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1. 发明授权

US08367367B2 Kit for positively detecting toxic material 有权
标题翻译：用于积极检测有毒物质的试剂盒
公开(公告)号：US08367367B2
公开(公告)日：2013-02-05
申请号：US13155944
申请日：2011-06-08
申请人： Jung-im Han , Soo-hyung Choi , Soo-suk Lee , Sung-ouk Jung , Joon-shik Park , Ki-eun Kim
发明人： Jung-im Han , Soo-hyung Choi , Soo-suk Lee , Sung-ouk Jung , Joon-shik Park , Ki-eun Kim
IPC分类号： C12Q1/26
CPC分类号： G01N33/5079 , G01N2333/90209
摘要： A method of positively detecting toxic materials within a sample, the method including contacting sub-mitochondrial particles having competent mitochondrial enzymes formed from inner membranes of mitochondria, an electron donor which transmits electrons to an electron transfer system of the sub-mitochondrial particles and the sample, and forming reaction resultants, adjusting a pH of a pH indicator which change color according to a change in pH, adding the pH indicators to each reaction resultant and identifying color changes of the pH indicator. Also provided is a kit for positively detecting toxic materials within a sample.
摘要翻译：一种积极检测样品内的有毒物质的方法，该方法包括使具有由线粒体内膜形成的感受态线粒体酶的亚线粒体颗粒，将电子传递到亚线粒体颗粒的电子转移系统的电子给体和样品，并形成反应产物，调节pH指示剂的pH值，根据pH的变化改变颜色，向每个反应产物添加pH指示剂并鉴定pH指示剂的颜色变化。还提供了用于积极检测样品中有毒物质的试剂盒。

2. 发明授权

US08052855B2 Carbon nanotube gas sensor and method of manufacturing the same 有权
标题翻译：碳纳米管气体传感器及其制造方法
公开(公告)号：US08052855B2
公开(公告)日：2011-11-08
申请号：US11745522
申请日：2007-05-08
申请人： Jung-im Han , Soo-hyung Choi , Jeong-hee Lee , Soo-suk Lee , Jeong-na Heo
发明人： Jung-im Han , Soo-hyung Choi , Jeong-hee Lee , Soo-suk Lee , Jeong-na Heo
IPC分类号： G01N27/403 , G01N27/414
CPC分类号： G01N27/127 , Y10S977/742 , Y10S977/743 , Y10S977/953 , Y10S977/957
摘要： A carbon nanotube (“CNT”) gas sensor includes a substrate, an insulating layer formed on the substrate, electrodes formed on the insulating layer, and CNT barriers that protrude higher than the electrodes in spaces between the electrodes to form gas detecting spaces. A method of manufacturing the gas sensor includes forming an insulating layer on a substrate, forming an electrode pattern on the insulating layer, coating CNT paste having a thickness greater than a thickness of electrodes in the electrode pattern on the electrodes and the insulating layer, and patterning and firing the carbon nanotube paste, including using a photolithography method, to retain only portions of the CNT paste coated on spaces between the electrodes.
摘要翻译：碳纳米管（“CNT”）气体传感器包括基板，形成在基板上的绝缘层，形成在绝缘层上的电极和在电极之间的空间中比电极突出的CNT势垒，以形成气体检测空间。制造气体传感器的方法包括在基板上形成绝缘层，在绝缘层上形成电极图案，在电极和绝缘层上涂覆厚度大于电极图案的电极厚度的CNT浆料，以及包括使用光刻法构图和烧制碳纳米管糊，仅保留涂覆在电极之间的间隙上的部分CNT浆料。

3. 发明申请

US20070259392A1 METHOD AND KIT FOR POSITIVELY DETECTING TOXIC MATERIAL 有权
标题翻译：用于阳极检测毒性材料的方法和工具包
公开(公告)号：US20070259392A1
公开(公告)日：2007-11-08
申请号：US11609979
申请日：2006-12-13
申请人： Jung-im Han , Soo-hyung Choi , Soo-suk Lee , Sung-ouk Jung , Joon-shik Park , Ki-eun Kim
发明人： Jung-im Han , Soo-hyung Choi , Soo-suk Lee , Sung-ouk Jung , Joon-shik Park , Ki-eun Kim
IPC分类号： C12Q1/26 , C12Q1/32
CPC分类号： G01N33/5079 , G01N2333/90209
摘要： A method of positively detecting toxic materials within a sample, the method including contacting sub-mitochondrial particles having competent mitochondrial enzymes formed from inner membranes of mitochondria, an electron donor which transmits electrons to an electron transfer system of the sub-mitochondrial particles and the sample, and forming reaction resultants, adjusting a pH of a pH indicator which change color according to a change in pH, adding the pH indicators to each reaction resultant and identifying color changes of the pH indicator. Also provided is a kit for positively detecting toxic materials within a sample.
摘要翻译：一种积极检测样品内的有毒物质的方法，该方法包括使具有由线粒体内膜形成的感受态线粒体酶的亚线粒体颗粒，将电子传递到亚线粒体颗粒的电子转移系统的电子给体和样品，并形成反应产物，调节pH指示剂的pH值，根据pH的变化改变颜色，向每个反应产物添加pH指示剂并鉴定pH指示剂的颜色变化。还提供了用于积极检测样品中有毒物质的试剂盒。

