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21. 发明授权

US07981634B2 Method for positively detecting toxic material 有权
标题翻译：积极检测有毒物质的方法
公开(公告)号：US07981634B2
公开(公告)日：2011-07-19
申请号：US11609979
申请日：2006-12-13
申请人： Jung-im Han , Soo-hyung Choi , Soo-suk Lee , Sung-ouk Jung , Joon-shik Park , Ki-eun Kim
发明人： Jung-im Han , Soo-hyung Choi , Soo-suk Lee , Sung-ouk Jung , Joon-shik Park , Ki-eun Kim
IPC分类号： C12Q1/26
CPC分类号： G01N33/5079 , G01N2333/90209
摘要： Disclosed herein is a method of positively detecting toxic materials within a sample, the method including contacting sub-mitochondrial particles with an electron donor. The electron donor is reacted with an electron transfer system of the sub-mitochondrial particles to produce a reactant. A pH indicator has its pH adjusted to be in a range of 9 to 11. The pH indicator is added to each reactant. Color changes in the pH indicator permit the detection of toxins present in the sample.
摘要翻译：本文公开了一种积极检测样品内有毒物质的方法，该方法包括使亚线粒体颗粒与电子给体接触。电子给体与亚线粒体颗粒的电子转移体系反应以产生反应物。 pH指示剂的pH调节在9至11的范围内。将pH指示剂加入每种反应物中。 pH指示剂中的颜色变化允许检测样品中存在的毒素。

22. 发明申请

US20100319439A1 SURFACE ACOUSTIC WAVE SENSOR DEVICE AND METHOD OF CONTROLLING LIQUID USING THE SAME 有权
标题翻译：表面声波传感器装置及其控制液体的方法
公开(公告)号：US20100319439A1
公开(公告)日：2010-12-23
申请号：US12568724
申请日：2009-09-29
申请人： Hun Joo LEE , Soo Suk LEE , Eun Chul CHO
发明人： Hun Joo LEE , Soo Suk LEE , Eun Chul CHO
IPC分类号： G01N29/02
CPC分类号： G01N29/022 , B01L3/50273 , G01N29/036 , G01N2291/0256 , G01N2291/02818 , G01N2291/0423
摘要： A surface acoustic wave sensor device includes a main body and a liquid controller disposed external to the main body. The main body includes a sample chamber, a surface acoustic wave sensor connected to the sample chamber, a first disposal chamber connected to the surface acoustic wave sensor and channels connecting the sample chamber, the surface acoustic wave sensor and the first disposal chamber. The liquid controller controls flow of a sample through the main body.
摘要翻译：表面声波传感器装置包括设置在主体外部的主体和液体控制器。主体包括样品室，连接到样品室的表面声波传感器，连接到表面声波传感器的第一处理室和连接样品室，表面声波传感器和第一处理室的通道。液体控制器控制样品通过主体的流动。

23. 发明申请

US20100314967A1 SURFACE ACOUSTIC WAVE SENSOR DEVICE 有权
标题翻译：表面声波传感器装置
公开(公告)号：US20100314967A1
公开(公告)日：2010-12-16
申请号：US12544515
申请日：2009-08-20
申请人： Hun Joo LEE , Soo Suk LEE , Yeol Ho LEE , Ki Eun KIM
发明人： Hun Joo LEE , Soo Suk LEE , Yeol Ho LEE , Ki Eun KIM
IPC分类号： H01L41/04 , H05K3/00
CPC分类号： H01L41/1132 , H01L27/20 , Y10T29/49124
摘要： Provided herein is a surface acoustic wave (SAW) sensor device including a surface acoustic wave sensor and an oscillator corresponding to the surface acoustic wave sensor. A horizontal plane defined by the oscillator is inclined at a predetermined angle with respect to a horizontal plane defined by the surface acoustic wave sensor. The predetermined angle is greater than zero degrees.
摘要翻译：本文提供的是包括声表面波传感器和对应于表面声波传感器的振荡器的表面声波（SAW）传感器装置。由振荡器限定的水平面相对于由声表面波传感器限定的水平面以预定角度倾斜。预定角度大于零度。

