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21. 发明申请

US20100003191A1 AURONE DERIVATIVE-CONTAINING COMPOSITION FOR DIAGNOSIS 审中-公开
标题翻译：用于诊断的含有衍生物的组合物
公开(公告)号：US20100003191A1
公开(公告)日：2010-01-07
申请号：US12517159
申请日：2007-10-26
申请人： Masahiro Ono
发明人： Masahiro Ono
IPC分类号： A61K51/04 , C07D307/77
CPC分类号： C07D307/83 , A61K51/0419 , C07D209/36
摘要： The present invention provides a composition for diagnosing amyloid-related diseases, comprising a compound represented by general formula (I): wherein X represents O or the like; R1, R3, R4, R5, R6, R8 and R9 represent a hydrogen atom or the like; R2 represents a halogen atom or the like; and R7 represents a dimethylamino group or the like; or the compound labeled with a radionuclide, or a pharmaceutically acceptable salt of the compound or the labeled compound. The compound represented by general formula (I) has all of the following properties: high binding specificity to amyloid β protein, high permeability through the blood-brain barrier, and rapid clearance from sites without senile plaques in the brain.
摘要翻译：本发明提供了一种用于诊断淀粉样蛋白相关疾病的组合物，其包含由通式（I）表示的化合物：其中X表示O等; R1，R3，R4，R5，R6，R8和R9表示氢原子等; R2表示卤素原子等; 并且R 7表示二甲基氨基等; 或用放射性核素标记的化合物或化合物或标记化合物的药学上可接受的盐。由通式（I）表示的化合物具有以下特性：对淀粉样β蛋白的高结合特异性，通过血脑屏障的高通透性，以及在脑中没有老年斑的位置的快速清除。

22. 发明授权

US07323301B2 Nucleic acid, probe comprising the nucleic acid and screening method using the probe 有权
标题翻译：核酸，包含核酸的探针和使用探针的筛选方法
公开(公告)号：US07323301B2
公开(公告)日：2008-01-29
申请号：US10309933
申请日：2002-12-04
申请人： Naomichi Matsumoto , Norio Niikawa
发明人： Naomichi Matsumoto , Norio Niikawa
IPC分类号： C12Q1/68
CPC分类号： C07K14/47 , C12Q1/6883 , C12Q2600/156
摘要： A nucleic acid is (a) a nucleic acid comprising a base sequence shown in base numbers 1–39726 of SEQ ID NO: 1, or (b) a nucleic acid wherein a part of the bases 1–39726 of SEQ ID NO: 1 is deleted, substituted or added, and having a homology of 80% for the base sequence. Also, a probe comprises the above nucleic acid, and a screening is carried out by using such a probe.
摘要翻译：核酸是（a）包含SEQ ID NO：1的碱基序号1-39726所示的碱基序列的核酸，或（b）核酸，其中部分SEQ ID NO：1的碱基1-39726 被删除，取代或添加，并且对于碱基序列具有80％的同源性。此外，探针包含上述核酸，并且通过使用这种探针进行筛选。

23. 发明申请

US20220135942A1 CULTURED TISSUE AND METHOD FOR PRODUCING SAME 有权
公开(公告)号：US20220135942A1
公开(公告)日：2022-05-05
申请号：US17435478
申请日：2020-03-27
申请人： NAGASAKI UNIVERSITY , Eisai R&D Management Co., Ltd.
发明人： Yusuke Sakai , Susumu EGUCHI , Tomohiko ADACHI , Yu HUANG , Raku Shinkyo , Saki SAGARA , Daichi ONOZATO
IPC分类号： C12N5/071
摘要： A cultured tissue, comprising: glandular cells; glandular cavities formed from the glandular cells; and ducts formed from epithelial cells, wherein the glandular cavities and the ducts are functionally connected ex vivo.

