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1. 发明申请

US20070197506A1 Modulators of 11-beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same 有权
标题翻译： 11-β羟基类固醇脱氢酶1型调节剂，其药物组合物及其使用方法
公开(公告)号：US20070197506A1
公开(公告)日：2007-08-23
申请号：US11652191
申请日：2007-01-11
申请人： Wenqing Yao , David Burns , Lihua Chen , Jincong Zhuo , Chunhong He
发明人： Wenqing Yao , David Burns , Lihua Chen , Jincong Zhuo , Chunhong He
IPC分类号： A61K31/55 , A61K31/501 , A61K31/497 , A61K31/506 , A61K31/4745 , A61K31/4439
CPC分类号： C07D403/04 , C07D207/16 , C07D209/96 , C07D471/10 , C07D487/10
摘要： The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1 and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-β hydroxyl steroid dehydrogenase type 1 such as obesity and diabetes.
摘要翻译：本发明涉及1型11-β羟基类固醇脱氢酶抑制剂及其药物组合物。本发明的化合物可用于治疗与11-β羟基类固醇脱氢酶1（例如肥胖症和糖尿病）的表达或活性相关的各种疾病。

2. 发明授权

US07998959B2 Modulators of 11-β hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same 有权
标题翻译： 11-调制器 1型羟基类固醇脱氢酶，其药物组合物及其使用方法
公开(公告)号：US07998959B2
公开(公告)日：2011-08-16
申请号：US11652191
申请日：2007-01-11
申请人： Wenqing Yao , David M. Burns , Lihua Chen , Jincong Zhuo , Chunhong He
发明人： Wenqing Yao , David M. Burns , Lihua Chen , Jincong Zhuo , Chunhong He
IPC分类号： C07D207/16 , C07D403/04 , A61K31/40 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , A61P27/00
CPC分类号： C07D403/04 , C07D207/16 , C07D209/96 , C07D471/10 , C07D487/10
摘要： The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1 and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-β hydroxyl steroid dehydrogenase type 1 such as obesity and diabetes.
摘要翻译：本发明涉及11-和bgr的抑制剂。羟基类固醇脱氢酶1型及其药物组合物。本发明的化合物可用于治疗与11-bgr的表达或活性相关的各种疾病; 羟基类固醇脱氢酶1型，如肥胖和糖尿病。

3. 发明申请

US20140155404A1 PIPERAZINYLPIPERIDINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS 有权
标题翻译：作为化合物受体拮抗剂的哌嗪衍生物
公开(公告)号：US20140155404A1
公开(公告)日：2014-06-05
申请号：US14176781
申请日：2014-02-10
申请人： Chu-Biao Xue , Genfeng Cao , Taisheng Huang , Lihua Chen , Ke Zhang , Anlai Wang , David J. Meloni , Rajan Anand , Joseph Glenn , Brian W. Metcalf
发明人： Chu-Biao Xue , Genfeng Cao , Taisheng Huang , Lihua Chen , Ke Zhang , Anlai Wang , David J. Meloni , Rajan Anand , Joseph Glenn , Brian W. Metcalf
IPC分类号： C07D401/14 , C07D417/14 , A61K31/496 , C07D471/04 , A61K31/506 , A61K31/502
CPC分类号： C07D401/14 , A61K31/496 , A61K31/502 , A61K31/506 , A61K45/06 , C07D401/06 , C07D417/14 , C07D471/04 , A61K2300/00
摘要： The present invention relates to compounds of Formula I: wherein variable substituents are defined herein, that modulate the activity of or bind to chemokine receptors such as CCR5. In some embodiments, the compounds of the invention are selective for CCR5. The compounds can be used, for example, to treat diseases associated with chemokine receptor expression or activity such as inflammatory diseases, immune diseases and viral infections.
摘要翻译：本发明涉及式I化合物：其中可变取代基在本文中定义，其调节趋化因子受体如CCR5的活性或与其结合。在一些实施方案中，本发明的化合物对CCR5是选择性的。该化合物可用于例如治疗与趋化因子受体表达或活性相关的疾病，例如炎性疾病，免疫疾病和病毒感染。