24. 发明授权

US07544505B2 Hybridization chamber agitation device using pump and valves 失效
标题翻译：使用泵和阀的杂化室搅拌装置
公开(公告)号：US07544505B2
公开(公告)日：2009-06-09
申请号：US11295844
申请日：2005-12-06
申请人： Sung-ouk Jung , Nam Huh , Soo-suk Lee , Chang-eun Yoo , Hun-joo Lee
发明人： Sung-ouk Jung , Nam Huh , Soo-suk Lee , Chang-eun Yoo , Hun-joo Lee
IPC分类号： C12M1/34
CPC分类号： B01L3/502738 , B01F13/0059 , B01F13/0222 , B01L3/50273 , B01L7/52 , B01L2300/0636 , B01L2300/0822 , B01L2300/0877
摘要： Provided is an agitation device used to agitate a solution in a hybridization chamber, the agitation device including: the hybridization chamber; first and second air channels connected to ends of the hybridization chamber; a first valve disposed in the first air channel; a second valve disposed in the second air channel; an integrated air channel connecting the first and second air channels; and a pump disposed in the integrated air channel. The agitation device is suitable for effective diffusion of a sample when performing hybridization using a DNA chip. Therefore, a probe can be effectively hybridized with a target material.
摘要翻译：提供了用于搅拌杂交室中的溶液的搅拌装置，搅拌装置包括：杂交室; 第一和第二空气通道连接到杂交室的末端; 设置在第一空气通道中的第一阀; 设置在第二空气通道中的第二阀; 连接第一和第二空气通道的集成空气通道; 以及设置在集成空气通道中的泵。搅拌装置适用于使用DNA芯片进行杂交时样品的有效扩散。因此，探针可以有效地与靶材料杂交。

25. 发明申请

US20070209143A1 Robot vacuum cleaner having microbe sensing function 审中-公开
标题翻译：具有微生物感应功能的机器人吸尘器
公开(公告)号：US20070209143A1
公开(公告)日：2007-09-13
申请号：US11491862
申请日：2006-07-24
申请人： Soo-hyung Choi , Jung-im Han , Soo-suk Lee
发明人： Soo-hyung Choi , Jung-im Han , Soo-suk Lee
IPC分类号： A47L9/00
CPC分类号： A47L9/2852 , A47L9/2805 , A47L9/2836 , A47L11/34 , A47L11/4011 , A47L11/4044 , A47L11/4086 , A47L2201/06
摘要： A robot vacuum cleaner having a microbe sensing function is provided. The robot vacuum cleaner includes: a cleaner body which automatically travels in an area to be cleaned; a suction unit which sucks dust in the area to be cleaned into a specific space included in the cleaner body; a microbe contamination sensor which detects a microbe contamination in the area to be cleaned; and a sterilizing unit which sterilizes a corresponding portion according to a microbe contamination measuring signal generated from the microbe contamination sensor. Accordingly, a robot vacuum cleaner directly measures a level of microbe contamination to perform a sterilizing operation according to the result obtained from measurement. As a result, the sterilizing operation is performed sufficiently in a severely contaminated area, the sterilizing operation is performed in a general manner in other areas, and thus a cleaning operation can be rapidly carried out. Therefore, efficiencies in the cleaning and sterilizing operations are improved.
摘要翻译：提供具有微生物感测功能的机器人真空吸尘器。机器人真空吸尘器包括：清洁器主体，其在待清洁的区域中自动行进; 抽吸单元，其将要清洁的区域中的灰尘吸入包括在吸尘器主体中的特定空间中; 微生物污染传感器，其检测待清洁区域中的微生物污染; 以及灭菌单元，其根据从微生物污染传感器产生的微生物污染测量信号对相应部分进行灭菌。因此，机器人真空吸尘器根据从测定得到的结果，直接测量微生物污染物的水平进行灭菌操作。结果，在严重污染的区域中充分进行灭菌操作，在其他区域中以一般的方式进行灭菌操作，从而可以快速进行清洁操作。因此，清洁消毒操作的效率提高。

