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21. 发明申请

US20070197506A1 Modulators of 11-beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same 有权
标题翻译： 11-β羟基类固醇脱氢酶1型调节剂，其药物组合物及其使用方法
公开(公告)号：US20070197506A1
公开(公告)日：2007-08-23
申请号：US11652191
申请日：2007-01-11
申请人： Wenqing Yao , David Burns , Lihua Chen , Jincong Zhuo , Chunhong He
发明人： Wenqing Yao , David Burns , Lihua Chen , Jincong Zhuo , Chunhong He
IPC分类号： A61K31/55 , A61K31/501 , A61K31/497 , A61K31/506 , A61K31/4745 , A61K31/4439
CPC分类号： C07D403/04 , C07D207/16 , C07D209/96 , C07D471/10 , C07D487/10
摘要： The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1 and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-β hydroxyl steroid dehydrogenase type 1 such as obesity and diabetes.
摘要翻译：本发明涉及1型11-β羟基类固醇脱氢酶抑制剂及其药物组合物。本发明的化合物可用于治疗与11-β羟基类固醇脱氢酶1（例如肥胖症和糖尿病）的表达或活性相关的各种疾病。

22. 发明申请

US20070054347A1 Oxidative stress measurement device and related methods 审中-公开
标题翻译：氧化应力测量装置及相关方法
公开(公告)号：US20070054347A1
公开(公告)日：2007-03-08
申请号：US11357060
申请日：2006-02-21
申请人： Scott Rosendahl , Dirk Bandilla , Hyman Schipper , David Burns
发明人： Scott Rosendahl , Dirk Bandilla , Hyman Schipper , David Burns
IPC分类号： C12Q1/26 , G06F19/00 , A61B5/00
CPC分类号： A61B5/412 , A61B5/0059 , A61B5/14542 , A61B5/14546 , A61B5/1455 , A61B5/4088 , A61B5/726 , A61B5/7275 , C12Q1/26 , G01N21/359 , G01N2800/2814 , G01N2800/2821 , G01N2800/2835
摘要： For measuring an oxidative stress component in a patient, an optical analyzer having a light source and a light detector is used for measuring an optical property of a medium and generating optical measurement data. A processor analyzes the optical measurement data and generates a value for one or more oxidative stress component in the form of a redox signature for the patient. Probability data of the presence of an oxidative stress dependent disease can be calculated. By observing at least one additional clinical condition of the disease, a diagnosis using said at least one additional condition and said redox signature can be obtained.
摘要翻译：为了测量患者的氧化应激成分，使用具有光源和光检测器的光学分析器来测量介质的光学特性并产生光学测量数据。处理器分析光学测量数据并且以用于患者的氧化还原特征的形式产生一个或多个氧化应激成分的值。可以计算存在氧化应激依赖性疾病的概率数据。通过观察疾病的至少一个额外的临床状况，可以获得使用所述至少一个附加条件和所述氧化还原特征的诊断。

23. 发明申请

US20070005409A1 Method and structure for overriding calendar entries based on context and business value 审中-公开
标题翻译：基于上下文和业务价值覆盖日历项的方法和结构
公开(公告)号：US20070005409A1
公开(公告)日：2007-01-04
申请号：US11170441
申请日：2005-06-30
申请人： Greg Boss , David Burns , Andrew Jones , Kevin McConnell
发明人： Greg Boss , David Burns , Andrew Jones , Kevin McConnell
IPC分类号： G06F9/46
CPC分类号： G06Q10/109 , G06Q10/1095
摘要： A method and structure for automatically scheduling a meeting in an electronic calendar system. Calendars of all participants invited to a meeting being scheduled are accessed. Each participant's calendar is checked whether that participant is available for the meeting, in accordance with a priority of the meeting. The meeting is scheduled on each participant's calendar if all said participants are available.
摘要翻译：一种用于在电子日历系统中自动安排会议的方法和结构。访问被邀请参加会议的所有参与者的日历被访问。根据会议的优先级，对每个参与者的日历进行检查，确定该参与者是否可用于会议。如果所有参与者都可用，会议将安排在每个参与者的日历上。

24. 发明申请

US20060116382A1 Lactam compounds and their use as pharmaceuticals 审中-公开
公开(公告)号：US20060116382A1
公开(公告)日：2006-06-01
申请号：US11269984
申请日：2005-11-09
申请人： Wenqing Yao , Chunghong He , Jincong Zhuo , Meizhong Xu , Colin Zhang , Ding-Quan Qian , David Burns , Brian Metcalf
发明人： Wenqing Yao , Chunghong He , Jincong Zhuo , Meizhong Xu , Colin Zhang , Ding-Quan Qian , David Burns , Brian Metcalf
IPC分类号： A61K31/52 , A61K31/496 , A61K31/4747 , C07D473/02 , C07D487/04
CPC分类号： C07D221/20 , C07D471/10
摘要： The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-β hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.