4. 发明申请

US20110214464A1 BIOCONTROL STRAIN AGAINST THE WILT OF CONTINUOUS CROPPING CUCUMBER AND WATERMELON AND ITS MICROBIAL ORGANIC FERTILIZER 审中-公开
标题翻译：生物农杆菌菌株对连续作物CUCUMBER和WATERMELON及其微生物有机肥的威胁
公开(公告)号：US20110214464A1
公开(公告)日：2011-09-08
申请号：US12747510
申请日：2009-11-23
申请人： Qirong Shen , Lihua Chen , Xingming Yang , Yangchun Xu , Wei Ran , Qiwei Huang , Biao Shen
发明人： Qirong Shen , Lihua Chen , Xingming Yang , Yangchun Xu , Wei Ran , Qiwei Huang , Biao Shen
IPC分类号： C05F11/08 , C12N1/14
CPC分类号： C05F11/08 , A01N63/00 , A01N63/04 , C12N1/14 , C12R1/885 , Y02W30/43
摘要： The present invention relates to a biocontrol strain against the wilt of continuous cropping cucumber and watermelon as well as its microbial organic fertilizer, which belongs to the technology for agricultural intensive production. The present invention separates Trichoderma harzianum SQR-T037, which has a remarkable biocontrol effect against wilt of cucumber and watermelon. Microbial organic fertilizer was produced from this biocontrol strain and organic compost. In this fertilizer, the content of the strain is above 1×108 cfu/g, the content of total nitrogen is 3˜5% (above 90% of the nitrogen is organic nitrogen), total nitrogen-phosphorus-kalium nutrient is 6˜10% and organic matter is 30˜35%. As indicated by the experiments, after this microbial organic fertilizer is applied to soil, it will enable rapid multiplication of biocontrol strain into a dominant microflora in the soil and achieve more than 85% of biocontrol rate of wilt in the soil suffering from serious cucumber and watermelon wilt. If this microbial organic fertilizer is applied to the soil without continuous cropping obstacle for a long time, its controlling rate of cucumber and watermelon wilt will be above 80%.
摘要翻译：本发明涉及连作黄瓜，西瓜枯萎病菌及其微生物有机肥的生物防治菌株，属于农业密集生产技术。本发明分离了哈茨木霉SQR-T037，对黄瓜和西瓜的枯萎具有显着的生物防治作用。该生物防治菌株和有机堆肥生产微生物有机肥。在该肥料中，菌株的含量高于1×10 8 cfu / g，总氮含量为3〜5％（氮有机氮的90％以上），总氮磷钾营养为6〜 10％，有机质为30〜35％。实验表明，将微生物有机肥施用于土壤后，能够将生物防治菌株快速繁殖为土壤中的主要微生物群落，在黄瓜和黄瓜的土壤中达到85％以上的枯萎病防治率西瓜枯萎。如果这种微生物有机肥长期施用于土壤，而不会产生连续的作物障碍，黄瓜和西瓜枯萎病的防治率将达到80％以上。

5. 发明授权

US07294624B2 Barbituric acid derivatives as inhibitors of TNF-α converting enzyme (TACE) and/or matrix metalloproteinases 有权
标题翻译：巴比妥酸衍生物作为TNF-α转化酶（TACE）和/或基质金属蛋白酶的抑制剂
公开(公告)号：US07294624B2
公开(公告)日：2007-11-13
申请号：US10321144
申请日：2002-12-17
申请人： Jingwu Duan , Bin Jiang , Lihua Chen , Zhonghui Lu , Joseph Barbosa , William J. Pitts
发明人： Jingwu Duan , Bin Jiang , Lihua Chen , Zhonghui Lu , Joseph Barbosa , William J. Pitts
IPC分类号： A01N43/58 , A61K31/50 , C07D237/00 , C07D239/02
CPC分类号： C07D239/54 , C07D239/62 , C07D239/70 , C07D401/12 , C07D403/12 , C07D417/12 , C07D471/10 , C07D487/10 , C07D491/10
摘要： The present application describes novel barbituric acid derivatives of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, L, R1, R2, R3, R4, R5, n, W, U, X, Y, Z, Ua, Xa, Ya, and Za are defined in the present specification, which are useful as TNF-α converting enzyme (TACE) and matrix metalloproteinases (MMP) inhibitors.
摘要翻译：本申请描述了式I的新型巴比妥酸衍生物或其药学上可接受的盐或前药形式，其中A，B，L，R 1，R 2， R 4，R 4，R 5，n，W，U，X，Y，Z，U a，在本说明书中定义，其可用作TNF-α转化酶（TACE）和/或基质金属蛋白酶（MMP）抑制剂。

6. 外观设计

USD851805S1 LED lighting 有权
公开(公告)号：USD851805S1
公开(公告)日：2019-06-18
申请号：US29638581
申请日：2018-02-27
申请人： Lihua Chen
设计人： Lihua Chen
摘要： FIG. 1 is a front perspective view of a LED lighting showing my new design;
FIG. 2 is a rear perspective view thereof;
FIG. 3 is a front elevational view thereof;
FIG. 4 is a left side elevational view thereof;
FIG. 5 is an enlarged top view thereof; and,
FIG. 6 is an enlarged bottom view thereof.
The broken lines in the drawings illustrate portions of the LED Lighting which forms no part of the claimed design.

