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1. 发明申请

US20070299036A1 PYRROLIDINE COMPOUNDS AND METHODS FOR SELECTIVE INHIBITION OF DIPEPTIDYL PEPTIDASE-IV 有权
标题翻译：吡咯啉化合物和选择性抑制DIPEPTIDYL PEPTIDASE-IV的方法
公开(公告)号：US20070299036A1
公开(公告)日：2007-12-27
申请号：US11833063
申请日：2007-08-02
申请人： David Campbell , David Winn , Juan Betancort
发明人： David Campbell , David Winn , Juan Betancort
IPC分类号： A61K31/69 , A61P3/10 , C12N9/99
CPC分类号： C07F5/025
摘要： The present invention is directed to a method of treatment of a malcondition that can be regulated or normalized via inhibition of DPP-IV. The method involves administration of an effective amount of a pyrrolidine compound of the invention, such as would be present in a pharmaceutical composition of the invention, to mammals, especially humans, to affect a malcondition that can be regulated or normalized via inhibition of DPP-IV.
摘要翻译：本发明涉及一种通过抑制DPP-IV来调节或归一化的病症的方法。该方法包括将有效量的本发明的吡咯烷化合物（例如将存在于本发明的药物组合物中）施用于哺乳动物，特别是人，以影响可通过抑制DPP-1调节或归一化的病症，四，

2. 发明申请

US20070060547A1 Heterocyclic boronic acid compounds 失效
标题翻译：杂环硼酸化合物
公开(公告)号：US20070060547A1
公开(公告)日：2007-03-15
申请号：US10514575
申请日：2004-11-12
申请人： David Campbell , David Winn , Juan Betancort
发明人： David Campbell , David Winn , Juan Betancort
IPC分类号： C07F5/02 , A61K31/69
CPC分类号： C07F5/025
摘要： Dipeptidyl peptidase IV (DPP-IV)-inhibiting compounds are provided that have formula I: wherein n is 1 to 3; X is CH2; S; O; CF2 or C(CH3)2; Z is H; halogen; hydroxyl; (C1-6)alkoxy; (C1-12)alkyl; (C3-12)cycloalkyl; phenyl; or heteroaryl; where the phenyl and heteroaryl groups are optionally mono- or independently plurisubstituted with R7; optionally, X together with an adjacent ring carbon and Z form a fused cyclopropyl; and optionally, one of the bonds in the ring containing X is a double bond; and CriRii, R1, R1, R3, R4 and R5 are as described herein. Methods for preparing these compounds, and methods for treating diabetes, especially Type II diabetes, and other related diseases are described using the compounds of formula I in pharmaceutical compositions which contain these compounds. Pharmaceutical compositions which contain combinations of these compounds with other antidiabetic agents are also described herein.
摘要翻译：提供二肽基肽酶IV（DPP-IV）抑制化合物，其具有式I：其中n为1至3; X是CH 2 2; S; O; CF 2或C（CH 3）2）2。 Z是H; 卤素; 羟; （C 1-6）烷氧基; （C 1-12）烷基; （C 3-12）环烷基; 苯基; 或杂芳基; 其中苯基和杂芳基任选被R7单取代或独立地被二取代; 任选地，X与相邻的环碳一起形成稠合的环丙基; 并且任选地，含有X的环中的一个键是双键; 和R i，R i，R i，R i，R i，R i，R i， R 4和R 5如本文所述。使用含有这些化合物的药物组合物中的式I化合物来描述制备这些化合物的方法，以及治疗糖尿病，特别是II型糖尿病和其它相关疾病的方法。含有这些化合物与其它抗糖尿病药物的组合的药物组合物也在本文中描述。

