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1. 发明申请

US20050158723A1 Irreversible colloidal chanis with recognition sites 审中-公开
标题翻译：具有识别位点的不可逆胶体chanis
公开(公告)号：US20050158723A1
公开(公告)日：2005-07-21
申请号：US10504776
申请日：2003-02-19
申请人： Jean-Louis Viovy , Jerome Bibette , Cecile Goubault , Marie Dutreix
发明人： Jean-Louis Viovy , Jerome Bibette , Cecile Goubault , Marie Dutreix
IPC分类号： B01J20/283 , G01N27/447 , G01N30/88 , G01N33/53 , G01N33/543 , G01N33/552 , G01N33/566 , C12Q1/68 , G01N33/551
CPC分类号： G01N33/5434
摘要： A collection of colloidal particles in the form of one or several chains, in which the chains are generated in an irreversible manner and have at least one recognition site for a species, the site being different from sites implicated in the linear organisation of the particles. The invention further relates to a method for production of the collection, particularly for detection and/or dosage of at least one species in a fluid and a surface element functionalised by a collection of colloidal chains and a hybridisation network including such a surface element.
摘要翻译：一种或多种链形式的胶体颗粒的集合，其中链以不可逆的方式产生并且具有至少一个物种的识别位点，该位点不同于涉及颗粒的线性组织的位点。本发明进一步涉及一种用于生产该收集物的方法，特别是用于通过胶体链的收集功能化的流体和表面元件中的至少一种物质的检测和/或剂量以及包括这种表面元素的杂交网络。

2. 发明申请

US20070197458A1 Nucleic acid useful for triggering tumor cell lethality 有权
标题翻译：可用于触发肿瘤细胞致死性的核酸
公开(公告)号：US20070197458A1
公开(公告)日：2007-08-23
申请号：US10576818
申请日：2004-10-25
申请人： Marie Dutreix , Jian-Sheng Sun
发明人： Marie Dutreix , Jian-Sheng Sun
IPC分类号： A61K48/00 , C07H21/02 , C07F9/6533 , C07F9/6512
CPC分类号： C12N15/11 , A61K38/00 , C12N2310/13 , C12N2310/53
摘要： The invention relates to double-stranded nucleic acid fragments comprising a chemically modified backbone and at least 4-1000 bp, preferably 8-500 bp, and most preferably 16-200 bp. The disclosed molecules (DRIL molecules) may interfere with DNA damage signalling and repair pathways, in particular the non homologous NHEJ pathway of double-stranded break repair. The invention discloses the application of the DRIL molecules as adjuvant compositions to be used in association with a DNA breaking treatment, particularly radiotherapy or chemotherapy, in combination with a pharmaceutically acceptable carrier, in an efficient amount to be introduced in the tumoral cell nuclei in order to trigger DNA repair induced lethality (DRIL in short) of tumoral cells/tissues.
摘要翻译：本发明涉及包含化学修饰的主链和至少4-1000bp，优选8-500bp，最优选16-200bp的双链核酸片段。所公开的分子（DRIL分子）可能干扰DNA损伤信号传导和修复途径，特别是双链断裂修复的非同源NHEJ途径。本发明公开了将DRIL分子作为辅助组合物的应用，其与DNA破坏处理（特别是放射治疗或化疗）联合使用，与药学上可接受的载体组合使用，以有效量依次引入肿瘤细胞核触发DNA修复诱导的细胞/组织的致死性（简称DRIL）。

3. 发明申请

US20140100266A1 CANCER TREATMENT BY COMBINING DNA MOLECULES MIMICKING DOUBLE STRAND BREAKS WITH HYPERTHERMIA 有权
标题翻译：通过组合DNA分子治疗癌症治疗双重断裂与高血压
公开(公告)号：US20140100266A1
公开(公告)日：2014-04-10
申请号：US14118583
申请日：2012-05-25
申请人： Marie Dutreix , Jian-Sheng Sun , Flavien Devun
发明人： Marie Dutreix , Jian-Sheng Sun , Flavien Devun
IPC分类号： A61K31/713 , C12N15/11
CPC分类号： A61K31/713 , A61K31/00 , C12N15/11 , C12N15/113 , C12N15/115 , C12N2310/13 , C12N2310/315 , C12N2310/3183 , C12N2310/3515 , C12N2310/53
摘要： The present invention relates to a method for treating a cancer including a combination of a treatment by a nucleic acid molecule mimicking double strand breaks with hyperthermia.
摘要翻译：本发明涉及一种治疗癌症的方法，包括通过模拟双链断裂的核酸分子与热疗的治疗的组合。

