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21. 发明授权

US4194684A Centifugal apparatus using polyester elastomer tubing 失效
标题翻译：使用聚酯弹性体管的中间装置
公开(公告)号：US4194684A
公开(公告)日：1980-03-25
申请号：US805951
申请日：1977-06-13
申请人： Daniel R. Boggs
发明人： Daniel R. Boggs
IPC分类号： B04B5/04 , B04B5/02
CPC分类号： B04B5/0442 , B04B2005/0492
摘要： Centrifugal processing apparatus in which a processing chamber is rotatably mounted with respect to a stationary base. An umbilical cable segment comprising polyester elastomer tubing is fixed at one end substantially along the axis of the processing chamber at one side thereof, with the other end of the cable segment being attached substantially on the axis in rotationally locked engagement to the processing chamber. In a preferred embodiment, the polyester elastomer is HYTREL.RTM. polyester elastomer.
摘要翻译：处理室相对于固定基座可旋转地安装的离心处理装置。包括聚酯弹性体管的脐带缆段在其一侧基本上沿处理室的轴线固定在一端，电缆段的另一端基本上被附接在轴线上，以与处理室旋转地锁定接合。在优选的实施方案中，聚酯弹性体是HYTREL TM聚酯弹性体。

22. 发明授权

US4120449A Centrifugal processing apparatus using tube drive 失效
标题翻译：离心式加工设备采用管驱动
公开(公告)号：US4120449A
公开(公告)日：1978-10-17
申请号：US805952
申请日：1977-06-13
申请人： Richard I. Brown , Daniel R. Boggs
发明人： Richard I. Brown , Daniel R. Boggs
IPC分类号： B04B5/00 , B04B5/04 , B04B9/00
CPC分类号： B04B5/0442 , B04B5/00 , B04B2005/0492
摘要： Centrifugal processing apparatus in which a processing chamber is rotatably mounted with respect to a stationary base. An umbilical cable segment formed of tubular material is fixed at one end substantially along the axis of the processing chamber at one side thereof, with the other end of the cable segment being attached substantially on the axis in rotationally locked engagement to the processing chamber. The tubular material has a dynamic stiffness of between 0.1 in. .sup.2 pounds and 100 in. .sup.2 pounds. The cable segment is driven by an enclosure carrying a drive pin and rotated by a drive shaft. The processing chamber forms an idling member which follows only the driving rotation of the cable segment to rotate at twice the speed of the cable segment without the need for any external drive.
摘要翻译：处理室相对于固定基座可旋转地安装的离心处理装置。由管状材料形成的脐带缆段在其一侧基本上沿着处理室的轴线固定在一端，电缆段的另一端基本上被附接在轴线上，以与处理室旋转锁定。管状材料的动态刚度为0.1英寸2磅和100英寸2磅。电缆段由带有驱动销并由驱动轴旋转的外壳驱动。处理室形成怠速构件，其仅跟随电缆段的驱动旋转，以电缆段的两倍的速度旋转，而不需要任何外部驱动。

23. 发明授权

US4109852A Centrifugal strain relief sheath for processing apparatus 失效
标题翻译：用于加工设备的离心应变消除护套
公开(公告)号：US4109852A
公开(公告)日：1978-08-29
申请号：US844225
申请日：1977-10-21
申请人： Richard I. Brown , Daniel R. Boggs
发明人： Richard I. Brown , Daniel R. Boggs
IPC分类号： B04B5/04 , B04B5/02
CPC分类号： B04B5/0442 , B04B2005/0492
摘要： Centrifugal processing apparatus in which a processing chamber is rotatably mounted with respect to a stationary base. An umbilical cable segment is fixed at one end substantially along the axis of the processing chamber at one side thereof, with the other end of the cable segment being attached substantially on the axis in rotationally locked engagement to the processing chamber. A flexible sheath member is carried by the umbilical cable segment with the flexible sheath member being connected to the axis and having a shank portion which extends from the axis and along a portion of the cable segment. The shank portion of the flexible sheath member has a thickness which decreases along the cable segment in the direction away from the axis. The flexible sheath member provides the umbilical cable segment with a localized stiffness at its anchor points sufficient to allow the umbilical cable segment to withstand high centrifugal forces without fracturing and without requiring other means of lateral support.
摘要翻译：处理室相对于固定基座可旋转地安装的离心处理装置。脐带缆段在其一侧基本上沿着处理室的轴线固定在一端，电缆段的另一端基本上被附接在轴线上，以与处理室旋转锁定接合。柔性护套构件由脐带缆段承载，柔性护套构件连接到轴线并且具有从轴线延伸并且沿着电缆段的一部分延伸的柄部分。柔性护套部件的柄部分具有沿远离轴线的方向沿电缆段减小的厚度。柔性护套构件在其锚固点处提供脐带缆段具有足够的局部刚度，以足以允许脐带缆段承受高离心力而不破裂，而不需要其他横向支撑装置。

