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21. 发明授权

US09062283B2 Method of reducing curvature in a meniscus of liquid medium 有权
标题翻译：降低液体介质弯液面弯曲度的方法
公开(公告)号：US09062283B2
公开(公告)日：2015-06-23
申请号：US12528781
申请日：2008-02-26
申请人： Steven Woodside , Jason Dowd , Gary Dossantos , Oliver Egeler
发明人： Steven Woodside , Jason Dowd , Gary Dossantos , Oliver Egeler
IPC分类号： C12M3/00 , B01L3/00 , B01L3/14 , C12M1/00 , C08J7/04 , C12M1/22 , C12M1/32
CPC分类号： C12M23/20 , B01L3/5085 , B01L2300/0654 , B01L2300/0829 , B01L2300/161 , C08J7/047 , C12M23/10 , C12M23/12
摘要： The present application is directed to methods of improving cell culture vessel assays. In one aspect the application is directed to a method of reducing the curvature of the meniscus comprising applying a coating material to the interior wall of the vessel, wherein the coating material provides a receding contact angle of about 90 degrees with aqueous solutions and culture media. In another aspect, the application is directed to a method of labeling cells in a first solution by generating droplets of a second solution containing at least one cell-labelling agent and allowing the droplets of the second solution to contact the surface of the first solution.
摘要翻译：本申请涉及改善细胞培养容器测定的方法。在一个方面，本申请涉及减少弯液面的曲率的方法，包括将涂层材料施加到容器的内壁，其中涂层材料与水溶液和培养基提供约90度的后退接触角。另一方面，本申请涉及通过产生含有至少一种细胞标记试剂的第二溶液的液滴并允许第二溶液的液滴接触第一溶液的表面的第一溶液中的细胞标记方法。

22. 发明申请

US20080295618A1 AUTOMATED PIPETTE MACHINE 有权
公开(公告)号：US20080295618A1
公开(公告)日：2008-12-04
申请号：US12189552
申请日：2008-08-11
申请人： Andrew Angus , Fred Davis , Adam Donath , Richard Grant , Dirk Kurpershoek
发明人： Andrew Angus , Fred Davis , Adam Donath , Richard Grant , Dirk Kurpershoek
IPC分类号： B01L3/02 , G01N1/14
CPC分类号： B01L3/0279 , B01L2200/023 , B01L2200/0689 , G01N35/10
摘要： A pipette nozzle is provided for use on a movable arm on an automated pipette machine. The pipette nozzle includes a body defining a passage therethrough. At least two seating surfaces are provided on the body, including a first seating surface and a second seating surface. The first seating surface is configured to receive and sealingly mate with a first size of pipette tip in a manner such that the first end of the passage is in fluid communication with the first size of pipette tip. The second seating surface is configured to receive and sealingly mate with a second size of pipette tip in a manner such that the first end of the passage is in fluid communication with the second size of pipette tip. There is also provided an automated pipette machine which includes a tip ejector system including an arm that is movable between a first position and a second position, wherein in the first position the arm is positioned to engage the tip during movement of the nozzle along a selected path and to prevent movement of the tip along the selected path while permitting the nozzle to move along the selected path, so that the movement of the nozzle along the selected path causes the nozzle and the tip to disengage from each other, and wherein in the second position the arm is positioned to avoid engagement with the tip during movement of the nozzle. There is also provided an apparatus for use on an automated pipette machine for transmitting pressure changes produced by a pump on the machine to a pipette nozzle. The apparatus comprises a housing defining a chamber a first conduit and a second conduit. The first conduit extends into the chamber and has a first opening positioned in the chamber. The first conduit is fluidically connectible to the nozzle. The second conduit extends into the chamber and has a first opening positioned in the chamber. The second conduit is fluidically connectible to the pump. The first opening of the first conduit is positioned above the first opening of the second conduit. The chamber defines at least a selected volume between the height of the first opening of the first conduit and the height of the first opening of the second conduit.

23. 发明申请

US20080264187A1 AUTOMATED PIPETTE MACHINE 有权
公开(公告)号：US20080264187A1
公开(公告)日：2008-10-30
申请号：US12164154
申请日：2008-06-30
申请人： Andrew Angus , Fred Davis , Adam Donath , Richard Grant , Dirk Kurpershoek
发明人： Andrew Angus , Fred Davis , Adam Donath , Richard Grant , Dirk Kurpershoek
IPC分类号： B01L3/02
CPC分类号： B01L3/0279 , B01L2200/023 , B01L2200/0689 , G01N35/10
摘要： A pipette nozzle is provided for use on a movable arm on an automated pipette machine. The pipette nozzle includes a body defining a passage therethrough. At least two seating surfaces are provided on the body, including a first seating surface and a second seating surface. The first seating surface is configured to receive and sealingly mate with a first size of pipette tip in a manner such that the first end of the passage is in fluid communication with the first size of pipette tip. The second seating surface is configured to receive and sealingly mate with a second size of pipette tip in a manner such that the first end of the passage is in fluid communication with the second size of pipette tip. There is also provided an automated pipette machine which includes a tip ejector system including an arm that is movable between a first position and a second position, wherein in the first position the arm is positioned to engage the tip during movement of the nozzle along a selected path and to prevent movement of the tip along the selected path while permitting the nozzle to move along the selected path, so that the movement of the nozzle along the selected path causes the nozzle and the tip to disengage from each other, and wherein in the second position the arm is positioned to avoid engagement with the tip during movement of the nozzle. There is also provided an apparatus for use on an automated pipette machine for transmitting pressure changes produced by a pump on the machine to a pipette nozzle. The apparatus comprises a housing defining a chamber a first conduit and a second conduit. The first conduit extends into the chamber and has a first opening positioned in the chamber. The first conduit is fluidically connectible to the nozzle. The second conduit extends into the chamber and has a first opening positioned in the chamber. The second conduit is fluidically connectible to the pump. The first opening of the first conduit is positioned above the first opening of the second conduit. The chamber defines at least a selected volume between the height of the first opening of the first conduit and the height of the first opening of the second conduit.

