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21. 发明授权

US5021236A Method of enhancing NMR imaging using chelated paramagnetic ions bound to biomolecules 失效
标题翻译：使用结合生物分子的螯合顺磁离子增强NMR成像的方法
公开(公告)号：US5021236A
公开(公告)日：1991-06-04
申请号：US20300
申请日：1987-03-02
申请人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hoyer , Heinrich Pfeiffer, deceased
发明人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hoyer , Heinrich Pfeiffer, deceased
IPC分类号： A61K49/04 , A61K49/06 , A61K49/10 , A61K49/18 , C07C323/25 , C07D257/02 , C07F9/38 , G01R33/28
CPC分类号： C07C323/25 , A61K49/04 , A61K49/085 , A61K49/10 , A61K49/103 , A61K49/105 , A61K49/106 , A61K49/108 , A61K49/143 , A61K49/16 , A61K49/18 , A61K49/1806 , A61K49/1809 , A61K49/1812 , C07D257/02 , C07F9/3817 , C07F9/386 , G01R33/5601 , Y10S436/806 , Y10S514/836 , Y10T436/24
摘要： Agents useful for influencing the relaxation times in NMR diagnostics, contain at least one paramagnetic, physiologically compatible complex salt comprising a chelate from an open-chain or cyclic complex-forming compound containing organic nitrogen, phosphorus, oxygen and/or sulfur, and a complexed ion of the lanthanide elements of atomic number 57-70 or of the transition metals of atomic numbers 21-29, 42 and 44, and, optionally, an inorganic or organic base or acid, wherein said chelate complex is bound to a biomolecule.
摘要翻译：可用于影响核磁共振诊断中松弛时间的试剂含有至少一种顺磁性，生理上相容的复盐，其包含来自含有机氮，磷，氧和/或硫的开链或环状络合物形成化合物的螯合物，以及络合物原子序数57-70的镧系元素或原子序数21-29,42和44的过渡金属的离子，以及任选的无机或有机碱或酸，其中所述螯合络合物与生物分子结合。

22. 发明授权

US4348252A Device for the insertion and extraction of a laminating pack in and from a press 失效
标题翻译：用于在压机中插入和提取层压包装置的装置
公开(公告)号：US4348252A
公开(公告)日：1982-09-07
申请号：US253017
申请日：1981-04-10
申请人： Heinrich Knoop , Heinrich Pfeiffer
发明人： Heinrich Knoop , Heinrich Pfeiffer
IPC分类号： B27N3/20 , B30B15/30 , B30B15/32
CPC分类号： B30B15/30 , B27N3/20 , B30B15/32 , Y10T156/17
摘要： A single unit moves into and out of a press to essentially simultaneously charge the press with the workpiece to be processed and discharge another workpiece which has been processed. The device is particularly suitable for preparing laminates in which the workpiece to be processed comprises a stack of alternating sheets of solid material and bonding material. This workpiece is referred to as a laminating pack. A table on a transfer car holds the unprocessed laminating pack. This same transfer car also has on its lower side a plurality of suction devices for grippingly engaging a processed laminate, i.e., a laminate that has been treated in the heat press. The transfer car holding the unprocessed laminating pack advances into an open press. In the press, the laminating pack is transported onto holding gibs, and the processed laminate in the press is taken up by the suction means on the bottom side of the transfer car. The transfer car is then retracted from the press with the processed laminate, and the laminating pack is left behind in the press for processing. This simultaneous charging and discharging operation is then repeated.
摘要翻译：单个单元移入和移出压力机，以基本上同时对要加工的工件对压机进行充电，并排出已经处理的另一个工件。该装置特别适用于制备层压板，其中待加工的工件包括一堆交替的固体材料和粘合材料片。该工件被称为层压包装。转运车上的一张桌子保持未加工的层压包装。该相同的转运车还在其下侧上具有多个用于夹紧地接合经处理的层压体，即已经在热压机中处理过的层压板的抽吸装置。保持未加工的层压包的转运车进入开式压机。在压机中，层压包装被运送到保持件上，并且压榨机中的加工层压体被转运车底部的抽吸装置吸收。然后将转运车从压榨机中与处理的层压体一起退回，并且将层压包装留在压机中用于加工。然后重复同时的充放电操作。

