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21. 发明申请

US20120123164A1 Combinations of Eszopiclone and Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-N-Methyl-1-Napthalenamine or Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-1-Napthalenamine, and Methods of Treatment of Menopause and Mood, Anxiety, and Cognitive Disorders 有权
标题翻译：依佐匹克隆和反式4-（3,4-二氯苯基）-1,2,3,4-四氢-N-甲基-1-萘胺或反式4-（3,4-二氯苯基）-1,2,3， 4-四氢-1-萘胺，以及更年期和心情，焦虑和认知障碍的治疗方法
公开(公告)号：US20120123164A1
公开(公告)日：2012-05-17
申请号：US13358155
申请日：2012-01-25
申请人： Judy CARON , Thomas Wessel , Karim Lalji , Mark A. Varney , Roger P. Bakale , Surendra P. Singh , H. Scott Wilkinson , Xiping Su , Zhengxu Steve Han , Stefan G. Koenig
发明人： Judy CARON , Thomas Wessel , Karim Lalji , Mark A. Varney , Roger P. Bakale , Surendra P. Singh , H. Scott Wilkinson , Xiping Su , Zhengxu Steve Han , Stefan G. Koenig
IPC分类号： C07C209/28
CPC分类号： A61K31/4985 , A61K31/135 , C07C211/42 , C07C2602/10 , A61K2300/00
摘要： One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component of the pharmaceutical composition is a sedative eszopiclone. The second component of the pharmaceutical composition is trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine. The present invention also relates to a method of treating menopause, perimenopause, mood disorders, anxiety disorders, and cognitive disorders.
摘要翻译：本发明的一个方面涉及含有两种或更多种活性剂的药物组合物，所述活性剂当一起用于治疗例如更年期，情绪障碍，焦虑障碍或认知障碍时。药物组合物的第一组分是镇静剂佐佐匹克。药物组合物的第二组分是反式4-（3,4-二氯苯基）-1,2,3,4-四氢-N-甲基-1-萘胺或反式4-（3,4-二氯苯基） 2,3,4-四氢-1-萘胺。本发明还涉及治疗绝经，围绝经期，情绪障碍，焦虑障碍和认知障碍的方法。

22. 发明申请

US20060257095A1 Light-emitting textile structure, in particular for medical purposes, and use thereof 有权
标题翻译：特别是用于医疗目的的发光织物结构及其用途
公开(公告)号：US20060257095A1
公开(公告)日：2006-11-16
申请号：US11126843
申请日：2005-05-11
申请人： Heinrich Walt , Barbel Selm , Thomas Wessel
发明人： Heinrich Walt , Barbel Selm , Thomas Wessel
IPC分类号： G02B6/00
CPC分类号： G02B6/001 , A61B5/0059 , A61B5/6804 , A61N5/0616 , A61N5/062 , A61N5/0621 , A61N5/0624 , A61N2005/063 , A61N2005/0645
摘要： A light-emitting textile structure, which in particular is useful for medical purposes, comprises a flat support (2) and a plurality of light-emitting elements (4) fixed thereto. Each light-emitting element comprises a light-supplying optical fiber (6), to each optical fiber (6) there being associated exactly one light-emitting element (4), which comprises at least one output zone formed by a local curvature of the optical fiber. The local curvature is selected in such a way that a lateral exit of light from the optical fiber occurs due to the absence of total reflection.
摘要翻译：特别是用于医疗目的的发光纺织品结构包括平坦支撑件（2）和固定到其上的多个发光元件（4）。每个发光元件包括供给光纤（6），其中每个光纤（6）与正好相关联的一个发光元件（4）相关联，该发光元件包括至少一个输出区域，该输出区域由光纤。选择局部曲率，使得由于不存在全反射而发生来自光纤的光的侧向出射。

