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21. 发明申请

US20060211696A1 IMIDAZO[1,2-b]PYRIDAZINE COMPOUND 审中-公开
标题翻译：咪唑并[1,2-b]吡啶化合物
公开(公告)号：US20060211696A1
公开(公告)日：2006-09-21
申请号：US11421740
申请日：2006-06-01
申请人： Shigeki HIBI , Yoshinori Takahashi , Yorihisa Hoshino , Koichi Kikuchi , Motohiro Soejima , Tatsuya Yoshiuchi , Kogyoku Shin , Mutsuko Ono , Hisashi Shibata , Mitsuhiro Ino , Tetsuya Hirakawa
发明人： Shigeki HIBI , Yoshinori Takahashi , Yorihisa Hoshino , Koichi Kikuchi , Motohiro Soejima , Tatsuya Yoshiuchi , Kogyoku Shin , Mutsuko Ono , Hisashi Shibata , Mitsuhiro Ino , Tetsuya Hirakawa
IPC分类号： A61K31/53 , A61K31/498 , A61K31/519 , C07D487/04
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula or a salt thereof. Wherein R1 denotes a hydrogen atom, a C1-6 alkyl group, a C1-6 alkoxy group and the like; R2 denotes a halogen atom, a cyano group, a nitro group, a C1-10 alkyl group, a C2-10 alkenyl group, C2-10 alkynyl group and the like; R3 denotes a C6-14 aromatic hydrocarbon cyclic group or a 5- to 14-membered aromatic heterocyclic group, each of which may have a substituent; and X, Y and X are independent of each other and each denotes N or CR4 (wherein R4 denotes a hydrogen atom, a halogen atom, a cyano group, a nitro group, an optionally halogenated C1-6 alkyl group and the like) and, in this case, at least two of X, Y and Z denote CR4.
摘要翻译：本发明提供具有优异的促肾上腺皮质激素释放因子受体拮抗活性的新型化合物。也就是说，它提供由下式表示的化合物或其盐。其中R 1表示氢原子，C 1-6烷基，C 1-6烷氧基等; R 2表示卤素原子，氰基，硝基，C 1-10烷基，C 2-10链烯基基团，C 2-10炔基等; R 3表示可以具有取代基的C 6-14芳族烃环基或5〜14元芳香族杂环基，并且X，Y和X彼此独立并且各自表示N或CR 4（其中R 4表示氢原子，卤素原子，氰基，硝基，任选卤代的C 1-6烷基等），在这种情况下，X，Y和Z中的至少两个表示CR 4。

22. 发明授权

US07078405B2 Imidazo[1,2-b]pyridazine compound 失效
标题翻译：咪唑并[1,2-b]哒嗪化合物
公开(公告)号：US07078405B2
公开(公告)日：2006-07-18
申请号：US10451741
申请日：2002-02-08
申请人： Shigeki Hibi , Yoshinori Takahashi , Yorihisa Hoshino , Koichi Kikuchi , Motohiro Soejima , Tatsuya Yoshiuchi , Kogyoku Shin , Mutsuko Ono , Hisashi Shibata , Mitsuhiro Ino
发明人： Shigeki Hibi , Yoshinori Takahashi , Yorihisa Hoshino , Koichi Kikuchi , Motohiro Soejima , Tatsuya Yoshiuchi , Kogyoku Shin , Mutsuko Ono , Hisashi Shibata , Mitsuhiro Ino
IPC分类号： A01N43/58 , A01N43/60 , A61K31/50 , A61K31/495 , C07D487/00
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula or a salt thereof. Wherein R1 denotes a hydrogen atom, a C1-6 alkyl group, a C1-6 alkoxy group and the like; R2 denotes a halogen atom, a cyano group, a nitro group, a C1-10 alkyl group, a C2-10 alkenyl group, C2-10 alkynyl group and the like; R3 denotes a C6-14 aromatic hydrocarbon cyclic group or a 5- to 14-membered aromatic heterocyclic group, each of which may have a substituent; and X, Y and X are independent of each other and each denotes N or CR4 (wherein R4 denotes a hydrogen atom, a halogen atom, a cyano group, a nitro group, an optionally halogenated C1-6 alkyl group and the like) and, in this case, at least two of X, Y and Z denote CR4.
摘要翻译：本发明提供具有优异的促肾上腺皮质激素释放因子受体拮抗活性的新型化合物。也就是说，它提供由下式表示的化合物或其盐。其中R 1表示氢原子，C 1-6烷基，C 1-6烷氧基等; R 2表示卤素原子，氰基，硝基，C 1-10烷基，C 2-10链烯基基团，C 2-10炔基等; R 3表示可以具有取代基的C 6-14芳族烃环基或5〜14元芳香族杂环基，并且X，Y和X彼此独立并且各自表示N或CR 4（其中R 4表示氢原子，卤素原子，氰基，硝基，任选卤代的C 1-6烷基等），在这种情况下，X，Y和Z中的至少两个表示CR 4。