7. 发明授权

US09190896B2 PWM strategy for reduction of inverter hotspot temperature and overall losses 有权
标题翻译：降低逆变器热点温度和总体损耗的PWM策略
公开(公告)号：US09190896B2
公开(公告)日：2015-11-17
申请号：US13234684
申请日：2011-09-16
申请人： Lihua Chen , Chingchi Chen , Michael W. Degner , Shahram Zarei
发明人： Lihua Chen , Chingchi Chen , Michael W. Degner , Shahram Zarei
IPC分类号： H02P1/04 , G05B11/28 , H02P27/04 , H02M1/32 , B60L3/00 , B60L11/00 , B60L11/14 , B60L11/18 , B60L15/00 , B60L15/20 , H02P27/08 , H02P29/00 , H02P29/02 , H02M7/5387 , H02M1/00
CPC分类号： H02M1/32 , B60L3/003 , B60L11/005 , B60L11/14 , B60L11/1887 , B60L15/007 , B60L15/2009 , B60L2210/40 , B60L2220/14 , B60L2240/423 , B60L2240/525 , B60L2240/527 , B60L2240/529 , H02M7/53871 , H02M2001/0054 , H02M2001/327 , H02P27/085 , H02P29/027 , H02P29/68 , Y02T10/644 , Y02T10/645 , Y02T10/70 , Y02T10/7022 , Y02T10/7077 , Y02T10/7241 , Y02T10/7275 , Y02T10/92 , Y02T90/34
摘要： A PWM strategy can be implemented to reduce device power losses and hotspot temperature in an inverter circuit that drives a synchronous motor. A method includes migrating a phase current from a power device with higher losses to a power device with lower losses. A PWM modulation signal can be modified to alter the inverter duty cycle and migrate phase current in the direction of lower losses. As an example, a PWM reference signal can be shifted to a lower value. A PWM loss reduction strategy can be performed while a motor is in a rotor-lock state to reduce device hotspot temperature. The PWM loss reduction strategy can also be performed when a motor is operating in a normal state, pushing PWM to DPWM, reducing switching and overall losses. The strategy can be practiced while a PMSM is operating as a motor, and can also be practiced during regenerative braking.
摘要翻译：可以实现PWM策略，以减少驱动同步电机的逆变器电路中的器件功率损耗和热点温度。一种方法包括将具有较高损耗的功率器件的相电流迁移到具有较低损耗的功率器件。可以修改PWM调制信号以改变反相器占空比，并在较低损耗的方向上迁移相电流。作为示例，PWM参考信号可以被移位到较低的值。当电机处于转子锁定状态以减少器件热点温度时，可以执行PWM损耗降低策略。当电机工作在正常状态时，也可以执行PWM损耗降低策略，将PWM推向DPWM，降低开关损耗和总体损耗。当PMSM作为电动机操作时，可以实施该策略，并且还可以在再生制动期间实施。

8. 发明申请

US20140292347A1 Low Cost Circuit to Detect Faults of ISC Outputs and/or HV Bus Shorted to Chassis 审中-公开
标题翻译：低成本电路检测ISC输出和/或HV总线短路到底盘的故障
公开(公告)号：US20140292347A1
公开(公告)日：2014-10-02
申请号：US13851439
申请日：2013-03-27
申请人： Lihua Chen
发明人： Lihua Chen
IPC分类号： G01R31/02 , G01R31/00
CPC分类号： B60L3/0069 , B60L3/04 , B60L15/007 , B60L50/40 , B60L50/51 , B60L2220/14 , Y02T10/645 , Y02T10/7005 , Y02T10/7022
摘要： A low cost fault detection and protection method and embodiment circuit can detect short circuit faults between an inverter system control (ISC) circuit outputs and a chassis, an electrical machine winding and a chassis, and a DC bus and a chassis. A fault protection unit (FPU) can monitor chassis voltage with respect to a DC bus to detect the presence of a short circuit fault, and provide status output indication of whether a fault is detected. By way of example, an FPU can include a window detector and a signal transmitter. An FPU can provide status output to an ISC controller configured to terminate ISC operation when any of the aformentioned faults is present, thereby preventing damage to devices contained in the ISC circuit.
摘要翻译：低成本故障检测保护方法和实施例电路可以检测逆变器系统控制（ISC）电路输出与底盘，电机绕组和底盘以及直流总线和机箱之间的短路故障。故障保护单元（FPU）可以监视相对于直流总线的机箱电压，以检测是否存在短路故障，并提供是否检测到故障的状态输出指示。作为示例，FPU可以包括窗口检测器和信号发射器。当存在任何上述故障时，FPU可以向被配置为终止ISC操作的ISC控制器提供状态输出，从而防止对包含在ISC电路中的设备的损坏。

