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21. 发明授权

US08337780B2 Apparatus for demineralizing osteoinductive bone 有权
标题翻译：使骨骼软骨脱矿质的装置
公开(公告)号：US08337780B2
公开(公告)日：2012-12-25
申请号：US12683002
申请日：2010-01-06
申请人： Barton D. Gaskins , Louis Ford , Debra Moore-Smith , Robert K. O'Leary , Anne Wilson , Lloyd Wolfinbarger, Jr.
发明人： Barton D. Gaskins , Louis Ford , Debra Moore-Smith , Robert K. O'Leary , Anne Wilson , Lloyd Wolfinbarger, Jr.
IPC分类号： B01D35/00
CPC分类号： A61L27/3683 , A61K35/32
摘要： The invention is directed to an apparatus for producing demineralized osteoinductive bone. The apparatus demineralizes bone by subjecting bone, including, for example, ground bone, bone cubes, chips, strips, or essentially intact bone, to either a rapid high volume pulsatile acidification wave process or to a rapid continuous acid demineralization process. The pulsatile acidification wave process includes subjecting bone to two or more rapid pulse/drain cycles in which one or more demineralizing acids is rapidly pulsed into a vessel containing bone, and after a desired period of time, is rapidly drained from the vessel. The continuous acid demineralization process includes subjecting bone to a continuous exchange of demineralizing acid solution in which the demineralizing acid solution is recirculated from the container holding the bone through an ion exchange media. Calcium and phosphate are thereby removed from the bone to produce a regenerated acid, and the regenerated acid is returned to the container holding the bone. Both processes allow bone to be rapidly demineralized to a precise and specific desired residual calcium level without sacrificing osteoinductivity.
摘要翻译：本发明涉及一种用于生产去矿物质的骨诱导骨的装置。该装置通过使骨骼（包括例如研磨骨，骨块，切片，条或基本上完整的骨）经受快速高体积的脉动酸化波过程或快速连续的酸脱矿过程来对骨进行软化。脉动酸化波过程包括使骨头进行两个或更多个快速的脉冲/排出循环，其中一个或多个软化酸迅速脉冲进入含有骨的容器中，并且在所需的时间段之后，迅速从容器中排出。连续酸性脱盐过程包括使骨头连续交换软化酸溶液，其中脱矿质酸溶液从容纳骨的容器通过离子交换介质再循环。因此，从骨中除去钙和磷酸盐以产生再生酸，再生酸返回到容纳骨的容器中。两种方法允许骨快速脱矿质至精确和特定的所需残留钙水平而不牺牲骨诱导能力。

22. 发明申请

US20110027871A1 Apparatus for Demineralizing Osteoinductive Bone 有权
标题翻译：骨质疏松矿化仪
公开(公告)号：US20110027871A1
公开(公告)日：2011-02-03
申请号：US12683002
申请日：2010-01-06
申请人： Barton D. Gaskins , Louis Ford , Debra Moore-Smith , Robert K. O'Leary , Anne Wilson , Lloyd Wolfinbarger, JR.
发明人： Barton D. Gaskins , Louis Ford , Debra Moore-Smith , Robert K. O'Leary , Anne Wilson , Lloyd Wolfinbarger, JR.
IPC分类号： C12M1/00
CPC分类号： A61L27/3683 , A61K35/32
摘要： The invention is directed to an apparatus for producing demineralized osteoinductive bone. The apparatus demineralizes bone by subjecting bone, including, for example, ground bone, bone cubes, chips, strips, or essentially intact bone, to either a rapid high volume pulsatile acidification wave process or to a rapid continuous acid demineralization process. The pulsatile acidification wave process includes subjecting bone to two or more rapid pulse/drain cycles in which one or more demineralizing acids is rapidly pulsed into a vessel containing bone, and after a desired period of time, is rapidly drained from the vessel. The continuous acid demineralization process includes subjecting bone to a continuous exchange of demineralizing acid solution in which the demineralizing acid solution is recirculated from the container holding the bone through an ion exchange media. Calcium and phosphate are thereby removed from the bone to produce a regenerated acid, and the regenerated acid is returned to the container holding the bone. Both processes allow bone to be rapidly demineralized to a precise and specific desired residual calcium level without sacrificing osteoinductivity.
摘要翻译：本发明涉及一种用于生产去矿物质的骨诱导骨的装置。该装置通过使骨骼（包括例如研磨骨，骨块，切片，条或基本上完整的骨）经受快速高体积的脉动酸化波过程或快速连续的酸脱矿过程来对骨进行软化。脉动酸化波过程包括使骨头进行两个或更多个快速的脉冲/排出循环，其中一个或多个软化酸迅速脉冲进入含有骨的容器中，并且在所需的时间段之后，迅速从容器中排出。连续酸性脱盐过程包括使骨头连续交换软化酸溶液，其中脱矿质酸溶液从容纳骨的容器通过离子交换介质再循环。因此，从骨中除去钙和磷酸盐以产生再生酸，再生酸返回到容纳骨的容器中。两种方法允许骨快速脱矿质至精确和特定的所需残留钙水平而不牺牲骨诱导能力。

