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1. 发明公开

US20240150421A1 NOVEL HUMAN INTERLEUKIN-18 VARIANT AND USE THEREOF 审中-公开
公开(公告)号：US20240150421A1
公开(公告)日：2024-05-09
申请号：US18546066
申请日：2022-02-09
申请人： NAGASAKI UNIVERSITY , Foundation for Biomedical Research and Innovation at Kobe , National Institutes for Quantum Science and Technology
发明人： Yoshimasa TANAKA , Shun SAKURABA
IPC分类号： C07K14/54 , A61K38/20 , C12N5/0783
CPC分类号： C07K14/54 , A61K38/2013 , C12N5/0636 , A61K2039/505
摘要： A novel interleukin-18 (IL-18) variant and a pharmaceutical composition using the same, which relates to a human IL-18 variant including (i) mutations of cysteine at positions 38, 68, 76, and 127 into serine and (ii) mutations of glutamic acid at position 6 and lysine at position 53 into alanine relative to an amino acid sequence of wild-type human IL-18, where the variant further includes (iii) at least one additional mutation, and a pharmaceutical composition containing the human IL-18 variant.

2. 发明申请

US20220174942A1 STORAGE CONTAINER 有权
公开(公告)号：US20220174942A1
公开(公告)日：2022-06-09
申请号：US17681432
申请日：2022-02-25
申请人： Nagasaki University
发明人： Masafumi UEMATSU , Takashi KITAOKA
IPC分类号： A01N1/02 , A61F2/14 , A61F2/00
摘要： Provided is a storage container for storing a cornea specimen in which an endothelium and an epithelium of a cornea can be immersed and stored in different storage solutions. The storage container 1A is provided with a specimen-supporting portion 3A which contains a first cornea exposure portion 31a and a second cornea exposure portion 31b that expose a cornea part 101, the specimen-supporting portion supporting a scleral rim 102 at an outer circumferential side of the first and second cornea exposure portions 31a, 31b; a first chamber 20a to which an endothelium side of the cornea part 101 in the cornea specimen 100 is exposed, the scleral rim 102 of the cornea specimen 100 being supported by the specimen-supporting portion 3A, and the first chamber containing a first storage solution 60a; and a second chamber 20b to which an epithelium side of the cornea part 101 in the cornea specimen 100 is exposed, the scleral rim 102 of the cornea specimen 100 being supported by the specimen-supporting portion, the second chamber being divided from the first chamber 20a by the specimen-supporting portion 3A, and the second chamber containing a second storage solution 60b that differs from the first storage solution 60a, wherein the storage container is configured to prevent the first and second storage solutions 60a, 60b from being circulated between the first and second chambers 20a, 20b.

3. 发明授权

US11345971B2 Primer set for detecting SARS-CoV-2, method for testing SARS-CoV-2, and reagent and kit of testing SARS-CoV-2 有权
公开(公告)号：US11345971B2
公开(公告)日：2022-05-31
申请号：US17489049
申请日：2021-09-29
申请人： NAGASAKI UNIVERSITY , CANON MEDICAL SYSTEMS CORPORATION
发明人： Jiro Yasuda , Rokusuke Yoshikawa , Haruka Abe
IPC分类号： C12Q1/70 , C12Q1/68 , C12Q1/6876 , G01N21/78 , C07H21/04
摘要： One embodiment according to the present invention relates to a primer set for detecting SARS-CoV-2, the set comprising a plurality of LAMP primers targeting one or more open reading frame (ORF) regions in a SARS-CoV-2 genome, wherein the one or more ORF regions are selected from the group consisting of Orf1b, OrfM, OrfN, and OrfS; and a technique relating to use of this primer set.

4. 发明授权

US11306317B2 Method of producing isoprenoids and proteins, genes, and transformants for the same 有权
公开(公告)号：US11306317B2
公开(公告)日：2022-04-19
申请号：US16612413
申请日：2018-05-11
申请人： KIKKOMAN CORPORATION , NAGASAKI UNIVERSITY
发明人： Yasuko Araki , Yasutomo Shinohara , Kiyoshi Kita
IPC分类号： C12N15/52 , C12N1/14 , C12P7/24 , C12P7/26 , C12P17/04
摘要： The problem to be solved by the present invention is to provide a method of producing isoprenoids including ascofuranone, ilicicolin A, and ascochlorin and derivatives thereof in a high yield as compared to the conventional art, which method enables industrial-scale production of isoprenoids. The problem can be solved by a method of producing isoprenoids such as ascofuranone, ilicicolin A, and ascochlorin, including using a transformant obtained by transformation with biosynthetic genes for ascofuranone, ilicicolin A, or ascochlorin or a knockout organism for these genes to obtain isoprenoids such as ascofuranone, ilicicolin A, and ascochlorin.

5. 发明申请

US20220010389A1 PRIMER SET FOR DETECTING SARS-COV-2, METHOD FOR TESTING SARS-COV-2, AND REAGENT AND KIT OF TESTING SARS-COV-2 有权
公开(公告)号：US20220010389A1
公开(公告)日：2022-01-13
申请号：US17489049
申请日：2021-09-29
申请人： NAGASAKI UNIVERSITY , CANON MEDICAL SYSTEMS CORPORATION
发明人： Jiro YASUDA , Rokusuke YOSHIKAWA , Haruka ABE
IPC分类号： C12Q1/70
摘要： One embodiment according to the present invention relates to a primer set for detecting SARS-CoV-2, the set comprising a plurality of LAMP primers targeting one or more open reading frame (ORF) regions in a SARS-CoV-2 genome, wherein the one or more ORF regions are selected from the group consisting of Orf1b, OrfM, OrfN, and OrfS; and a technique relating to use of this primer set.