23. 发明授权

US06951865B2 Fused heterotricyclic compounds, process for preparing the compounds and drugs containing the same 失效
标题翻译：融合的异三环化合物，制备化合物的方法和含有它们的药物
公开(公告)号：US06951865B2
公开(公告)日：2005-10-04
申请号：US10148836
申请日：2000-12-13
申请人： Shigeki Hibi , Yorihisa Hoshino , Tatsuya Yoshiuchi , Kogyoku Shin , Kouichi Kikuchi , Motohiro Soejima , Mutsuko Tabata , Yoshinori Takahashi , Hisashi Shibata , Tetsuya Hirakawa
发明人： Shigeki Hibi , Yorihisa Hoshino , Tatsuya Yoshiuchi , Kogyoku Shin , Kouichi Kikuchi , Motohiro Soejima , Mutsuko Tabata , Yoshinori Takahashi , Hisashi Shibata , Tetsuya Hirakawa
IPC分类号： A61P1/04 , A61P1/08 , A61P1/10 , A61P1/12 , A61P1/14 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , C07D471/14 , C07D487/14 , C07D491/14 , A61K31/4353 , A61K31/519 , A61P25/24 , C07D487/04
CPC分类号： C07D471/14 , C07D487/14 , C07D491/14
摘要： The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula, a pharmacologically acceptable salt thereof or hydrates thereof. Wherein A, B and D are the same as or different from each other and each represents a group represented by the formula —(CR1R2)m— (wherein R1 and R2 are the same as or different from each other and each represents a C1-6 alkyl group etc.), —NR3— (wherein R3 represetns hydrogen etc.) etc.; E and G are the same as or different from each other and each represents a group represented by the formula —(CR6R7)p— (wherein R6and R7 are the same as or different from each other and each represents hydrogen etc.; and p represents an integer of 0, 1 or 2); J represents a carbon atom or nitrogen atom, each substituted with C1-6 alkyl group optionally substituted with a halogen atom, etc.; K and L are the same as or different from each other and each represents carbon atom or nitrogen atom; M means hydrogen, a halogen atom, an optionally substituted C1-6 alkyl group etc.; and the partial structure means a single or double bond.
摘要翻译：本发明提供具有优异的促肾上腺皮质激素释放因子受体拮抗活性的新型化合物。也就是说，它提供由下式表示的化合物，其药理学上可接受的盐或其水合物。其中A，B和D彼此相同或不同，并且各自表示由下式表示的基团 - （CR 1）2 - /其中R 1和R 2彼此相同或不同，并且各自表示C 1-6烷基基团等），-NR 3 - （其中R 3代表氢等）等; E和G彼此相同或不同，并且各自表示由下式表示的基团： - （CR 6），R 7， - （其中R 6和R 7彼此相同或不同，各自表示氢等; p表示0,1或2的整数） ; J表示碳原子或氮原子，各自被任选被卤素原子取代的C 1-6烷基取代; K和L彼此相同或不同，各自表示碳原子或氮原子; M表示氢，卤素原子，任选取代的C 1-6烷基等; 并且部分结构表示单键或双键。

24. 发明授权

US06031687A Disk table in magnetic disk drive 失效
标题翻译：磁盘驱动器中的磁盘表
公开(公告)号：US06031687A
公开(公告)日：2000-02-29
申请号：US19590
申请日：1998-02-06
申请人： Makoto Konno , Hisashi Shibata , Toshinori Kurosaka
发明人： Makoto Konno , Hisashi Shibata , Toshinori Kurosaka
IPC分类号： G11B17/028 , G11B19/20 , G11B23/00
CPC分类号： G11B17/0282 , G11B19/2009 , G11B23/0035
摘要： A disk table in a magnetic disk drive is disclosed. The disk table comprises a disk table body having an opening, a chucking arm made of an elastic body, where one end of the chucking arm is fixed on a lower face of the disk table body and the other end of the chucking arm is set free, a chucking roller disposed on the other fee end of the chucking arm, where the chucking roller is protruded from an upper face of the disk table through the opening, and a stopper provided on the lower face of the disk table in the vicinity of the free end of the chucking arm, wherein the chucking arm is freely floatable in vertical direction, and the amount of separation of the free end of the chucking arm from the lower face of the disk table body is restricted by stopper when the chucking roller is urged downwards. The restricted amount of displacement of the free end of the chucking arm is set such that the chucking arm would not deform plastically, or such that the chucking roller would not slip off or remove from said opening of the disk table body.
摘要翻译：公开了磁盘驱动器中的磁盘表。盘台包括具有开口的盘台主体，由弹性体制成的夹持臂，夹持臂的一端固定在盘台主体的下表面上，夹持臂的另一端被释放设置在所述夹持臂的另一个收费端上的夹持辊，其中所述夹持辊通过所述开口从所述盘台的上表面突出;以及止动件，设置在所述盘台的下表面附近夹持臂的自由端，其中夹持臂在垂直方向上可自由浮动，并且当夹紧辊被推动时夹持臂的自由端与盘台主体的下表面的分离量被制动器限制向下。夹持臂的自由端的限制的位移量被设定为使得夹持臂不会塑性变形，或者使得夹持辊不会从盘台主体的所述开口脱落或移除。

