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21. 发明授权

US08840029B2 Multi wavelength excitation/emission authentication and detection scheme 有权
标题翻译：多波长激发/发射认证和检测方案
公开(公告)号：US08840029B2
公开(公告)日：2014-09-23
申请号：US13352953
申请日：2012-01-18
申请人： Nabil Lawandy , Andrei Smuk , Leif Olson , Charles Zepp
发明人： Nabil Lawandy , Andrei Smuk , Leif Olson , Charles Zepp
IPC分类号： G06K19/06
CPC分类号： G01N21/25 , B42D25/355 , G01J3/4406 , G01N21/643 , G01N2021/6419 , G07D7/1205
摘要： A system and method for authentication of secure products is disclosed. The security feature contains a first component in the form of an emitter capable of emitting light in response to external pump light. The security feature also contains a second component in the form of a taggant that absorbs light in a spectrally narrow range compared to the broader excitation spectrum of the first material. In this manner the emitter and taggant work in combination with one another to create an emission response significantly dependent on the illumination wavelengths and unique to the specific combination of the components. The emitter and taggant can be in the form of a mixture. Further the emitter and taggant may be applied in close proximity to one another, such as within two separate coating layers on a suitable substrate.
摘要翻译：公开了一种用于认证安全产品的系统和方法。安全特征包含能够响应于外部泵浦光而发光的发射器形式的第一部件。安全特征还包含标签牌形式的第二组分，其与第一材料的较宽的激发光谱相比吸收光谱窄范围内的光。以这种方式，发射器和标签牌彼此组合工作以产生明显取决于照明波长的发射响应，并且对于组件的具体组合是唯一的。发射体和标记物可以是混合物的形式。此外，发射器和标签剂可以彼此紧邻地施加，例如在合适的衬底上的两个单独的涂层内。

22. 发明授权

US08629151B2 Immunomodulatory agent-polymeric compounds 有权
标题翻译：免疫调节剂 - 聚合物
公开(公告)号：US08629151B2
公开(公告)日：2014-01-14
申请号：US12788266
申请日：2010-05-26
申请人： Charles Zepp , Grayson B. Lipford , Yun Gao , Lloyd Johnston , Fen-ni Fu , Mark J. Keegan , Sam Baldwin
发明人： Charles Zepp , Grayson B. Lipford , Yun Gao , Lloyd Johnston , Fen-ni Fu , Mark J. Keegan , Sam Baldwin
IPC分类号： A01N43/90
CPC分类号： A61K39/385 , A61K9/5138 , A61K39/0013 , A61K39/39 , A61K47/58 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/64 , A61K47/6925 , A61K47/6935 , A61K47/6937 , A61K2039/55511 , A61K2039/55544 , A61K2039/55555 , A61K2039/55561 , A61K2039/6093 , A61K2039/62 , A61K2039/627 , B82Y5/00 , C07D471/04 , C07D473/34 , C08G63/06 , C08G63/08 , C08G63/912 , C08G64/42 , C08J3/24 , C08J2367/04
摘要： This invention relates to compositions, and related compounds and methods, of conjugates of immunomodulatory agents and polymers or unit(s) thereof. The conjugates may be contained within synthetic nanocarriers, and the immunomodulatory agents may be released from the synthetic nanocarriers in a pH sensitive manner.
摘要翻译：本发明涉及免疫调节剂和聚合物或其单元的缀合物的组合物及相关化合物和方法。缀合物可以包含在合成纳米载体内，并且免疫调节剂可以以pH敏感的方式从合成纳米载体中释放。

23. 发明申请

US20130182241A1 MULTI WAVELENGTH EXCITATION/EMISSION AUTHENTICATION AND DETECTION SCHEME 有权
标题翻译：多波长激励/排放认证和检测方案
公开(公告)号：US20130182241A1
公开(公告)日：2013-07-18
申请号：US13352953
申请日：2012-01-18
申请人： Nabil Lawandy , Andrei Smuk , Leif Olson , Charles Zepp
发明人： Nabil Lawandy , Andrei Smuk , Leif Olson , Charles Zepp
IPC分类号： G01N21/64 , G01N21/55
CPC分类号： G01N21/25 , B42D25/355 , G01J3/4406 , G01N21/643 , G01N2021/6419 , G07D7/1205
摘要： A system and method for authentication of secure products is disclosed. The security feature contains a first component in the form of an emitter capable of emitting light in response to external pump light. The security feature also contains a second component in the form of a taggant that absorbs light in a spectrally narrow range compared to the broader excitation spectrum of the first material. In this manner the emitter and taggant work in combination with one another to create an emission response significantly dependent on the illumination wavelengths and unique to the specific combination of the components. The emitter and taggant can be in the form of a mixture. Further the emitter and taggant may be applied in close proximity to one another, such as within two separate coating layers on a suitable substrate.
摘要翻译：公开了一种用于认证安全产品的系统和方法。安全特征包含能够响应于外部泵浦光而发光的发射器形式的第一部件。安全特征还包含标签牌形式的第二组分，其与第一材料的较宽的激发光谱相比吸收光谱窄范围内的光。以这种方式，发射器和标签牌彼此组合工作以产生明显取决于照明波长的发射响应，并且对于组件的具体组合是唯一的。发射体和标记物可以是混合物的形式。此外，发射器和标签剂可以彼此紧邻地施加，例如在合适的衬底上的两个单独的涂层内。

