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21. 发明授权

US5100373A Techniques for controlling osteoporosis using non-invasive magnetic fields 失效
标题翻译：使用非入侵磁场控制骨质疏松的技术
公开(公告)号：US5100373A
公开(公告)日：1992-03-31
申请号：US295164
申请日：1989-01-09
申请人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
发明人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
IPC分类号： A61N2/00 , A61N2/02 , A61N2/04
CPC分类号： A61N2/02
摘要： An apparatus and method for preventing and therapeutically treating osteoporosis are provided. The apparatus includes a magnetic field generator for producing a controlled, fluctuating, directionally oriented magnetic field parallel to a predetermined axis projecting through the target bone or skeletal system. In one aspect, a field detector samples the magnetic flux density along the predetermined axis and provides a signal to a microprocessor which determines the average value of the flux density. The applied magnetic field is oscillated at predetermined frequencies to maintain a preselected ratio of frequency to average flux density which controls osteoporosis. This ratio is maintained by adjusting the frequency of the fluctuating magnetic field and/or by adjusting the intensity of the applied magnetic field as the composite magnetic flux density changes in response to changes in the local magnetic field to which the target bone is subjected.
摘要翻译：提供了预防和治疗骨质疏松症的装置和方法。该装置包括磁场发生器，用于产生平行于通过目标骨骼或骨骼系统突出的预定轴线的受控的，波动的定向取向的磁场。在一个方面，场检测器沿着预定轴对磁通密度进行采样，并向确定通量密度的平均值的微处理器提供信号。施加的磁场以预定频率振荡，以保持频率与控制骨质疏松的平均磁通密度的预选比率。当复合磁通密度根据目标骨经受的局部磁场的变化而变化时，通过调节波动磁场的频率和/或调整所施加的磁场的强度来维持该比例。

22. 发明授权

US5067940A Method and apparatus for controlling the growth of cartilage 失效
标题翻译：控制软骨生长的方法和装置
公开(公告)号：US5067940A
公开(公告)日：1991-11-26
申请号：US265265
申请日：1988-10-31
申请人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
发明人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
IPC分类号： A61N2/02 , A61N2/04
CPC分类号： A61N2/02
摘要： An apparatus and method for regulating the growth of cartilage in vivo are provided. The apparatus includes a magnetic field generator and a magnetic field detector for producing a controlled, fluctuating, directionally oriented magnetic field parallel to a predetermined axis projecting through the target tissue. The field detector samples the magnetic flux density along the predetermined axis and provides a signal to a microprocessor which determines the average value of the flux density. The applied magnetic field is oscillated at predetermined frequencies to maintain a preselected ratio of frequency to average flux density. This ratio is maintained by adjusting the frequency of the fluctuating magnetic field and/or by adjusting the intensity of the applied magnetic field as the composite magnetic flux density changes in response to changes in the local magnetic field to which the target tissue is subjected. By maintaining these precise predetermined ratios of frequency to average magnetic flux density, growth characteristics of the target cartilage are controlled.
摘要翻译：提供了一种用于调节体内软骨生长的装置和方法。该装置包括磁场发生器和磁场检测器，用于产生平行于通过目标组织突出的预定轴线的受控的，波动的定向取向的磁场。场检测器沿着预定轴对磁通密度进行采样，并向确定通量密度的平均值的微处理器提供信号。施加的磁场以预定频率振荡，以保持频率与平均磁通密度的预选比率。当复合磁通密度根据目标组织受到的局部磁场的变化而变化时，通过调节波动磁场的频率和/或调整所施加的磁场的强度来维持该比例。通过将这些精确的预定比例频率维持在平均磁通密度上，可以控制目标软骨的生长特性。