24. 发明授权

US11286261B2 Fourth-generation EGFR tyrosine kinase inhibitor 有权
公开(公告)号：US11286261B2
公开(公告)日：2022-03-29
申请号：US16497917
申请日：2018-03-29
申请人： NAGASAKI UNIVERSITY , IWATE MEDICAL UNIVERSITY , JAPANESE FOUNDATION FOR CANCER RESEARCH
发明人： Masatomo Iwao , Tsutomu Fukuda , Fumito Ishibashi , Yoshimasa Uehara , Naoyuki Nishiya , Yusuke Oku , Shingo Dan , Takao Yamori
IPC分类号： C07D491/147
摘要： Provided is a compound having a tyrosine kinase inhibitory activity specific to C797S resistant mutant EGFR (particularly C797S tertiary-resistant mutant EGFR) and is useful as a C797S resistant mutant EGFR (particularly C797S mutant tertiary-resistant EGFR) specific tyrosine kinase inhibitor, an agent for preventing and/or treating non-small cell lung cancer with resistance mutant EGFR and the like, and the like.

25. 发明申请

US20210307890A1 SHEET-SHAPED OBJECT ATTACHING DEVICE 有权
公开(公告)号：US20210307890A1
公开(公告)日：2021-10-07
申请号：US17351295
申请日：2021-06-18
申请人： NAGASAKI UNIVERSITY , TERUMO KABUSHIKI KAISHA
发明人： Yusuke SAKAI , Susumu EGUCHI , Yasuhiro MARUYA , Fumiya OHASHI , Tadashi SAMESHIMA
IPC分类号： A61F2/00
摘要： A device for efficiently attaching a sheet-shaped object to a target site includes a support body for supporting a sheet-shaped object, and a protective member having a low coefficient of friction for protecting one surface of the support, in which the support body supporting the sheet-shaped object is rolled while being protected by the protective member and can be inserted into a tubular body.

26. 发明授权

US09939404B2 CO sensor having electromotive force response 有权
公开(公告)号：US09939404B2
公开(公告)日：2018-04-10
申请号：US15016487
申请日：2016-02-05
申请人： Nagasaki University , Figaro Engineering Inc.
发明人： Yasuhiro Shimizu , Takeo Hyodo , Taro Ueda , Hirotaka Takeda , Kai Kamada
IPC分类号： G01N27/407 , G01N33/00
CPC分类号： G01N27/4071 , G01N27/4075 , G01N27/4076 , G01N33/004
摘要： A CO sensor includes a solid electrolyte substrate, a sensing electrode, and a reference electrode, and outputs electromotive forces in accordance with CO concentrations. The sensing electrode and the reference electrode are provided on the same surface of the solid electrolyte substrate. The sensing electrode contains a metal oxide such as Bi2O3 that generates a positive electromotive force response when coming into contact with CO. The reference electrode contains a metal oxide such as CeO2 that generates a negative electromotive force response when coming into contact with CO.

27. 发明申请

US20180022769A1 NOVEL FLUORINE-CONTAINING BISPHOSPHONIC ACID DERIVATIVE AND USE THEREOF 审中-公开
公开(公告)号：US20180022769A1
公开(公告)日：2018-01-25
申请号：US15548303
申请日：2016-02-01
申请人： NAGASAKI UNIVERSITY
发明人： Yoshimasa TANAKA , Satoshi MIZUTA , Hiroshi UEDA
IPC分类号： C07F9/6506 , A61K35/17 , A61K31/683
CPC分类号： C07F9/6506 , A61K31/683 , A61K35/17 , C07F9/3873
摘要： A series of fluorine-containing bisphosphonic acids in which an alkylamine side chain is added, a series of fluorine-containing bisphosphonic acids in which an amino group substituted by a heterocyclic group or a heterocyclic group containing a nitrogen atom is added, to the carbon atom of P—C(F)—P, and a series of fluorine-containing bisphosphonate derivatives in which the acid moiety thereof is esterified by an alkoxymethyl group such as POM group, n-butanoyloxymethyl (BuOM) group and the like, that is, the fluorine-containing bisphosphonic acid and fluorine-containing bisphosphonate derivative represented by the following formula (I): wherein each symbol is as defined in the DESCRIPTION, can efficiently induce proliferation of peripheral blood γδ T cells that express Vγ2Vδ2 T cell receptor having superior cytotoxicity against tumor cells and virus infected cells, immunize tumor cells and virus infected cells, and can induce cytotoxicity by γδ T cells.