3. 发明申请

US20060276410A1 COMPOUNDS AND METHODS FOR SELECTIVE INHIBITION OF DIPEPTIDYL PEPTIDASE-IV 失效
标题翻译：选择性抑制DIPEPTIDYL PEPTIDASE-IV的化合物和方法
公开(公告)号：US20060276410A1
公开(公告)日：2006-12-07
申请号：US11420273
申请日：2006-05-25
申请人： David Campbell , David Winn , Juan Betancort
发明人： David Campbell , David Winn , Juan Betancort
IPC分类号： A61K38/04 , C07F5/02 , A61K31/69
CPC分类号： C07F5/025
摘要： Compounds that selectively inhibit dipeptidyl peptidase-IV over closely related dipeptidyl peptidases are those of Formula (I): as well as pharmaceutically acceptable salts thereof, cyclic isomers thereof, prodrugs thereof, and solvates thereof, where all the variables are defined herein. These compounds can be used, alone or in combination with other drugs, for the treatment of diabetes and related diseases.
摘要翻译：选择性抑制二肽基肽酶-IV超过密切相关的二肽基肽酶的化合物是式（I）的化合物：及其药学上可接受的盐，其环状异构体，其前药和溶剂合物，其中所有变量均在本文中定义。这些化合物可以单独使用或与其他药物组合使用，用于治疗糖尿病和相关疾病。

4. 发明授权

US07923433B2 Activity-based probes and methods of their preparation and use 有权
标题翻译：基于活性的探针及其制备和使用方法
公开(公告)号：US07923433B2
公开(公告)日：2011-04-12
申请号：US10530646
申请日：2003-10-08
申请人： David Winn , David Alan Campbell
发明人： David Winn , David Alan Campbell
IPC分类号： A61K38/05
CPC分类号： C07D311/90 , C07D311/82 , C12Q1/37
摘要： The present invention provides compositions and methods for assessing profiles of catalytically active enzymes in compositions containing a plurality of proteins. In preferred embodiments, the enzyme is a hydrolase, most preferably a cysteine protease. The methods described herein use activity based probes (“ABPs”) that have an affinity moiety for directing the binding of the ABP to one or more catalytically active target enzymes, a reactive group for forming a covalent bond at an active site of the target enzyme(s), and a TAG (e.g., a detectable label, preferably a fluorophore). One or more ABPs may be combined with a protein-containing sample under conditions for binding and reaction of the ABP(s) with target enzyme(s) that are present in the sample. The resulting products may then be used to assess the active enzyme profile of the sample, and can be correlated to the presence, amount, or activity of one or more target enzyme(s) present in the original complex protein mixture.
摘要翻译：本发明提供了用于在含有多种蛋白质的组合物中评估催化活性酶的谱的组合物和方法。在优选的实施方案中，酶是水解酶，最优选半胱氨酸蛋白酶。本文描述的方法使用具有亲和部分的活性基探针（“ABP”），该亲和部分用于引导ABP与一种或多种催化活性靶酶的结合，用于在靶酶的活性位点形成共价键的反应性基团（例如，可检测标记，优选荧光团）。可以在ABP与样品中存在的目标酶的结合和反应的条件下，将一种或多种ABP与含蛋白质的样品组合。然后可以将所得产物用于评估样品的活性酶谱，并且可与存在于原始复合蛋白混合物中的一种或多种目标酶的存在，量或活性相关。

5. 发明授权

US07312779B1 Method of color calibration for transmissive displays 有权
标题翻译：透射显示器颜色校准方法
公开(公告)号：US07312779B1
公开(公告)日：2007-12-25
申请号：US10670084
申请日：2003-09-23
申请人： David Winn Blevins
发明人： David Winn Blevins
IPC分类号： G09G3/36
CPC分类号： G09G3/3413 , G09G3/2003 , G09G3/3696 , G09G2320/0646 , G09G2320/0693 , G09G2360/144
摘要： A transmissive display system is calibrated by applying DAC values for a target color and noting the color displayed on the screen. The displayed color is compared to the target color in high and low ambient light levels to determine if it is within a specified tolerance of the target color. Should the displayed color not be within the tolerance range, a calibration procedure is launched for both the high and low light levels which establishes new DAC values and backlight levels for accurate target color presentation on the screen over a wide dynamic range of input signal levels.
摘要翻译：通过对目标颜色应用DAC值并注意屏幕上显示的颜色来校准透射显示系统。将所显示的颜色与高和低环境光级别中的目标颜色进行比较，以确定其是否在目标颜色的指定容差范围内。如果所显示的颜色不在公差范围内，则会在高和低亮度级别上启动校准程序，以建立新的DAC值和背光级别，以便在宽的动态范围的输入信号电平下在屏幕上精确的目标色彩呈现。

