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21. 发明授权

US10710045B2 Capsules containing mammalian cells 有权
公开(公告)号：US10710045B2
公开(公告)日：2020-07-14
申请号：US14375612
申请日：2013-01-31
申请人： Jerome Bibette , Nicolas Atrux-Tallau , Hugo Domejean , Anette Funfak , Nicolas Bremond , Pierre Nassoy , Kevin Alessandri
发明人： Jerome Bibette , Nicolas Atrux-Tallau , Hugo Domejean , Anette Funfak , Nicolas Bremond , Pierre Nassoy , Kevin Alessandri
IPC分类号： G01N33/50 , B01J13/22 , B01J13/08 , B01J13/10
摘要： A capsule containing at least one mammalian cell, includes a liquid core, and at least one external envelope totally encapsulating the liquid core at its periphery, the external envelope including at least one gelled polyelectrolyte and/or a stiffened biopolymer and being able to retain the liquid core when the capsule is immersed in a gas. The present invention further relates to the method for preparing such a capsule, to a method for screening cosmetic active ingredients as well as a culture method using such capsules.

22. 发明授权

US10092506B2 Encapsulation of lipophilic or amphiphilic therapeutic agents in nano-emulsion 有权
公开(公告)号：US10092506B2
公开(公告)日：2018-10-09
申请号：US13058850
申请日：2009-08-14
申请人： Veronique Mourier-Robert , Jerome Bibette , Mathieu Goutayer , Fabrice Navarro y Garcia , Isabelle Texier-Nogues
发明人： Veronique Mourier-Robert , Jerome Bibette , Mathieu Goutayer , Fabrice Navarro y Garcia , Isabelle Texier-Nogues
IPC分类号： A61K9/00 , A61K47/69 , A61K41/00 , A61K9/107 , B82Y5/00
摘要： The present invention relates to a therapeutic agent formulation in the form of a nano-emulsion, comprising a continuous aqueous phase and at least one dispersed oily phase, in which the oily phase comprises further to the therapeutic agent, at least one amphiphilic lipid and at least one solubilizing lipid, and in which the aqueous phase comprises at least one polyalkoxylated cosurfactant.The invention also relates to a preparation method and use of this formulation.

23. 发明申请

US20150017676A1 CAPSULES CONTAINING MAMMALIAN CELLS 审中-公开
标题翻译：含有MAMMALIAN细胞的胶囊
公开(公告)号：US20150017676A1
公开(公告)日：2015-01-15
申请号：US14375612
申请日：2013-01-31
申请人： Jerome Bibette , Nicolas Atrux-Tallau , Hugo Domejean , Annette Funfak , Nicolas Bremond , Pierre Nassoy , Kevin Allessandri
发明人： Jerome Bibette , Nicolas Atrux-Tallau , Hugo Domejean , Annette Funfak , Nicolas Bremond , Pierre Nassoy , Kevin Allessandri
IPC分类号： G01N33/50
摘要： A capsule containing at least one mammalian cell, includes a liquid core, and at least one external envelope totally encapsulating the liquid core at its periphery, the external envelope including at least one gelled polyelectrolyte and/or a stiffened biopolymer and being able to retain the liquid core when the capsule is immersed in a gas. The present invention further relates to the method for preparing such a capsule, to a method for screening cosmetic active ingredients as well as a culture method using such capsules.
摘要翻译：包含至少一个哺乳动物细胞的胶囊包括液芯，以及在其周边完全包封液芯的至少一个外包络，所述外封套包括至少一个胶凝聚电解质和/或加强的生物聚合物，并且能够保持当胶囊浸入气体中时，液芯。本发明还涉及制备这种胶囊的方法，用于筛选化妆品活性成分的方法以及使用这种胶囊的培养方法。

24. 发明申请

US20100284932A1 FLUORESCENT EMULSIONS FOR OPTICAL IMAGING 有权
标题翻译：用于光学成像的荧光乳液
公开(公告)号：US20100284932A1
公开(公告)日：2010-11-11
申请号：US12527314
申请日：2008-02-14
申请人： Mathieu Goutayer , Isabelle Texier-Nogues , Jacques Fattaccioli , Jerome Bibette , Anabela Da Silva
发明人： Mathieu Goutayer , Isabelle Texier-Nogues , Jacques Fattaccioli , Jerome Bibette , Anabela Da Silva
IPC分类号： C09K11/06 , A61B5/00
CPC分类号： A61K49/0078 , A61K9/1075 , A61K49/0032 , A61K49/0056 , B01F17/0078
摘要： The invention relates to a fluorescent emulsion, to a diagnostic reagent containing the same, and to the use thereof in the preparation of a diagnostic reagent for in vivo fluorescence imaging.
摘要翻译：本发明涉及荧光乳剂，含有该荧光乳剂的诊断试剂及其在制备用于体内荧光成像的诊断试剂中的用途。