23. 发明申请

US20110015757A1 Plasticized Bone and Soft Tissue Grafts and Methods of Making and Using Same 有权
标题翻译：增塑骨和软组织移植物及其制备和使用方法
公开(公告)号：US20110015757A1
公开(公告)日：2011-01-20
申请号：US12701634
申请日：2010-02-08
申请人： Lloyd Wolfinbarger, JR. , Robert K. O'Leary , Billy G. Anderson
发明人： Lloyd Wolfinbarger, JR. , Robert K. O'Leary , Billy G. Anderson
IPC分类号： A61F2/28 , A61F2/02 , B05D7/00
CPC分类号： A61L27/362 , A61F2/02 , A61F2/4644 , A61F2002/2825 , A61F2002/2835 , A61F2002/2839 , A61F2002/30535 , A61F2002/4646 , A61F2002/4649 , A61F2250/0058 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/502 , A61L2430/02
摘要： The present invention provides a plasticized dehydrated or freeze-dried bone and/or soft tissue product that does not require special conditions of storage, for example refrigeration or freezing, exhibits materials properties that approximate those properties present in normal hydrated tissue, is not brittle, does not necessitate rehydration prior to clinical implantation and is not a potential source for disease transmission. The invention replaces water in the molecular structure of the bone or soft tissue matrix with one or more plasticizers allowing for dehydration of the tissue, yet not resulting in an increase in brittleness of the plasticized product, and resulting in compressive and/or tensile properties similar to those of normal hydrated bone. Replacement of the chemical plasticizers by water prior to implantation is not required and thus, the dehydrated bone or soft tissue plasticized product can be placed directly into an implant site without significant preparation in the operating room.
摘要翻译：本发明提供一种不需要特殊储存条件（例如冷冻或冷冻）的塑化脱水或冷冻干燥的骨和/或软组织产品，其表现出近似于在正常水合组织中存在的性质的材料性质不脆，在临床植入之前不需要补液，并不是疾病传播的潜在来源。本发明用一种或多种允许组织脱水的增塑剂代替骨或软组织基质的分子结构中的水，但不会导致增塑产品的脆性增加，并且导致压缩和/或拉伸性能类似与正常水合骨的那些。不需要在植入之前用水替代化学增塑剂，因此，脱水的骨或软组织增塑产品可以直接放置在植入部位，而无需在手术室中大量准备。

24. 发明授权

US06926901B2 Suberization of a polymeric sustain release matrix for animal repellancy 失效
标题翻译：用于动物排斥的聚合物维持释放基质的消融
公开(公告)号：US06926901B2
公开(公告)日：2005-08-09
申请号：US10419882
申请日：2003-04-22
申请人： Robert K. O'Leary
发明人： Robert K. O'Leary
IPC分类号： A61K36/896 , A61K35/78
CPC分类号： A01N65/00 , A01N65/40 , A01N65/42 , A01N25/10 , A01N25/24
摘要： The invention is an animal repellant composition containing one or more plant derived toxins, including for example one or more alkaloids isolated from for example, one or more members of the family Narcissus, and optionally containing one or more polymers, including for example one or more bioerodible polymers and/or more non-absorbable polymers. The animal repellant composition is useful for repelling animals from vegetation and for rendering vegetation unpalatable to animals. The invention also includes methods for repelling animals, as well as methods for treating vegetation to render the vegetation unpalatable to animals, such animals including for example, deer, voles, moles, ground hogs, mice, rats, rodents, raccoons, nematodes, larvae, worms, fungi, molds, bacteria, vegetative organisms, and insects. A suberin-polymer-repellant chemical complex and a method for treating damaged vegetation are also disclosed.
摘要翻译：本发明是含有一种或多种植物来源的毒素的动物驱避剂组合物，其包括例如从例如水仙属的一种或多种成分分离的一种或多种生物碱，以及任选地含有一种或多种聚合物，包括例如一种或多种生物可腐蚀聚合物和/或更多不可吸收的聚合物。动物驱避剂组合物可用于从植物排斥动物并使植物对动物不好吃。本发明还包括排斥动物的方法，以及用于处理植物以使动植物变得不可食用的植物的方法，包括例如鹿，动物，鼹鼠，土豆，小鼠，大鼠，啮齿动物，浣熊，线虫，幼虫蠕虫，真菌，霉菌，细菌，营养生物和昆虫。还公开了一种苏维林聚合物驱除剂化合物及其处理受损植被的方法。

25. 发明授权

US06878938B2 High frequency infrared radiation source 失效
公开(公告)号：US06878938B2
公开(公告)日：2005-04-12
申请号：US10620886
申请日：2003-07-16
申请人： Robert K. O'Leary , William Manning , Christopher G. Poirier , David Jacobsen , David Vidal
发明人： Robert K. O'Leary , William Manning , Christopher G. Poirier , David Jacobsen , David Vidal
IPC分类号： G01J3/10 , G01J5/26
CPC分类号： G01J3/108
摘要： A high frequency infrared radiation source including a hermetically sealed chamber with a plasma generating gas therein, a pair of spaced electrodes in the chamber for creating a plasma therebetween, a window in the chamber, and a collimating lens made of infrared radiation transmissive material disposed between the pair of electrodes and the window.

