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21. 发明授权

US5021043A Method and catheter for dilatation of the lacrimal system 失效
标题翻译：用于扩张泪道系统的方法和导管
公开(公告)号：US5021043A
公开(公告)日：1991-06-04
申请号：US405766
申请日：1989-09-11
申请人： Bruce B. Becker , William A. Berthiaume
发明人： Bruce B. Becker , William A. Berthiaume
IPC分类号： A61F2/04 , A61F2/94 , A61F9/007 , A61M29/02
CPC分类号： A61F2/94 , A61F2/04 , A61F2/958 , A61F9/00772 , A61M29/02 , A61M2025/0008 , A61M2025/1079
摘要： A dilatation catheter having an inflatable member and a method of using same to restore patency to an obstructed portion of the lacrimal system. The catheter is inserted into the lacrimal system and its inflatable member is positioned in the obstructed portion. The inflatable member is inflated to dilate the obstructed portion to restore patency to the lacrimal system. Preferably, the catheter includes one or more visually perceivable markers having a known spaced relationship to one of the ends of the inflatable member. Positioning of the inflatable member is assisted by aligning the marker relative to an opening into the lacrimal system.
摘要翻译：具有可膨胀构件的扩张导管及其使用方法来恢复泪道系统阻塞部分的通畅。将导管插入泪液系统中，其可充气构件位于阻塞部分中。将充气构件充气以扩张阻塞部分以恢复泪液系统的通畅。优选地，导管包括一个或多个视觉可感知的标记，其具有与可膨胀构件的一个端部已知的间隔关系。通过将标记物相对于泪道系统的开口对准来辅助可充气构件的定位。

22. 发明授权

US09216293B2 Delivery system assemblies for implantable medical devices 有权
标题翻译：可植入医疗器械的输送系统组件
公开(公告)号：US09216293B2
公开(公告)日：2015-12-22
申请号：US13298821
申请日：2011-11-17
申请人： William A. Berthiaume , H. Allan Steingisser , Don H. Tran , Erik Griswold , Brent L. Locsin , James C. Allan
发明人： William A. Berthiaume , H. Allan Steingisser , Don H. Tran , Erik Griswold , Brent L. Locsin , James C. Allan
IPC分类号： A61B19/00 , A61N1/372 , A61B5/00 , A61B5/042 , A61N1/375
CPC分类号： A61N1/37205 , A61B5/0422 , A61B5/6869 , A61B5/6882 , A61B2560/066 , A61M25/0136 , A61M25/0147 , A61N1/3756
摘要： An inner subassembly of a delivery system assembly extends within a lumen of an elongate outer tube of the assembly, and includes a flared distal end, which is preferably configured to conform to a proximal end of an implantable medical device; a distal-most portion of the outer tube is sized to contain both the flared distal end and an entirety of the medical device. The inner subassembly includes a core, an elongate pull-wire, extending along the core, and a sheath surrounding the pull-wire and the core; the sheath includes a slot opening that allows the pull-wire to pass laterally therethrough. The assembly preferably has a pre-formed curvature along a length of the sheath, and the slot opening extends along the pre-formed curvature. The outer tube is longitudinally moveable relative to the inner subassembly, for example, to deploy the medical device.
摘要翻译：输送系统组件的内部子组件在组件的细长外管的内腔中延伸，并且包括扩口远端，其优选地构造成符合可植入医疗装置的近端; 外管的最远部分的尺寸被设计成容纳扩张的远端和整个医疗装置。所述内部子组件包括芯，沿所述芯延伸的细长拉线和围绕所述拉线和所述芯的护套; 护套包括允许拉线横向通过的槽口。组件优选地沿着护套的长度具有预先形成的曲率，并且槽开口沿着预先形成的曲率延伸。外管可相对于内部子组件纵向移动，例如，以部署医疗装置。