25. 发明申请

US20070053988A1 Monodispersed solid lipid particle compositions 审中-公开
标题翻译：单分散固体脂质颗粒组成
公开(公告)号：US20070053988A1
公开(公告)日：2007-03-08
申请号：US10575449
申请日：2004-09-30
申请人： Audrey Royere , Jerome Bibette , Didier Bazile
发明人： Audrey Royere , Jerome Bibette , Didier Bazile
IPC分类号： A61K9/14
CPC分类号： A61K9/113 , A61K9/107 , A61K47/44
摘要： A composition includes a monodispersed lipid phase which is dispersed in a continuous aqueous phase, wherein the lipid phase includes at least one crystallizable lipid, at least one active ingredient and at least one compound including two chains of fatty acids and one glycol polyethylene chain. A method for the preparation of the compositions via a simple monodispersed O/W or O/W/O double emulsion is also disclosed.
摘要翻译：组合物包括分散在连续水相中的单分散脂质相，其中所述脂质相包含至少一种可结晶脂质，至少一种活性成分和至少一种包含两条脂肪酸链和一个二醇聚乙烯链的化合物。还公开了通过简单的单分散O / W或O / W / O双重乳液制备组合物的方法。

26. 发明授权

US5242964A Process for the preparation of aqueous dispersions of magnetizable polymer particles with a desired size narrow distribution, and aqueous dispersions thereof, and uses thereof 失效
标题翻译：制备具有所需尺寸窄分布的可磁化聚合物颗粒的水分散体及其水分散体的方法及其用途
公开(公告)号：US5242964A
公开(公告)日：1993-09-07
申请号：US737084
申请日：1991-07-29
申请人： Jerome Bibette , Dominique Charmot , Gilbert Schorsch
发明人： Jerome Bibette , Dominique Charmot , Gilbert Schorsch
IPC分类号： C08F6/04 , C08J3/03 , C08J3/12 , C08L101/00 , H01F1/44
CPC分类号： C08J3/03 , H01F1/44 , Y10S530/812 , Y10S530/815 , Y10T428/2982 , Y10T428/2991 , Y10T428/2995
摘要： A process for the preparation of aqueous dispersions of magnetizable polymer particles with a narrow distribution from aqueous dispersions with a wide distribution. The amount of water in the aqueous dispersion with a wide distribution is adjusted so that the proportion by weight of magnetizable polymer particles is between about 1 and 40% of said dispersion. The surfactant concentration of the dispersion after the water adjustment is increased until two phases are obtained: a so-called liquid phase and a so-called solid phase. After separation of these two phases is accomplished, these steps are repeated as desired. An aqueous dispersion with a narrow size distribution is recovered.
摘要翻译：一种从具有广泛分布的水性分散体分布窄的可磁化聚合物颗粒的水性分散体的制备方法。调节具有宽分布的水分散体中的水的量，使得可磁化聚合物颗粒的重量比例在所述分散体的约1至40％之间。水调节后的分散体的表面活性剂浓度增加直至获得两相：所谓的液相和所谓的固相。在完成这两个阶段的分离之后，根据需要重复这些步骤。回收具有窄尺寸分布的水分散体。

27. 发明授权

US08798341B2 Method and device for reading an emulsion 有权
标题翻译：读取乳液的方法和装置
公开(公告)号：US08798341B2
公开(公告)日：2014-08-05
申请号：US13054194
申请日：2009-07-13
申请人： Jean Baudry , Julien Sylvestre , Jerome Bibette , Laurent Boitard , Nicolas Bremond
发明人： Jean Baudry , Julien Sylvestre , Jerome Bibette , Laurent Boitard , Nicolas Bremond
IPC分类号： G06K9/00
CPC分类号： G01N15/1475 , G01N2015/003 , G01N2015/0092
摘要： A method for reading an emulsion (3) including droplets and a continuous phase surrounding the droplets, the method includes: two-dimensional scanning of the emulsion (3), and construction of a two-dimensional image of the emulsion (3) based on the scanning. Preferably, the droplets do not move during scanning, for example by solidifying the continuous phase or by using a two-dimensional compact or semi-compact network of droplets. The method can further include time-based monitoring of a chemical or biological reaction taking place in at least one of the droplets. A device implementing this method is also described. The method is applicable for the detection and/or sorting of microdroplets performing the role of microreactors or containing specific cells or molecules, in fields such as gene expression or diagnosis.
摘要翻译：一种用于读取包括液滴和围绕液滴的连续相的乳液（3）的方法，所述方法包括：乳液（3）的二维扫描，以及基于乳液（3）的二维图像的构建扫描。优选地，液滴在扫描期间不移动，例如通过固化连续相或通过使用二维紧凑或半紧凑的液滴网络。该方法还可以包括在至少一个液滴中发生的化学或生物反应的基于时间的监测。还描述了实现该方法的设备。该方法适用于在诸如基因表达或诊断的领域中进行微量反应器或包含特定细胞或分子的作用的微滴的检测和/或分选。

