专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明授权

US07189523B2 Methods of identifying compounds that modulate IL-4 receptor-mediated IgE synthesis utilizing a B-cell associated protein 有权
标题翻译：鉴定使用B细胞相关蛋白调节IL-4受体介导的IgE合成的化合物的方法
公开(公告)号：US07189523B2
公开(公告)日：2007-03-13
申请号：US10197919
申请日：2002-07-16
申请人： Esteban Masuda , Todd M. Kinsella , Justin E. Warner , Taisei Kinoshita , Mark K. Bennett , David C. Anderson
发明人： Esteban Masuda , Todd M. Kinsella , Justin E. Warner , Taisei Kinoshita , Mark K. Bennett , David C. Anderson
IPC分类号： G01N33/566 , G01N33/567 , C07K4/00 , A61K45/00 , A61K38/00
CPC分类号： G01N33/6869 , C07K7/08 , G01N33/5052 , G01N2500/20
摘要： The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a BAP-37 as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.
摘要翻译：本发明提供能够调节IL-4受体介导的IgE产生的化合物以及与其相关的IL-4诱导的过程，用于鉴定利用BAP-37作为替代分析物的这些化合物的方法和试剂盒以及使用该化合物的方法在各种体外，体外和体外上下文中。

22. 发明授权

US5801019A DNA encoding fused alpha-beta globin pseuodimer and production of pseudotetrameric hemoglobin 失效
标题翻译：编码融合的α-β球蛋白pseuodimer的DNA和伪三聚体血红蛋白的产生
公开(公告)号：US5801019A
公开(公告)日：1998-09-01
申请号：US444939
申请日：1995-05-19
申请人： David C. Anderson , Antony James Mathews
发明人： David C. Anderson , Antony James Mathews
IPC分类号： A61K38/16 , A61K38/00 , A61K47/48 , A61P7/08 , C07K20060101 , C07K1/113 , C07K14/805 , C12N15/00 , C12N15/09 , C12N15/12 , C12N15/81 , C12P21/02 , C12R1/19 , C12R1/91 , C12P21/06 , C07H17/00
CPC分类号： C07K14/805 , A61K47/48307 , C12N15/81 , A61K38/00 , C07K2319/00 , C07K2319/50 , C07K2319/92
摘要： The alpha subunits of hemoglobin, which in nature are formed as separate polypeptide chains which bind noncovalently to the beta subunits, are here provided in the form of the novel molecule di-alpha globin, a single polypeptide chain defined by connecting the two alpha subunits either directly via peptide bond or indirectly by a flexible amino acid or peptide linker. Di-alpha globin may be combined in vivo or in vitro with beta globin and heme to form hemoglobin. Di-alpha globin is expressed by recombinant DNA techniques. Di-beta globin may be similarly obtained.
摘要翻译：在本文中，血红蛋白的α亚基本质上被形成为与β-亚基非共价结合的分离的多肽链，这里以新分子二-α球蛋白的形式提供，单链多肽链通过将两个α亚基连接而定义直接通过肽键或通过柔性氨基酸或肽接头间接。 Di-α珠蛋白可以在体内或体外与β球蛋白和血红素组合以形成血红蛋白。 Di-α球蛋白通过重组DNA技术表达。可以类似地获得二β-珠蛋白。