9. 发明申请

US20120295912A1 PIPERAZINYLPIPERIDINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS 有权
标题翻译：作为化合物受体拮抗剂的哌嗪衍生物
公开(公告)号：US20120295912A1
公开(公告)日：2012-11-22
申请号：US13564434
申请日：2012-08-01
申请人： Chu-Biao Xue , Ganfeng Cao , Taisheng Huang , Lihua Chen , Ke Zhang , Anlai Wang , David Meloni , Rajan Anand , Joseph Glenn , Brian W. Metcalf
发明人： Chu-Biao Xue , Ganfeng Cao , Taisheng Huang , Lihua Chen , Ke Zhang , Anlai Wang , David Meloni , Rajan Anand , Joseph Glenn , Brian W. Metcalf
IPC分类号： A61K31/506 , A61K31/496 , A61P29/00 , C12N5/071 , A61P31/12 , A61P31/18 , A61P37/06 , A61K31/502 , A61P37/00
CPC分类号： C07D401/14 , A61K31/496 , A61K31/502 , A61K31/506 , A61K45/06 , C07D401/06 , C07D417/14 , C07D471/04 , A61K2300/00
摘要： The present invention relates to compounds of Formula I: wherein variable substituents are defined herein, that modulate the activity of or bind to chemokine receptors such as CCR5. In some embodiments, the compounds of the invention are selective for CCR5. The compounds can be used, for example, to treat diseases associated with chemokine receptor expression or activity such as inflammatory diseases, immune diseases and viral infections.
摘要翻译：本发明涉及式I化合物：其中可变取代基在本文中定义，其调节趋化因子受体如CCR5的活性或与其结合。在一些实施方案中，本发明的化合物对CCR5是选择性的。该化合物可用于例如治疗与趋化因子受体表达或活性相关的疾病，例如炎性疾病，免疫疾病和病毒感染。

10. 发明授权

US07678798B2 Piperazinylpiperidine derivatives as chemokine receptor antagonists 有权
标题翻译：哌嗪基哌啶衍生物作为趋化因子受体拮抗剂
公开(公告)号：US07678798B2
公开(公告)日：2010-03-16
申请号：US11104041
申请日：2005-04-12
申请人： Chu-Biao Xue , Ganfeng Cao , Taisheng Huang , Lihua Chen , Ke Zhang , Anlai Wang , David Meloni , Rajan Anand , Joseph Glenn , Brian W. Metcalf
发明人： Chu-Biao Xue , Ganfeng Cao , Taisheng Huang , Lihua Chen , Ke Zhang , Anlai Wang , David Meloni , Rajan Anand , Joseph Glenn , Brian W. Metcalf
IPC分类号： A61K31/497 , C07D247/02 , A61K31/496 , A61P29/00 , C07D237/28 , C07D487/00 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D411/04 , C07D413/04 , C07D417/04 , C07D419/04 , C07D241/04 , C07D277/22 , C07D307/78 , C07D303/08 , C07C49/297 , C07C33/46
CPC分类号： C07D401/14 , A61K31/496 , A61K31/502 , A61K31/506 , A61K45/06 , C07D401/06 , C07D417/14 , C07D471/04 , A61K2300/00
摘要： The present invention relates to compounds of Formula I: wherein variable substituents are defined herein, that modulate the activity of or bind to chemokine receptors such as CCR5. In some embodiments, the compounds of the invention are selective for CCR5. The compounds can be used, for example, to treat diseases associated with chemokine receptor expression or activity such as inflammatory diseases, immune diseases and viral infections.
摘要翻译：本发明涉及式I化合物：其中可变取代基在本文中定义，其调节趋化因子受体如CCR5的活性或与其结合。在一些实施方案中，本发明的化合物对CCR5是选择性的。该化合物可用于例如治疗与趋化因子受体表达或活性相关的疾病，例如炎性疾病，免疫疾病和病毒感染。

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