26. 发明授权

US5482854A Growth environment assembly and method of use thereof 失效
标题翻译：生长环境装配及其使用方法
公开(公告)号：US5482854A
公开(公告)日：1996-01-09
申请号：US319348
申请日：1994-10-06
申请人： Robert K. O'Leary , Paul J. LaRocca
发明人： Robert K. O'Leary , Paul J. LaRocca
IPC分类号： C12M3/06 , C12M3/00 , C12M1/24
CPC分类号： C12M23/08 , C12M23/38 , C12M29/04
摘要： A method and assembly for treating living and non-living biological environments with varying doses of fluids in vitro. The assembly comprises a vessel, a closure and a tubular membrane extending from the closure and suspended into the vessel to provide rapid and uniform equilibration of fluids into the vessel. The assembly provides means for carrying out pharmacokinetic and toxicokinetic studies.
摘要翻译：用于在体外用不同剂量的流体处理活的和非生物的生物环境的方法和装置。组件包括容器，封闭件和从封闭件延伸并悬浮到容器中的管状膜，以便使流体快速均匀地平衡到容器中。该组件提供进行药代动力学和毒代动力学研究的手段。

27. 发明授权

US5298222A Process for disinfecting musculoskeletal tissue and tissues prepared thereby 失效
标题翻译：消毒由此制备的肌肉骨骼组织和组织的方法
公开(公告)号：US5298222A
公开(公告)日：1994-03-29
申请号：US391233
申请日：1989-08-09
申请人： Robert K. O'Leary
发明人： Robert K. O'Leary
IPC分类号： A61K31/00 , A61K31/045 , A61L2/00 , A61L27/36 , A61L2/18
CPC分类号： A61L27/36 , A61K31/00 , A61K31/045 , A61L2/0088 , A61L2430/02
摘要： A process for treating musculoskeletal tissue which comprises contacting musculoskeletal tissue with both an effective amount of at least one treating agent selected from the class consisting of antibiotics and disinfectants, and an agent to increase diffusion of the treating agent into the tissue, such as a surfactant or a permeation enhancer. The disinfectant and/or antibiotic function in killing bacteria, vegetative organisms, and viruses (including HIV virus) which may be remaining in the musculoskeletal tissue. A preferred disinfectant is ethanol.
摘要翻译：一种治疗肌肉骨骼组织的方法，其包括将肌肉骨骼组织与有效量的选自抗生素和消毒剂的至少一种治疗剂接触，以及增加治疗剂扩散到组织中的药剂，例如表面活性剂或渗透增强剂。杀死细菌，营养生物和可能存在于肌肉骨骼组织中的病毒（包括HIV病毒）的消毒剂和/或抗生素功能。优选的消毒剂是乙醇。

28. 发明授权

US5290558A Flowable demineralized bone powder composition and its use in bone repair 失效
标题翻译：可流动的软骨骨粉组合物及其在骨修复中的应用
公开(公告)号：US5290558A
公开(公告)日：1994-03-01
申请号：US573458
申请日：1990-08-27
申请人： Robert K. O'Leary , Patrick A. McBrayer
发明人： Robert K. O'Leary , Patrick A. McBrayer
IPC分类号： A61K35/32 , A61L24/00 , A61L27/00 , A61L27/22 , A61L27/36 , A61K47/06 , A61K , A61K47/36
CPC分类号： A61L27/3608 , A61B17/686 , A61B17/82 , A61F2/2803 , A61F2/2846 , A61F2/4644 , A61K35/32 , A61L24/0005 , A61L27/227 , A61L27/365 , A61L27/3683 , A61F2/4455 , A61F2002/2817 , A61F2002/2835 , A61F2002/30075 , A61F2002/302 , A61F2002/30224 , A61F2002/30235 , A61F2002/30261 , A61F2210/0061 , A61F2230/0065 , A61F2230/0069 , A61F2230/0082 , A61L2400/06 , A61L2430/02 , Y10S514/801 , Y10S514/802 , Y10S514/953
摘要： A flowable demineralized bone powder composition is provided for use in surgical bone repair.
摘要翻译：提供可用于外科手术骨修复的可流动的软化骨粉组合物。

29. 发明授权

US4946792A Process for debriding bone 失效
标题翻译：清创骨的方法
公开(公告)号：US4946792A
公开(公告)日：1990-08-07
申请号：US395782
申请日：1989-08-18
申请人： Robert K. O'Leary
发明人： Robert K. O'Leary
IPC分类号： A61L27/36
CPC分类号： A61L27/3608 , A61L27/3683 , A61L2430/40 , Y10S623/923
摘要： Bone is enzymatically debrided prior to undergoing further processing which renders the bone suitable for osteoprosthetic use.
摘要翻译：骨在进行进一步加工之前被酶促清除，这使得骨适合于骨质假体使用。

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