专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明申请

US20130264473A1 ION DETECTION 有权
标题翻译：离子检测
公开(公告)号：US20130264473A1
公开(公告)日：2013-10-10
申请号：US13993316
申请日：2011-12-14
申请人： Alexander A. Makarov
发明人： Alexander A. Makarov
IPC分类号： H01J49/28
CPC分类号： H01J49/282 , H01J49/027 , H01J49/08 , H01J49/38 , H01J49/4245
摘要： Mass analysers and methods of ion detection for a mass analyser are provided. An electrostatic field generator provides an electrostatic field causing ion packets to oscillate along a direction. A pulse transient signal is detected over a time duration that is significantly shorter than a period of the ion oscillation or using pulse detection electrodes having a width that is significantly smaller than a span of ion harmonic motion. A harmonic transient signal is also detected. Ion intensity with respect to mass-to-charge ratio is then identified based on the pulse transient signal and the harmonic transient signal.
摘要翻译：提供了用于质量分析仪的质量分析仪和离子检测方法。静电场发生器提供静电场，使离子包沿着一个方向振荡。在比离子振荡的周期短的持续时间内检测脉冲瞬态信号，或使用具有明显小于离子谐波运动的跨度的宽度的脉冲检测电极。还检测到谐波瞬态信号。然后基于脉冲瞬态信号和谐波瞬态信号来识别关于质荷比的离子强度。

22. 发明授权

US08513595B2 Parallel mass analysis 有权
公开(公告)号：US08513595B2
公开(公告)日：2013-08-20
申请号：US13164693
申请日：2011-06-20
申请人： Alexander A. Makarov , Stevan Horning
发明人： Alexander A. Makarov , Stevan Horning
IPC分类号： H01J49/26 , H01J27/02
CPC分类号： H01J49/009 , H01J49/425
摘要： A system and method of mass spectrometry is provided. Ions from an ion source are stored in a first ion storage device and in a second ion storage device. Ions are ejected from the first ion storage device to a first mass analysis device during a first ejection time period, for analysis during a first analysis time period. Ions are ejected from the second ion storage device to a second mass analysis device during a second ejection time period. The ion storage devices are connected in series such that an ion transport aperture of the first ion storage device is in communication with an ion transport aperture of the second ion storage device. The first analysis time period and the second ejection time period at least partly overlap.

23. 发明授权

US08278618B2 Collision cell 有权
标题翻译：碰撞细胞
公开(公告)号：US08278618B2
公开(公告)日：2012-10-02
申请号：US12996226
申请日：2009-06-03
申请人： Alexander A. Makarov , Eduard V. Denisov , Wilko Balschun , Dirk Nolting , Jens Griep-Raming
发明人： Alexander A. Makarov , Eduard V. Denisov , Wilko Balschun , Dirk Nolting , Jens Griep-Raming
IPC分类号： H01J49/40
CPC分类号： H01J49/0422 , H01J49/0031 , H01J49/0045 , H01J49/0072 , H01J49/0081 , H01J49/0481 , H01J49/06 , H01J49/26 , H01J49/40
摘要： A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis. Ions are caused to enter the collision cell. A trapping field is generated within the collision cell so as to trap the ions within a trapping volume of the collision cell, the trapping volume being defined by the trapping field and extending along the longitudinal axis. Trapped ions are processed in the collision cell and a DC potential gradient is provided, using an electrode arrangement, resulting in a non-zero electric field at all points along the axial length of the trapping volume so as to cause processed ions to exit the collision cell. The electric field along the axial length of the trapping volume has a standard deviation that is no greater than its mean value.
摘要翻译：提供了在质谱仪中操作充气碰撞池的方法。碰撞单元具有纵向轴线。导致离子进入碰撞池。在碰撞单元内产生捕获场，以便将离子捕获在碰撞池的捕获体积内，捕获体积由捕获场限定并沿着纵轴延伸。捕获的离子在碰撞单元中被处理，并且使用电极布置提供DC电位梯度，导致沿着捕获体积的轴向长度的所有点处的非零电场，从而使经处理的离子离开碰撞细胞。沿着捕集体积的轴向长度的电场具有不大于其平均值的标准偏差。