25. 发明授权

US6031686A Disk drive with reinforced frame plate structure made of two thin metal plates adhered together, and a reinforcing bead formed thereon 失效
标题翻译：具有由两个薄金属板粘合在一起的加强框架板结构的磁盘驱动器和形成在其上的增强焊珠
公开(公告)号：US6031686A
公开(公告)日：2000-02-29
申请号：US993279
申请日：1997-12-18
申请人： Makoto Konno , Hisashi Shibata
发明人： Makoto Konno , Hisashi Shibata
IPC分类号： G11B25/04 , G11B33/12 , G11B33/00 , G11B17/04
CPC分类号： G11B33/121 , G11B25/043
摘要： A disk drive comprises a frame plate having a principal surface on which a receiving portion for receiving a disk and a recording/reproducing unit for carrying out recording/reproducing operations onto and from the disk are provided. The frame plate comprises a metal thin plate and has a rear surface to which a thin reinforcing plate substantially equal in length and width to the frame plate is adhered.
摘要翻译：磁盘驱动器包括具有主表面的框架板，用于接收盘的接收部分和用于在盘上进行记录/再现操作的记录/再现单元。框架板包括金属薄板，并且具有背面，粘合有与框架板的长度和宽度基本相等的薄的加强板。

26. 发明授权

US6028740A Structure for preventing head judder of magnetic disk drive 失效
标题翻译：用于防止磁盘驱动器头部抖动的结构
公开(公告)号：US6028740A
公开(公告)日：2000-02-22
申请号：US38231
申请日：1998-03-11
申请人： Makoto Konno , Hisashi Shibata , Koichi Seno
发明人： Makoto Konno , Hisashi Shibata , Koichi Seno
IPC分类号： G11B21/21 , G11B5/48 , G11B21/20 , G11B17/32
CPC分类号： G11B5/4813
摘要： A structure for preventing head judder of a magnetic disk drive is disclosed. The structure comprises an opening provided at front end portion of an upper plate of a head carriage, a gimbal disposed within the opening, a magnetic head hangingly disposed on a central lower face of the gimbal, a pivot spacer disposed between the upper plate and a central upper face of the magnetic head, and at least one pair of adhesive tapes, inner ends of the adhesive tapes are respectively stuck on near central upper face of the gimbal, and the adhesive tapes symmetrically extend towards right and left end of the gimbal.
摘要翻译：公开了一种用于防止磁盘驱动器的头部抖动的结构。该结构包括设置在头部托架的上板的前端部的开口，设置在开口内的万向节，悬挂地设置在万向节的中心下表面上的磁头，设置在上板和磁头的中央上表面和至少一对粘合带，粘合带的内端分别卡在万向架的中央上表面附近，并且粘合带对称地延伸到万向架的右端和左端。

27. 发明授权

US6004143A Mounting structure of I/O connector in magnetic disk drive 失效
标题翻译：磁盘驱动器中I / O连接器的安装结构
公开(公告)号：US6004143A
公开(公告)日：1999-12-21
申请号：US25445
申请日：1998-02-17
申请人： Makoto Konno , Hisashi Shibata
发明人： Makoto Konno , Hisashi Shibata
IPC分类号： G11B25/04 , H01R13/74 , H01R9/09
CPC分类号： H01R13/743
摘要： A mounting structure for an I/O (input/output) connector in a magnetic disk drive comprises a frame of the magnetic disk drive including a side wall, an I/O connector mounted on a printed board, and an engagement piece formed within the side wall that obliquely extends downwards and toward the inside of the side wall. The engagement piece is pushed towards the sidewall by side faces of the I/O connector and the printed board facing the inner face of the side wall when the printed board, on which the I/O connector is mounted, is inserted into the frame of the magnetic disk drive. A tip end of the engagement piece contacts a top face of the I/O connector when the printed board, on which the mounted board is mounted, is completely mounted onto the frame of the magnetic disk drive.
摘要翻译：用于磁盘驱动器中的I / O（输入/输出）连接器的安装结构包括：磁盘驱动器的框架，其包括侧壁，安装在印刷电路板上的I / O连接器，侧壁向下倾斜并朝向侧壁的内侧倾斜。当将安装有I / O连接器的印刷板插入到框架中时，接合件被I / O连接器的侧面朝向侧壁推压，并且印刷板面向侧壁的内表面磁盘驱动器。当安装有安装板的印刷电路板完全安装在磁盘驱动器的框架上时，接合件的末端接触I / O连接器的顶面。