24. 发明授权

US09656013B2 Membrane separation devices, systems and methods employing same, and data management systems and methods 有权
公开(公告)号：US09656013B2
公开(公告)日：2017-05-23
申请号：US14003290
申请日：2012-03-09
申请人： Benjamin E. Kusters , Christopher J. Wegener , Daniel R. Boggs , Kyungyoon Min
发明人： Benjamin E. Kusters , Christopher J. Wegener , Daniel R. Boggs , Kyungyoon Min
IPC分类号： A61M1/34 , A61M1/14 , A61M1/20 , A61M1/28 , A61M1/02 , A61M1/36 , B01D61/18 , B01D63/06 , B01D63/16 , G06F19/00 , A61M1/38 , A61M1/26
CPC分类号： A61M1/34 , A61M1/0272 , A61M1/0281 , A61M1/265 , A61M1/3403 , A61M1/3496 , A61M1/3633 , A61M1/3687 , A61M1/3692 , A61M1/38 , A61M2205/3331 , A61M2205/50 , A61M2205/60 , B01D61/18 , B01D63/06 , B01D63/16 , B01D2313/08 , B01D2313/20 , B01D2315/02 , G16H10/40
摘要： A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.

25. 发明申请

US20140010738A1 MEMBRANE SEPARATION DEVICES, SYSTEMS AND METHODS EMPLOYING SAME AND DATA MANAGEMENT SYSTEMS AND METHODS 有权
标题翻译：膜分离装置，系统及其使用方法和数据管理系统及方法
公开(公告)号：US20140010738A1
公开(公告)日：2014-01-09
申请号：US14003273
申请日：2012-03-09
申请人： Daniel R. Boggs , Mark J. Brierton , Benjamin E. Kusters , Kyungyoon Min , Christopher J. Wegener
发明人： Daniel R. Boggs , Mark J. Brierton , Benjamin E. Kusters , Kyungyoon Min , Christopher J. Wegener
IPC分类号： A61M1/34 , G06F17/50
CPC分类号： A61M1/34 , A61M1/0272 , A61M1/0281 , A61M1/265 , A61M1/3403 , A61M1/3496 , A61M1/3633 , A61M1/3687 , A61M1/3692 , A61M1/38 , A61M2205/3331 , A61M2205/50 , A61M2205/60 , B01D61/18 , B01D63/06 , B01D63/16 , B01D2313/08 , B01D2313/20 , B01D2315/02 , G16H10/40
摘要： A membrane separation device for use in blood processing procedures is disclosed. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the spinning membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib or ridge associated with the spinning membrane that decreases the gap between the spinning membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into selected blood components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.
摘要翻译：公开了一种用于血液处理程序的膜分离装置。在一个实施方案中，提供了纺丝膜分离器，其中在纺丝膜和壳体之间的间隙中形成至少两个区域或区域，使得两个区域之间的流体的混合被相关联的径向肋或脊部抑制通过纺丝膜减少纺丝膜和壳体之间的间隙以限定两个流体区域，脊部将两个区域中的流体隔离以最小化两者之间的混合。公开了自动化系统和方法，用于将先前收集的全血的单位分离成选定的血液成分，例如浓缩红细胞和血浆，以单次从供体中直接收集红细胞和血浆，并进行细胞洗涤。还公开了数据管理系统和方法以及启动方法。