23. 发明授权

US4221740A Process for the preparation of serinol (1,3-dihydroxy-2-aminopropane) 失效
标题翻译：丝氨醇（1,3-二羟基-2-氨基丙烷）的制备方法
公开(公告)号：US4221740A
公开(公告)日：1980-09-09
申请号：US943094
申请日：1978-09-18
申请人： Heinrich Pfeiffer
发明人： Heinrich Pfeiffer
IPC分类号： C07C213/02 , C07C20060101 , C07C67/00 , C07C213/00 , C07C215/10 , C07C85/11
CPC分类号： C07C213/02
摘要： The sodium salt of 1,3-dihydroxy-2-nitropropane is catalytically hydrogenated in an inert solvent to produce 1,3-dihydroxy-2-aminopropane, which can be isolated in crystalline form.
摘要翻译： 1,3-二羟基-2-硝基丙烷的钠盐在惰性溶剂中催化氢化，得到1,3-二羟基-2-氨基丙烷，其可以以结晶形式分离。

24. 发明授权

US5595725A Diagnostic media 失效
标题翻译：诊断媒体
公开(公告)号：US5595725A
公开(公告)日：1997-01-21
申请号：US330954
申请日：1994-10-28
申请人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang M utzel , Georg-Alexander Hoyer , Heinrich Pfeiffer, deceased , Franz-Josef Renneke
发明人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang M utzel , Georg-Alexander Hoyer , Heinrich Pfeiffer, deceased , Franz-Josef Renneke
IPC分类号： A61K49/04 , A61K49/06 , A61K49/10 , A61K49/18 , C07C323/25 , C07D257/02 , C07F9/38 , G01R33/28 , A61B5/055
CPC分类号： C07C323/25 , A61K49/04 , A61K49/085 , A61K49/10 , A61K49/103 , A61K49/105 , A61K49/106 , A61K49/108 , A61K49/143 , A61K49/16 , A61K49/18 , A61K49/1806 , A61K49/1809 , A61K49/1812 , C07D257/02 , C07F9/3817 , C07F9/386 , G01R33/5601 , Y10S436/806 , Y10S514/836 , Y10T436/24
摘要： A diagnostic medium contains at least one physiologically well tolerated complex salt comprising an anion of a complexing acid and one or more central ion or ions of an element with an atomic number of 21 to 29, 42, 44 or 57 to 83 and, optionally, one or more physiologically biocompatible cation or cations of an inorganic and/or organic base or amino acid, optionally, with additives customary in galenic formulations, dissolved or suspended in an aqueous medium.
摘要翻译：诊断介质包含至少一种生理上良好耐受的复合盐，其包含络合酸的阴离子和一种或多种原子序数为21至29,42,44或57至83的元素的中心离子或离子，以及任选地，一种或多种无机和/或有机碱或氨基酸的生理学上生物相容的阳离子或阳离子，任选地与通常用于盖伦制剂中的添加剂一起溶解或悬浮在水性介质中。