28. 发明授权

US5998445A Pyridine derivatives having anti-ulcerative activity 失效
标题翻译：具有抗溃疡活性的吡啶衍生物
公开(公告)号：US5998445A
公开(公告)日：1999-12-07
申请号：US679473
申请日：1996-07-09
申请人： Shigeru Souda , Norihiro Ueda , Shuhei Miyazawa , Katsuya Tagami , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Masatoshi Fujimoto , Manabu Murakami , Kiyoshi Oketani , Hideaki Fujisaki , Hisashi Shibata , Tsuneo Wakabayashi
发明人： Shigeru Souda , Norihiro Ueda , Shuhei Miyazawa , Katsuya Tagami , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Masatoshi Fujimoto , Manabu Murakami , Kiyoshi Oketani , Hideaki Fujisaki , Hisashi Shibata , Tsuneo Wakabayashi
IPC分类号： A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/54 , A61P1/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： Pyridine derivatives useful for preventing or treating peptic ulcers, pharmaceutical preparations and methods of treating peptic ulcers are described.
摘要翻译：描述了可用于预防或治疗消化性溃疡的吡啶衍生物，药物制剂和治疗消化性溃疡的方法。

29. 发明授权

US5960156A Video camera combined with recording and reproducing system having a camera unit, a viewfinder unit, and a battery unit arranged in a projection area of a recording and reproducing deck unit 失效
标题翻译：与具有相机单元，取景器单元和布置在记录和再现台单元的投影区域中的电池单元的记录和再现系统相结合的摄像机
公开(公告)号：US5960156A
公开(公告)日：1999-09-28
申请号：US938841
申请日：1992-08-31
申请人： Takanori Nishiyama , Akira Takahashi , Hiroto Takita , Toshiharu Watanabe , Takeshi Kawarai , Hisashi Shibata
发明人： Takanori Nishiyama , Akira Takahashi , Hiroto Takita , Toshiharu Watanabe , Takeshi Kawarai , Hisashi Shibata
IPC分类号： H04N5/225 , H04N5/247
CPC分类号： H04N5/2252
摘要： A video camera combined with a recording and reproducing system having a recording and reproducing deck unit having a generally flat shape, a camera unit, a viewfinder unit, and a battery unit. As viewed from the direction perpendicular to the widest surface of the recording and reproducing deck unit, the camera unit, viewfinder unit, and battery unit are arranged so that they are set almost in the projection area of the widest surface.
摘要翻译：一种与具有大致平坦形状的记录和再现台单元的记录和再现系统相结合的摄像机，相机单元，取景器单元和电池单元。从垂直于记录和再现台面单元的最宽表面的方向观察，相机单元，取景器单元和电池单元被布置成使得它们几乎设置在最宽表面的投影区域中。

30. 发明授权

US5956205A Disk holding mechanism capable of preventing a disk from undesirable vibration within a disk holder unit 失效
标题翻译：盘保持机构能够防止盘在盘保持器单元内的不期望的振动
公开(公告)号：US5956205A
公开(公告)日：1999-09-21
申请号：US972592
申请日：1997-11-18
申请人： Makoto Konno , Hisashi Shibata , Masaki Kato
发明人： Makoto Konno , Hisashi Shibata , Masaki Kato
IPC分类号： G11B17/03 , G11B17/028 , G11B17/035 , G11B17/04 , G11B17/041 , G11B17/022
CPC分类号： G11B17/035
摘要： A disk holding mechanism for use in a disk apparatus includes a disk holder unit (60) for holding a disk (40) inserted into the disk apparatus. The disk holder unit includes a leaf spring (63) which serves as an urging member for urging a substantial center of the disk downwardly from an upper surface of the disk with the disk held in the disk holder unit. The urging member prevents the disk from vibrating within the disk holder unit and restricts vertical movement of the disk itself even if the disk apparatus is subjected to external shake or shock. Thus, it is possible to constantly maintain stable head touch of a magnetic head to a magnetic disk medium (41) of the disk.
摘要翻译：用于盘装置的盘保持机构包括：盘保持单元（60），用于保持插入到盘装置中的盘（40）。盘保持器单元包括板簧（63），其用作从盘的上表面向下推动盘的大致中心的推动构件，其中盘保持在盘保持器单元中。推动构件防止盘在盘保持器单元内振动，并且即使盘装置遭受外部震动或震动也限制盘自身的垂直运动。因此，可以将磁头的稳定的头部接触保持在盘的磁盘介质（41）上。

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