23. 发明授权

US5744329A DNA encoding fused di-beta globins and production of pseudotetrameric hemoglobin 失效
标题翻译：编码融合的二-β珠蛋白的DNA和伪三聚体血红蛋白的产生
公开(公告)号：US5744329A
公开(公告)日：1998-04-28
申请号：US444942
申请日：1995-05-19
申请人： Stephen J. Hoffman , Douglas L. Looker , Mary S. Rosendahl , Gary L. Stetler , Michael Wagenbach , David C. Anderson , Antony James Mathews , Kiyoshi Nagai
发明人： Stephen J. Hoffman , Douglas L. Looker , Mary S. Rosendahl , Gary L. Stetler , Michael Wagenbach , David C. Anderson , Antony James Mathews , Kiyoshi Nagai
IPC分类号： A61K38/16 , A61K38/00 , A61K47/48 , A61P7/08 , C07K20060101 , C07K1/113 , C07K14/805 , C12N15/00 , C12N15/09 , C12N15/12 , C12N15/81 , C12P21/02 , C12R1/19 , C12R1/91 , C12P21/06 , C07H17/00
CPC分类号： C07K14/805 , A61K47/48307 , C12N15/81 , A61K38/00 , C07K2319/00 , C07K2319/50 , C07K2319/92
摘要： The alpha subunits of hemoglobin, which in nature are formed as separate polypeptide chains which bind noncovalently to the beta subunits, are here provided in the form of the novel molecule di-alpha globin, a single polypeptide chain defined by connecting the two alpha subunits either directly via peptide bond or indirectly by a flexible amino acid or peptide linker. Di-alpha globin may be combined in vivo or in vitro with beta globin and heme to form hemoglobin. Di-alpha globin is expressed by recombinant DNA techniques. Di-beta globin may be similarly obtained.
摘要翻译：在本文中，血红蛋白的α亚基本质上被形成为与β-亚基非共价结合的分离的多肽链，这里以新分子二-α球蛋白的形式提供，单链多肽链通过将两个α亚基连接而定义直接通过肽键或通过柔性氨基酸或肽接头间接。 Di-α珠蛋白可以在体内或体外与β球蛋白和血红素组合以形成血红蛋白。 Di-α球蛋白通过重组DNA技术表达。可以类似地获得二β-珠蛋白。

24. 发明授权

US5739011A DNA for the production of multimeric hemoglobins 失效
标题翻译：用于生产多聚体血红蛋白的DNA
公开(公告)号：US5739011A
公开(公告)日：1998-04-14
申请号：US443890
申请日：1995-05-31
申请人： David C. Anderson , Antony James Mathews , Gary L. Stetler
发明人： David C. Anderson , Antony James Mathews , Gary L. Stetler
IPC分类号： A61K38/00 , A61K47/48 , C07K14/805 , C12N15/12 , C12N15/81 , C12P21/02 , C07H21/04
CPC分类号： C12N15/81 , A61K47/48307 , C07K14/805 , A61K38/00 , C07K2319/00 , C07K2319/50 , C07K2319/92 , Y10S530/829
摘要： DNA molecules which encode pseudodimeric globin-like polypeptides with an asymmetric cysteine mutation suitable for crosslinking two tetramers, or which encode pseudooligomeric globin-like polypeptides comprising four or more globin-like domains, are useful in the preparation of multimeric hemoglobin-like proteins.
摘要翻译：编码具有适用于交联两个四聚体的不对称半胱氨酸突变的伪二聚球蛋白样多肽的DNA分子或编码包含四个或更多个珠蛋白样结构域的假寡聚寡核苷酸样多肽的DNA分子可用于制备多聚体血红蛋白样蛋白。

25. 发明授权

US5599907A Production and use of multimeric hemoglobins 失效
标题翻译：多聚体血红蛋白的生产和使用
公开(公告)号：US5599907A
公开(公告)日：1997-02-04
申请号：US240712
申请日：1994-05-09
申请人： David C. Anderson , Antony J. Mathews , Gary L. Stetler
发明人： David C. Anderson , Antony J. Mathews , Gary L. Stetler
IPC分类号： A61K38/00 , A61K47/48 , C07K14/805 , C12N15/12 , C12N15/81 , A61K35/14 , C07H21/04 , C12P21/00
CPC分类号： C12N15/81 , A61K47/48307 , C07K14/805 , A61K38/00 , C07K2319/00 , C07K2319/50 , C07K2319/92 , Y10S530/829
摘要： Multimeric hemoglobin-like proteins are obtained by crosslinking cysteines of the component tetramers, or by genetically fusing globin-like domains of one tetramer with those of another, by means of an interdomain spacer sequence. Artificial cysteines are introduced selectively in a single globin-like domain per tetramer to control polymerization.
摘要翻译： PCT No.PCT / US92 / 09752 Sec。 371日期1994年5月9日 102（e）日期1994年5月9日PCT提交1992年11月6日PCT公布。公开号WO93 / 09143 日期1993年5月13日多聚体血红蛋白样蛋白质通过交联组分四聚体的半胱氨酸，或通过间隔区间序列通过将一个四聚体的球蛋白样结构域与另一个四聚体的球蛋白样结构域交联而获得。人造半胱氨酸被选择性地引入单个珠蛋白样结构域每四聚体以控制聚合。