24. 发明申请

US20110017907A1 Multireflection Time-Of-Flight Mass Spectrometer 有权
标题翻译：多反射飞行时间质谱仪
公开(公告)号：US20110017907A1
公开(公告)日：2011-01-27
申请号：US12809867
申请日：2008-12-22
申请人： Alexander A. Makarov , Dmitry E. Grinfield , Mikhail A. Monastyrskiy
发明人： Alexander A. Makarov , Dmitry E. Grinfield , Mikhail A. Monastyrskiy
IPC分类号： H01J49/40
CPC分类号： H01J49/406 , H01J49/061 , H01J49/405
摘要： The present invention provides a method of reflecting ions in a multireflection time of flight mass spectrometer comprising providing an ion mirror having a plurality of electrodes, the ion mirror having a cross section with a first, minor axis (Y) and a second, major axis (X) each perpendicular to a longitudinal axis (Z) of the ion mirror which lies generally in the direction of time of flight separation of the ions in the mirror; guiding ions towards the ion mirror; applying a voltage to the electrodes so as to create an electric field which: (a) causes the mean trajectory of the ions to intersect a plane of symmetry of the ion mirror which contains the longitudinal (Z) and major axes (X) of the mirror; (b) causes the ions to reflect in the ion mirror; and (c) causes the ions to exit the ion mirror in a direction such that the mean trajectory of ions passing through the ion mirror has a component of movement in a direction (Y) perpendicular to and diverging from the said plane of symmetry thereof.
摘要翻译：本发明提供一种在多反射飞行时间质谱仪中反射离子的方法，包括提供具有多个电极的离子反射镜，所述离子反射镜具有具有第一短轴（Y）和第二长轴（Y）的横截面（X），每个垂直于离子镜的纵向轴线（Z），其通常位于反射镜中的离子的飞行时间分离方向上; 引导离子到离子镜; 向电极施加电压以产生电场：（a）使离子的平均轨迹与包含纵向（Z）和长轴（X）的离子镜的对称平面相交，镜子; （b）使离子在离子反射镜中反射; 和（c）使得离子离开离子反射镜的方向，使得通过离子镜的离子的平均轨迹具有与所述对称平面垂直的方向（Y）和与其对称的发散方向的运动分量。

25. 发明授权

US07829842B2 Mass spectrometer arrangement with fragmentation cell and ion selection device 有权
标题翻译：质谱仪排列与碎裂细胞和离子选择装置
公开(公告)号：US07829842B2
公开(公告)日：2010-11-09
申请号：US12296736
申请日：2007-04-13
申请人： Alexander A. Makarov
发明人： Alexander A. Makarov
IPC分类号： H01J49/26
CPC分类号： H01J49/42 , H01J49/0031 , H01J49/0045
摘要： A method of mass spectrometry having the steps of, in a first cycle: storing sample ions in a first ion storage device; ejecting the stored ions out of the first ion storage device into a separate ion selection device; selecting a subset of the ions in the ion selection device; ejecting the subset of ions selected within the ion selection device to a fragmentation device; directing ions from the fragmentation device back to the first ion storage device without passing them through the said ion selection device; receiving at least some of the ions ejected from the first ion storage device, or their derivatives, back into the first ion storage device; and storing the received ions in the first ion storage device.
摘要翻译：一种质谱法，其具有以下步骤：在第一循环中：将样品离子储存在第一离子存储装置中; 将存储的离子从第一离子存储装置中排出到单独的离子选择装置中; 选择离子选择装置中的离子的子集; 将离子选择装置内选择的离子的子集喷射到碎裂装置; 将离子从碎裂装置引导回第一离子存储装置，而不使它们通过所述离子选择装置; 将从所述第一离子存储装置或其衍生物排出的至少一些离子接收回所述第一离子存储装置; 以及将接收到的离子存储在第一离子存储装置中。