23. 发明授权

US08721587B2 Delivery system assemblies and associated methods for implantable medical devices 有权
标题翻译：可植入医疗器械的输送系统组件和相关方法
公开(公告)号：US08721587B2
公开(公告)日：2014-05-13
申请号：US13298973
申请日：2011-11-17
申请人： William A. Berthiaume , H. Allan Steingisser , Don H. Tran , Erik Griswold , Brent L. Locsin
发明人： William A. Berthiaume , H. Allan Steingisser , Don H. Tran , Erik Griswold , Brent L. Locsin
IPC分类号： A61M25/01 , A61M31/00 , A61M5/142 , A61K9/00
CPC分类号： A61N1/0587 , A61B2017/00331 , A61K9/0024 , A61M5/14276 , A61M25/0041 , A61M25/0102 , A61M25/0147 , A61M31/00 , A61N1/3622 , A61N1/37205 , A61N1/3756 , A61N2001/0578
摘要： A delivery system assembly includes an elongate outer tube, an elongate inner member extending within a lumen of the outer tube, and an articulation sheath surrounding the outer tube between a handle of the assembly and a distal-most portion of the outer tube. The outer tube is longitudinally moveable within the sheath; and an inner diameter of the sheath is preferably smaller than that of the handle and the distal-most portion of the outer tube. Navigation of the assembly through a venous system, for deployment of an implantable medical device, is facilitated by deflection of the sheath, to orient a distal-most portion of the outer tube, within which an entirety of the medical device is contained/loaded, and by subsequent advancement of the distal-most portion, with respect to the sheath, to move the distal end of the inner member, along with the contained/loaded device into proximity with a target implant site.
摘要翻译：输送系统组件包括细长的外管，在外管的内腔内延伸的细长内部构件，以及围绕组件的手柄和外管的最远部分之间的外管围绕的关节护套。外管可在鞘内纵向移动; 并且护套的内径优选地小于手柄和外管的最远部分的内径。通过静脉系统的导引，用于部署可植入医疗装置，通过护套的偏转来促进，以使外管的最远端部分定向，其中整个医疗装置被包含/装载在该外管的最远部分，并且通过相对于护套随后推进最远部分，将内部构件的远端与所容纳/加载的装置一起移动到目标植入部位附近。

24. 发明授权

US08504156B2 Holding members for implantable cardiac stimulation devices 有权
标题翻译：持有植入式心脏刺激装置的成员
公开(公告)号：US08504156B2
公开(公告)日：2013-08-06
申请号：US13219279
申请日：2011-08-26
申请人： Matthew D. Bonner , Thomas A. Anderson , William A. Berthiaume , Noelle C. Hurtig
发明人： Matthew D. Bonner , Thomas A. Anderson , William A. Berthiaume , Noelle C. Hurtig
IPC分类号： A61N1/00
CPC分类号： A61N1/37205 , A61N1/0573 , A61N1/362 , A61N1/3756
摘要： A holding member for an implantable cardiac device facilitates tether attachment and removal, at time of implant, and snaring, or otherwise capturing, for subsequent explant. Preferably located in proximity to a proximal end wall of a shell of the device, the holding member includes a strut portion, being spaced proximally apart from the proximal end wall, a waist portion, defining a recess, and an engagement section, extending between the strut portion and the waist portion and overhanging the recess. The waist portion may either extend between the strut portion and the proximal end wall, or be formed in the shell, distal to the proximal end wall. Alternately, the holding member includes a loop element and an engagement element coupled thereto, between first and second segments thereof. The segments are initially formed to give the loop element an opening, and have a flexibility to be compressed together.
摘要翻译：用于可植入心脏装置的保持构件促进在植入时的系链附着和移除，并且用于后续外植体的瘢痕或其它捕获。优选地，所述保持构件优选地位于所述装置的壳体的近端壁附近，所述支撑构件包括支撑部分，所述支柱部分与所述近端壁向近侧间隔开，限定凹部的腰部和接合部分支撑部分和腰部，并且突出于凹部。腰部可以在支柱部分和近端壁之间延伸，或者形成在远离近端壁的壳体中。或者，保持构件包括环形元件和联接到其上的接合元件，在其第一和第二段之间。这些段最初形成为使环形元件成为开口，并且具有被压缩在一起的柔性。