6. 发明申请

US20210228069A1 RIGID ENDOSCOPE COVER AND ENDOSCOPE UNIT 有权
公开(公告)号：US20210228069A1
公开(公告)日：2021-07-29
申请号：US17050943
申请日：2019-06-12
申请人： TRYTEC Co. Ltd. , NAGASAKI UNIVERSITY
发明人： Keitaro MATSUMOTO , Katsunori TAKAGI , Takeshi NAGAYASU , Hiroshi TAKEZAKI
IPC分类号： A61B1/12 , A61B1/00
摘要： A cover 20 for covering a circumferential portion of an outer circumferential surface of a rigid endoscope 10 having an observation window portion 14 provided at a tip thereof includes a flexible outer cover member 22 covering the circumferential portion of the circumferential surface of the rigid endoscope 10 and a tubular member 26, provided inside the outer cover member 22, through which a cleaning fluid to be supplied from a base end of the rigid endoscope 10 to the observation window portion 14 of the rigid endoscope 10 flows inside, and the outer cover member 22 is attached to the outer circumference surface of the rigid endoscope 10 by flexing the outer cover member 22.

7. 发明授权

US10130357B2 Instrument for delivering a surgical thread 有权
公开(公告)号：US10130357B2
公开(公告)日：2018-11-20
申请号：US15129698
申请日：2015-03-26
申请人： Nagasaki University
发明人： Susumu Eguchi , Tamotu Kuroki , Taiichiro Kosaka , Takakazu Ishimatu , Syunji Moromugi
IPC分类号： A61B17/04 , A61B17/06 , A61B17/12 , A61B17/00
摘要： To reduce the risk of damaging organs in a body while delivering a thread during surgery, an instrument for delivering a surgical thread has a grip, an outer cylinder fixed the grip, a hollow needle extending inside the outer cylinder and being configured to be moved relative to the outer cylinder in an axial direction and a loop configured to be housed in the outer cylinder. An end of the outer cylinder is bent in a state where force is not applied. The hollow needle is exposed from the outer cylinder when puncturing skin or etc., and the hollow needle is housed in the outer cylinder when it travels near organs which should not be damaged.

8. 发明授权

US09980937B2 Therapeutic agent for Alzheimer's disease 有权
公开(公告)号：US09980937B2
公开(公告)日：2018-05-29
申请号：US15460846
申请日：2017-03-16
申请人： NAGASAKI UNIVERSITY
发明人： Nobuhisa Iwata , Keiro Shirotani , Masashi Asai , Takashi Tanaka
IPC分类号： A61K31/35 , A61K31/352 , A61K31/353
CPC分类号： A61K31/352 , A61K31/353
摘要： The present invention aims to provide a pharmaceutical agent for the prophylaxis and/or treatment of Alzheimer's disease, which has a novel action mechanism and shows less side effects. A polyphenol derivative having liposolubility enhanced by the introduction of at least one kind of a liposoluble group selected from the group consisting of a chain saturated hydrocarbon group, a chain unsaturated hydrocarbon group, a cyclic saturated hydrocarbon group, a cyclic unsaturated hydrocarbon group, an aromatic hydrocarbon group, a liposoluble vitamin residue and a sterol residue has an action to potentiate neprilysin activity, and is useful as a pharmaceutical agent for the prophylaxis and/or treatment of Alzheimer's disease.

9. 发明授权

US09763973B2 Agent for treating HTLV-I associated myelopathy 有权
公开(公告)号：US09763973B2
公开(公告)日：2017-09-19
申请号：US14351242
申请日：2012-10-12
申请人： NAGASAKI UNIVERSITY , ReqMed Company, Ltd.
发明人： Tatsufumi Nakamura , Tadashi Matsumoto
IPC分类号： A61K31/737
CPC分类号： A61K31/737
摘要： The present invention provides a or therapeutic agent for HAM, containing pentosan polysulfate or a pharmaceutically acceptable salt thereof as an active ingredient. The present invention also provides an agent for improving a HAM-associated movement disorder, containing pentosan polysulfate or a pharmaceutically acceptable salt thereof as an active ingredient.

10. 发明授权

US09617324B2 Ameliorating agent for blood-brain barrier dysfunction 有权
公开(公告)号：US09617324B2
公开(公告)日：2017-04-11
申请号：US14378323
申请日：2013-02-13
申请人： Nagasaki University , Shin Nippon Biomedical Laboratories, Ltd.
发明人： Hiroshi Ueda
IPC分类号： C07K14/575 , A61K38/08 , A61K45/06 , A61K38/00
CPC分类号： C07K14/57581 , A61K38/00 , A61K38/08 , A61K45/06
摘要： To provide a peptide which can be produced and processed more readily compared with prothymosin α , which is conventionally known, or a peptide thereof and has an activity at a level equivalent to or higher than that of prothymosin α or a peptide thereof. The present invention provides an ameliorating agent for blood-organ barrier dysfunction, a therapeutic agent for diseases associated with blood-organ barrier dysfunction or ischemic diseases or a nerve cell death inhibitor, each comprising, as an active ingredient, a peptide comprising the amino acid sequence represented by SEQ ID NO: 1 or a peptide having substantially the same function as that of the aforementioned peptide.

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