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    • 21. 发明授权
    • Ocular implants with asymmetric flexibility
    • 具有不对称柔性的眼植入物
    • US08734377B2
    • 2014-05-27
    • US12236225
    • 2008-09-23
    • Andrew T. SchieberCharles L. Euteneuer
    • Andrew T. SchieberCharles L. Euteneuer
    • A61M5/00A61F2/14
    • A61F9/00781A61F2/14A61F2/15A61F2220/0008A61F2250/0067
    • An ocular implant having a body extending along a generally curved longitudinal axis, the curved longitudinal axis defining a first plane, the body having a diameter of between 0.005 inches and 0.04 inches and being adapted to be disposed within a canal of Schlemm in a human subject's eye; wherein the body has a first flexibility when bent along the first plane and a second flexibility different from the first flexibility when bent along a second plane that intersects the first plane and is not coincident with the first plane. Another aspect of the invention provides a method of treating a human eye, including the steps of: inserting an implant into Schlemm's canal of a human eye, the implant having a first flexibility when bent along a first plane and a second flexibility different from the first flexibility when bent along a second plane that intersects the first plane and is not coincident with the first plane; and supporting tissue forming Schlemm's canal with the implant.
    • 一种眼部植入物,其具有沿着大致弯曲的纵向轴线延伸的主体,所述弯曲纵向轴线限定第一平面,所述主体具有在0.005英寸和0.04英寸之间的直径,并且适于设置在人类受试者的Schlemm的管道内 眼; 其中当沿着与所述第一平面相交并且与所述第一平面不一致的第二平面弯曲时,所述主体沿着所述第一平面弯曲时具有第一柔性,并且所述第二柔性不同于所述第一柔性。 本发明的另一方面提供了一种治疗人眼的方法,包括以下步骤:将植入物插入人眼的施莱姆氏管中,所述植入物沿着第一平面弯曲时具有第一柔性,并且具有与第一平面不同的第二柔性 当沿着与第一平面相交并且不与第一平面重合的第二平面弯曲时的柔性; 并用植入物支撑组织形成Schlemm的运河。
    • 22. 发明授权
    • Delivering ocular implants into the eye
    • 将眼部植入物投入眼睛
    • US08663150B2
    • 2014-03-04
    • US13330592
    • 2011-12-19
    • John WardleAndrew T. Schieber
    • John WardleAndrew T. Schieber
    • A61F9/007A61M5/00
    • A61F9/0026A61B17/3421A61B17/3468A61B2017/3454A61F9/0017A61F9/00781A61F2220/0033
    • A method of deploying an ocular implant into Schlemm's canal of an eye. The method includes the steps of inserting a distal end of a cannula through a cornea of the eye and into an anterior chamber of the eye, the cannula having a distal opening extending from the distal end and through a side wall; placing the distal opening of the cannula into fluid communication with Schlemm's canal; advancing the ocular implant distally through the cannula with a delivery tool engaged with the ocular implant, a proximal portion of the ocular implant engaging the delivery tool proximal to a distal portion of the delivery tool; and disengaging the ocular implant and the delivery tool when the proximal portion of the ocular implant reaches the cannula distal opening. The invention also includes a system for practicing the method.
    • 将眼部植入物部署到施莱姆的眼睛的运河中的方法。 该方法包括以下步骤:将套管的远端插入眼睛的角膜并插入眼睛的前房,该套管具有从远端延伸并穿过侧壁的远端开口; 放置套管的远端开口与施莱姆氏管流体连通; 通过具有与眼部植入物接合的输送工具将眼部植入物向远端推进通过套管,眼睛植入物的近端部分接近输送工具的远端部分; 并且当眼部植入物的近端部分到达套管远端开口时,使眼部植入物和递送工具脱离接合。 本发明还包括实施该方法的系统。
    • 25. 发明授权
    • Ocular implants for placement in schlemm's canal
    • 用于放置在施莱姆运河中的眼部植入物
    • US07740604B2
    • 2010-06-22
    • US11860318
    • 2007-09-24
    • Andrew T. SchieberCharles L. Euteneuer
    • Andrew T. SchieberCharles L. Euteneuer
    • A61M27/00
    • A61F9/00781A61F9/0017A61F2009/00891A61M27/002A61M2210/0612
    • An ocular implant adapted to reside at least partially in a portion of Schlemm's canal of an eye. In some embodiments the implant has a body extending in a curved volume whose longitudinal axis forms an arc of a circle, and a plurality of open areas and strut areas formed in the body, the open areas extending over more than 50% of a surface defining the curved volume, the strut areas surrounding the open areas, the body having a diameter of between 0.005 inches and 0.04 inches. The invention also provides a method of treating glaucoma including the steps of supporting tissue forming Schlemm's canal in an eye with an implant extending at least partially in the canal along an axial length within the canal; and contacting with the implant less than 50% of the tissue forming the canal along the axial length.
