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21. 发明申请

US20040023260A1 29 human secreted proteins 审中-公开
标题翻译： 29人分泌蛋白
公开(公告)号：US20040023260A1
公开(公告)日：2004-02-05
申请号：US10373809
申请日：2003-02-27
申请人： Human Genome Sciences, Inc.
发明人： Steven M. Ruben , Craig A. Rosen , Ping Fan , Hla Kyaw , Ying-Fei Wei
IPC分类号： C12Q001/68 , C07H021/04 , C12N009/00 , C12P021/02 , C12N005/06 , C07K014/47 , C07K016/18
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

22. 发明申请

US20040014110A1 Dendritic enriched secreted lymphocyte activation molecule 审中-公开
标题翻译：树突状细胞分泌淋巴细胞活化分子
公开(公告)号：US20040014110A1
公开(公告)日：2004-01-22
申请号：US10445888
申请日：2003-05-28
申请人： Human Genome Sciences, Inc.
发明人： Paul Young , Steven M. Ruben
IPC分类号： C12Q001/68 , C07H021/04 , C12P021/02 , C12N005/08 , C07K014/74 , C07K016/28
CPC分类号： C07K14/47 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , A61K2039/5154 , C07K14/70596 , C07K2319/00 , C07K2319/30 , C12N2799/026
摘要： The present invention relates to a novel human protein called Dendritic Enriched Secreted Lymphocyte Activation Molecule, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to this novel human protein.
摘要翻译：本发明涉及一种称为树突状分泌型分泌淋巴细胞活化分子的新型人类蛋白质，以及编码该蛋白质的分离的多核苷酸。还提供了用于产生该人蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与该新型人蛋白相关的疾病的诊断和治疗方法。

23. 发明申请

US20040014039A1 Nucleic acids, proteins, and antibodies 审中-公开
公开(公告)号：US20040014039A1
公开(公告)日：2004-01-22
申请号：US10158057
申请日：2002-05-31
申请人： Human Genome Sciences, Inc.
发明人： Craig A. Rosen , Steven M. Ruben , Steven C. Barash
IPC分类号： C12Q001/68 , G01N033/53 , C07H021/04 , C12N009/00 , C12P021/02 , C12N005/06 , C07K014/47
CPC分类号： C07K14/47
摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

24. 发明申请

US20040005577A1 Nucleic acids, proteins, and antibodies 审中-公开
标题翻译：核酸，蛋白质和抗体
公开(公告)号：US20040005577A1
公开(公告)日：2004-01-08
申请号：US10242747
申请日：2002-09-13
申请人： Human Genome Sciences, Inc.
发明人： Craig A. Rosen , Steven M. Ruben , Steven C. Barash
IPC分类号： C12Q001/68 , C07H021/04 , C12P021/02 , C12N005/06 , C07K014/435
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00
摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及新型蛋白质。更具体地，提供编码新型多肽的分离的核酸分子。提供结合这些多肽的新型多肽和抗体。还提供了载体，宿主细胞，以及用于产生人多核苷酸和/或多肽的抗体的重组和合成方法。本发明还涉及用于诊断，治疗，预防和/或预测与这些新型多肽相关的疾病的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还涉及用于抑制或增强本发明多肽的产生和功能的方法和/或组合物。

25. 发明申请

US20030235829A1 Nucleic acids, proteins, and antibodies 审中-公开
公开(公告)号：US20030235829A1
公开(公告)日：2003-12-25
申请号：US10227646
申请日：2002-08-26
申请人： Human Genome Sciences, Inc.
发明人： Steven M. Ruben , Steven C. Barash , Craig A. Rosen , Charles E. Birse
IPC分类号： C12Q001/68 , C07H021/04 , C12N009/00 , C12P021/02 , C12N005/06 , C07K014/435
CPC分类号： C07K14/705 , A61K38/00 , C07K14/47 , C12N9/00 , G01N33/68
摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

26. 发明申请

US20030215893A1 Nucleic acids, proteins, and antibodies 审中-公开
公开(公告)号：US20030215893A1
公开(公告)日：2003-11-20
申请号：US10212872
申请日：2002-08-07
申请人： Human Genome Sciences, Inc.
发明人： Craig A. Rosen , Steven M. Ruben , Steven C. Barash
IPC分类号： C12Q001/68 , G01N033/574 , C07H021/04 , C12N009/00 , C12P021/02 , C12N005/06
CPC分类号： C07H21/04 , C12N5/06 , C12N9/00 , C12P21/02 , C12Q1/68 , G01N33/574
摘要： The present invention relates to novel respiratory system related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as nullrespiratory system antigens,null and the use of such respiratory system antigens for detecting disorders of the respiratory system, particularly the presence of cancer of respiratory system tissues and cancer metastases. More specifically, isolated respiratory system associated nucleic acid molecules are provided encoding novel respiratory system associated polypeptides. Novel respiratory system polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human respiratory system associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the respiratory system, including cancer of respiratory system tissues, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.