28. 发明申请

US20170128062A1 Instrument for Delivering a Surgical Thread 审中-公开
公开(公告)号：US20170128062A1
公开(公告)日：2017-05-11
申请号：US15129698
申请日：2015-03-26
申请人： Nagasaki University
发明人： Susumu EGUCHI , Tamotu KUROKI , Taiichiro KOSAKA , Takakazu ISHIMATU , Syunji MOROMUGI
IPC分类号： A61B17/04 , A61B17/12 , A61B17/06
CPC分类号： A61B17/0485 , A61B17/0469 , A61B17/06066 , A61B17/06109 , A61B17/12009 , A61B2017/00309 , A61B2017/00331 , A61B2017/00358 , A61B2017/06071 , A61B2017/06095 , A61B2017/061
摘要： [Problem]To reduce the risk of damaging organs in a body while delivering a thread during surgery.[Means for Solving Problem]An instrument for delivering a surgical thread has a grip 10, an outer cylinder 70 fixed the grip, a hollow needle 80 extending inside the outer cylinder 70 and being configured to be moved relative to the outer cylinder 70 in an axial direction and a loop 90 configured to be housed in the outer cylinder 70. An end of the outer cylinder 70 is bent in a state where force is not applied. The hollow needle 80 is exposed from the outer cylinder 70 when puncturing skin or etc., and the hollow needle 80 is housed in the outer cylinder 70 when it travels near organs which should not be damaged.

29. 发明授权

US09543836B2 Control device of a power conversion circuit 有权
标题翻译：电源转换电路的控制装置
公开(公告)号：US09543836B2
公开(公告)日：2017-01-10
申请号：US14404890
申请日：2013-05-31
申请人： NAGASAKI UNIVERSITY , PANASONIC CORPORATION
发明人： Fujio Kurokawa , Masahito Ohnishi
IPC分类号： H02M3/156 , H02M1/00 , H02M1/42
CPC分类号： H02M3/156 , G01R19/175 , H02M1/42 , H02M1/4225 , H02M2001/0009 , H02M2001/4291 , Y02B70/126
摘要： In a control device of a power converter circuit repeating accumulation of energy to an inductor and release of energy from the inductor at each turn on/turn off timing of a switch, a zero cross detecting circuit detects a time when a current flowing through the inductor becomes zero by inputting a voltage between both terminals of the inductor directly without any resistance for detecting the inductor current. There is no electricity loss caused by the resistance for detecting the inductor current and critical mode control of the power converter circuit is precisely carried out.
摘要翻译：在功率转换器电路的控制装置中，在开关的每个导通/关断定时处，将电能重复累积到电感器并释放能量，零交叉检测电路检测流过电感器的电流的时间通过在电感器的两个端子之间直接输入电压而没有任何用于检测电感器电流的电阻而变为零。检测电感电流的电阻没有电损耗，并且精确地执行了功率转换器电路的临界模式控制。

30. 发明授权

US09481893B2 DNA capable of inducing osteoblast-specific expression 有权
标题翻译：能够诱导成骨细胞特异性表达的DNA
公开(公告)号：US09481893B2
公开(公告)日：2016-11-01
申请号：US13389204
申请日：2010-08-06
申请人： Toshihisa Komori , Shinichi Izumi , Toshihiro Miyazaki , Satoshi Rokutanda , Hisato Komori , Wenguang Liu
发明人： Toshihisa Komori , Shinichi Izumi , Toshihiro Miyazaki , Satoshi Rokutanda , Hisato Komori , Wenguang Liu
IPC分类号： C12N15/85 , C12N15/63 , G01N33/50
CPC分类号： C12N15/85 , A01K2267/0393 , C12N15/63 , C12N15/8509 , C12N2830/008 , G01N33/5044 , G01N33/5073
摘要： The invention provides nucleotide sequences that function as enhancers and induce osteoblast-specific expression, expression vectors comprising such an enhancer, a promoter, and a gene containing a coding region, as well as screening methods utilizing such expression vectors.
摘要翻译：本发明提供用作增强子并诱导成骨细胞特异性表达的核苷酸序列，包含这种增强子的表达载体，启动子和含有编码区的基因，以及利用这些表达载体的筛选方法。

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