26. 发明申请

US20090166528A1 METHOD OF ION ABUNDANCE AUGMENTATION IN A MASS SPECTROMETER 有权
标题翻译：离子扩散方法在质谱仪中的应用
公开(公告)号：US20090166528A1
公开(公告)日：2009-07-02
申请号：US12296746
申请日：2007-04-13
申请人： Alexander A. Makarov
发明人： Alexander A. Makarov
IPC分类号： B01D59/44
CPC分类号： H01J49/42 , H01J49/0031 , H01J49/0045
摘要： A method of improving the detection limits of a mass spectrometer by: generating sample ions from an ion source; storing the sample ions in a first ion storage device; ejecting the stored ions into an ion selection device; selecting and ejecting ions of a chosen mass to charge ratio out of the ion selection device; storing the ions ejected from the ion selection device in a second ion storage device without passing them back through the ion selection device; repeating the preceding steps so as to augment the ions of the said chosen mass to charge ratio stored in the second ion storage device; and transferring the augmented ions of the said chosen mass to charge ratio back to the first ion storage device for subsequent analysis.
摘要翻译：一种通过以下步骤改进质谱仪的检测限的方法：从离子源产生样品离子; 将样品离子存储在第一离子存储装置中; 将所储存的离子喷射到离子选择装置中; 从所述离子选择装置中选择和排出所选择的质荷比的离子; 将从所述离子选择装置喷出的离子存储在第二离子存储装置中，而不将其返回通过所述离子选择装置; 重复前述步骤，以便增加存储在第二离子存储装置中的所选择的质荷比的离子; 以及将所述选择的质量与充电比例的增强离子转移回到第一离子存储装置，用于随后的分析。

27. 发明授权

US06864479B1 High dynamic range mass spectrometer 有权
标题翻译：高动态范围质谱仪
公开(公告)号：US06864479B1
公开(公告)日：2005-03-08
申请号：US10070118
申请日：2000-08-31
申请人： Stephen Davis , Alexander A. Makarov , Jonathan Hughes
发明人： Stephen Davis , Alexander A. Makarov , Jonathan Hughes
IPC分类号： G01N27/62 , G01Q30/04 , G01Q60/00 , H01J49/02 , H01J49/06 , H01J49/40 , H01J49/04
CPC分类号： H01J49/025
摘要： A mass spectrometer comprises an ion source which produces an ion beam from a substance to be analysed and a detector to detect a quantity of ions incident thereon. The detector includes two elements (16, 18) each of which detect a part of the quantity of ions and an attenuation device attenuates the quantity of ions reaching one of the detector elements. At least one of the detector elements (16, 18) is connected to a time to digital converter (TDC) to allow counting of the ions and at least one of the detector elements is connected in parallel to both a time to digital converter (TDC) and an analogue to digital converter (ADC).
摘要翻译：质谱仪包括从待分析的物质产生离子束的离子源和检测入射在其上的离子的量的检测器。检测器包括两个元件（16,18），每个元件检测一部分离子量，并且衰减器件衰减到达其中一个检测器元件的离子量。检测器元件（16,18）中的至少一个被连接到时间到数字转换器（TDC）以允许对离子的计数，并且至少一个检测器元件与时间数字转换器（TDC）并联连接）和模数转换器（ADC）。