26. 发明申请

US20070003967A1 Method of manufacturing DNA chip 失效
标题翻译：制造DNA芯片的方法
公开(公告)号：US20070003967A1
公开(公告)日：2007-01-04
申请号：US11479306
申请日：2006-06-30
申请人： Jeo-young Shim , Soo-suk Lee , Chin-sung Park , Kyu-youn Hwang
发明人： Jeo-young Shim , Soo-suk Lee , Chin-sung Park , Kyu-youn Hwang
IPC分类号： C12Q1/68
CPC分类号： B01L3/50857 , B01L2200/12 , B01L2300/0636 , B01L2300/0819 , B82Y10/00 , G01N27/4145 , H01L21/823828 , H01L51/0093 , H01L51/0545 , Y10T436/2575
摘要： A method of manufacturing a DNA (deoxyribonucleic acid) chip is provided. The DNA chip has a plurality of transistors formed on a substrate and an organic layer and a DNA probe sequentially stacked on a gate of the transistor. The method includes forming an inter-layer insulation layer on the substrate to cover the transistors, planarizing the inter-layer insulation layer, forming at least two contact holes exposing gate electrodes of the transistors in the inter-layer insulation layer, selectively forming organic layers on the exposed gate electrodes, attaching a first DFR (dry film resist) layer to the upper surface of the inter-layer insulation layer to cover the contact holes, removing a portion of the first DFR layer covering a first contact hole among the contact holes, attaching a first DNA probe to the organic layers in the first contact hole, and removing a remaining portion of the first DFR layer.
摘要翻译：提供了DNA（脱氧核糖核酸）芯片的制造方法。 DNA芯片具有形成在基板上的多个晶体管，并且顺序层叠在晶体管的栅极上的有机层和DNA探针。该方法包括在衬底上形成层间绝缘层以覆盖晶体管，平坦化层间绝缘层，形成暴露在层间绝缘层中的晶体管的栅电极的至少两个接触孔，选择性地形成有机层在暴露的栅电极上，将第一DFR（干膜抗蚀剂）层附着到层间绝缘层的上表面以覆盖接触孔，去除覆盖接触孔中的第一接触孔的第一DFR层的一部分将第一DNA探针连接到第一接触孔中的有机层，以及去除第一DFR层的剩余部分。

27. 发明申请

US20060188906A1 Microfluidic chip for multiple bioassay and method of manufacturing the same 有权
标题翻译：微流控芯片用于多种生物测定及其制造方法
公开(公告)号：US20060188906A1
公开(公告)日：2006-08-24
申请号：US11335939
申请日：2006-01-20
申请人： Joon-ho Kim , Jun-hong Min , Kyung-hwan Park , Soo-suk Lee , Hyun-gyu Park
发明人： Joon-ho Kim , Jun-hong Min , Kyung-hwan Park , Soo-suk Lee , Hyun-gyu Park
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： B01L3/502707 , B01J2219/00522 , B01J2219/00527 , B01J2219/00585 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00632 , B01J2219/00644 , B01J2219/00657 , B01J2219/00659 , B01J2219/00711 , B01J2219/0072 , B01L3/5025 , B01L2200/12 , B01L2300/0636 , B01L2300/0816 , B01L2300/0887 , B82Y30/00
摘要： Provided are a microfluidic chip for multiple bioassay and a method of manufacturing the same. The method includes: forming microfluidic channels by coupling a channel structure having grooves for sample channels and probe channels in a bottom surface and a substrate; forming probe immobilization regions at intersections between the probe channels and the sample channels; and forming blocking walls in the probe channels before and after each of the probe immobilization regions to prevent mixing of target sample. Since the probes are immobilized in the microfluidic channels after the formation of the microfluidic channels, difficulty in connecting fluidic channels after the immobilization of probes on a substrate can be removed. In addition, a microfluidic platform for a multiple bioassay into which a plurality of samples can be simultaneously loaded can be formed.
摘要翻译：提供了用于多重生物测定的微流控芯片及其制造方法。该方法包括：通过在底表面和基底中耦合具有用于样品通道和探针通道的沟槽的通道结构来形成微流体通道; 在探针通道和样品通道之间的交叉处形成探针固定区域; 并且在每个探针固定区域之前和之后在探针通道中形成阻挡壁以防止靶样品混合。由于在形成微流体通道之后将探针固定在微流体通道中，因此可以除去在探针固定在基底上之后连接流体通道的困难。此外，可以形成用于多个生物测定的微流体平台，多个样品可以同时装载到该微生物测定中。

