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21. 发明授权

US5497053A Micro-electron deflector 失效
标题翻译：微电子偏转器
公开(公告)号：US5497053A
公开(公告)日：1996-03-05
申请号：US151678
申请日：1993-11-15
申请人： Cha-Mei Tang , Antonio C. Ting , Thomas A. Swyden
发明人： Cha-Mei Tang , Antonio C. Ting , Thomas A. Swyden
IPC分类号： G21K1/087 , H01J3/02 , H01J3/26 , H01J23/06 , H01J29/48 , H01J35/06 , H03F3/56 , G09G1/04 , G21K1/08 , H03F3/54
CPC分类号： H01J29/481 , G21K1/087 , H01J23/06 , H01J3/022 , H01J3/26 , H01J35/065 , H03F3/56
摘要： An electron deflection device responsive to an electrical input signal for producing an output signal includes a focusing array for producing a collimated electron beam input ribbon in the direction of a propagation axis, the input ribbon being elongated along an array axis perpendicular to the propagation axis, and being relatively thin along a deflection axis perpendicular to the array axis and to the propagation axis. The focusing array is preferably a linear array of gated cold cathode units with lens electrodes. The deflection device further includes first and second electrically conductive deflector faces, forming a deflection region therebetween and being disposed so that the propagation-axis passes through the deflection region. The deflection device further includes means responsive to the input signal for applying time varying potentials to the deflector faces so as to produce a modulated electric field in the deflection region for deflecting the input ribbon over the course of a temporal deflection cycle to produce a continuously modulated output ribbon. The deflection device further includes an anode section responsive to the continuously modulated output ribbon for producing an output signal.The output signal can be in the form of an electrical output signal or a chopped output ribbon suitable for input to a high power amplifier, such as a klystron, klystrode, traveling wave tube, distributed amplifier or a gigatron, or to a free electron laser.
摘要翻译：响应于用于产生输出信号的电输入信号的电子偏转装置包括用于在传播轴线的方向上产生准直的电子束输入带的聚焦阵列，输入带沿垂直于传播轴线的阵列轴细长，并且沿着垂直于阵列轴线和传播轴线的偏转轴线相对较薄。聚焦阵列优选是具有透镜电极的门控冷阴极单元的线性阵列。偏转装置还包括第一和第二导电偏转器面，在它们之间形成偏转区域并设置成传播轴线穿过偏转区域。偏转装置还包括响应于输入信号的装置，用于向偏转器面施加时变电位，以便在偏转区域中产生调制电场，用于在时间偏转周期的过程中偏转输入色带，以产生连续调制输出色带偏转装置还包括响应于连续调制的输出带的阳极部分，用于产生输出信号。输出信号可以是电输出信号或适于输入到诸如速调管，klystrode，行波管，分布式放大器或千兆位的大功率放大器的斩波输出带的形式，或者是自由电子激光。

22. 发明授权

US11613115B2 Polymer microfilters and methods of manufacturing the same 有权
公开(公告)号：US11613115B2
公开(公告)日：2023-03-28
申请号：US13696139
申请日：2011-04-01
申请人： Olga V. Makarova , Cha-Mei Tang , Platte T Amstutz
发明人： Olga V. Makarova , Cha-Mei Tang , Platte T Amstutz
IPC分类号： G01N1/40 , G01N33/50 , B01L3/00 , B01D29/00 , B01D39/16 , B01D71/46 , B01L9/00 , B41F33/00 , B31B50/00 , B31B100/00 , B31B50/88
摘要： A microfilter comprising a polymer layer formed from epoxy-based photo-definable dry film, and a plurality of apertures each extending through the polymer layer. A method of forming a microfilter is also disclosed. The method includes providing a first layer of epoxy-based photo-definable dry film disposed on a substrate, exposing the first layer to energy through a mask to form a pattern, defined by the mask, in the first layer of dry film, forming, from the exposed first layer of dry film, a polymer layer having a plurality of apertures extending therethrough, the plurality of apertures having a distribution defined by the pattern, and removing the polymer layer from the substrate.