23. 发明授权

US06645904B2 Aminophosphonium compounds 有权
标题翻译：氨基鏻化合物
公开(公告)号：US06645904B2
公开(公告)日：2003-11-11
申请号：US10135252
申请日：2002-04-30
申请人： Berthold Schiemenz , Thomas Wessel , Ralf Pfirmann
发明人： Berthold Schiemenz , Thomas Wessel , Ralf Pfirmann
IPC分类号： C07D26530
CPC分类号： B01J31/0268 , B01J31/0237 , B01J2531/985 , C07B39/00 , C07C45/63 , C07F9/06 , C07F9/572 , C07F9/59 , C07F9/650952 , C07F9/6533 , C07C47/55
摘要： The present invention relates to compounds of the formula in which one, two or three of the radicals R1, R2, R3 and R4 are where m and n are an integer from 1 to 10, R5, R6, R7 and R8 are, independently of one another, identical or different and are a straight-chain or branched alkyl radical having 1 to 10 carbon atoms, and the remaining radical(s) R1 to R4 are or —NR9R10, where R9 and R10 are identical or different and are a straight-chain or branched alkyl radical having 1 to 10 carbon atoms, and X− is an inorganic or organic anion or an equivalent of a multiply charged inorganic or organic anion. The invention further relates to mixtures of substances comprising compounds of the formula (1), to a process for preparing the compounds of the formula (1) and to the use thereof.
摘要翻译：本发明涉及式（1）中的一个，两个或三个基团R 1，R 2，R 3和R 4的化合物，其中m和n是1-10的整数，R R 5，R 7和R 8彼此独立地相同或不同，为具有1-10个碳原子的直链或支链烷基，剩余的基团（ s）R 1至R 4为-NR 9 R 10，其中R 9和R 10相同或不同，为具有1至10个碳原子的直链或支链烷基碳原子，X 1是无机或有机阴离子或等效的多电荷无机或有机阴离子。本发明还涉及包含式（1）化合物的物质的混合物，与制备式（1）化合物的方法及其用途。

24. 发明授权

US06530197B1 Ground contact height sensor 有权
标题翻译：接地高度传感器
公开(公告)号：US06530197B1
公开(公告)日：2003-03-11
申请号：US09571247
申请日：2000-05-16
申请人： Timothy Franklin Christensen , Klaus Ernst Becker , Paul Thomas Wessel
发明人： Timothy Franklin Christensen , Klaus Ernst Becker , Paul Thomas Wessel
IPC分类号： A01D7500
CPC分类号： A01D41/141 , Y10S56/10
摘要： A ground contact height sensor for a harvesting header comprises a transverse rotatable shaft, a first rigid arm, a second rigid arm and a connecting member. The rotatable shaft is rotatively mounted to the frame of the header. The first rigid arm is rigidly mounted to the rotatable shaft. The first arm extends downwardly and rearwardly from the rotatable shaft in a curved manner. The second rigid arm is pivotally coupled to the first rigid arm by a hinge joint. The second rigid arm extends upwardly and rearwardly from the second end of the first rigid arm. The first and second rigid arms defining a relatively large radius. The connecting member secures the rearmost end of the second rigid arm to the frame of the header. To maintain the radius of the two pivotally connected rigid arms the hinge joint joining the two rigid arms is provided with a torsion spring.
摘要翻译：用于采集头的接地高度传感器包括横向可旋转轴，第一刚性臂，第二刚性臂和连接构件。旋转轴可旋转地安装在集管的框架上。第一刚性臂刚性地安装到可旋转的轴上。第一臂以可弯曲的方式从旋转轴向下和向后延伸。第二刚性臂通过铰链接头枢转地联接到第一刚性臂。第二刚性臂从第一刚性臂的第二端向上和向后延伸。第一和第二刚性臂限定相对较大的半径。连接构件将第二刚性臂的最后端固定到集管的框架。为了保持两个枢转连接的刚性臂的半径，连接两个刚性臂的铰链接头设置有扭转弹簧。