26. 发明授权

US08469916B2 Systems and methods for single needle continuous plasma processing 有权
公开(公告)号：US08469916B2
公开(公告)日：2013-06-25
申请号：US13036814
申请日：2011-02-28
申请人： Christopher J. Wegener , Daniel R. Boggs , Kyungyoon Min , Prakash Mathew , Marc N. Weasler , Benjamin E. E. Kusters
发明人： Christopher J. Wegener , Daniel R. Boggs , Kyungyoon Min , Prakash Mathew , Marc N. Weasler , Benjamin E. E. Kusters
IPC分类号： A61M37/00
CPC分类号： A61M1/3496 , A61M1/262 , A61M1/3603 , A61M1/38 , A61M2202/0415
摘要： Certain examples describe systems and methods for increasing plasma extracted from donor blood. An example method includes receiving blood extracted from a donor connected to a blood collection machine. The example method includes filtering the blood using a filtration device to remove at least a portion of plasma included in the blood to separate the plasma removed from remaining blood. The example method includes routing the plasma removed for collection. The example method includes re-filtering the remaining blood using a or the filtration device to remove additional plasma from the remaining blood. The example method includes routing the additional plasma removed for collection.

27. 发明授权

US08377375B2 Methods for the inactivation of microorganisms in biological fluids, flow through reactors and methods of controlling the light sum dose to effectively inactivate microorganisms in batch reactors 有权
标题翻译：生物流体中微生物灭活的方法，流经反应器的方法和控制光总剂量以有效灭活间歇反应器中的微生物的方法
公开(公告)号：US08377375B2
公开(公告)日：2013-02-19
申请号：US13100570
申请日：2011-05-04
申请人： Heinz Anderle , Peter Matthiessen , Hans-Peter Schwarz , Peter Turecek , Thomas Kreil , Daniel R. Boggs
发明人： Heinz Anderle , Peter Matthiessen , Hans-Peter Schwarz , Peter Turecek , Thomas Kreil , Daniel R. Boggs
IPC分类号： A61L2/00 , G01N31/16 , G01N23/00 , G01N11/00 , A61N5/00
CPC分类号： A61L2/10 , A23L3/26 , A23L3/28 , A61L2/0011 , A61L2/28 , G01N21/33 , H05B3/0052
摘要： The present invention relates to a method for determining an effective dose of monochromatic or polychromatic light from one or more light sources to inactivate microorganisms present in a biological fluid, preferably a non-transparent fluid. Moreover, there is provided a method for the inactivation of microorganism in a biological fluid in a flow-through-reactor. Moreover, the invention advantageously provides a flow-through-reactor with one or more thermostated light sources. The invention further provides a method of controlling the light sum dose of monochromatic or polychromatic light emitted from one or more light sources to effectively inactivate microorganisms present in a biological fluid in a batch reactor.
摘要翻译：本发明涉及一种用于确定来自一种或多种光源的有效剂量的单色或多色光以灭活存在于生物流体中，优选非透明流体中的微生物的方法。此外，提供了在流通反应器中的生物流体中的微生物灭活的方法。此外，本发明有利地提供具有一个或多个恒温光源的流通反应器。本发明还提供一种控制从一个或多个光源发射的单色或多色光的光总量的方法，以有效地灭活间歇反应器中存在于生物流体中的微生物。

28. 发明申请

US20120220915A1 SYSTEMS AND METHODS FOR SINGLE NEEDLE CONTINUOUS PLASMA PROCESSING 有权
标题翻译：单针连续等离子体处理的系统与方法
公开(公告)号：US20120220915A1
公开(公告)日：2012-08-30
申请号：US13036814
申请日：2011-02-28
申请人： Christopher J. Wegener , Daniel R. Boggs , Kyungyoon Min , Prakash Mathew , Marc N. Weasler , Benjamin E. Kusters
发明人： Christopher J. Wegener , Daniel R. Boggs , Kyungyoon Min , Prakash Mathew , Marc N. Weasler , Benjamin E. Kusters
IPC分类号： A61M1/26 , B01D37/00 , A61M1/16
CPC分类号： A61M1/3496 , A61M1/262 , A61M1/3603 , A61M1/38 , A61M2202/0415
摘要： Certain examples describe systems and methods for increasing plasma extracted from donor blood. An example method includes receiving blood extracted from a donor connected to a blood collection machine. The example method includes filtering the blood using a filtration device to remove at least a portion of plasma included in the blood to separate the plasma removed from remaining blood. The example method includes routing the plasma removed for collection. The example method includes re-filtering the remaining blood using a or the filtration device to remove additional plasma from the remaining blood. The example method includes routing the additional plasma removed for collection.
摘要翻译：某些实例描述了用于增加从供体血液中提取的血浆的系统和方法。示例性方法包括接收从连接到采血机的供体供体的血液。该示例性方法包括使用过滤装置过滤血液以去除包含在血液中的血浆中的至少一部分血浆以分离从剩余血液中除去的血浆。示例性方法包括将已去除的等离子体进行路由以进行采集。示例性方法包括使用或过滤装置对剩余血液进行再过滤以从剩余血液中除去附加血浆。示例性方法包括路由附加的等离子体以进行收集。