28. 发明申请

US20060099711A1 Cell lysis method by immobilized metal-ligand complex 失效
标题翻译：固定化金属配体复合物的细胞裂解法
公开(公告)号：US20060099711A1
公开(公告)日：2006-05-11
申请号：US11267005
申请日：2005-11-04
申请人： Chang-eun Yoo , Joon-ho Kim , Kyu-youn Hwang , Hun-joo Lee , Hee-kyun Lim , Soo-min Ma , Nam Huh , Soo-suk Lee
发明人： Chang-eun Yoo , Joon-ho Kim , Kyu-youn Hwang , Hun-joo Lee , Hee-kyun Lim , Soo-min Ma , Nam Huh , Soo-suk Lee
IPC分类号： G01N1/00
CPC分类号： C12Q1/6806 , Y10T436/25 , C12Q2523/308
摘要： Provided is a lysis method for cells or viruses, including: immobilizing a metal-ligand complex on a solid support; and mixing the complex immobilized on the support with a cell or virus solution. According to the lysis method, by immobilizing a chemical on a solid support to perform cell lysis, the dilution problem according to the addition of a cell lysis solution can be resolved and a separate process of removing the chemical is not required so as to reduce the steps upon LOC implementation. In addition, since a variety of solid supports, such as chips, beads, nanoparticles etc. can be used, cell lysis apparatuses of various forms can be fabricated.
摘要翻译：提供了一种细胞或病毒的裂解方法，包括：将固定支持物上的金属 - 配体复合物固定; 并将固定在载体上的复合物与细胞或病毒溶液混合。根据裂解方法，通过将化学物质固定在固体支持体上以进行细胞裂解，可以解决根据细胞溶解溶液的添加的稀释问题，并且不需要单独的除去化学品的方法，以减少 LOC实施步骤。此外，由于可以使用各种固体支持体，例如芯片，珠粒，纳米粒子等，因此可以制造各种形式的细胞裂解装置。

29. 发明申请

US20060035247A1 Biochip with radio frequency identification tag attached thereto, hybridization system, and hybridization management method 审中-公开
标题翻译：带有射频识别标签的生物芯片，杂交系统和杂交管理方法
公开(公告)号：US20060035247A1
公开(公告)日：2006-02-16
申请号：US11121481
申请日：2005-05-04
申请人： Christopher Ko , Soo-suk Lee , Hun-joo Lee , Gal Ju , Joon-soo Han
发明人： Christopher Ko , Soo-suk Lee , Hun-joo Lee , Gal Ju , Joon-soo Han
IPC分类号： C12Q1/68 , G06F19/00 , G01N33/48 , G01N33/50
CPC分类号： G01N33/54373 , B01J2219/00527 , B01J2219/00547 , B01J2219/00565 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01L3/545 , B01L2300/022 , B01L2300/0819 , G01N2035/00782
摘要： A biochip with a radio frequency (RF) identification (ID) chip attached thereto, a hybridization system, and a hybridization management method are provided. Probes used for analyzing living body molecules are highly integrated on a substrate of the biochip, and biochip information including information obtained in the process of combining the living body molecules with the probes of the biochip is recorded in the RF ID tag of the biochip. Accordingly, it is possible to efficiently manage the biochip information using the RF ID tag and to prevent the biochip from being reused.
摘要翻译：提供了附有射频（RF）识别（ID）芯片的生物芯片，杂交系统和杂交管理方法。用于分析活体分子的探针高度集成在生物芯片的基板上，并且生物芯片信息包括在生物芯片的生物体分子与生物芯片的探针组合的过程中获得的信息。因此，可以使用RF ID标签有效地管理生物芯片信息，并且防止生物芯片被再次使用。

30. 发明授权

US06924111B2 Microarray substrate comprising patterned photoresist film with spot regions, microarray, and method of detecting target material 失效
标题翻译：微阵列基板包括具有点区域的图案化光致抗蚀剂膜，微阵列和检测靶材料的方法
公开(公告)号：US06924111B2
公开(公告)日：2005-08-02
申请号：US10761516
申请日：2004-01-20
申请人： Soo-suk Lee , Sun-hee Kim , Young Choi
发明人： Soo-suk Lee , Sun-hee Kim , Young Choi
IPC分类号： G01N33/538 , B01J19/00 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , G01N33/545 , C12Q1/68
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00387 , B01J2219/00432 , B01J2219/00533 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , G01N33/545 , Y10S435/962
摘要： Provided is a microarray substrate. The microarray substrate includes a patterned photoresist film having one or more spot regions therein. The photoresist film can be detached from the substrate.
摘要翻译：提供了一种微阵列基板。微阵列基板包括其中具有一个或多个点区域的图案化的光致抗蚀剂膜。光致抗蚀剂膜可以从衬底上分离出来。

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