24. 发明申请

US20110027217A1 IMMUNOMODULATORY AGENT-POLYMERIC COMPOUNDS 有权
标题翻译：免疫组化试剂 - 聚合物
公开(公告)号：US20110027217A1
公开(公告)日：2011-02-03
申请号：US12788266
申请日：2010-05-26
申请人： CHARLES ZEPP , GRAYSON B. LIPFORD , YUN GAO , LLOYD JOHNSTON , FEN-NI FU FU , MARK J. KEEGAN , SAM BALDWIN
发明人： CHARLES ZEPP , GRAYSON B. LIPFORD , YUN GAO , LLOYD JOHNSTON , FEN-NI FU FU , MARK J. KEEGAN , SAM BALDWIN
IPC分类号： A61K47/48 , A61P37/02
CPC分类号： A61K39/385 , A61K9/5138 , A61K39/0013 , A61K39/39 , A61K47/58 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/64 , A61K47/6925 , A61K47/6935 , A61K47/6937 , A61K2039/55511 , A61K2039/55544 , A61K2039/55555 , A61K2039/55561 , A61K2039/6093 , A61K2039/62 , A61K2039/627 , B82Y5/00 , C07D471/04 , C07D473/34 , C08G63/06 , C08G63/08 , C08G63/912 , C08G64/42 , C08J3/24 , C08J2367/04
摘要： This invention relates to compositions, and related compounds and methods, of conjugates of immunomodulatory agents and polymers or unit(s) thereof. The conjugates may be contained within synthetic nanocarriers, and the immunomodulatory agents may be released from the synthetic nanocarriers in a pH sensitive manner.
摘要翻译：本发明涉及免疫调节剂和聚合物或其单元的缀合物的组合物及相关化合物和方法。缀合物可以包含在合成纳米载体内，并且免疫调节剂可以以pH敏感的方式从合成纳米载体中释放。

25. 发明申请

US20110020388A1 TARGETED SYNTHETIC NANOCARRIERS WITH PH SENSITIVE RELEASE OF IMMUNOMODULATORY AGENTS 审中-公开
标题翻译：具有敏感性释放免疫调节剂的靶向合成纳米颗粒
公开(公告)号：US20110020388A1
公开(公告)日：2011-01-27
申请号：US12788260
申请日：2010-05-26
申请人： CHARLES ZEPP , Yun Gao , Mark J. Keegan , Sam Baldwin , Fen-ni Fu , Lloyd Johnston , Grayson B. Lipford
发明人： CHARLES ZEPP , Yun Gao , Mark J. Keegan , Sam Baldwin , Fen-ni Fu , Lloyd Johnston , Grayson B. Lipford
IPC分类号： A61K39/385 , C07D471/04 , C07D473/34 , C07H21/00 , A61P37/02
CPC分类号： A61K39/385 , A61K9/5138 , A61K39/0013 , A61K39/39 , A61K47/58 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/64 , A61K47/6925 , A61K47/6935 , A61K47/6937 , A61K2039/55511 , A61K2039/55544 , A61K2039/55555 , A61K2039/55561 , A61K2039/6093 , A61K2039/62 , A61K2039/627 , B82Y5/00 , C07D471/04 , C07D473/34 , C08G63/06 , C08G63/08 , C08G63/912 , C08G64/42 , C08J3/24 , C08J2367/04
摘要： This invention relates to compositions, and related methods, of synthetic nanocarriers that target sites of action in cells, such as antigen presenting cells (APCs), and comprise immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner. Also disclosed are compositions and methods relating to synthetic nanocarriers that encapsulate labile immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner.
摘要翻译：本发明涉及靶细胞中诸如抗原呈递细胞（APC）的作用位点的合成纳米载体的组合物和相关方法，并且包含以pH敏感方式从合成纳米载体解离的免疫调节剂。还公开了与合成纳米载体相关的组合物和方法，其包封以pH敏感方式从合成纳米载体解离的不稳定免疫调节剂。

26. 发明申请

US20050119273A1 Small molecule toll-like receptor (TLR) antagonists 失效
标题翻译：小分子toll样受体（TLR）拮抗剂
公开(公告)号：US20050119273A1
公开(公告)日：2005-06-02
申请号：US10872196
申请日：2004-06-18
申请人： Grayson Lipford , Alexandra Forsbach , Charles Zepp
发明人： Grayson Lipford , Alexandra Forsbach , Charles Zepp
IPC分类号： A01N43/54 , A61K31/517 , C07D239/72 , C07D471/00 , C07K20060101
CPC分类号： A61K31/437 , A61K31/122 , A61K31/382 , A61K31/4462 , A61K31/4709 , A61K31/496 , A61K31/517 , A61K31/5415 , A61K31/55 , A61K31/553 , C07D221/10 , C07D239/94 , C07D239/95 , C07D405/12
摘要： The invention provides methods and compositions useful for modulating signaling through Toll-like receptors. The methods involve contacting a TLR-expressing cell with a small molecule having a core structure including at least two rings. Certain of the compounds are 4-primary amino quinolines. Many of the compounds and methods are useful specifically for inhibiting immune stimulation involving at least one of TLR9, TLR8, TLR7, and TLR3. The methods may have use in the treatment of autoimmunity, inflammation, allergy, asthma, graft rejection, graft versus host disease, infection, sepsis, cancer, and immunodeficiency.
摘要翻译：本发明提供了用于通过Toll样受体调节信号传导的方法和组合物。所述方法包括使TLR表达细胞与具有包含至少两个环的核心结构的小分子接触。某些化合物是4-伯氨基喹啉。许多化合物和方法专门用于抑制涉及TLR9，TLR8，TLR7和TLR3中的至少一种的免疫刺激。该方法可用于治疗自身免疫，炎症，过敏，哮喘，移植物排斥，移植物抗宿主病，感染，败血症，癌症和免疫缺陷。

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