)oxazoles or 2-substituted-5-(4-fluorophenyl)-4-(4-(methylsulfonyl)phenyl)oxazoles and derivatives thereof are found to posses significant antiinflammatory activity, especially useful for the treatment of arthritis without deleterious side effects.
摘要翻译： 2-取代的4-（4-氟苯基）-5-（4-（甲基磺酰基）苯基）恶唑或2-取代-5-（4-氟苯基）-4-（4-（甲基磺酰基）苯基）恶唑及其衍生物被发现具有显着的抗炎活性，特别可用于治疗关节炎而没有有害的副作用。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式