25. 发明授权

US06200305B1 Catheter having a variable length shaft segment and method of use 失效
标题翻译：导管具有可变长度的轴段和使用方法
公开(公告)号：US06200305B1
公开(公告)日：2001-03-13
申请号：US09164007
申请日：1998-09-30
申请人： William A. Berthiaume , John Hudson
发明人： William A. Berthiaume , John Hudson
IPC分类号： A61M3100
CPC分类号： A61M25/104 , A61M2025/1068
摘要： The invention relates to a catheter device and guidewire system to enable the catheter to be exchanged over a conventional length guidewire without the use of a guidewire extension or exchange wire. The catheter device includes an elongated inflation shaft having a longitudinal inflation lumen, an extension shaft having a longitudinal extension lumen coupled in fluid communication with the inflation lumen, a balloon member disposed at the distal end of the extension shaft and in fluid communication with the inflation lumen, a guidewire shaft having a longitudinal guidewire lumen which extends from the distal end of the balloon member, through the balloon member and extension shaft, to the proximal end of the extension shaft, and a variable length shaft coupled to the proximal end of the extension shaft. The variable length shaft comprises an elastomeric material which may be rolled about its outside surface such that the shaft may selectively extend from a rolled up state having a length of about 1 centimeters to a fully unrolled state having a length of about 140 centimeters.
摘要翻译：本发明涉及一种导管装置和导丝系统，其能够使导管在常规长度导丝上更换，而不需要使用导丝延伸或交换线。导管装置包括具有纵向充气腔的细长充气轴，延伸轴，其具有与膨胀腔流体连通的连接的纵向延伸腔;设置在延伸轴的远端并与膨胀流体连通的球囊构件导丝轴，其具有从球囊构件的远端延伸穿过球囊构件和延伸轴的纵向导丝内腔到延伸轴的近端，以及可变长度的轴，其耦合到延长轴。可变长度轴包括可以围绕其外表面卷绕的弹性体材料，使得轴可以选择性地从具有约1厘米长度的卷起状态延伸到具有约140厘米长度的完全展开状态。

26. 发明授权

US6027474A Hydraulic exchange catheter 失效
标题翻译：液压交换导管
公开(公告)号：US6027474A
公开(公告)日：2000-02-22
申请号：US164006
申请日：1998-09-30
申请人： Nareak Douk , William A. Berthiaume
发明人： Nareak Douk , William A. Berthiaume
IPC分类号： A61M25/01 , A61M29/02 , A61M37/00
CPC分类号： A61M25/104 , A61M25/0169
摘要： The invention relates to a catheter device and method of use for exchanging a catheter having a full-length guidewire lumen over a conventional-length guidewire without the use of a guidewire extension or an exchange wire. The catheter device includes an elongated shaft defining an inflation lumen and a guidewire lumen extending longitudinally throughout its length, and a hydraulic exchange lumen extending from the proximal end of the shaft and terminating proximal the distal end of the shaft, wherein the hydraulic exchange lumen is in fluid communication with the guidewire lumen. A balloon is coupled to the distal section of the shaft and is in fluid communication with the inflation lumen. A flow guiding member is disposed within the guiding catheter and functions to redirect the distal flow of pressurized fluid traveling through the hydraulic exchange lumen in a proximal direction through the guidewire lumen.
摘要翻译：本发明涉及一种用于在常规长度导丝上更换具有全长导丝管腔的导管的导管装置和方法，而不使用导线延伸部或交换线。所述导管装置包括细长轴，所述细长轴限定充气腔和在其整个长度上纵向延伸的导丝管腔，以及从所述轴的近端延伸并且在所述轴的远端终止的液压更换腔，其中所述液压更换腔是与导丝管腔流体连通。球囊联接到轴的远侧部分并且与膨胀腔流体连通。流动引导构件设置在引导导管内，并且用于将通过液压更换腔行进的加压流体的远端流动在近端方向上重定向穿过导丝管腔。