23. 发明申请

US20120183946A1 Fabrication of Microfilters and Nanofilters and Their Applications 审中-公开
标题翻译：微滤器和纳米过滤器的制造及其应用
公开(公告)号：US20120183946A1
公开(公告)日：2012-07-19
申请号：US13345538
申请日：2012-01-06
申请人： Cha-Mei Tang , Olga Makarova
发明人： Cha-Mei Tang , Olga Makarova
IPC分类号： C12Q1/04 , G03F7/20 , C12N5/078 , C12N5/077 , C12Q1/68 , G01N21/64 , C12Q1/25 , C12N5/071 , C12M1/12 , B01D61/14 , B01D61/18 , B01D61/24 , B32B3/26 , B01D39/00 , C12N5/09
CPC分类号： B01D67/0034 , A61M1/34 , B01D61/147 , B01D67/0027 , B01D67/0088 , B01D69/12 , B01D71/46 , B01D71/64 , B01D2323/34 , B01D2325/02 , B01D2325/08 , C12M47/02 , G01N21/6428 , G03F7/2022 , Y10T428/249978
摘要： Micro- and nanofilters with precision pore sizes and pore layout have applications in many fields including capturing circulating tumor cells and fetal cells in blood, water treatment, pathogen detection in water, etc. Methods to fabricate micro- and nanofilters not using track etching or reactive ion etching are provided, allowing easy fabrication of single layer or stack of films simultaneously, and/or stack of films on rolls. Microfilter can be made using one or more layers of material. Invention enables mass production of microfilters with lithographic quality at low cost. Isolation, enumeration and characterization of circulating tumor cells using microfilters provides (i) guides to cancer treatment selection and personalize dosage, (ii) low cost monitoring for treatment response, disease progression and recurrence, (iii) assessment of pharmacodynamic effects, (iv) information on mechanisms of resistance to therapy, and (v) cancer staging. Microfabrication methods are also applicable to fabrication of any free standing patterned polymeric films.
摘要翻译：具有精密孔径和孔布局的微型和纳米过滤器应用于许多领域，包括捕获血液中的循环肿瘤细胞和胎儿细胞，水处理，水中的病原体检测等。制备不使用轨道蚀刻或反应性的微米和纳米过滤器的方法提供了离子蚀刻，允许同时容易地制造单层或多层膜，和/或辊上的薄膜叠层。微滤器可以使用一层或多层材料制成。本发明能够以低成本大量生产具有平版印刷质量的微型过滤器。使用微型过滤器分离，计数和表征循环肿瘤细胞提供（i）指导癌症治疗选择和个性化剂量，（ii）低成本监测治疗反应，疾病进展和复发，（iii）药效学评估，（iv）关于治疗抵抗机制的信息，（v）癌症分期。微加工方法也适用于任何自由站立的图案化聚合物薄膜的制造。

24. 发明申请

US20100279322A1 Direct detection of intracellular fluorescently tagged cells in solution 审中-公开
标题翻译：在溶液中直接检测细胞内荧光标记的细胞
公开(公告)号：US20100279322A1
公开(公告)日：2010-11-04
申请号：US12773370
申请日：2010-05-04
申请人： Cha-Mei Tang , Peixuan Zhu , Daniel L. Adams
发明人： Cha-Mei Tang , Peixuan Zhu , Daniel L. Adams
IPC分类号： C12Q1/06 , G01N33/552 , G01N33/574 , G01N33/53 , G01N33/569 , G01N33/551
CPC分类号： G01N33/569 , C12Q1/04 , G01N33/54313 , G01N33/574 , G01N33/582
摘要： A method of detecting target cells and pathogens in a test sample concentrates to target cells in solution by filtering or capturing the target cells on a solid support. The target cells are tagged with a fluorescent dye and dispersed in a solution or suspension. The resulting solution or suspension are introduced to a fluorometer to specifically identify and quantitate the target cells. The target cells can be lysed or whole when introduced to the fluorometer.
摘要翻译：在测试样品中检测靶细胞和病原体的方法通过在固体支持物上过滤或捕获靶细胞而浓缩以靶向溶液中的细胞。靶细胞用荧光染料标记并分散在溶液或悬浮液中。将所得溶液或悬浮液引入荧光计以特异性鉴定和定量靶细胞。当引入荧光计时，靶细胞可以裂解或整合。

25. 发明申请

US20060072704A1 Anti-scatter grids and collimator designs, and their motion, fabrication and assembly 有权
公开(公告)号：US20060072704A1
公开(公告)日：2006-04-06
申请号：US11188210
申请日：2005-07-25
申请人： Cha-Mei Tang , Olga Makarova
发明人： Cha-Mei Tang , Olga Makarova
IPC分类号： G21K1/00
CPC分类号： G21K1/025
摘要： Grids and collimators, for use with electromagnetic energy emitting devices, include at least a metal layer that is formed, for example, by electroplating/electroforming or casting. The metal layer includes top and bottom surfaces, and a plurality of solid integrated walls. Each of the solid integrated walls extends from the top to bottom surface and has a plurality of side surfaces. The side surfaces of the solid integrated walls are arranged to define a plurality of openings extending entirely through the layer. At least some of the walls also can include projections extending into the respective openings formed by the walls. The projections can be of various shapes and sizes, and are arranged so that a total amount of wall material intersected by a line propagating in a direction along an edge of the grid is substantially the same as another total amount of wall material intersected by another line propagating in another direction substantially parallel to the edge of the grid at any distance from the edge. Methods to fabricate these grids using copper, lead, nickel, gold, any other electroplating/electroforming materials or low melting temperature metals are described.