25. 发明申请

US20060064695A1 Thread livelock unit 有权
标题翻译：线程活动锁单元
公开(公告)号：US20060064695A1
公开(公告)日：2006-03-23
申请号：US10948878
申请日：2004-09-23
申请人： David Burns , K. Venkatraman
发明人： David Burns , K. Venkatraman
IPC分类号： G06F9/46
CPC分类号： G06F9/3851
摘要： Method, apparatus and system embodiments to assign priority to a thread when the thread is otherwise unable to proceed with instruction retirement. For at least one embodiment, the thread is one of a plurality of active threads in a multiprocessor system that includes memory livelock breaker logic and/or starvation avoidance logic. Other embodiments are also described and claimed.
摘要翻译：方法，装置和系统实施例，当线程否则不能进行指令退出时，为线程分配优先级。对于至少一个实施例，线程是多处理器系统中的多个活动线程之一，其包括存储器活动锁定断路器逻辑和/或饥饿避免逻辑。还描述和要求保护其他实施例。

26. 发明申请

US20050113344A1 Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases 有权
标题翻译：取代的环状异羟肟酸盐作为基质金属蛋白酶的抑制剂
公开(公告)号：US20050113344A1
公开(公告)日：2005-05-26
申请号：US10965215
申请日：2004-10-15
申请人： Yun-Long Li , Jincong Zhuo , David Burns , Wenqing Yao , Ravi Kumar Jalluri
发明人： Yun-Long Li , Jincong Zhuo , David Burns , Wenqing Yao , Ravi Kumar Jalluri
IPC分类号： A61K31/195 , A61K31/4166 , A61K31/426 , A61K31/66 , C07D207/08 , C07D211/32 , C07D213/50 , C07D241/04 , C07D401/06 , C07D401/08 , C07D403/08 , C07D405/08 , C07D405/14 , C07D413/08
CPC分类号： C07D401/14 , C07D207/06 , C07D207/08 , C07D211/16 , C07D211/32 , C07D211/60 , C07D213/50 , C07D241/04 , C07D295/185 , C07D401/06 , C07D401/08 , C07D401/10 , C07D401/12 , C07D403/08 , C07D403/12 , C07D405/08 , C07D405/12 , C07D405/14 , C07D413/08 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D495/04
摘要： The present invention provides compounds of the formula I: its enantiomers, diastereomers, racemic mixtures thereof, prodrugs, crystalline forms, non-crystalline forms, amorphous forms thereof, solvates thereof, metabolites thereof, and pharmaceutically acceptable salts, wherein the ring A substituent groups are fully defined in the following disclosure. The compounds of formula I are inhibitors of metalloproteases such as matrix metalloproteases and sheddases, and are useful in treating diseases such as rheumatoid arthritis, psoriasis, neoplastic diseases, allergies and all those diseases wherein inhibition of MMPs is desirable.
摘要翻译：本发明提供了式I化合物：其对映异构体，非对映体，外消旋混合物，前体药物，结晶形式，非结晶形式，其无定形形式，其溶剂化物，其代谢物和药学上可接受的盐，其中环A取代基在下面的公开内容中被完全定义。式I化合物是金属蛋白酶如基质金属蛋白酶和脱落酶的抑制剂，可用于治疗诸如类风湿性关节炎，牛皮癣，肿瘤性疾病，过敏症以及所有需要MMP抑制的疾病。

27. 发明授权

US5705090A Absorption of mercaptans 失效
标题翻译：吸附硫醇
公开(公告)号：US5705090A
公开(公告)日：1998-01-06
申请号：US708978
申请日：1996-09-06
申请人： Paul Garland , Craig Norman Schubert , Richard Alan Gregory , Eduardo Garcia-Rameau , Rickey Epps , David Burns , Robert Jerry Hlozek
发明人： Paul Garland , Craig Norman Schubert , Richard Alan Gregory , Eduardo Garcia-Rameau , Rickey Epps , David Burns , Robert Jerry Hlozek
IPC分类号： B01D53/14 , C09K3/00
CPC分类号： B01D53/1487 , B01D53/1493 , B01D2257/306
摘要： Absorption solvents for removing mercaptans from gas streams are disclosed. The absorption solvents comprise an alkylether of a polyalkylene glycol, e.g., methoxytriglycol, and a secondary monoalkanolamine, e.g., N-methylethanolamine, as well as optionally other amines, e.g., methyldiethanolamine and diethanolamine. The absorption solvents do not require the presence of iodine for removal of mercaptans. Absorption processes utilizing the solvents are also disclosed.
摘要翻译：公开了从气流中除去硫醇的吸收溶剂。吸收溶剂包括聚亚烷基二醇的烷基醚，例如甲氧基三甘醇和仲烷醇胺，例如N-甲基乙醇胺，以及任选的其它胺，例如甲基二乙醇胺和二乙醇胺。吸收溶剂不需要碘来除去硫醇。还公开了利用溶剂的吸收方法。