28. 发明授权

US06707036B2 Ionization apparatus and method for mass spectrometer system 失效
标题翻译：电离装置及质谱仪系统
公开(公告)号：US06707036B2
公开(公告)日：2004-03-16
申请号：US10105172
申请日：2002-03-21
申请人： Alexander A. Makarov , Pavel V. Bondarenko
发明人： Alexander A. Makarov , Pavel V. Bondarenko
IPC分类号： H01J4900
CPC分类号： H01J49/067 , H01J49/0418 , H01J49/164
摘要： An ionization apparatus for connection to a mass analyzer is provided. The ionization apparatus comprises a sample slide having at least two sample spots containing analytes to be analyzed by a mass analyzer, means for delivering energy to one of the sample spots to release and ionize the analytes to form ions, and an interface connecting the one of the sample spot to the analyzer. The interface comprises a chamber having an orifice in close proximity to the one of the sample spots and defining a first region encompassing the one of the sample spots, and an ion guide disposed in the chamber and leading to the mass analyzer in a second region. Means for sustaining a pressure substantially lower than atmospheric within the first region is provided for capturing the ions while other sample spots are maintained at atmospheric pressure. Means for sustaining a pressure within the second region substantially lower than the pressure within the first region is provided.
摘要翻译：提供了一种用于连接到质量分析器的电离装置。电离装置包括具有至少两个样品点的样品载片，所述样品点含有要由质量分析仪分析的分析物，用于将能量传递到样品点之一以释放和离子化分析物以形成离子的装置，以及将样品点到分析仪。所述界面包括具有紧邻所述一个所述样品斑点的孔口并且限定包围所述样品斑点中的一个的第一区域的腔室和设置在所述腔室中并在第二区域中通向所述质量分析器的离子导管。提供用于在第一区域内维持基本上低于大气压力的装置用于捕获离子，而其它样品斑点保持在大气压。提供了在第二区域内保持基本上低于第一区域内的压力的装置。

29. 发明授权

US10074528B2 Data acquisition system and method for mass spectrometry 有权
公开(公告)号：US10074528B2
公开(公告)日：2018-09-11
申请号：US13994312
申请日：2011-12-15
申请人： Alexander A. Makarov , Anastassios Giannakopulos , Matthias Biel
发明人： Alexander A. Makarov , Anastassios Giannakopulos , Matthias Biel
IPC分类号： H01J49/02 , H01J49/00
CPC分类号： H01J49/025 , H01J49/0036
摘要： The invention provides a data acquisition system and method for detecting ions in a mass spectrometer, comprising: a detection system for detecting ions comprising two or more detectors for outputting two or more detection signals in separate channels in response to ions arriving at the detection system; and a data processing system for receiving and processing the detection signals in separate channels of the data processing system and for merging the processed detection signals to construct a mass spectrum; wherein the processing in separate channels comprises removing noise from the detection signals by applying a threshold to the detection signals. The detection signals are preferably produced in response to the same ions, the signals being shifted in time relative to each other. The invention is suitable for a TOF mass spectrometer.

30. 发明授权

US09520280B2 Ion detection 有权
标题翻译：离子检测
公开(公告)号：US09520280B2
公开(公告)日：2016-12-13
申请号：US13993316
申请日：2011-12-14
申请人： Alexander A. Makarov
发明人： Alexander A. Makarov
IPC分类号： H01J49/00 , H01J49/28 , H01J49/02 , H01J49/38 , H01J49/42
CPC分类号： H01J49/282 , H01J49/027 , H01J49/08 , H01J49/38 , H01J49/4245
摘要： Mass analyzers and methods of ion detection for a mass analyzer are provided. An electrostatic field generator provides an electrostatic field causing ion packets to oscillate along a direction. A pulse transient signal is detected over a time duration that is significantly shorter than a period of the ion oscillation or using pulse detection electrodes having a width that is significantly smaller than a span of ion harmonic motion. A harmonic transient signal is also detected. Ion intensity with respect to mass-to-charge ratio is then identified based on the pulse transient signal and the harmonic transient signal.
摘要翻译：提供了用于质量分析仪的质量分析仪和离子检测方法。静电场发生器提供静电场，使离子包沿着一个方向振荡。在比离子振荡的周期短的持续时间内检测脉冲瞬态信号，或使用具有明显小于离子谐波运动的跨度的宽度的脉冲检测电极。还检测到谐波瞬态信号。然后基于脉冲瞬态信号和谐波瞬态信号来识别关于质荷比的离子强度。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式