25. 发明授权

US5047228A Nonionic 5-C-substituted 2,4,6-triiodoisophthalic acid derivatives 失效
标题翻译：非离子型5-C取代的2,4,6-三碘代邻苯二甲酸衍生物
公开(公告)号：US5047228A
公开(公告)日：1991-09-10
申请号：US318454
申请日：1989-03-02
申请人： Heinz Gries , Heinrich Pfeiffer , Ulrich Speck , Wolfgang Mutzel
发明人： Heinz Gries , Heinrich Pfeiffer , Ulrich Speck , Wolfgang Mutzel
IPC分类号： C07C69/80 , A61K49/04 , C07C63/68 , C07C67/00 , C07C69/76 , C07C231/00 , C07C231/02 , C07C231/06 , C07C233/65 , C07C233/68 , C07C233/69 , C07C237/30 , C07C237/32
CPC分类号： C07C233/69
摘要： Nonionic compounds of the formula ##STR1## wherein X is --CONR.sub.1 R.sub.2, --COOR.sub.3, --CH.sub.2 NHR.sub.7 or --CH.sub.2 OH; Y is --1R.sub.1 R.sub.2 or --OR.sub.3 ; and Z is --NR.sub.1 R.sub.2, --NHR.sub.7 or --OR.sub.3 ; and wherein R.sub.1 R.sub.2 and R.sub.3 in X, Y or Z, and R.sub.7 in X and Z, are identical or different, R.sub.1 and R.sub.2, and each is hydrogen, C.sub.1-6 -alkyl or C.sub.2-8 - alkyl substituted by 1-5 OH groups and/or by a C.sub.1-3 -alkoxy group; R.sub.3 is C.sub.1-4 -alkyl or C.sub.2-4 -alkyl substituted by 1-2 OH groups and/or by a C.sub.1-3 -alkoxy group; and R.sub.7 is an acyl group of a C.sub.2-5 OH group and/or by a C.sub.1-3 -alkoxy group are highly advantageous X-ray contrast agents.
摘要翻译：其中X为-CONR1R2，-COOR3，-CH2NHR7或-CH2OH的式（I）的非离子化合物; Y为-1R1R2或-OR3; 并且Z是-NR 1 R 2，-NHR 7或-OR 3; 并且其中X，Y或Z中的R 1和R 3以及X和Z中的R 7相同或不同，R 1和R 2各自为氢，C 1-6 - 烷基或被1-5 OH取代的C 2-8 - 烷基基团和/或被C 1-3 - 烷氧基取代; R3是被1-2个OH基团和/或被C1-3烷氧基取代的C 1-4 - 烷基或C 2-4 - 烷基; R7是C2-5OH基和/或C1-3烷氧基的酰基是非常有利的X射线造影剂。

26. 发明授权

US4963344A Method to enhance NMR imaging using chelated paramagnetic ions 失效
标题翻译：使用螯合顺磁离子增强核磁共振成像的方法
公开(公告)号：US4963344A
公开(公告)日：1990-10-16
申请号：US370139
申请日：1989-06-23
申请人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hayden , Heinrich Pfeiffer
发明人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hayden , Heinrich Pfeiffer
IPC分类号： A61K49/04 , A61K49/06 , A61K49/10 , A61K49/18 , C07C323/25 , C07D257/02 , C07F9/38 , G01R33/28
CPC分类号： C07C323/25 , A61K49/04 , A61K49/085 , A61K49/10 , A61K49/103 , A61K49/105 , A61K49/106 , A61K49/108 , A61K49/143 , A61K49/16 , A61K49/18 , A61K49/1806 , A61K49/1809 , A61K49/1812 , C07D257/02 , C07F9/3817 , C07F9/386 , G01R33/5601 , Y10S436/806 , Y10S514/836 , Y10T436/24
摘要： Agents useful for influencing the relaxation times in NMR diagnostics, contain at least one paramagnetic, physiologically compatible complex salt comprising a chelate from an open-chain or cyclic complex-forming compound containing organic nitrogen, phosphorus, oxygen and/or sulfur, and a complexed ion of the lanthanide elements of atomic number 57-70 or of the transition metals of atomic numbers 21-29, 42 and 44, and, optionally, an inorganic or organic base or acid.
摘要翻译：可用于影响核磁共振诊断中松弛时间的试剂含有至少一种顺磁性，生理上相容的复盐，其包含来自含有机氮，磷，氧和/或硫的开链或环状络合物形成化合物的螯合物，以及络合物原子序数57-70的镧系元素或原子序数21-29,42和44的过渡金属的离子，以及任选的无机或有机碱或酸。

27. 发明授权

US4046500A Press spar for heated panel press 失效
标题翻译：加热面板压力机
公开(公告)号：US4046500A
公开(公告)日：1977-09-06
申请号：US645213
申请日：1975-12-29
申请人： Heinrich Pfeiffer
发明人： Heinrich Pfeiffer
IPC分类号： B30B15/06 , B29C3/00
CPC分类号： B30B15/062
摘要： A press spar construction for a heated panel press producing chipboard panels and the like under elevated temperatures and pressures, the press spar structure having a thermal barrier arranged between each pressure plate and its supporting structure, the thermal barrier consisting of rows of insulating pressure blocks and spaced steel pressure blocks arranged between the insulating pressure blocks in the areas of maximum pressure concentration. The insulating pressure blocks are coated for imperviousness against humidity, and both types of blocks have metallic shrouds with anti-friction surface coatings. Shimming sheets are placed between the blocks and the shrouds, where necessary.

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