4. 发明授权

US07981634B2 Method for positively detecting toxic material 有权
标题翻译：积极检测有毒物质的方法
公开(公告)号：US07981634B2
公开(公告)日：2011-07-19
申请号：US11609979
申请日：2006-12-13
申请人： Jung-im Han , Soo-hyung Choi , Soo-suk Lee , Sung-ouk Jung , Joon-shik Park , Ki-eun Kim
发明人： Jung-im Han , Soo-hyung Choi , Soo-suk Lee , Sung-ouk Jung , Joon-shik Park , Ki-eun Kim
IPC分类号： C12Q1/26
CPC分类号： G01N33/5079 , G01N2333/90209
摘要： Disclosed herein is a method of positively detecting toxic materials within a sample, the method including contacting sub-mitochondrial particles with an electron donor. The electron donor is reacted with an electron transfer system of the sub-mitochondrial particles to produce a reactant. A pH indicator has its pH adjusted to be in a range of 9 to 11. The pH indicator is added to each reactant. Color changes in the pH indicator permit the detection of toxins present in the sample.
摘要翻译：本文公开了一种积极检测样品内有毒物质的方法，该方法包括使亚线粒体颗粒与电子给体接触。电子给体与亚线粒体颗粒的电子转移体系反应以产生反应物。 pH指示剂的pH调节在9至11的范围内。将pH指示剂加入每种反应物中。 pH指示剂中的颜色变化允许检测样品中存在的毒素。

5. 发明申请

US20070209143A1 Robot vacuum cleaner having microbe sensing function 审中-公开
标题翻译：具有微生物感应功能的机器人吸尘器
公开(公告)号：US20070209143A1
公开(公告)日：2007-09-13
申请号：US11491862
申请日：2006-07-24
申请人： Soo-hyung Choi , Jung-im Han , Soo-suk Lee
发明人： Soo-hyung Choi , Jung-im Han , Soo-suk Lee
IPC分类号： A47L9/00
CPC分类号： A47L9/2852 , A47L9/2805 , A47L9/2836 , A47L11/34 , A47L11/4011 , A47L11/4044 , A47L11/4086 , A47L2201/06
摘要： A robot vacuum cleaner having a microbe sensing function is provided. The robot vacuum cleaner includes: a cleaner body which automatically travels in an area to be cleaned; a suction unit which sucks dust in the area to be cleaned into a specific space included in the cleaner body; a microbe contamination sensor which detects a microbe contamination in the area to be cleaned; and a sterilizing unit which sterilizes a corresponding portion according to a microbe contamination measuring signal generated from the microbe contamination sensor. Accordingly, a robot vacuum cleaner directly measures a level of microbe contamination to perform a sterilizing operation according to the result obtained from measurement. As a result, the sterilizing operation is performed sufficiently in a severely contaminated area, the sterilizing operation is performed in a general manner in other areas, and thus a cleaning operation can be rapidly carried out. Therefore, efficiencies in the cleaning and sterilizing operations are improved.
摘要翻译：提供具有微生物感测功能的机器人真空吸尘器。机器人真空吸尘器包括：清洁器主体，其在待清洁的区域中自动行进; 抽吸单元，其将要清洁的区域中的灰尘吸入包括在吸尘器主体中的特定空间中; 微生物污染传感器，其检测待清洁区域中的微生物污染; 以及灭菌单元，其根据从微生物污染传感器产生的微生物污染测量信号对相应部分进行灭菌。因此，机器人真空吸尘器根据从测定得到的结果，直接测量微生物污染物的水平进行灭菌操作。结果，在严重污染的区域中充分进行灭菌操作，在其他区域中以一般的方式进行灭菌操作，从而可以快速进行清洁操作。因此，清洁消毒操作的效率提高。