6. 发明申请

US20090069186A1 FORMULATIONS 审中-公开
标题翻译：配方
公开(公告)号：US20090069186A1
公开(公告)日：2009-03-12
申请号：US11908994
申请日：2006-03-10
申请人： Ian Malcolm Shirley , Alexander Mark Heming , Peter David Winn
发明人： Ian Malcolm Shirley , Alexander Mark Heming , Peter David Winn
IPC分类号： A01N25/00 , A01P3/00 , A01P13/00
CPC分类号： B01F17/00 , A01N25/30
摘要： A dispersion comprising a discontinuous phase of solid particles or liquid droplets in a liquid continuous phase; a polymeric dispersant having a segment soluble in the continuous phase and a segment insoluble in the continuous phase; and a network around the solid particles or liquid droplets of the discontinuous phase formed by cross-linking of the polymeric dispersant; where the cross-linking is between segments that are soluble in the continuous phase.
摘要翻译：包含在液体连续相中的固体颗粒或液滴的不连续相的分散体; 具有可溶于连续相的链段和不可溶于连续相的链段的聚合物分散剂; 以及围绕通过聚合物分散剂的交联形成的不连续相的固体颗粒或液滴的网络; 其中交联在可溶于连续相的链段之间。

7. 发明申请

US20070185061A1 HETEROCYCLIC BORONIC ACID COMPOUNDS 审中-公开
标题翻译：杂环硼酸化合物
公开(公告)号：US20070185061A1
公开(公告)日：2007-08-09
申请号：US11556944
申请日：2006-11-06
申请人： David Campbell , David Winn , Juan Betancort , Kevin Shreder , Yi Hu , Bei Li , Melissa Wong , Lifu Ma , William Ripka , Min Wu
发明人： David Campbell , David Winn , Juan Betancort , Kevin Shreder , Yi Hu , Bei Li , Melissa Wong , Lifu Ma , William Ripka , Min Wu
IPC分类号： A61K31/69 , C07F5/02
CPC分类号： C07F5/025
摘要： Dipeptidyl peptidase IV (DPP-IV)-inhibiting compounds are provided that have formula I: wherein n is 1 to 3; X is CH2; S; O; CF2 or C(CH3)2; Z is H; halogen; hydroxyl; (C1-6)alkoxy; (C1-12)alkyl; (C3-12)cycloalkyl; phenyl; or heteroaryl; where the phenyl and heteroaryl groups are optionally mono- or independently plurisubstituted with R7; optionally, X together with an adjacent ring carbon and Z form a fused cyclopropyl; and optionally, one of the bonds in the ring containing X is a double bond; and CRiRii, R1, R2, R3, R4 and R5 are as described herein.
摘要翻译：提供二肽基肽酶IV（DPP-IV）抑制化合物，其具有式I：其中n为1至3; X是CH 2 2; S; O; CF 2或C（CH 3）2）2。 Z是H; 卤素; 羟; （C 1-6）烷氧基; （C 1-12）烷基; （C 3-12）环烷基; 苯基; 或杂芳基; 其中苯基和杂芳基任选被R 7独立或独立地取代; 任选地，X与相邻的环碳一起形成稠合的环丙基; 并且任选地，含有X的环中的一个键是双键; 和R 1，R 2，R 2，R 3，R 3， R 4和R 5如本文所述。