25. 发明授权

US06465643B1 Aminophosphonium compounds 有权
标题翻译：氨基鏻化合物
公开(公告)号：US06465643B1
公开(公告)日：2002-10-15
申请号：US09617471
申请日：2000-07-17
申请人： Berthold Schiemenz , Thomas Wessel , Ralf Pfirmann
发明人： Berthold Schiemenz , Thomas Wessel , Ralf Pfirmann
IPC分类号： C07D26530
CPC分类号： B01J31/0268 , B01J31/0237 , B01J2531/985 , C07B39/00 , C07C45/63 , C07F9/06 , C07F9/572 , C07F9/59 , C07F9/650952 , C07F9/6533 , C07C47/55
摘要： The present invention relates to compounds of the formula in which one, two or three of the radicals R1, R2, R3 and R4 are where m and n are an integer from 1 to 10, R5, R6, R7 and R8 are, independently of one another, identical or different and are a straight-chain or branched alkyl radical having 1 to 10 carbon atoms, and the remaining radical(s) R1 to R4 are or —NR9R10, where R9 and R10 are identical or different and are a straight-chain or branched alkyl radical having 1 to 10 carbon atoms, and X− is an inorganic or organic anion or an equivalent of a multiply charged inorganic or organic anion. The invention further relates to mixtures of substances comprising compounds of the formula (1), to a process for preparing the compounds of the formula (1) and to the use thereof.
摘要翻译：本发明涉及式中的一个，两个或三个基团R 1，R 2，R 3和R 4的化合物，其中m和n是1至10的整数，R 5，R 6，R 7和R 8彼此独立地是相同或不同，为具有1至10个碳原子的直链或支链烷基，其余的R 1至R 4基团为-NR 9 R 10，其中R 9和R 10相同或不同，为直链或具有1-10个碳原子的支链烷基，X-是无机或有机阴离子或当量的多电荷无机或有机阴离子。本发明还涉及包含式（1）化合物的物质的混合物，与制备式（1）化合物的方法及其用途。

26. 发明授权

US5705674A Process for preparing ortho-nitrobenzonitriles 失效
标题翻译：邻硝基苯腈制备方法
公开(公告)号：US5705674A
公开(公告)日：1998-01-06
申请号：US698792
申请日：1996-08-16
申请人： Thomas Wessel , Peter Koch
发明人： Thomas Wessel , Peter Koch
IPC分类号： C07B61/00 , C07C253/14 , C07C255/50
CPC分类号： C07C253/14 , C07C255/50
摘要： The present invention relates to a process for preparing ortho-nitrobenzonitriles of the formula I, ##STR1## where R.sup.1 and R.sup.2 are as defined in claim 1, by reacting the corresponding ortho-fluoronitrobenzenes with alkali metal cyanides or cyanide-donating substances in the presence of phase transfer catalysts.
摘要翻译：本发明涉及通过在相转移催化剂存在下使相应的邻氟代硝基苯与碱金属氰化物或氰化物供体物质反应来制备式I，权利要求1的邻硝基苯腈的方法。

27. 发明授权

US5654493A Process for preparing 4-bromophenyl alkyl ethers 失效
标题翻译：制备4-溴苯基烷基醚的方法
公开(公告)号：US5654493A
公开(公告)日：1997-08-05
申请号：US702812
申请日：1996-08-26
申请人： Thomas Wessel
发明人： Thomas Wessel
IPC分类号： C07C41/22 , C07C43/225 , C07C41/24
CPC分类号： C07C41/22
摘要： The present invention relates to a process for preparing 4-bromophenyl alkyl ethers by reacting phenyl alkyl ethers with bromine in a water-miscible solvent in the presence of an oxidizing agent which is able to oxidize hydrogen bromide to bromine.
摘要翻译：本发明涉及在能够将溴化氢氧化成溴的氧化剂的存在下，使苯基烷基醚与溴在水混溶性溶剂中反应来制备4-溴苯基烷基醚的方法。