28. 发明申请

US20110188717A1 METHOD AND DEVICE FOR READING AN EMULSION 有权
标题翻译：用于读取乳液的方法和装置
公开(公告)号：US20110188717A1
公开(公告)日：2011-08-04
申请号：US13054194
申请日：2009-07-13
申请人： Jean Baudry , Julien Sylvestre , Jerome Bibette , Laurent Boitard , Nicolas Bremond
发明人： Jean Baudry , Julien Sylvestre , Jerome Bibette , Laurent Boitard , Nicolas Bremond
IPC分类号： G06K9/00
CPC分类号： G01N15/1475 , G01N2015/003 , G01N2015/0092
摘要： A method for reading an emulsion (3) including droplets and a continuous phase surrounding the droplets, the method includes: two-dimensional scanning of the emulsion (3), and construction of a two-dimensional image of the emulsion (3) based on the scanning. Preferably, the droplets do not move during scanning, for example by solidifying the continuous phase or by using a two-dimensional compact or semi-compact network of droplets. The method can further include time-based monitoring of a chemical or biological reaction taking place in at least one of the droplets. A device implementing this method is also described. The method is applicable for the detection and/or sorting of microdroplets performing the role of microreactors or containing specific cells or molecules, in fields such as gene expression or diagnosis.
摘要翻译：一种用于读取包括液滴和围绕液滴的连续相的乳液（3）的方法，所述方法包括：乳液（3）的二维扫描，以及基于乳液（3）的二维图像的构建扫描。优选地，液滴在扫描期间不移动，例如通过固化连续相或通过使用二维紧凑或半紧凑的液滴网络。该方法还可以包括在至少一个液滴中发生的化学或生物反应的基于时间的监测。还描述了实现该方法的装置。该方法适用于在诸如基因表达或诊断的领域中进行微量反应器或包含特定细胞或分子的作用的微滴的检测和/或分选。

29. 发明申请

US20100144899A1 METHOD FOR PREPARING NANO-EMULSIONS 审中-公开
标题翻译：制备纳米乳液的方法
公开(公告)号：US20100144899A1
公开(公告)日：2010-06-10
申请号：US12527371
申请日：2008-02-14
申请人： Mathieu Goutayer , Isabelle Texier-Nogues , Jerome Bibette
发明人： Mathieu Goutayer , Isabelle Texier-Nogues , Jerome Bibette
IPC分类号： A61K47/34 , A61K47/44 , A61P43/00
CPC分类号： A61K49/0078 , A61K9/1075 , A61K49/0032 , A61K49/0056 , B01F17/0078
摘要： The present invention relates to a method for preparing nano-emulsions comprising at least one aqueous continuous phase and at least one oily dispersed phase, comprising the steps of: (i) preparing the oily phase comprising at least one amphiphilic lipid and at least one solubilising lipid; (ii) dispersing the oily phase in an aqueous phase under the effect of sufficient shear force to form a nano-emulsion; and (iii) recovering the nano-emulsion thus formed.
摘要翻译：本发明涉及一种制备包含至少一种含水连续相和至少一种油分散相的纳米乳液的方法，其包括以下步骤：（i）制备包含至少一种两亲脂质和至少一种增溶的油相脂质; （ii）在足够剪切力的作用下将油相分散在水相中以形成纳米乳液; 和（iii）回收如此形成的纳米乳液。

30. 发明申请

US20050158723A1 Irreversible colloidal chanis with recognition sites 审中-公开
标题翻译：具有识别位点的不可逆胶体chanis
公开(公告)号：US20050158723A1
公开(公告)日：2005-07-21
申请号：US10504776
申请日：2003-02-19
申请人： Jean-Louis Viovy , Jerome Bibette , Cecile Goubault , Marie Dutreix
发明人： Jean-Louis Viovy , Jerome Bibette , Cecile Goubault , Marie Dutreix
IPC分类号： B01J20/283 , G01N27/447 , G01N30/88 , G01N33/53 , G01N33/543 , G01N33/552 , G01N33/566 , C12Q1/68 , G01N33/551
CPC分类号： G01N33/5434
摘要： A collection of colloidal particles in the form of one or several chains, in which the chains are generated in an irreversible manner and have at least one recognition site for a species, the site being different from sites implicated in the linear organisation of the particles. The invention further relates to a method for production of the collection, particularly for detection and/or dosage of at least one species in a fluid and a surface element functionalised by a collection of colloidal chains and a hybridisation network including such a surface element.
摘要翻译：一种或多种链形式的胶体颗粒的集合，其中链以不可逆的方式产生并且具有至少一个物种的识别位点，该位点不同于涉及颗粒的线性组织的位点。本发明进一步涉及一种用于生产该收集物的方法，特别是用于通过胶体链的收集功能化的流体和表面元件中的至少一种物质的检测和/或剂量以及包括这种表面元素的杂交网络。

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