4. 发明申请

US20100022622A1 Dbait and its Standalone Uses Thereof 有权
标题翻译： Dbait及其独有用途
公开(公告)号：US20100022622A1
公开(公告)日：2010-01-28
申请号：US12520961
申请日：2008-01-11
申请人： Marie Dutreix
发明人： Marie Dutreix
IPC分类号： A61K31/713 , A61P35/00 , C12Q1/68 , C12N5/00
CPC分类号： C12N15/115 , A61K38/00 , C12N2310/13 , C12N2310/16 , C12N2310/3125 , C12N2310/53
摘要： The invention relates to compositions and methods for interfering with the DNA repair of double strand breaks (DSBs). The invention discloses double-stranded nucleic acid molecules that act as baits and hijack the holocomplex of enzymes responsible of DNA DSB sensing, signaling and/or repair pathways, in particular the non-homologous end joining (NHEJ) pathway of DSB repair. The invention discloses the use of these molecules as a standalone anticancer drug in an efficient amount to be introduced in the tumor cell nuclei in order to trigger their death.
摘要翻译：本发明涉及用于干扰双链断裂（DSB）的DNA修复的组合物和方法。本发明公开了作为诱饵和劫持负责DNA DSB感测，信号传导和/或修复途径的酶的全复合物的双链核酸分子，特别是DSB修复的非同源末端连接（NHEJ）途径。本发明公开了将这些分子作为独立抗癌药物在有效量引入到肿瘤细胞核中以引发其死亡的用途。

5. 发明授权

US09205099B2 Optimized in vivo delivery system with endosomolytic agents for nucleic acid conjugates 有权
标题翻译：优化的体内递送系统与核酸缀合物的内分解酶
公开(公告)号：US09205099B2
公开(公告)日：2015-12-08
申请号：US13703965
申请日：2011-06-21
申请人： Jian-Sheng Sun , Marie Dutreix , Maria Quanz
发明人： Jian-Sheng Sun , Marie Dutreix , Maria Quanz
IPC分类号： A61K45/06 , C07H21/02 , A61K31/7088 , A61K31/4706 , A61K47/48
CPC分类号： A61K47/549 , A61K31/4706 , A61K31/7088 , A61K31/713 , A61K45/06 , A61K47/542 , A61K47/543 , A61K47/551 , A61K47/554 , A61K48/00 , A61P35/00 , C07H21/04
摘要： The present invention relates to an optimized in vivo delivery system with endosomolytic agents for nucleic acid of therapeutic interest conjugated to molecules facilitating endocytosis, in particular for use in the treatment of cancer.
摘要翻译：本发明涉及优化的体内递送系统，其具有与促进内吞作用的分子缀合的治疗感兴趣的核酸的内体分解试剂，特别是用于治疗癌症。