26. 发明申请

US20060068490A1 Flow-through chemical and biological sensor 审中-公开
标题翻译：流通化学和生物传感器
公开(公告)号：US20060068490A1
公开(公告)日：2006-03-30
申请号：US11073430
申请日：2005-03-04
申请人： Cha-Mei Tang , Platte Amstutz
发明人： Cha-Mei Tang , Platte Amstutz
IPC分类号： C12M1/34
CPC分类号： G01N21/05 , B01F5/0603 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01L3/502715 , B01L2300/0654 , B01L2300/0861 , B01L2300/0867 , B01L2300/0877 , B01L2400/086 , B82Y15/00 , B82Y30/00 , G01N33/54373 , G01N2021/0346
摘要： The invention provides a mixing flow apparatus. The mixing flow apparatus consists of a waveguide and a mixing flow chamber; the waveguide having a higher index of refraction material than its surroundings for propagation of a signal, and the mixing flow chamber having a body forming a flow chamber with an inlet, an outlet, a radiation transmissive wall and a surface positioned to disrupt flow regularity of a sample fluid, the body of the mixing flow chamber surrounding at least a portion of the waveguide, wherein constituents of a sample fluid entering the inlet are mixed by disruption of sample fluid flow regularity prior to discharge at the outlet. Also provided is a detection apparatus. The detection apparatus consists of a waveguide, a mixing flow chamber and a radiation detector; the waveguide having a higher index of refraction material than its surroundings for propagation of a signal; the mixing flow chamber having a body forming a flow chamber with an inlet, an outlet, a radiation transmissive wall and a surface positioned to disrupt flow regularity of a sample fluid, the body of the mixing flow chamber surrounding at least a portion of the waveguide, wherein constituents of a sample fluid entering the inlet are mixed by disruption of sample fluid flow regularity prior to discharge at the outlet, and the radiation detector being disposed facing the direction of oncoming propagated signal from the waveguide. The detection apparatus can include an illumination source.
摘要翻译：本发明提供一种混合流动装置。混合流动装置由波导和混合流动室构成; 所述波导具有比其周围的更高的折射率折射材料以传播信号，并且所述混合流动室具有形成流动室的主体，所述主体具有入口，出口，辐射透射壁和定位成破坏流动规则性的表面样品流体，混合流动室的主体围绕波导的至少一部分，其中进入入口的样品流体的组分通过在出口排放之前破坏样品流体流动规则性而混合。还提供了检测装置。检测装置由波导管，混合流室和放射线检测器构成，波导具有比其周围更高的折射材料折射率以传播信号; 所述混合流动室具有形成具有入口，出口，辐射透射壁和定位成破坏样品流体的流动规则的流动室的主体，所述混合流动室的主体围绕所述波导的至少一部分其中进入入口的样品流体的组分通过在出口处排出之前破坏样品流体流动规则性而被混合，并且辐射检测器被布置为面对来自波导的迎面传播信号的方向。检测装置可以包括照明源。

27. 发明授权

US06987836B2 Anti-scatter grids and collimator designs, and their motion, fabrication and assembly 有权
公开(公告)号：US06987836B2
公开(公告)日：2006-01-17
申请号：US10060399
申请日：2002-02-01
申请人： Cha-Mei Tang , Olga V. Makarova
发明人： Cha-Mei Tang , Olga V. Makarova
IPC分类号： G21K1/00
CPC分类号： G21K1/025
摘要： Grids and collimators, for use with electromagnetic energy emitting devices, include at least a metal layer that is formed, for example, by electroplating/electroforming or casting. The metal layer includes top and bottom surfaces, and a plurality of solid integrated walls. Each of the solid integrated walls extends from the top to bottom surface and has a plurality of side surfaces. The side surfaces of the solid integrated walls are arranged to define a plurality of openings extending entirely through the layer. At least some of the walls also can include projections extending into the respective openings formed by the walls. The projections can be of various shapes and sizes, and are arranged so that a total amount of wall material intersected by a line propagating in a direction along an edge of the grid is substantially the same as another total amount of wall material intersected by another line propagating in another direction substantially parallel to the edge of the grid at any distance from the edge. Methods to fabricate these grids using copper, lead, nickel, gold, any other electroplating/electroforming materials or low melting temperature metals are described.