27. 发明授权

US5339833A Swivel exchange guidewire 失效
标题翻译：旋转交换导线
公开(公告)号：US5339833A
公开(公告)日：1994-08-23
申请号：US748037
申请日：1991-08-21
申请人： William A. Berthiaume , Michel J. LeBlanc
发明人： William A. Berthiaume , Michel J. LeBlanc
IPC分类号： A61M25/01 , A61B5/00
CPC分类号： A61M25/0172 , A61M25/0905 , A61M25/0133 , A61M25/0136
摘要： An exchange length guidewire for use in percutaneous transluminal coronary angioplasty is formed in two sections including a proximal section and a distal section. The proximal end of the distal section is rotatably attached to the distal end of the proximal section so that it may be rotated freely with respect to the proximal section. The proximal section may be maintained in a coiled configuration in a storage hoop while the distal portion may be used as a steerable guidewire to assist in navigating a catheter to the intended vascular treatment site. When it is desired to perform a catheter exchange, the proximal section is removed from the storage hoop to permit the wire to extend to its full exchange length, typically slightly more than twice the length of the catheter. The catheter exchange then may be performed. Thereafter, the proximal section of the exchange wire may be reinserted into the storage hoop and while the distal portion may continue to serve as a steerable guidewire.
摘要翻译：用于经皮腔内冠状动脉血管成形术的交换长度导线形成在包括近端部分和远端部分的两个部分中。远端部分的近端可旋转地附接到近端部分的远端，使得其可以相对于近端部分自由旋转。近端部分可以保持在存放箍中的盘绕构造中，而远端部分可以用作可转向导丝，以帮助将导管导航到预期的血管治疗部位。当需要执行导管更换时，将近端部分从储存环上移除，以允许电线延伸到其完全交换长度，通常略高于导管长度的两倍。然后可以执行导管交换。此后，交换线的近侧部分可以重新插入到存储环中，并且远端部分可以继续用作可引导导丝。

28. 发明授权

US5169386A Method and catheter for dilatation of the lacrimal system 失效
标题翻译：用于扩张泪道系统的方法和导管
公开(公告)号：US5169386A
公开(公告)日：1992-12-08
申请号：US542598
申请日：1990-06-25
申请人： Bruce B. Becker , William A. Berthiaume
发明人： Bruce B. Becker , William A. Berthiaume
IPC分类号： A61F2/04 , A61F2/94 , A61F9/007 , A61M29/02
CPC分类号： A61F2/958 , A61F2/04 , A61F2/94 , A61F9/00772 , A61M29/02 , A61M2025/0008 , A61M2025/1079
摘要： A dilation catheter having an inflatable member and an element for retaining a curved shape, and a method of using same to restore patency to an obstructed portion of the lacrimal system. The catheter is inserted into the lacrimal system and the inflatable member is positioned in the obstructed portion. Insertion of the catheter is facilitated by mechanically imparting a curved shape to a distal portion of the catheter. The inflatable member is inflated to dilate the obstructed portion to restore patency to the lacrimal system. Preferably, the catheter includes one or more visually perceivable markers having a known spaced relationship to one of the ends of the inflatable member. Positioning of the inflatable member is assisted by aligning the marker relative to an opening into the lacrimal system.
摘要翻译：具有充气构件和保持弯曲形状的元件的扩张导管及其使用方法来恢复泪道系统阻塞部分的通畅。将导管插入泪液系统中，并且将可膨胀构件定位在阻塞部分中。通过机械地将弯曲形状赋予导管的远端部分来促进插入导管。将充气构件充气以扩张阻塞部分以恢复泪液系统的通畅。优选地，导管包括一个或多个视觉可感知的标记，其具有与可膨胀构件的一个端部已知的间隔关系。通过将标记物相对于泪道系统的开口对准来辅助可充气构件的定位。

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