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    • 23. 发明申请
    • Heterocyclic boronic acid compounds
    • 杂环硼酸化合物
    • US20070060547A1
    • 2007-03-15
    • US10514575
    • 2004-11-12
    • David CampbellDavid WinnJuan Betancort
    • David CampbellDavid WinnJuan Betancort
    • C07F5/02A61K31/69
    • C07F5/025
    • Dipeptidyl peptidase IV (DPP-IV)-inhibiting compounds are provided that have formula I: wherein n is 1 to 3; X is CH2; S; O; CF2 or C(CH3)2; Z is H; halogen; hydroxyl; (C1-6)alkoxy; (C1-12)alkyl; (C3-12)cycloalkyl; phenyl; or heteroaryl; where the phenyl and heteroaryl groups are optionally mono- or independently plurisubstituted with R7; optionally, X together with an adjacent ring carbon and Z form a fused cyclopropyl; and optionally, one of the bonds in the ring containing X is a double bond; and CriRii, R1, R1, R3, R4 and R5 are as described herein. Methods for preparing these compounds, and methods for treating diabetes, especially Type II diabetes, and other related diseases are described using the compounds of formula I in pharmaceutical compositions which contain these compounds. Pharmaceutical compositions which contain combinations of these compounds with other antidiabetic agents are also described herein.
    • 提供二肽基肽酶IV(DPP-IV)抑制化合物,其具有式I:其中n为1至3; X是CH 2 2; S; O; CF 2或C(CH 3)2)2。 Z是H; 卤素; 羟; (C 1-6)烷氧基; (C 1-12)烷基; (C 3-12)环烷基; 苯基; 或杂芳基; 其中苯基和杂芳基任选被R7单取代或独立地被二取代; 任选地,X与相邻的环碳一起形成稠合的环丙基; 并且任选地,含有X的环中的一个键是双键; 和R i,R i,R i,R i,R i,R i,R i, R 4和R 5如本文所述。 使用含有这些化合物的药物组合物中的式I化合物来描述制备这些化合物的方法,以及治疗糖尿病,特别是II型糖尿病和其它相关疾病的方法。 含有这些化合物与其它抗糖尿病药物的组合的药物组合物也在本文中描述。
    • 25. 发明申请
    • Sealed off building drainage and vent system
    • 密封建筑物排水和排气系统
    • US20060201088A1
    • 2006-09-14
    • US11077460
    • 2005-03-10
    • John SwaffieldDavid Campbell
    • John SwaffieldDavid Campbell
    • E04B1/70E04F17/00
    • E03C1/122E03C1/1225
    • A drainage and ventilation system for a building is provided which includes two or more stacks which communicate fluid therein. The stacks are connected to a sewer for discharging liquid thereto, with at least one of the stacks having a discharge source for delivering liquid to a wet stack portion of that stack. A trap is positioned between the wet stack portion and the discharge source for inhibiting the passage of gas therethrough. The stacks are interconnected at an upper end thereof by a connecting member such as a connecting pipe or manifold, whereby air may be communicated between the stacks. An air admittance valve and a positive air pressure attenuation device are located above the connecting member, whereby air may be introduced into the stacks to compensate for entrained air moving with the liquid into the sewer, and air may be accumulated during increased pressure events, both helping to preserve trap seal integrity without releasing foul air into the surrounding environment.
    • 提供了一种用于建筑物的排水和通风系统,其包括两个或更多个在其中连通流体的堆叠。 堆叠件连接到用于将液体排出的下水道,其中至少一个堆叠具有用于将液体输送到该堆叠的湿堆叠部分的排放源。 陷阱位于湿堆叠部分和排放源之间,用于阻止气体通过其中。 这些堆叠在其上端通过诸如连接管或歧管的连接构件互连,由此空气可以在堆叠之间连通。 空气导纳阀和正空气压力衰减装置位于连接构件上方,由此空气可以被引入到堆叠中以补偿随液体进入下水道的夹带空气,并且在增加的压力事件期间可以积聚空气 有助于保持陷阱密封完整性,而不会将恶臭空气释放到周围环境中。
    • 28. 发明申请
    • Method of computerized monitoring of investment trading and associated system
    • 投资交易及相关制度计算机化监控方法
    • US20050273418A1
    • 2005-12-08
    • US10861261
    • 2004-06-04
    • David Campbell
    • David Campbell
    • G06Q40/00G06F17/60
    • G06Q40/04G06Q10/063G06Q10/0639G06Q40/02G06Q40/06
    • A method of computerized monitoring of investment trading includes providing historic trading data for a specific trader, selecting a plurality of trading parameters for the specific trader and obtaining current information regarding the selected parameters, and/or providing historic trading data and applying rules to the current information and/or historic trading data to determine if behavior of interest which may involve a rules violation, a departure from the rules which is not technically a violation or a potential departure from the rules which might make desirable further investigation has occurred. The system may be employed to monitor whether market timing of mutual fund investments has occurred. A corresponding computerized system is disclosed.
    • 投资交易的计算机化监控的方法包括为特定交易者提供历史交易数据,为特定交易者选择多个交易参数并获得关于所选参数的当前信息,和/或提供历史交易数据并将规则应用于当前 信息和/或历史交易数据,以确定可能涉及规则违规的利益行为,偏离技术上不属于违规行为的规则或潜在偏离可能进行理想进一步调查的规则。 该制度可用于监测共同基金投资的市场时机是否发生。 公开了相应的计算机化系统。
    • 30. 发明申请
    • Dispensing device using multiple gas cartridges
    • 点胶装置使用多个气瓶
    • US20050230434A1
    • 2005-10-20
    • US10828105
    • 2004-04-20
    • David CampbellAllen Brelsford
    • David CampbellAllen Brelsford
    • B67D7/60B05C17/01B05C17/015B67B7/00
    • B05C17/0146B05C17/015
    • A manifold includes a plurality of inlet passages provided in fluid communication between an inlet and an outlet passage. A housing retains a pressurized gas cartridge in sealed fluid communication with each of the inlet passages. A check valve is located in at least one of the inlet passages. The check valve is biased to a closed position that prevents gas from flowing through the check valve to the inlet of the inlet passage. Thus, gas cannot exit through the inlet when a pressurized gas cartridge is not sealed thereto. The housing retains a viscous product cartridge and forms a gas enclosure separated from a product enclosure by a movable wall. The gas from the pressurized gas cartridges passes into the gas enclosure and generates a force on the movable wall to dispense product from the product cartridge.
    • 歧管包括设置成在入口和出口通道之间流体连通的多个入口通道。 壳体保持与每个入口通道密封的流体连通的加压气体盒。 止回阀位于至少一个入口通道中。 止回阀被偏压到关闭位置,以防止气体流过止回阀到入口通道的入口。 因此,当加压气瓶未被密封到其中时,气体不能通过入口排出。 壳体保持粘稠的产品盒,并形成一个通过活动壁与产品外壳隔开的气体外壳。 来自加压气瓶的气体进入气体外壳,并在可移动壁上产生一个力,从产品盒中分配产品。