28. 发明授权

US4777630A Processing of reflected signals 失效
标题翻译：反射信号的处理
公开(公告)号：US4777630A
公开(公告)日：1988-10-11
申请号：US715017
申请日：1985-03-21
申请人： David Burns
发明人： David Burns
IPC分类号： G01S7/292 , G01S7/32 , G01S7/526 , G01S13/18 , G01S15/02 , G01S15/96 , G01S9/66
CPC分类号： G01S15/02 , G01S15/96 , G01S7/526
摘要： Signal processing circuitry is disclosed for processing the echo signals of echo sounders to extract the leading edge of bottom echo components of the echo signals and to provide a reading of the average area under successive leading edges. Second and later bottom echo processing is additionally disclosed. Processing is achieved with a sample and hold circuit comprising an integrator (34), a first switch (33) for switching the required echo signal portion to the integrator, storage means (C2) for storing integrated values to be displayed, and a second switch (35) for selectively coupling values from the integrator to the storage means.
摘要翻译：公开了信号处理电路，用于处理回声测深仪的回波信号，以提取回波信号的底部回波分量的前沿，并提供连续前沿下平均面积的读数。另外公开了第二次和后续的底部回波处理。采用包括积分器（34），用于将所需回波信号部分切换到积分器的第一开关（33），用于存储要显示的积分值的存储装置（C2）和第二开关（35），用于选择性地将来自积分器的值耦合到存储装置。

29. 发明授权

US4207918A Insulation jacket 失效
标题翻译：绝缘外套
公开(公告)号：US4207918A
公开(公告)日：1980-06-17
申请号：US030882
申请日：1979-04-17
申请人： David Burns , James R. Spicer
发明人： David Burns , James R. Spicer
IPC分类号： F16L59/16
CPC分类号： F16L59/168 , Y10S150/901 , Y10T137/7036
摘要： An insulation jacket for use as a valve cover. The jacket comprises a body portion comprising a central section and two lateral sections. Each of the lateral sections comprises an inboard and outboard belt and each of the belts extends along each of the lateral sections. The ends of each of the belts is adapted to interlock whereby the insulation jacket may be securely fastened around a valve casting.
摘要翻译：用作阀盖的绝缘护套。护套包括主体部分，其包括中心部分和两个横向部分。每个横向部分包括内侧和外侧带，并且每个带沿着每个横向部分延伸。每个带的端部适于互锁，由此绝缘护套可以牢固地固定在阀门铸件周围。

30. 发明授权

US08967597B2 Device for mixing gas into a flowing liquid 有权
标题翻译：用于将气体混入流动液体的装置
公开(公告)号：US08967597B2
公开(公告)日：2015-03-03
申请号：US12991046
申请日：2009-05-08
申请人： David Burns , Jason Yeo , Richard Lonetto
发明人： David Burns , Jason Yeo , Richard Lonetto
IPC分类号： B01F3/04 , B01F5/00
CPC分类号： B01F3/0446 , B01F5/0068
摘要： A device for the mixing of a gas into a liquid comprises a hollow frustum shape housing having a central axis, extended from a small diameter fluid outlet end, defining a fluid outlet opening, to a large diameter end; a liquid inlet port positioned adjacent the large diameter end is formed in said housing which allows delivery of pressurized liquid into said hollow housing, and a helically cut conical member is positioned and affixed within the hollow center of the housing with its axis aligned with that of the hollow frustum shape housing such that fluid delivered into the housing forms a swirling motion around the outside of the conical member as it passes from inlet port to outlet opening. The housing has a gas inlet for delivery of gas to the fluid within the frustum shaped housing at a position adjacent to the fluid outlet opening as the fluid moves from inlet to fluid outlet opening.
摘要翻译：用于将气体混合到液体中的装置包括中空的截头锥形壳体，其中心轴线从限定流体出口的小直径流体出口端延伸到大直径端; 在所述壳体中形成一个邻近大直径端定位的液体入口，其允许将加压液体输送到所述中空壳体中，螺旋切割的圆锥形构件被定位并固定在壳体的中空中心内，其轴线与空心平截头体形状的壳体使得当锥形构件从入口到出口开口时，输送到壳体中的流体围绕锥形构件的外部形成旋转运动。壳体具有气体入口，用于当流体从入口移动到流体出口开口时，在邻近流体出口开口的位置处将天然气输送到截头锥形壳体内的流体。

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