6. 发明授权

US07713716B2 Method for detecting presence of toxic material within sample 有权
标题翻译：检测样品中有毒物质的存在的方法
公开(公告)号：US07713716B2
公开(公告)日：2010-05-11
申请号：US11610851
申请日：2006-12-14
申请人： Jung-im Han , Soo-hyung Choi
发明人： Jung-im Han , Soo-hyung Choi
IPC分类号： C12Q1/26
CPC分类号： G01N33/5079 , G01N33/5035 , G01N2333/90209
摘要： Provided is a method for detecting the degree of toxicity of toxic materials within a sample. The method includes contacting sub-mitochondrial particles having competent mitochondrial enzyme formed from the inner membranes of mitochondria, an electron donor which transmits electrons to the electron transfer system of the sub-mitochondrial particles, and a sample which will be tested; adding tris-2,2′-bipyridyl-ruthenium (II) ion to the reaction mixture; and measuring electrical variables of the reaction mixture. Also, provided is an apparatus and kit for detecting the presence of toxic materials within a sample.
摘要翻译：提供了用于检测样品中有毒物质的毒性程度的方法。该方法包括使具有由线粒体内膜形成的具有感受态的线粒体酶的亚线粒体颗粒和将电子传递到亚线粒体颗粒的电子传递系统的电子供体以及待测试的样品; 向反应混合物中加入三 - 2,2'-联吡啶 - 钌（II）离子; 并测量反应混合物的电变量。此外，提供了用于检测样品中有毒物质的存在的装置和试剂盒。

7. 发明授权

US07819138B2 Microfluidic device using centrifugal force and pump to control fluid movement, microfluidic system comprising the same and method of manufacturing the microfluidic device 有权
标题翻译：使用离心力和泵来控制流体运动的微流体装置，包括其的微流体系统和制造微流体装置的方法
公开(公告)号：US07819138B2
公开(公告)日：2010-10-26
申请号：US11869835
申请日：2007-10-10
申请人： Hun-joo Lee , Nam Huh , Soo-suk Lee , Sung-ouk Jung , Soo-hyung Choi
发明人： Hun-joo Lee , Nam Huh , Soo-suk Lee , Sung-ouk Jung , Soo-hyung Choi
IPC分类号： F15C1/04
CPC分类号： G05D7/0694 , Y10T29/494 , Y10T137/0753 , Y10T137/2191 , Y10T137/86187
摘要： The microfluidic device includes a rotatable platform, a plurality of connection ports disposed at a portion of the platform proximate to a shaft connection hole, the plurality of connection ports capable of being connected to an external connector for selectively injecting and discharging fluid and being closed by the connector, a trap chamber disposed at a portion of the platform further away from the shaft connection hole than the plurality of connection ports, the trap chamber including an inlet connected with at least one connection port of the plurality of connection ports, an outlet connected with another connection port of the plurality of connection ports and structures which enlarge a contact area with the fluid and a temporary storage including an inlet connected with the outlet of the trap chamber and an outlet connected with another connection port of the plurality of connection ports.
摘要翻译：所述微流体装置包括可旋转平台，多个连接端口，设置在所述平台的靠近轴连接孔的部分处，所述多个连接端口能够连接到外部连接器，用于选择性地注入和排出流体并且由所述连接器，设置在所述平台的远离所述轴连接孔的所述平台部分处的所述收集室，所述收集室包括与所述多个连接端口中的至少一个连接端口连接的入口，所述入口连接到所述入口多个连接端口中的另一个连接端口和扩大与流体的接触面积的结构以及包括与捕集室的出口连接的入口的临时存储器和与多个连接端口中的另一连接端口连接的出口。