26. 发明授权

US5420105A Polymeric carriers for non-covalent drug conjugation 失效
标题翻译：用于非共价药物共轭的聚合载体
公开(公告)号：US5420105A
公开(公告)日：1995-05-30
申请号：US95515
申请日：1993-07-26
申请人： Linda M. Gustavson , David C. Anderson , Alton C. Morgan, Jr.
发明人： Linda M. Gustavson , David C. Anderson , Alton C. Morgan, Jr.
IPC分类号： A61K38/00 , A61K47/48 , C07K14/36 , C07K14/465 , C07K14/47 , C07K14/72 , C07K14/76 , A61K31/415 , A61K47/42
CPC分类号： B82Y5/00 , A61K47/48238 , A61K47/48692 , A61K47/48746 , A61K47/48753 , C07K14/36 , C07K14/465 , C07K14/47 , C07K14/473 , C07K14/721 , C07K14/723 , C07K14/76 , A61K38/00
摘要： Polymeric carriers are polypeptides comprising at least one drug-binding domain that non-covalently binds a drug. A polymeric carrier may be attached to an antibody specific for desired target cells to form immunoconjugates that deliver a drug to the target cells in vivo. A polymeric carrier may be attached to a proteinaceous or a non-proteinaceous ligand or anti-ligand to form a conjugate useful in pretargeting protocols to deliver a drug to target cells in vivo. The carriers are derived from drug-binding proteins and produced through peptide synthesis or recombinant DNA technology.
摘要翻译：聚合载体是包含非共价结合药物的至少一个药物结合结构域的多肽。聚合物载体可以连接到对所需靶细胞特异性的抗体，以形成在体内将药物递送至靶细胞的免疫缀合物。聚合物载体可以连接到蛋白质或非蛋白质配体或抗配体上以形成用于预靶向方案的缀合物，以将药物在体内递送至靶细胞。载体衍生自药物结合蛋白并通过肽合成或重组DNA技术产生。

27. 发明授权

US5171563A Cleavable linkers for the reduction of non-target organ retention of immunoconjugates 失效
标题翻译：用于减少免疫缀合物的非目标器官保留的可切割接头
公开(公告)号：US5171563A
公开(公告)日：1992-12-15
申请号：US830973
申请日：1992-02-10
申请人： Paul G. Abrams , John M. Reno , Alan R. Fritzberg , Ananthachari Srinivasan , David C. Anderson
发明人： Paul G. Abrams , John M. Reno , Alan R. Fritzberg , Ananthachari Srinivasan , David C. Anderson
IPC分类号： A61K47/48 , A61K51/08 , A61K51/10
CPC分类号： A61K47/48338 , A61K51/088 , A61K51/1093 , A61K2121/00 , A61K2123/00 , Y10S514/836 , Y10S514/922 , Y10S530/807
摘要： A process for reducing the non-target organ accumulation of immunoconjugates administered in vivo during therapeutic or diagnostic procedures involves the use of immunoconjugates comprising linkers that are cleavable at the non-target organs. The linkers are cleavable under conditions present, or induced, at one or more non-target organs, which include the kidneys or the liver.
摘要翻译：在治疗或诊断过程中减少在体内施用的免疫缀合物的非靶器官积累的方法涉及使用包含在非靶器官可切割的接头的免疫缀合物。接头可在包括肾脏或肝脏的一个或多个非靶器官存在或诱导的条件下切割。