24. 发明授权

US07135340B2 Tetrameric antibody complexes for blocking non-specific labeling of antigens 有权
公开(公告)号：US07135340B2
公开(公告)日：2006-11-14
申请号：US10289213
申请日：2002-11-07
申请人： Albertus Wernerus Wognum , Peter Michael Lansdorp
发明人： Albertus Wernerus Wognum , Peter Michael Lansdorp
IPC分类号： G01N33/53
CPC分类号： G01N33/5306 , G01N2333/70535 , Y10S435/962 , Y10S436/819 , Y10S436/825
摘要： A method for preventing or inhibiting non-specific binding reactions between a detection reagent and an antigen in an immunological assay is described. The method involves using tetrameric antibody complexes that can bind to the antigen and are comprised of two monoclonal antibodies of a first animal species linked to two monoclonal antibodies of a second animal species that can bind the antibodies of the first animal species. Preferably, the antigen is an Fc Receptor and the method reduces the binding of a detection antibody with Fc receptors present on the surface of many cells.

25. 发明授权

US10983114B2 Method for the in situ formation of bifunctional immunological complexes 有权
公开(公告)号：US10983114B2
公开(公告)日：2021-04-20
申请号：US15580708
申请日：2016-06-03
申请人： StemCell Technologies Inc.
发明人： Andy Isamu Kokaji
IPC分类号： C07K1/22 , G01N33/543 , G01N33/569 , G01N33/80 , C07K16/28 , C07K16/44 , C07K16/00 , C07K16/42
摘要： An improved method for the preparation of tetrameric antibody complexes directly on the surface of target entities in a sample is described. In particular, this method involves linking, in the sample, a first target entity with a second target entity in a sample using antibodies with specificity for the first and second target entities.

26. 发明授权

US09708582B2 Method of differentiating stem cells 有权
公开(公告)号：US09708582B2
公开(公告)日：2017-07-18
申请号：US13829783
申请日：2013-03-14
申请人： STEMCELL TECHNOLOGIES INC.
发明人： Alexandra A. Blak , Sharon A. Louis , Michael John Riedel
IPC分类号： C12N5/071 , C12N5/0735 , C12N5/0797
CPC分类号： C12N5/0608 , C12N5/0606 , C12N5/0623 , C12N2500/60 , C12N2500/90 , C12N2500/92 , C12N2500/98 , C12N2502/13 , C12N2506/02 , C12N2509/00 , C12N2533/32 , C12N2533/90
摘要： The present disclosure provides methods of generating germ layers from stem cells comprising culturing the stem cells in a culture media having osmolality ranges that promote the generation of specific germ layer progenitor cells. The present disclosure also includes a method to generate different cell lineages from the germ layers as well as to detect them by immunological methods. The present disclosure further provides methods for the generation, isolation, cultivation and propagation of committed progenitor cells and for the production of differentiated cells from the three germ layers. The present disclosure also provides culture media and kits for use in inducing the three germ layers.

27. 发明授权

US09683983B2 Method and insert for density gradient separation 有权
公开(公告)号：US09683983B2
公开(公告)日：2017-06-20
申请号：US14115446
申请日：2012-05-03
申请人： Steven M. Woodside
发明人： Steven M. Woodside
IPC分类号： B01L3/00 , G01N33/49 , B03D3/00 , B04B7/12 , C12M1/26 , G01N33/569
CPC分类号： G01N33/491 , B01L3/5021 , B01L2200/0684 , B01L2300/0618 , B03D3/00 , B04B7/12 , C12M33/10 , G01N33/56972
摘要： An insert for a centrifuge tube suitable for use in density gradient separation is described. The insert includes a member sized to fit within the tube for dividing the tube into a top portion and a bottom portion. Optionally the insert has a support extending or depending from the member for positioning the member within the tube. At least two openings are located on the member so that a first opening is closer to a bottom end of the tube relative to a second opening when the insert is positioned in the centrifuge tube. Also described are methods for separating a target population of cells from a sample using the insert for a centrifuge tube.

