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    • 22. 发明申请
    • DISULPHIDE BOND-STABILIZED FUNCTIONAL SOLUBLE MHC CLASS II HETERODIMERS
    • 可溶性粘结稳定功能溶剂MHC II类HETERODIMERS
    • US20130171668A1
    • 2013-07-04
    • US13579887
    • 2011-02-18
    • Geir Age Loset
    • Geir Age Loset
    • C07K14/46
    • C07K14/47C07K14/46C07K14/70539C07K19/00C07K2319/00C07K2319/30G01N33/6869
    • The present invention relates to disulphide bond stabilized recombinant MHC class II molecules. In particular, the present invention provides a recombinant MHC class II molecule, which comprises: (i) all or part of the extracellular portion of an MHC class II α chain; (ii) all or part of the extracellular portion of an MHC class II β chain; wherein (i) and (ii) provide a functional peptide binding domain and wherein (i) and (ii) are linked by a disulphide bond between cysteine residues located in the α2 domain of said α chain and the β2 domain of said β chain, wherein said cysteine residues are not present in native MHC class II α2 and β2 domains. Methods of producing these molecules in prokaryotic systems and various uses of these molecules form further aspects.
    • 本发明涉及二硫键稳定的重组MHC II类分子。 特别地,本发明提供重组MHC II类分子,其包括:(i)MHC II类α链的全部或部分细胞外部分; (ii)MHC II类β链的全部或部分细胞外部分; 其中(i)和(ii)提供功能性肽结合结构域,并且其中(i)和(ii)通过位于所述α链的α2结构域和所述β链的β2结构域的半胱氨酸残基之间的二硫键连接, 其中所述半胱氨酸残基在天然MHC II类α2和β2结构域中不存在。 在原核系统中产生这些分子的方法和这些分子的各种用途形成其他方面。
    • 26. 发明申请
    • INTRUSION DETECTION FOR COMPUTER PROGRAMS
    • 计算机程序的入侵检测
    • US20100064367A1
    • 2010-03-11
    • US11815288
    • 2006-01-30
    • Tore Lysemose Hansen
    • Tore Lysemose Hansen
    • G06F21/00G06F11/00
    • G06F21/54
    • A method of detecting intrusion in a computer program which has number of defined libraries and includes cross border instructions which cause execution to branch from a source library to a target library. The method comprises the step of determining whether execution of the program is in an area consistent with normal execution of the program, by checking whether the source library of a cross border instruction is the expected current execution library of the program. Each cross border instruction has a code stub identifying the source library, and when a legal cross border instruction is executed the target library becomes the current execution library. The method also checks that the target address of a cross border instruction is a legal address. In another arrangement, areas of the program are set so that a cross border instruction will generate page protection fault which is intercepted by the intrusion detection system so that the cross border instruction can be checked.
    • 一种检测计算机程序中的入侵的方法,该计算机程序具有多个定义的库,并且包括导致执行从源库分支到目标库的跨边界指令。 该方法包括通过检查跨边界指令的源库是否是程序的预期当前执行库来确定程序的执行是否处于与程序的正常执行相一致的区域中的步骤。 每个跨境指令都有一个代码存根标识源库,当执行合法的跨边界指令时,目标库成为当前的执行库。 该方法还检查跨境指令的目标地址是否为合法地址。 在另一种布置中,程序的区域被设置为使得跨边界指令将产生由入侵检测系统拦截的页面保护故障,从而可以检查跨边界指令。
    • 27. 发明申请
    • ACTIVATION OF SURFACES THROUGH GAS PHASE REACTIONS
    • 通过气相反应活化表面
    • US20090286674A1
    • 2009-11-19
    • US12305565
    • 2007-06-19
    • Helmer FjellvagOla Nilsen
    • Helmer FjellvagOla Nilsen
    • B01J31/02C07C215/24C23C16/00C23C16/06
    • B05D1/185B05D1/60B05D5/00B82Y30/00B82Y40/00
    • A process for the preparation of active surfaces terminated by a desired form of organic, organic-inorganic, or inorganic nature comprising growing with a gas phase deposition technique preferable the ALCVD (atomic layer chemical vapour deposition) technique. As an example, trimethylaluminium (TMA), hydroquinone (Hq) and phloroglucinol (Phl) have been used as precursors to fabricate surfaces that are terminated by hydroxyl groups attached to aromates. Further types of active surfaces are described. These surfaces can be used to produce surfaces: suitable for adhesion through the use of glue or other adhesive, providing receptors for biological molecules, making the surfaces biocompatible, of catalytically active materials, where upon subsequent types of chemical reactions can take place, with different degrees of wetting properties.
    • 制备以所需形式的有机,无机或无机性质终止的活性表面的方法,包括用气相沉积技术生长,优选ALCVD(原子层化学气相沉积)技术。 作为实例,三甲基铝(TMA),氢醌(Hq)和间苯三酚(Phl)已被用作前体,以制造由连接到芳族化合物上的羟基封端的表面。 描述其他类型的活性表面。 这些表面可用于产生表面:适用于通过使用胶水或其他粘合剂的粘合剂,为生物分子提供受体,使表面生物相容的催化活性材料,其中随后可能发生的化学反应发生,具有不同的 润湿性能。