23. 发明授权

US5312534A Techniques for enhancing the permeability of ions through membranes 失效
公开(公告)号：US5312534A
公开(公告)日：1994-05-17
申请号：US280848
申请日：1988-12-07
申请人： Abraham R. Liboff , Bruce R. McLeod , Steven D. Smith
发明人： Abraham R. Liboff , Bruce R. McLeod , Steven D. Smith
IPC分类号： A61N1/30 , A61N1/32 , A61N2/00 , A61N2/02 , B01D61/00 , C12N13/00 , G05D21/02 , G05F7/00 , B65D85/18
CPC分类号： C12N13/00 , A61N1/325 , A61N2/02
摘要： A method is provided for enhancing the transport of a selected ion having a predetermined charge-to-mass ratio through a biomolecular membrane located in a space subjected to a local magnetic field. The space defines at least one reference path passing through the membrane in opposite first and second directions. The method includes the steps of creating a magnetic field which, when combined with the local magnetic field, produces a magnetic field having a flux density with at least one component representable by a component vector having a direction extending in the first direction along the path. This component of the magnetic field has a magnitude that fluctuates at a predetermined rate to produce a nonzero average value. A predetermined relationship between the ratio of the selected rate to the nonzero average value and the charge-to-mass ratio of the predetermined ion is thereby created. The predetermined relationship, is a function of the cyclotron resonance frequency of the ion.The present invention also provides an apparatus for enhancing the transport of a selected ion having a predetermined charge-to-mass ratio through a biomolecular membrane. The apparatus includes field creating means responsive to signals for creating a magnetic field which, when combined with the local magnetic field, produces a magnetic field having a flux density with at least one component representable by a component vector having a direction extending along a path through the membrane and having a magnitude that fluctuates at a predetermined rate to create a nonzero average value. The ratio of the predetermined rate to the nonzero average value has a predetermined relationship with respect to the charge-to-mass ratio of the predetermined ion which is a function of the cyclotron resonance frequency of the ion. Signal generating means is provided for generating the signals, at least some of which are generated at the predetermined rate.

24. 发明授权

US5290409A Methods and apparatus for regulating transmembrane ion movement utilizing selective harmonic frequencies and simultaneous multiple ion regulation 失效
标题翻译：使用选择性谐波频率和同时多个离子调节来调节跨膜离子运动的方法和装置
公开(公告)号：US5290409A
公开(公告)日：1994-03-01
申请号：US932615
申请日：1992-08-20
申请人： Abraham R. Liboff , Stephen D. Smith , Bruce R. McLeod
发明人： Abraham R. Liboff , Stephen D. Smith , Bruce R. McLeod
IPC分类号： A61N1/32 , A61N2/02 , A61N2/04 , C12N13/00 , A61N1/40
CPC分类号： A61N2/02 , A61N1/325 , C12N13/00
摘要： Methods and apparatus for regulating ion movement across biological membranes are provided. In one aspect, harmonic frequencies of a fluctuating magnetic field based on cyclotron resonance principles are provided for selectively enhancing transmembrane ion movement. In another aspect, a method and apparatus are provided for simultaneously regulating the transmembrane movement of multiple distinct ionic species using a fluctuating magnetic field. Therapeutic applications of harmonic tuning and multiple tuning are also provided.
摘要翻译：提供了用于调节跨越生物膜的离子运动的方法和装置。在一个方面，提供了基于回旋加速器共振原理的波动磁场的谐波频率，用于选择性地增强跨膜离子运动。在另一方面，提供一种方法和装置，用于使用波动的磁场同时调节多个不同离子物质的跨膜运动。还提供了谐波调谐和多重调谐的治疗应用。

25. 发明授权

US5215633A Techniques for enhancing the permeability of ions through membranes 失效
标题翻译：通过膜增强离子渗透性的技术
公开(公告)号：US5215633A
公开(公告)日：1993-06-01
申请号：US813240
申请日：1991-12-23
申请人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
发明人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
IPC分类号： A61N1/32 , A61N2/02 , C12N13/00
CPC分类号： A61N2/02 , A61N1/325 , C12N13/00
摘要： A method is provided for enhancing the transport of a selected ion having a predetermined charge-to-mass ratio through a biomolecular membrane located in a space subjected to a local magnetic field. The space defines at least one reference path passing through the membrane in opposite first and second directions. The method includes the steps of creating a magnetic field which, when combined with the local magnetic field, produces a magnetic field having a flux density with at least one component representable by a component vector having a direction extending in the first direction along the path. This component of the magnetic field has a magnitude that fluctuates at a predetermined rate to produce a nonzero average value. A predetermined relationship between the ratio of the selected rate to the nonzero average value and the charge-to-mass ratio of the predetermined ion is thereby created. The predetermined relationship, is a function of the cyclotron resonance frequency of the ion.
摘要翻译：提供了一种通过位于经受局部磁场的空间中的生物分子膜来增强具有预定电荷质量比的选定离子的输送的方法。该空间限定了沿相反的第一和第二方向穿过膜的至少一个参考路径。该方法包括产生磁场的步骤，当与局部磁场组合时，产生具有磁通密度的磁场，该磁场具有至少一个分量，该分量矢量具有沿着该路径在第一方向上延伸的分量矢量。磁场的这个分量具有以预定速率波动以产生非零平均值的幅度。由此产生所选择的速率与非零平均值的比率与预定离子的电荷质量比之间的预定关系。该预定关系是离子的回旋共振频率的函数。