27. 发明申请

US20030208058A1 B7-like polypeptides and polynucleotides 审中-公开
标题翻译： B7样多肽和多核苷酸
公开(公告)号：US20030208058A1
公开(公告)日：2003-11-06
申请号：US10023339
申请日：2001-12-20
申请人： Human Genome Sciences, Inc.
发明人： Michele Fiscella , Jian Ni , Steven M. Ruben
IPC分类号： C07K014/705 , C07H021/04 , C12P021/02 , C12N005/06
CPC分类号： C07K14/70532 , C07K16/2827 , G01N2333/70532
摘要： The present invention relates to novel human B7-like polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human B7-like polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human B7-like polypeptides.
摘要翻译：本发明涉及新型人B7样多肽和含有编码这些多肽的基因的编码区的分离的核酸。还提供了用于产生人B7样多肽的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人B7样多肽有关的紊乱的诊断和治疗方法。

28. 发明申请

US20030204071A1 109 human secreted proteins 审中-公开
标题翻译： 109人分泌蛋白
公开(公告)号：US20030204071A1
公开(公告)日：2003-10-30
申请号：US10372876
申请日：2003-02-26
申请人： Human Genome Sciences, Inc.
发明人： Paul A. Moore , Steven M. Ruben , Kenneth C. Carter , Yanggu Shi , Craig A. Rosen , Daniel R. Soppet , Hla Kyaw , Ying-Feig Wei , Kimberly Florence , Roxanne Duan , Charles Florence , John M. Greene , Ping Feng , Ann M. Ferrie , Guo-Liang Yu , Fouad Janat , Jian Ni
IPC分类号： C07H021/04 , C12N009/00 , C12P021/02 , C12N005/06 , C07K014/47
CPC分类号： C07K14/4702 , A61K38/00 , A61K48/00 , C07K14/47 , C07K14/4718 , C07K14/705 , C07K2319/00 , C07K2319/02 , C12N15/11 , C12N2799/026
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

29. 发明申请

US20030199008A1 Nucleic Acids, Proteins, and antibodies 审中-公开
标题翻译：核酸，蛋白质和抗体
公开(公告)号：US20030199008A1
公开(公告)日：2003-10-23
申请号：US10080254
申请日：2002-02-22
申请人： Human Genome Sciences, Inc.
发明人： Craig A. Rosen , Steven M. Ruben , Steven C. Barash
IPC分类号： G01N033/574 , C07H021/04 , C12N009/00 , C12P021/02 , C12N005/06
CPC分类号： C07K14/47
摘要： The present invention relates to novel bladder related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as nullbladder antigens,null and the use of such bladder antigens for detecting disorders of the bladder system, particularly the presence of bladder cancer and bladder cancer metastases. More specifically, isolated bladder associated nucleic acid molecules are provided encoding novel bladder associated polypeptides. Novel bladder polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human bladder associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the bladder, including bladder cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及新颖的膀胱相关多核苷酸和由这些多核苷酸编码的多肽本文统称为“膀胱抗原”，以及使用这种膀胱抗原来检测膀胱系统疾病，特别是膀胱癌和膀胱癌转移的存在。更具体地，提供分离的膀胱相关核酸分子，其编码新的膀胱相关多肽。提供结合这些多肽的新型膀胱多肽和抗体。还提供了载体，宿主细胞以及用于产生人膀胱相关多核苷酸和/或多肽的重组和合成方法。本发明还涉及可用于诊断，治疗，预防和/或预测与膀胱相关的疾病（包括膀胱癌）和用于治疗这些疾病的治疗方法的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还涉及用于抑制本发明多肽的产生和功能的方法和/或组合物。

30. 发明申请

US20030186387A1 Interleukins-21 and 22 审中-公开
标题翻译：白细胞介素-21和22
公开(公告)号：US20030186387A1
公开(公告)日：2003-10-02
申请号：US10397282
申请日：2003-03-27
申请人： Human Genome Sciences, Inc.
发明人： Reinhard Ebner , Steven M. Ruben
IPC分类号： C07H021/04 , C12P021/04 , C07K014/54 , C12P021/02 , C12N005/06 , A61K038/20
CPC分类号： C07K14/54 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K2319/00 , C07K2319/30 , C12N2799/026 , G01N2333/54 , G01N2500/10
摘要： The present invention relates to novel human proteins designated Interleukin-21 (IL-21) and Interleukin-22 (IL-22), and isolated polynucleotides encoding these proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing these human proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, and/or preventing disorders related to these novel human proteins.
摘要翻译：本发明涉及命名为白细胞介素-21（IL-21）和白细胞介素-22（IL-22）的新型人蛋白质和编码这些蛋白质的分离的多核苷酸。还提供了用于产生这些人蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及可用于诊断，治疗和/或预防与这些新型人蛋白相关的疾病的诊断和治疗方法。

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