    • 适于至少部分地居住在眼睛的施莱姆氏管的一部分中的眼部植入物。 在一些实施例中,植入物具有在弯曲体积中延伸的主体,其纵向轴线形成圆弧,以及形成在主体中的多个开放区域和支柱区域,所述开放区域延伸超过表面的50%以上 弯曲的体积,围绕开放区域的支柱区域,主体具有在0.005英寸和0.04英寸之间的直径。 本发明还提供一种治疗青光眼的方法,包括以下步骤:在眼睛中支撑组织形成施莱姆氏管,其中植入物至少部分地沿着管内的轴向长度延伸至管内; 并且沿着轴向长度与植入物接触形成管的少于50%的组织。
    • 26. 发明申请
    • Methods and Apparatus for Delivering Ocular Implants Into the Eye
    • 眼睛植入眼睛的方法和装置
    • US20100121342A1
    • 2010-05-13
    • US12632738
    • 2009-12-07
    • Andrew T. SchieberJohn WardleEdward MattheesCharles L. Euteneuer
    • Andrew T. SchieberJohn WardleEdward MattheesCharles L. Euteneuer
    • A61F9/007
    • A61F9/00781A61M25/0068A61M25/01A61M31/00A61M2025/0004
    • A cannula for an ocular implant delivery system. In some embodiments, the cannula includes a tubular member having a curved portion, a distal opening surrounded by a distal opening surface, and a distal tip, the distal tip being adapted to be inserted into an anterior chamber of a human subject's eye, through trabecular meshwork and into Schlemm's canal of the eye, a proximal portion of the tubular member being adapted to extend from a location exterior to the eye when the distal tip is in Schlemm's canal of the eye, the cannula being further adapted to cooperate with an advancement mechanism to advance an ocular implant through the tubular member toward and through the distal opening into Schlemm's canal of the eye when the distal tip is disposed in Schlemm's canal. The invention also includes a method of deploying an ocular implant into Schlemm's canal of a human eye including the following steps: inserting a distal tip of a delivery tool within an anterior chamber of the eye through trabecular meshwork of the eye into Schlemm's canal of the eye; and advancing an ocular implant through a curved portion and a distal opening of the delivery tool to place a body portion of the ocular implant in Schlemm's canal and an inlet portion of the ocular implant in the anterior chamber.
    • 用于眼部植入物输送系统的插管。 在一些实施例中,套管包括管状构件,其具有弯曲部分,由远侧开口表面包围的远侧开口和远侧末端,远侧末端适于通过小梁插入人类受试者眼睛的前房中 网状物并进入眼睛的施莱姆氏管,管状构件的近端部分适于当远侧末端位于眼睛的施莱姆氏管中时从眼睛外部延伸,套管还适于与前进机构配合 当远侧末端设置在施莱姆氏管中时,将眼部植入物穿过管状构件朝向并穿过远端开口进入眼睛的施莱姆氏管。 本发明还包括将眼部植入物部署到人眼的施莱姆氏管中的方法,包括以下步骤:将眼睛的前房中的输送工具的远端通过眼睛的小梁网插入眼睛的施莱姆氏管 ; 并且将眼睛植入物推进通过输送工具的弯曲部分和远端开口,以将眼部植入物的主体部分放置在施莱姆氏管中,并将眼部植入物的入口部分放置在前房中。
    • 27. 发明申请
    • Ocular Implants
    • 眼部植入物
    • US20090082863A1
    • 2009-03-26
    • US11860318
    • 2007-09-24
    • Andrew T. SchieberCharles L. Euteneuer
    • Andrew T. SchieberCharles L. Euteneuer
    • A61F2/16
    • A61F9/00781A61F9/0017A61F2009/00891A61M27/002A61M2210/0612
    • An ocular implant adapted to reside at least partially in a portion of Schlemm's canal of an eye. In some embodiments the implant has a body extending in a curved volume whose longitudinal axis forms an arc of a circle, and a plurality of open areas and strut areas formed in the body, the open areas extending over more than 50% of a surface defining the curved volume, the strut areas surrounding the open areas, the body having a diameter of between 0.005 inches and 0.04 inches. The invention also provides a method of treating glaucoma including the steps of supporting tissue forming Schlemm's canal in an eye with an implant extending at least partially in the canal along an axial length within the canal; and contacting with the implant less than 50% of the tissue forming the canal along the axial length.
    • 适于至少部分地居住在眼睛的施莱姆氏管的一部分中的眼部植入物。 在一些实施例中,植入物具有在弯曲体积中延伸的主体,其纵向轴线形成圆弧,以及形成在主体中的多个开放区域和支柱区域,所述开放区域延伸超过表面的50%以上 弯曲的体积,围绕开放区域的支柱区域,主体具有在0.005英寸和0.04英寸之间的直径。 本发明还提供一种治疗青光眼的方法,包括以下步骤:在眼睛中支撑组织形成施莱姆氏管,其中植入物至少部分地沿着管内的轴向长度延伸至管内; 并且沿着轴向长度与植入物接触形成管的少于50%的组织。