6. 发明授权

US07741308B2 DBAIT and uses thereof 有权
标题翻译： DBAIT及其用途
公开(公告)号：US07741308B2
公开(公告)日：2010-06-22
申请号：US12324030
申请日：2008-11-26
申请人： Marie Dutreix , Jian-Sheng Sun
发明人： Marie Dutreix , Jian-Sheng Sun
IPC分类号： A61K31/70 , C07H21/04
CPC分类号： C12N15/1137 , A61K38/00 , C12N15/11 , C12N2310/13 , C12N2310/312 , C12N2310/3125 , C12N2310/315 , C12N2310/317 , C12N2310/3183 , C12N2310/321 , C12N2310/323 , C12N2310/3231 , C12N2310/3515 , C12N2310/3517 , C12N2310/53 , C12N2310/3521
摘要： The invention relates to compositions and methods for interfering with the DNA repair of double strand breaks (DSBs). The invention discloses novel double-stranded nucleic acid molecules. that act as baits and hijack the holocomplex of enzymes responsible of DNA DSB sensing, signaling and/or repair pathways, in particular the non homologous end joining (NHEJ) pathway of DSB repair.The invention discloses the use of these molecules as adjuvant compositions to be used in association with a DNA breaking treatment, particularly radiotherapy or chemotherapy, in combination with a pharmaceutically acceptable carrier, in an efficient amount to be introduced in the tumor cell nuclei in order to neutralize transiently their DNA repair capacity and trigger their death.
摘要翻译：本发明涉及用于干扰双链断裂（DSB）的DNA修复的组合物和方法。本发明公开了新型双链核酸分子。其作为诱饵和劫持负责DNA DSB感测，信号传导和/或修复途径的酶的全复合物，特别是DSB修复的非同源末端连接（NHEJ）途径。本发明公开了将这些分子作为辅助组合物与DNA破坏处理，特别是放射治疗或化学疗法联合使用，与药学上可接受的载体组合使用，以有效量引入肿瘤细胞核，以便中和它们的DNA修复能力并触发他们的死亡。

7. 发明授权

US07476729B2 Dbait and uses thereof 有权
标题翻译： Dbait及其用途
公开(公告)号：US07476729B2
公开(公告)日：2009-01-13
申请号：US11524528
申请日：2006-09-21
申请人： Marie Dutreix , Jian-Sheng Sun
发明人： Marie Dutreix , Jian-Sheng Sun
IPC分类号： C07H21/04 , A61K31/70
CPC分类号： C12N15/1137 , A61K38/00 , C12N15/11 , C12N2310/13 , C12N2310/312 , C12N2310/3125 , C12N2310/315 , C12N2310/317 , C12N2310/3183 , C12N2310/321 , C12N2310/323 , C12N2310/3231 , C12N2310/3515 , C12N2310/3517 , C12N2310/53 , C12N2310/3521
摘要： The invention relates to compositions and methods for interfering with the DNA repair of double strand breaks (DSBs). The invention discloses novel double-stranded nucleic acid molecules that act as baits and hijack the holocomplex of enzymes responsible of DNA DSB sensing, signaling and/or repair pathways, in particular the non homologous end joining (NHEJ) pathway of DSB repair. The invention discloses the use of these molecules as adjuvant compositions to be used in association with a DNA breaking treatment, particularly radiotherapy or chemotherapy, in combination with a pharmaceutically acceptable carrier, in an efficient amount to be introduced in the tumor cell nuclei in order to neutralize transiently their DNA repair capacity and trigger their death.
摘要翻译：本发明涉及用于干扰双链断裂（DSB）的DNA修复的组合物和方法。本发明公开了新型双链核酸分子，其作为诱饵并劫持负责DNA DSB感测，信号传导和/或修复途径的酶的全复合物，特别是DSB修复的非同源末端连接（NHEJ）途径。本发明公开了将这些分子作为辅助组合物与DNA破坏处理，特别是放射治疗或化学疗法联合使用，与药学上可接受的载体组合使用，以有效量引入到肿瘤细胞核中，以便中和它们的DNA修复能力并触发他们的死亡。

8. 发明申请

US20130131155A1 Optimized In Vivo Delivery System with Endosomolytic Agents for Nucleic Acid Conjugates 有权
标题翻译：用于核酸结合体的具有内体分解剂的体内递送系统的优化
公开(公告)号：US20130131155A1
公开(公告)日：2013-05-23
申请号：US13703965
申请日：2011-06-21
申请人： Jian-Sheng Sun , Marie Dutreix , Maria Quanz
发明人： Jian-Sheng Sun , Marie Dutreix , Maria Quanz
IPC分类号： A61K31/7088 , A61K31/4706 , A61K45/06
CPC分类号： A61K47/549 , A61K31/4706 , A61K31/7088 , A61K31/713 , A61K45/06 , A61K47/542 , A61K47/543 , A61K47/551 , A61K47/554 , A61K48/00 , A61P35/00 , C07H21/04
摘要： The present invention relates to an optimized in vivo delivery system with endosomolytic agents for nucleic acid of therapeutic interest conjugated to molecules facilitating endocytosis, in particular for use in the treatment of cancer.
摘要翻译：本发明涉及优化的体内递送系统，其具有与促进内吞作用的分子缀合的治疗感兴趣的核酸的内体分解试剂，特别是用于治疗癌症。