8. 发明申请

US20050200205A1 On-site power generation system with redundant uninterruptible power supply 审中-公开
标题翻译：具有冗余不间断电源的现场发电系统
公开(公告)号：US20050200205A1
公开(公告)日：2005-09-15
申请号：US11048621
申请日：2005-01-31
申请人： David Winn , Alfredo Hernandez , Gary Carr
发明人： David Winn , Alfredo Hernandez , Gary Carr
IPC分类号： H02J9/00 , H02K7/02 , H02P11/00
CPC分类号： H02J9/062 , H02J3/42 , H02J9/066 , H02J9/08 , Y10T307/615
摘要： Disclosed is a method and system for providing constant critical AC electrical load with primary, secondary, and in some cases a tertiary source of power with higher reliability and lower operating and capital costs and lower emissions than the traditional utility supply, uninterruptible power supply (UPS), and battery primary power source, and diesel generator back-up systems that are predominately used today. Specifically, the disclosed system utilizes on-site power generation to provide primary power and includes full utility and UPS/DC storage back-up systems.
摘要翻译：公开了一种方法和系统，用于在传统的公用电源，不间断电源（UPS）中提供具有较高可靠性和更低运行和资本成本以及更低排放的三次电源的一次，二次和三次电源，）和电池一次电源，以及今天主要使用的柴油发电机备用系统。具体地说，所公开的系统利用现场发电来提供一次电力，并且包括完整的公用事业和UPS / DC存储备用系统。

9. 发明授权

US06305406B1 Spray hood protector in a fluid-based cooling system 失效
标题翻译：基于流体的冷却系统中的喷雾保护罩
公开(公告)号：US06305406B1
公开(公告)日：2001-10-23
申请号：US09089333
申请日：1998-06-02
申请人： Lennart Ståhl , John Francis Wallace, Jr. , John Cardenas Parraz , Montford Henry Clark , David Winn
发明人： Lennart Ståhl , John Francis Wallace, Jr. , John Cardenas Parraz , Montford Henry Clark , David Winn
IPC分类号： F28F2700
CPC分类号： H05K7/20345 , Y10T137/5762 , Y10T137/7306
摘要： A spray hood device for containing a fluid spray leak in a fluid-based cooling system. A cover member surrounds a given component subject to a fluid spray leak, containing fluid sprays, preventing the fluid sprays from reaching equipment therebelow and minimizing fluid leakage damage.
摘要翻译：一种用于在基于流体的冷却系统中容纳流体喷射泄漏的喷雾罩装置。覆盖构件围绕给定的部件受到流体喷射泄漏的影响，其包含流体喷雾，防止流体喷雾到达其下的设备并且最小化流体泄漏损坏。

10. 发明授权

US6034873A System and method for separating air flows in a cooling system 失效
标题翻译：用于在冷却系统中分离空气流的系统和方法
公开(公告)号：US6034873A
公开(公告)日：2000-03-07
申请号：US88981
申请日：1998-06-02
申请人： Lennart St.ang.hl , John Francis Wallace, Jr. , John Carlenas Parraz , Montford Henry Clark , David Winn
发明人： Lennart St.ang.hl , John Francis Wallace, Jr. , John Carlenas Parraz , Montford Henry Clark , David Winn
IPC分类号： H05K7/20
CPC分类号： H05K7/20745
摘要： A cooling system and method employing separation chutes and baffles is disclosed. The separation chutes separate the cooled air descending from a heat exchanger positioned above heat-generating equipment in an equipment room from heated air ascending from the heat-generating equipment. Separation of the airflows reduces turbulence and increases cooling efficiencies. The separation chutes are made of a variety of materials, both rigid and flexible, for a variety of applications.
摘要翻译：公开了一种使用分离槽和挡板的冷却系统和方法。分离槽将从设置在发电设备上方的发热设备上方的热交换器下降的冷却空气与从发热设备上升的加热空气分离。气流的分离减少了湍流并提高了冷却效率。分离滑道由各种材料制成，既可以是刚性又可以灵活的，用于各种应用。

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