26. 发明授权

US5211622A Method and apparatus for the treatment of cancer 失效
公开(公告)号：US5211622A
公开(公告)日：1993-05-18
申请号：US703383
申请日：1991-05-21
申请人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
发明人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
IPC分类号： A61N2/02 , A61N2/04
CPC分类号： A61N2/02
摘要： A method and apparatus for therapeutically treating cancer is provided. The apparatus includes a magnetic field generator for producing a controlled, fluctuating, directionally oriented magnetic field parallel to a predetermined axis projecting through a malignant neoplasm. In one aspect, a field detector measures the magnetic flux density along the predetermined axis. The applied magnetic field may comprise a full-wave rectified signal oscillated at predetermined frequencies to maintain a preselected ratio of frequency to the effective flux density, where the ratio regulates the growth characteristics of cancer cells of the neoplasm. This ratio is maintained by adjusting the frequency of the fluctuating magnetic field and/or by adjusting the intensity of the applied magnetic field after nulling out the local magnetic field at that region containing the neoplasm. In one aspect, a synergistic therapeutic cancer treatment is obtained by exposing cancer cells to the magnetic fields of the invention in the presence of a chemotherapeutic cancer agent.

27. 发明授权

US5183456A Method and apparatus for the treatment of cancer 失效
标题翻译：治疗癌症的方法和装置
公开(公告)号：US5183456A
公开(公告)日：1993-02-02
申请号：US902929
申请日：1992-06-23
申请人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
发明人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
IPC分类号： A61N2/02 , A61N2/04
CPC分类号： A61N2/02
摘要： A method and apparatus for therapeutically treating cancer is provided. The apparatus includes a magnetic field generator for producing a controlled, fluctuating, directionally oriented magnetic field parallel to a predetermined axis projecting through a malignant neoplasm. In one aspect, a field detector measures the magnetic flux density along the predetermined axis. The applied magnetic field may comprise a full-wave rectified signal oscillated at predetermined frequencies to maintain a preselected ratio of frequency to the effective flux density, where the ratio regulates the growth characteristics of cancer cells of the neoplasm. This ratio is maintained by adjusting the frequency of the fluctuating magnetic field and/or by adjusting the intensity of the applied magnetic field after nulling out the local magnetic field at that region containing the neoplasm. In one aspect, a synergistic therapeutic cancer treatment is obtained by exposing cancer cells to the magnetic fields of the invention in the presence of a chemotherapeutic cancer agent.
摘要翻译：提供了治疗癌症的方法和装置。该装置包括用于产生平行于通过恶性肿瘤突出的预定轴线的受控的，波动的定向取向的磁场的磁场发生器。一方面，场检测器测量沿预定轴线的磁通密度。所施加的磁场可以包括以预定频率振荡的全波整流信号，以将频率的预选比率保持到有效磁通密度，其中比率调节肿瘤的癌细胞的生长特性。通过调节波动磁场的频率和/或通过调整在包含肿瘤的区域中的局部磁场消失后施加的磁场的强度来维持该比率。在一个方面，通过在化疗癌症药物的存在下将癌细胞暴露于本发明的磁场来获得协同治疗性癌症治疗。

28. 发明授权

US5077934A Method and apparatus for controlling plant growth 失效
标题翻译：控制植物生长的方法和装置
公开(公告)号：US5077934A
公开(公告)日：1992-01-07
申请号：US411545
申请日：1989-09-22
申请人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
发明人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
IPC分类号： A01G7/04
CPC分类号： A01G7/04
摘要： A method and apparatus for controlling plant growth is provided. The apparatus includes a magnetic field generator for producing a controlled, fluctuating, directionally oriented magnetic field parallel to a predetermined axis projecting through viable plant material. In one aspect, a magnetic field detector measures the magnetic flux density along the predetermined axis. The applied magnetic field may comprise a full-wave rectified signal oscillated at predetermined frequencies to maintain a preselected ratio of frequency to the non-zero average value of the flux density, where the ratio is effective in altering the natural growth characteristics of the target plant material, such as accelerating growth rate. This ratio is maintained by adjusting the frequency of the fluctuating magnetic field and/or by adjusting the intensity of the applied magnetic field after nulling out or measuring and accounting for the local magnetic field in that region containing the target plant material.
摘要翻译：提供了一种控制植物生长的方法和装置。该装置包括磁场发生器，用于产生平行于通过活的植物材料突出的预定轴线的受控的，波动的定向取向的磁场。一方面，磁场检测器测量沿预定轴线的磁通密度。施加的磁场可以包括以预定频率振荡的全波整流信号，以将频率的预选比率保持为磁通密度的非零平均值，其中该比率在改变目标装置的自然生长特性方面是有效的材料，如加速增长率。通过调节波动磁场的频率和/或通过调整在归零或测量之后施加的磁场的强度并考虑包含目标植物材料的区域中的局部磁场来保持该比率。

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