9. 发明授权

US07595302B2 Nucleic acids useful for triggering tumor cell lethality 有权
标题翻译：可用于触发肿瘤细胞致死性的核酸
公开(公告)号：US07595302B2
公开(公告)日：2009-09-29
申请号：US10576818
申请日：2004-10-25
申请人： Marie Dutreix , Jian-Sheng Sun
发明人： Marie Dutreix , Jian-Sheng Sun
IPC分类号： A61K31/70 , C07H21/04 , C07H21/00 , C12Q1/68 , C12P19/34
CPC分类号： C12N15/11 , A61K38/00 , C12N2310/13 , C12N2310/53
摘要： The invention relates to double-stranded nucleic acid fragments comprising a chemically modified backbone and at least 4-1000 bp, preferably 8-500 bp, and most preferably 16-200 bp. The disclosed molecules (DRIL molecules) may interfere with DNA damage signaling and repair pathways, in particular the non homologous NHEJ pathway of double-stranded break repair. The invention discloses the application of the DRIL molecules as adjuvant compositions to be used in association with a DNA breaking treatment, particularly radiotherapy or chemotherapy, in combination with a pharmaceutically acceptable carrier, in an efficient amount to be introduced in the tumoral cell nuclei in order to trigger DNA repair induced lethality (DRIL in short) of tumoral cells/tissues.
摘要翻译：本发明涉及包含化学修饰的主链和至少4-1000bp，优选8-500bp，最优选16-200bp的双链核酸片段。所公开的分子（DRIL分子）可能干扰DNA损伤信号传导和修复途径，特别是双链断裂修复的非同源NHEJ途径。本发明公开了将DRIL分子作为辅助组合物的应用，其与DNA破坏处理（特别是放射治疗或化疗）联合使用，与药学上可接受的载体组合使用，以有效量依次引入肿瘤细胞核触发DNA修复诱导的细胞/组织的致死性（简称DRIL）。

10. 发明申请

US20070111961A1 Dbait and uses thereof 有权
标题翻译： Dbait及其用途
公开(公告)号：US20070111961A1
公开(公告)日：2007-05-17
申请号：US11524528
申请日：2006-09-21
申请人： Marie Dutreix , Jian-Sheng Sun
发明人： Marie Dutreix , Jian-Sheng Sun
IPC分类号： A61K48/00 , C07H21/02 , C07F9/6533
CPC分类号： C12N15/1137 , A61K38/00 , C12N15/11 , C12N2310/13 , C12N2310/312 , C12N2310/3125 , C12N2310/315 , C12N2310/317 , C12N2310/3183 , C12N2310/321 , C12N2310/323 , C12N2310/3231 , C12N2310/3515 , C12N2310/3517 , C12N2310/53 , C12N2310/3521
摘要： The invention relates to compositions and methods for interfering with the DNA repair of double strand breaks (DSBs). The invention discloses novel double-stranded nucleic acid molecules. that act as baits and hijack the holocomplex of enzymes responsible of DNA DSB sensing, signaling and/or repair pathways, in particular the non homologous end joining (NHEJ) pathway of DSB repair. The invention discloses the use of these molecules as adjuvant compositions to be used in association with a DNA breaking treatment, particularly radiotherapy or chemotherapy, in combination with a pharmaceutically acceptable carrier, in an efficient amount to be introduced in the tumor cell nuclei in order to neutralize transiently their DNA repair capacity and trigger their death.
摘要翻译：本发明涉及用于干扰双链断裂（DSB）的DNA修复的组合物和方法。本发明公开了新型双链核酸分子。其作为诱饵和劫持负责DNA DSB感测，信号传导和/或修复途径的酶的全复合物，特别是DSB修复的非同源末端连接（NHEJ）途径。本发明公开了将这些分子作为辅助组合物与DNA破坏处理，特别是放射治疗或化学疗法联合使用，与药学上可接受的载体组合使用，以有效量引入到肿瘤细胞核中，以便中和它们的DNA修复能力并触发他们的死亡。

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