28. 发明授权

US5156301A Constant ratio post-mix beverage dispensing valve 失效
标题翻译：恒定比混合饮料分配阀
公开(公告)号：US5156301A
公开(公告)日：1992-10-20
申请号：US628818
申请日：1990-12-17
申请人： David A. Hassell , David C. Anderson
发明人： David A. Hassell , David C. Anderson
IPC分类号： B01F15/02 , B67D1/00 , B67D1/10 , B67D1/12 , F04C2/12 , G05D11/00
CPC分类号： G05D11/005 , B01F15/0218 , B67D1/0031 , B67D1/0037 , B67D1/107 , B67D1/12 , F04C2/126 , G05D11/008 , Y10T137/2516
摘要： The present invention is a post-mix beverage dispensing valve for accurately maintaining the proper ratio of two liquid beverage components. The present invention includes a valve main body having a gear pump secured thereto. The gear pump includes two sets of oval gears. One set of oval gears is in fluid communication with a source of pressurized carbonated water, and the second set is in fluid communication with a source of syrup. The valve body also includes solenoid operated pallet valves for each of the beverage components. Ratioing of the solenoid provides for simultaneous opening of both pallet valves whereby the pressurized carbonated water flows between the carbonated water gears and is swept thereby through the valve body to the dispensing nozzle. One gear of each gear pair is secured to a common rotating shaft. Pressurized carbonated water provides for the rotation of the syrup gears, thereby providing for the pumping of the syrup to the nozzle. The gear pairs are sized so that the desired ratio between the beverage components is maintained.
摘要翻译：本发明是用于精确地保持两种液体饮料组分的适当比例的后混合饮料分配阀。本发明包括具有固定在其上的齿轮泵的阀主体。齿轮泵包括两套椭圆形齿轮。一组椭圆形齿轮与加压碳酸水源流体连通，第二组与糖浆源流体连通。阀体还包括用于每个饮料部件的电磁操作的托盘阀。螺线管的比例提供了两个托盘阀的同时打开，由此加压的碳酸水在碳酸水齿轮之间流动并且被扫过，从而通过阀体到达分配喷嘴。每个齿轮对的一个齿轮固定到共同的转轴上。加压的碳酸水提供糖浆齿轮的旋转，从而提供将糖浆泵送到喷嘴。齿轮对的尺寸使得维持饮料部件之间所需的比例。

29. 发明授权

US4986979A Imaging tissue sites of inflammation 失效
标题翻译：成像组织部位炎症
公开(公告)号：US4986979A
公开(公告)日：1991-01-22
申请号：US364687
申请日：1989-06-09
申请人： A. Charles Morgan, Jr. , David C. Anderson
发明人： A. Charles Morgan, Jr. , David C. Anderson
IPC分类号： G01N33/53 , A61K49/00 , A61K51/00 , A61K51/04 , A61K51/10 , A61K51/12 , G01N33/534 , G01N33/577
CPC分类号： A61K51/1203 , A61K49/0004 , A61K51/0478 , A61K51/1093 , A61K2123/00
摘要： The present invention involves method of enhancing the amount of label accumulating at tissue sites of inflammation. Methods of the present invention take advantage of the up-regulation of surface antigenic markers on leukocytes upon activation thereof. A method of imaging utilizing a chemotactic peptide containing an affinity label and a radionuclide label conjugated to leukocytes is taught. Imaging applications of such enhancement are described.
摘要翻译：本发明涉及增加在炎症组织部位积聚的标记量的方法。本发明的方法利用在其激活时白细胞上的表面抗原标志物的上调。教导了利用含有亲和标记的趋化肽和与白细胞结合的放射性核素标记的成像方法。描述这种增强的成像应用。

30. 发明授权

US07422867B2 Methods of identifying compounds that modulate IL-4 receptor mediated IgE synthesis utilizing a CLLD8 protein 有权
公开(公告)号：US07422867B2
公开(公告)日：2008-09-09
申请号：US11784176
申请日：2007-04-04
申请人： Esteban Masuda , Todd M. Kinsella , Justin E. Warner , Taisei Kinoshita , Mark K. Bennett , David C. Anderson
发明人： Esteban Masuda , Todd M. Kinsella , Justin E. Warner , Taisei Kinoshita , Mark K. Bennett , David C. Anderson
IPC分类号： C12Q1/37
CPC分类号： C07K7/08 , A61K38/1709 , C07K14/5406 , G01N33/6869 , G01N2333/5406 , G01N2500/00 , Y10S435/975
摘要： The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a CLLD8 protein as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式