29. 发明授权

US07993580B2 Methods for the inactivation of microorganisms in biological fluids, flow through reactors and methods of controlling the light sum dose to effectively inactivate microorganisms in batch reactors 有权
标题翻译：生物流体中微生物灭活的方法，流经反应器的方法和控制光总剂量以有效灭活间歇反应器中的微生物的方法
公开(公告)号：US07993580B2
公开(公告)日：2011-08-09
申请号：US10924579
申请日：2004-08-24
申请人： Heinz Anderle , Peter Matthiessen , Hans-Peter Schwarz , Peter Turecek , Thomas Kreil , Daniel R. Boggs
发明人： Heinz Anderle , Peter Matthiessen , Hans-Peter Schwarz , Peter Turecek , Thomas Kreil , Daniel R. Boggs
IPC分类号： A61L2/24 , A61L2/00 , G01N21/01
CPC分类号： A61L2/10 , A23L3/26 , A23L3/28 , A61L2/0011 , A61L2/28 , G01N21/33 , H05B3/0052
摘要： The present invention relates to a method for determining an effective dose of monochromatic or polychromatic light from one or more light sources to inactivate microorganisms present in a biological fluid, preferably a non-transparent fluid. Moreover, there is provided a method for the inactivation of microorganism in a biological fluid in a flow-through-reactor. Moreover, the invention advantageously provides a flow-through-reactor with one or more thermostated light sources. The invention further provides a method of controlling the light sum dose of monochromatic or polychromatic light emitted from one or more light sources to effectively inactivate microorganisms present in a biological fluid in a batch reactor.
摘要翻译：本发明涉及一种用于确定来自一种或多种光源的有效剂量的单色或多色光以灭活存在于生物流体中，优选非透明流体中的微生物的方法。此外，提供了在流通反应器中的生物流体中的微生物灭活的方法。此外，本发明有利地提供具有一个或多个恒温光源的流通反应器。本发明还提供了一种控制从一个或多个光源发射的单色或多色光的光总量的方法，以有效地灭菌间歇反应器中存在于生物流体中的微生物。

30. 发明授权

US06899834B2 Composite membranes and methods for making such membranes 有权
标题翻译：复合膜和制造这种膜的方法
公开(公告)号：US06899834B2
公开(公告)日：2005-05-31
申请号：US09997822
申请日：2001-11-30
申请人： Daniel R. Boggs , Shmuel Sternberg , Robin G. Pauley , Donna L. McLarty
发明人： Daniel R. Boggs , Shmuel Sternberg , Robin G. Pauley , Donna L. McLarty
IPC分类号： B01D69/12 , A61M1/36 , B01D69/14 , B01D71/20 , B01D71/30 , B01D71/38 , B01D71/54 , B01J20/28 , B29D33/48
CPC分类号： B01J20/28033 , A61M1/3686 , B01D69/141 , B01J20/28004 , B01J20/28026 , B01J20/28035
摘要： Membranes and methods for making membranes are disclosed. The membranes include a polymeric matrix and a particulate material immobilized within the matrix. The membranes may find particular application in methods and apparatus for removing organic compounds from a biological fluid as part of a pathogen inactivation treatment.
摘要翻译：公开了膜和膜的制造方法。膜包括聚合物基质和固定在基质内的颗粒物质。作为病原体灭活处理的一部分，膜可以特别适用于从生物液体中除去有机化合物的方法和装置。

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