8. 发明授权

US07662614B2 Biochip platform including dielectric particle layer and optical assay apparatus using the same 失效
标题翻译：生物芯片平台包括电介质颗粒层和使用其的光学测定装置
公开(公告)号：US07662614B2
公开(公告)日：2010-02-16
申请号：US11330566
申请日：2006-01-11
申请人： Jang-seok Ma , Heon-su Jeon , Soo-hyung Choi , In-ho Lee , Fu Wang
发明人： Jang-seok Ma , Heon-su Jeon , Soo-hyung Choi , In-ho Lee , Fu Wang
IPC分类号： C12M1/34
CPC分类号： G01N21/6428 , B82Y20/00
摘要： Provided are a biochip platform for biochemically analyzing a sample such as DNA or protein, including a dielectric particle layer, and an optical assay apparatus including the same. The biochip platform includes the dielectric particle layer uniformly formed on a substrate. The particle uniformity of the dielectric particle layer enables good wavelength separation of fluorescence signal, and the large surface area of the dielectric particle layer guarantees better amplifications efficiency of fluorescence signal. Furthermore, the biochip platform shows good economical efficiency due to easy fabrication process, and is particularly useful in an optical assay apparatus for analyzing a biochemical sample due to good assay efficiency.
摘要翻译：提供了用于生物化学分析诸如DNA或蛋白质的样品（包括电介质颗粒层）的生物芯片平台和包括其的光学测定装置。生物芯片平台包括均匀地形成在基板上的电介质颗粒层。电介质颗粒层的粒子均匀性使得荧光信号的波长分离良好，并且电介质颗粒层的大的表面积保证了荧光信号的更好的放大效率。此外，生物芯片平台由于易于制造工艺而显示出良好的经济效率，并且在由于良好的测定效率分析生物化学样品的光学测定装置中特别有用。

9. 发明授权

US07803540B2 Method of increasing discrimination for single base mismatch using hurdle DNA and artificially mismatched probe 有权
标题翻译：使用障碍DNA和人为错配探针增加单碱基错配的鉴别方法
公开(公告)号：US07803540B2
公开(公告)日：2010-09-28
申请号：US11335229
申请日：2006-01-19
申请人： Soo-hyung Choi , Jang-seok Ma , Joon-shik Park , Ji-young Oh , Jong-suk Chung
发明人： Soo-hyung Choi , Jang-seok Ma , Joon-shik Park , Ji-young Oh , Jong-suk Chung
IPC分类号： C12P19/34 , C12Q1/68 , C07H21/02 , C07H21/04 , C07H21/00
CPC分类号： C12Q1/6827 , C12Q2537/113 , C12Q2527/107 , C12Q2525/185
摘要： A method of increasing discrimination for a target DNA having a polymorphic site is provided. The method comprising immobilizing first and second probes on a substrate; hybridizing the immobilized first and second probes with first and second hurdle DNAs, respectively; and hybridizing the target DNA with the hybrids, and determining the ratio of a signal of the target DNA hybridized to the first probe to a signal of the target DNA hybridized to the second probe. The addition of a hurdle DNA and variation of a probe base can improve an ability of discriminating a single base mismatch.
摘要翻译：提供了增加具有多态位点的靶DNA的鉴别方法。所述方法包括将第一和第二探针固定在基底上; 分别将固定的第一和第二探针与第一和第二障碍DNA杂交; 并且将目标DNA与杂交体杂交，并确定与第一探针杂交的靶DNA的信号与与第二探针杂交的靶DNA的信号的比率。障碍DNA的添加和探针碱基的变异可以提高鉴别单一碱基不匹配的能力。

10. 发明授权

US07659149B2 Method of electrically detecting biomolecule 失效
标题翻译：电气检测生物分子的方法
公开(公告)号：US07659149B2
公开(公告)日：2010-02-09
申请号：US11345790
申请日：2006-02-02
申请人： Kyu-tae Yoo , Sung-ouk Jung , Jun-hong Min , Ji-na Namgoong , Soo-hyung Choi , Jeo-young Shim
发明人： Kyu-tae Yoo , Sung-ouk Jung , Jun-hong Min , Ji-na Namgoong , Soo-hyung Choi , Jeo-young Shim
IPC分类号： C12Q1/68 , H01L21/66 , H01L21/00 , H01L21/336 , H01L29/80
CPC分类号： G01N33/54306
摘要： Provided is a method of sensing biomolecules using a bioFET, the method including: forming a layer including Au on a gate of the bioFET; forming a probe immobilized on a substrate separated from the gate by a predetermined distance, and a biomolecule having a thiol group (—SH) which is incompletely bonded to the probe; reacting the probe with a sample including a target molecule; and measuring a current flowing in a channel region between a source and a drain of the bioFET.
摘要翻译：提供了一种使用bioFET感测生物分子的方法，该方法包括：在bioFET的栅极上形成包含Au的层; 形成固定在与栅极分离预定距离的基板上的探针，以及具有与探针不完全结合的硫醇基（-SH）的生物分子; 使探针与包含靶分子的样品反应; 以及测量在bioFET的源极和漏极之间的沟道区域中流动的电流。

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