28. 发明申请

US20100280038A1 METHODS OF TREATMENT OF CHRONIC PAIN USING ESZOPICLONE 有权
标题翻译：使用兴奋剂治疗慢性疼痛的方法
公开(公告)号：US20100280038A1
公开(公告)日：2010-11-04
申请号：US12838554
申请日：2010-07-19
申请人： Thomas Wessel , Judy Caron
发明人： Thomas Wessel , Judy Caron
IPC分类号： A61K31/4985 , A61P29/00
CPC分类号： A61K31/4985 , Y02A50/401
摘要： The invention relates to the use of eszopiclone for the treatment of low-level, chronic pain and fatigue associated with pain.
摘要翻译：本发明涉及使用依佐唑隆治疗与疼痛相关的低水平，慢性疼痛和疲劳。

29. 发明授权

US07541489B2 Method of making halophthalic acids and halophthalic anhydrides 有权
标题翻译：制备卤代邻苯二甲酸和卤代邻苯二甲酸酐的方法
公开(公告)号：US07541489B2
公开(公告)日：2009-06-02
申请号：US11170708
申请日：2005-06-29
申请人： Robert Edgar Colborn , David Bruce Hall , Peter Alois Koch , Bernd Volker Demuth , Thomas Wessel , KarlErnst Mack , Prashant Anil Tatake , Utpal Mahendra Vakil , Shyamal Bhaskar Gondkar , John Edward Pace , Kwang Woong Won
发明人： Robert Edgar Colborn , David Bruce Hall , Peter Alois Koch , Bernd Volker Demuth , Thomas Wessel , KarlErnst Mack , Prashant Anil Tatake , Utpal Mahendra Vakil , Shyamal Bhaskar Gondkar , John Edward Pace , Kwang Woong Won
IPC分类号： C07C51/16
CPC分类号： C07C51/265 , C07C63/68
摘要： A method of preparing a halophthalic acid is disclosed which comprises the steps of contacting in a liquid phase reaction mixture at least one halogen-substituted ortho-xylene with oxygen and acetic acid at a temperature in a range between about 120° C. and about 220° C. in the presence of a catalyst system yielding a product mixture comprising less than 10 percent halogen-substituted ortho-xylene starting material, a halophthalic acid product, and less than about 10,000 ppm halobenzoic acid and less than about 1000 ppm halophthalide by-products based on a total amount of halophthalic acid present in the product mixture. In addition methods for the preparation of halophthalic anhydride, and recovery of high purity acetic acid from an aqueous acetic acid stream comprising HCl, which is generated during the preparation of the halophthalic acid are also disclosed.
摘要翻译：公开了一种制备卤代邻苯二甲酸的方法，其包括以下步骤：在液相反应混合物中使至少一种卤素取代的邻二甲苯与氧和乙酸在约120℃至约220℃的温度下接触在催化剂体系的存在下，产生包含小于10％的卤素取代的邻二甲苯原料，卤代邻苯二甲酸产物和小于约10,000ppm的卤代苯甲酸和小于约1000ppm的卤代苯甲酸副产物的产物混合物，基于产物混合物中存在的卤代邻苯二甲酸的总量的产物。另外还公开了制备卤代邻苯二甲酸酐的方法，以及在制备卤代邻苯二甲酸期间产生的包含HCl的乙酸水溶液中回收高纯度乙酸。

30. 发明授权

US07465729B2 Methods of treatment of menopause and perimenopause using eszopiclone 有权
标题翻译：使用左前列酮治疗绝经和围绝经期的方法
公开(公告)号：US07465729B2
公开(公告)日：2008-12-16
申请号：US11099155
申请日：2005-04-05
申请人： Thomas Wessel , Judy Caron
发明人： Thomas Wessel , Judy Caron
IPC分类号： A61K31/495
CPC分类号： A61K31/498
摘要： The invention relates to the use of eszopiclone for the treatment of symptoms accompanying perimenopause or menopause.
摘要翻译：本发明涉及依曲普洛酮用于治疗伴随围绝经期或更年期的症状的用途。

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