28. 发明授权

US5955849A Cold field emitters with thick focusing grids 失效
标题翻译：冷场发射器具有较厚的聚焦网格
公开(公告)号：US5955849A
公开(公告)日：1999-09-21
申请号：US201963
申请日：1994-02-25
申请人： Cha-Mei Tang , Antonio C. Ting , Thomas A. Swyden
发明人： Cha-Mei Tang , Antonio C. Ting , Thomas A. Swyden
IPC分类号： G21K1/087 , H01J3/02 , H01J3/26 , H01J23/06 , H01J29/48 , H01J35/06 , H03F3/56 , G09G1/04 , H01J29/70
CPC分类号： G21K1/087 , H01J23/06 , H01J29/481 , H01J3/022 , H01J3/26 , H01J35/065 , H03F3/56
摘要： A field emitter for producing an electron beam includes at least one cold cathode unit. Each of the cold cathode units includes an emitter cone having an emitter tip and a gate spaced apart from the emitter tip for extracting electrons from the emitter tip in a propagation direction upon application of a positive dc voltage on the gate with respect to the emitter tip. The gate forms a gate cavity for propagation of the extracted electrons therethrough. Each of the cold cathode units further includes at least one lens electrode disposed further in the propagation direction from the emitter tip than the gate, the at least one lens electrode forming at least one lens cavity for propagation of the extracted electrons therethrough. The at least one lens electrode is for focusing the extracted electrons in part of the gate cavity, part of the at least one lens cavity, and part of the region therebetween.
摘要翻译：用于产生电子束的场致发射体包括至少一个冷阴极单元。每个冷阴极单元包括发射极锥体，发射极尖端和与发射极尖端间隔开的栅极，用于在栅极上相对于发射极尖端施加正直流电压时沿传播方向从发射极尖端提取电子。栅极形成用于通过其提取的电子的传播的栅极腔。每个冷阴极单元还包括至少一个透镜电极，该透镜电极在发射极尖端的传播方向上比栅极进一步设置，所述至少一个透镜电极形成至少一个透镜腔，用于传播所提取的电子。所述至少一个透镜电极用于将提取的电子聚焦在所述栅极空腔的一部分中，所述至少一个透镜腔的一部分以及其间的区域的一部分。

29. 发明授权

US5729583A Miniature x-ray source 失效
标题翻译：微型x射线源
公开(公告)号：US5729583A
公开(公告)日：1998-03-17
申请号：US536364
申请日：1995-09-29
申请人： Cha-Mei Tang , Richard D. Deslattes
发明人： Cha-Mei Tang , Richard D. Deslattes
IPC分类号： A61B6/14 , A61N5/10 , H01J35/06 , H01J35/32 , H05G2/00
CPC分类号： H01J35/32 , A61B6/145 , A61N5/1001 , H01J35/06 , H01J2201/304
摘要： An x-ray head according to the invention includes an evacuated chamber in which a cathode and an anode are disposed and electrical connections from the anode and cathode extending through the wall of the evacuated chamber. The cathode may include a gated array of field emission elements, an array of solid state miniature thermionic cathodes, or ferroelectric cathodes. The anode is a metal producing x-ray radiation in response to the impact of electrons produced by the cathode. The anode may be a foil, a thin film of metal deposited on the inside surface of a wall of the evacuated chamber, or a self-supporting body of a metal that produces x-rays in response to electron impacts. The wiring may include conventional pins penetrating through and sealed to the wall of the chamber for connection to a flexible cable.
摘要翻译：根据本发明的X射线头包括其中设置阴极和阳极的抽真空室，并且来自阳极和阴极的电连接延伸穿过抽真空室的壁。阴极可以包括场发射元件的选通阵列，固态微型热阴极阵列或铁电阴极。阳极是响应于由阴极产生的电子的影响而产生x射线辐射的金属。阳极可以是箔，沉积在真空室的壁的内表面上的金属薄膜，或者是响应于电子冲击而产生X射线的金属的自支撑体。布线可以包括穿透并密封到室的壁的传统的销，用于连接到柔性电缆。

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