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21. 发明申请

US20170022555A1 MODULAR FLOW CELLS AND METHODS OF SEQUENCING 审中-公开
标题翻译：模块化流动细胞和序列化方法
公开(公告)号：US20170022555A1
公开(公告)日：2017-01-26
申请号：US15215234
申请日：2016-07-20
申请人： INTELLIGENT BIO-SYSTEMS, Inc. , QIAGEN INSTRUMENTS AG
发明人： Jerzy Olejnik , Dirk Zimmerman
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q2563/107 , C12Q2565/629
摘要： Modular flow cells, devices with modular flow cells, and methods of sequencing using modular flow cells, as well as systems and kits including modular flow cells, are described, permitting sequencing wherein less than the full capacity for sequencing is desired.
摘要翻译：描述了模块化流动池，具有模块化流动池的装置以及使用模块化流动池的排序方法，以及包括模块化流动池的系统和试剂盒，其允许测序，其中需要小于全部测序能力。

22. 发明申请

US20160222446A1 Methods and Compositions for Sequencing Nucleic Acids Using Charge 有权
标题翻译：使用电荷测序核酸的方法和组合
公开(公告)号：US20160222446A1
公开(公告)日：2016-08-04
申请号：US15095560
申请日：2016-04-11
申请人： Intelligent Bio-Systems, Inc.
发明人： Steven Gordon , Jerzy Olejnik
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q1/6869 , C12Q2525/117 , C12Q2565/30
摘要： The invention provides methods and compositions, and systems for determining the identity of nucleic acids in nucleotide sequences, including sequences with one or more homopolymer regions. The methods of the invention include improvements so as to accurately identify sequences, including the difficult homopolymer sequences that are encountered during nucleotide sequencing, such as pyrosequencing.
摘要翻译：本发明提供了用于确定核苷酸序列中核酸的同一性的方法和组合物以及系统，包括具有一个或多个均聚物区域的序列。本发明的方法包括改进以便准确地鉴定序列，包括在核苷酸测序期间遇到的困难的均聚物序列，如焦磷酸测序。

23. 发明授权

US08900810B2 Methods and devices for sequencing nucleic acids in smaller batches 有权
标题翻译：用于较小批次测序核酸的方法和装置
公开(公告)号：US08900810B2
公开(公告)日：2014-12-02
申请号：US13786895
申请日：2013-03-06
申请人： Intelligent Bio Systems, Inc.
发明人： Steven Gordon , Thomas Hagerott , Edmund Golaski , Jerzy Olejnik
IPC分类号： C12Q1/68 , C12M3/00 , B01L3/00
CPC分类号： G01N27/44791 , B01L3/502715 , B01L3/502761 , B01L2200/0668 , B01L2300/0877 , B01L2400/0487 , C12Q1/6869 , G01N27/44726
摘要： The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. A plurality of smaller flow cells is employed, each with a relatively small area to be imaged, in order to provide greater flexibility and efficiency.
摘要翻译：本发明提供了方法和组合物，包括但不限于使用例如通过合成方法的测序获得的数据来确定核苷酸序列中核酸的身份的算法，计算机可读介质，计算机程序，装置和系统。为了提供更大的灵活性和效率，采用多个较小的流动池，每个具有相对小的要被成像的面积。

24. 发明申请

US20140342363A1 Sample Preparation 审中-公开
标题翻译：样品制备
公开(公告)号：US20140342363A1
公开(公告)日：2014-11-20
申请号：US13898064
申请日：2013-05-20
申请人： Intelligent Bio-Systems, Inc.
发明人： Steven Gordon , Phillip A. Veatch
IPC分类号： C12Q1/68
摘要： The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that are encountered during nucleotide sequencing, such as using sequencing by synthesis methods. These phenomena include, without limitation, sequence lead, sequence lag, spectral crosstalk, and noise resulting from variations in illumination and/or filter responses.
摘要翻译：本发明提供了方法和组合物，包括但不限于使用例如通过合成方法的测序获得的数据来确定核苷酸序列中核酸的身份的算法，计算机可读介质，计算机程序，装置和系统。本发明的方法包括校正核苷酸测序期间遇到的一种或多种现象，例如通过合成方法进行测序。这些现象包括但不限于序列引导，序列滞后，光谱串扰以及由照明和/或滤波器响应变化引起的噪声。

25. 发明申请

US20140267669A1 FLOW CELL ALIGNMENT METHODS AND SYSTEMS 有权
标题翻译：流动细胞对比方法和系统
公开(公告)号：US20140267669A1
公开(公告)日：2014-09-18
申请号：US13832509
申请日：2013-03-15
申请人： INTELLIGENT BIO-SYSTEMS, INC.
发明人： DAVID RAY STOOPS , Phillip Alan Veatch , Steven Jeffrey Gordon
IPC分类号： G01N33/483 , H04N7/18
CPC分类号： G06T7/0012 , G01N15/14 , G01N2015/0038 , G01N2015/144 , G02B21/10 , G02B21/16 , G02B21/365 , G06T7/73 , G06T2200/32 , G06T2207/10056 , G06T2207/30024 , H04N7/18
摘要： Imagers and alignment methods for use by imagers imaging deoxyribonucleic acid (DNA) fragments on a flow cell are disclosed. The imagers capture intensity values at DNA fragment bead locations in tiles with each tile having a reference location in the flow cell. Flow cells may be aligned by obtaining a dark field image of each tile during a first imaging session, identifying dark field constellations of bead locations within two separate tiles during the first imaging session, identifying corresponding constellations during a second imaging session, altering the reference location of at least one tile during the second imaging session to correct for a linear offset in the corresponding constellations, and applying at least one correction factor for reading out intensity values from the imager for the bead locations in the flow cell to correct for an angular offset determined from offsets in the corresponding constellations.
摘要翻译：公开了成像仪使用的成像仪和对准方法，其在流动池上成像脱氧核糖核酸（DNA）片段。成像器捕获瓷砖中DNA片段珠位置的强度值，每个瓦片在流动池中具有参考位置。可以通过在第一成像会话期间获得每个瓦片的暗场图像来对准流动池，在第一成像会话期间识别两个单独的瓦片内的珠粒位置的暗场星座，在第二成像会话期间识别相应的星座，改变参考位置的第二成像会话期间的至少一个瓦片以校正相应星座中的线性偏移，以及应用至少一个校正因子来从成像器读出强度值以用于流动池中的珠子位置以校正角度偏移从相应星座中的偏移确定。

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