28. 发明申请

US20140168764A1 CELL CULTURE VESSELS FOR MENISCUS REDUCTION WITH AQUEOUS SOLUTIONS 有权
标题翻译：用浓缩溶液还原的细胞培养液
公开(公告)号：US20140168764A1
公开(公告)日：2014-06-19
申请号：US14101892
申请日：2013-12-10
申请人： STEMCELL TECHNOLOGIES INC
发明人： Oliver Egeler , Steven M. Woodside
IPC分类号： G01N21/03
CPC分类号： G01N21/03 , B01L3/5082 , B01L2300/0858 , B01L2300/165 , B01L2400/086 , B01L2400/088
摘要： A meniscus reducing member for use in a vessel for containing a liquid including a surface feature overlying at least a portion of an interior surface of the vessel. The surface feature includes at least two surfaces for contacting the liquid that cooperate to reduce a width of a meniscus formed at an interface between the liquid and the surface feature by physically altering a contact angle between the liquid and the surface feature.
摘要翻译：一种用于容纳液体的弯液面减少构件，所述液体包括覆盖所述容器的内表面的至少一部分的表面特征。表面特征包括用于接触液体的至少两个表面，该表面通过物理地改变液体和表面特征之间的接触角来减少在液体和表面特征之间的界面处形成的弯液面的宽度。

29. 发明申请

US20110233148A1 FILTER APPARATUS AND FILTER PLATE SYSTEM 有权
标题翻译：过滤设备和过滤板系统
公开(公告)号：US20110233148A1
公开(公告)日：2011-09-29
申请号：US13139044
申请日：2009-12-16
申请人： Jennifer Antonchuk , Cindy Miller
发明人： Jennifer Antonchuk , Cindy Miller
IPC分类号： B01D35/28 , B01D39/08 , B01D39/10 , B01D37/00 , B01D35/30
CPC分类号： B01D39/1692 , B01D35/30 , B01D2201/30 , C12M47/02 , G01N1/34 , G01N1/405 , G01N1/4077 , G01N2001/4088
摘要： A filter apparatus comprises a filter having first and second opposed surfaces. A first reservoir is positioned adjacent with the first surface and in communication with the first surface, and a first inlet-outlet port is in communication with the first reservoir and spaced from the first surface. A second reservoir is positioned adjacent the second surface, and in communication with the second surface, and a second inlet-outlet port is in communication with the second reservoir and spaced from the second surface. A filter plate system comprises a reservoir plate. The reservoir plate comprises at least one reservoir well. The filter plate system further comprises a strainer plate. The strainer plate comprises at least one strainer well, which is removably receivable in the reservoir well. The strainer well comprises at least one mesh wall portion.
摘要翻译：过滤器装置包括具有第一和第二相对表面的过滤器。第一储存器定位成与第一表面相邻并且与第一表面连通，并且第一入口 - 出口与第一储存器连通并且与第一表面间隔开。第二储存器定位成与第二表面相邻并且与第二表面连通，并且第二入口 - 出口与第二储存器连通并且与第二表面间隔开。滤板系统包括储存器板。储存器板包括至少一个储存器井。滤板系统还包括过滤板。过滤板包括至少一个过滤器孔，其可移除地容纳在储层井中。过滤器井包括至少一个网壁部分。

30. 发明申请

US20100047845A1 METHOD OF REDUCING CURVATURE IN A MENISCUS OF LIQUID MEDIUM 有权
标题翻译：减少液体液体中的曲率的方法
公开(公告)号：US20100047845A1
公开(公告)日：2010-02-25
申请号：US12528781
申请日：2008-02-26
申请人： Steven Woodside , Jason Dowd , Gary Dossantos , Oliver Egeler
发明人： Steven Woodside , Jason Dowd , Gary Dossantos , Oliver Egeler
IPC分类号： C12Q1/02 , B05D7/22 , C12N5/00 , C12M1/00 , C12M1/34
CPC分类号： C12M23/20 , B01L3/5085 , B01L2300/0654 , B01L2300/0829 , B01L2300/161 , C08J7/047 , C12M23/10 , C12M23/12
摘要： The present application is directed to methods of improving cell culture vessel assays. In one aspect the application is directed to a method of reducing the curvature of the meniscus comprising applying a coating material to the interior wall of the vessel, wherein the coating material provides a receding contact angle of about 90 degrees with aqueous solutions and culture media. In another aspect, the application is directed to a method of labeling cells in a first solution by generating droplets of a second solution containing at least one cell-labelling agent and allowing the droplets of the second solution to contact the surface of the first solution.
摘要翻译：本申请涉及改善细胞培养容器测定的方法。在一个方面，本申请涉及减少弯液面的曲率的方法，包括将涂层材料施加到容器的内壁，其中涂层材料与水溶液和培养基提供约90度的后退接触角。另一方面，本申请涉及通过产生含有至少一种细胞标记试剂的第二溶液的液滴并允许第二溶液的液滴接触第一溶液的表面的第一溶液中的细胞标记方法。

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