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221. 发明申请

US20050256360A1 Methods of enhancing radiation effects with metal nanoparticles 有权
公开(公告)号：US20050256360A1
公开(公告)日：2005-11-17
申请号：US11186675
申请日：2005-07-21
申请人： James Hainfeld , Daniel Slatkin
发明人： James Hainfeld , Daniel Slatkin
IPC分类号： A61B6/00 , A61K41/00 , A61K47/48 , A61K49/22 , A61N1/40 , A61N5/00 , A61N5/06 , A61N5/10
CPC分类号： A61N5/00 , A61K41/0038 , A61K41/0052 , A61K47/6849 , A61K47/6923 , A61K47/6929 , A61K49/222 , A61K49/226 , A61N1/406 , A61N5/062 , A61N5/10 , A61N2005/1098 , B82Y5/00 , Y10S977/728 , Y10S977/777 , Y10S977/91 , Y10S977/911 , Y10S977/923 , Y10S977/927 , Y10S977/928 , Y10S977/929 , Y10S977/93
摘要： The present invention provides methods of using metal nanoparticles 0.5 to 400 nm in diameter to enhance the dose and effectiveness of x-rays or of other kinds of radiation in therapeutic regimes of ablating a target tissue such as tumor. The metal nanoparticles can be administered intravenously, intra-arterially, or locally to achieve specific loading in and around the target tissue. The metal nanoparticles can also be linked to chemical and/or biochemical moieties which bind specifically to the target tissue. The enhanced radiation methods can also be applied to ablate unwanted tissues or cells ex vivo.

222. 发明申请

US20050175702A1 Thermosensitive polymer carriers having a modifiable physical structure for biochemical analysis, diagnosis and therapy 审中-公开
标题翻译：具有生化分析，诊断和治疗的可修改物理结构的热敏聚合物载体
公开(公告)号：US20050175702A1
公开(公告)日：2005-08-11
申请号：US10516629
申请日：2003-05-28
申请人： Detlef Muller-Schulte
发明人： Detlef Muller-Schulte
IPC分类号： G01N33/545 , A61B5/055 , A61K9/52 , A61K41/00 , A61K47/34 , A61K47/42 , A61K47/48 , A61K49/00 , A61N2/10 , A61P35/00 , B01J20/28 , C08F2/44 , C08K9/04 , C08L33/26 , C08L101/00 , C09K3/00 , A61K48/00 , A61K9/14 , A61K33/24 , A61K38/43 , A61K39/395
CPC分类号： B82Y5/00 , A61K41/00 , A61K47/6923
摘要： The invention relates to thermosensitive polymers which contain magnetic and/or metallic colloids and whose physical structure can be altered through magnetic induction or through the supply of energy. The invention also relates to processes for the production of such thermosensitive polymers, and the use of such polymers for diagnostic and therapeutic purposes.
摘要翻译：本发明涉及含有磁性和/或金属胶体的热敏聚合物，其物理结构可以通过磁感应或通过能量的供给来改变。本发明还涉及生产这种热敏聚合物的方法，以及这些聚合物用于诊断和治疗目的的用途。

223. 发明申请

US20050025971A1 Magnetic nanoparticle 审中-公开
标题翻译：磁性纳米颗粒
公开(公告)号：US20050025971A1
公开(公告)日：2005-02-03
申请号：US10741238
申请日：2003-12-19
申请人： Hui-Ju Cho , Sheng-Ming Shih , Yuh-Jiuan Lin , Hong-Dun Lin , Kang-Ping Lin
发明人： Hui-Ju Cho , Sheng-Ming Shih , Yuh-Jiuan Lin , Hong-Dun Lin , Kang-Ping Lin
IPC分类号： A61K47/48 , A61K49/18 , B32B5/16 , B32B15/02 , B32B23/02 , B32B27/02
CPC分类号： B82Y5/00 , A61K47/6923 , A61K49/1818 , A61K49/183 , Y10T428/2991
摘要： A magnetic nanoparticle applicable in imaging, diagnosis, therapy and biomaterial separation. The magnetic nanoparticle is characterized as comprising at least an inner-transition element, represented as FexMavZy, wherein Ma is an inner-transition element, Z is an element of the group VIa, x is greater or equal to 0, and both v and y are positive numbers. The magnetic nanoparticle may further comprise a shell to form a core-shell structure, wherein the shell is an inner-transition element Mb or the compound thereof.
摘要翻译：适用于成像，诊断，治疗和生物材料分离的磁性纳米颗粒。磁性纳米颗粒的特征在于至少包含内部过渡元素，表示为FexMaAvZy，其中M是>内部过渡元素，Z是VIa的元素，x大于或等于 0，v和y均为正数。磁性纳米颗粒还可以包含壳形成核 - 壳结构，其中壳是内部过渡元素M或其化合物。

224. 发明申请

US20040142041A1 Triggerable delivery system for pharmaceutical and nutritional compounds and methods of utilizing same 审中-公开
标题翻译：用于药物和营养化合物的可触发递送系统及其利用方法
公开(公告)号：US20040142041A1
公开(公告)日：2004-07-22
申请号：US10731256
申请日：2003-12-09
发明人： John Gavin MacDonald , Jason Lye
IPC分类号： A61K009/14
CPC分类号： A23L27/32 , A23L27/77 , A23P10/30 , A23P20/00 , A23V2002/00 , A23V2200/25 , A61K31/197 , A61K31/375 , A61K31/57 , A61K31/65 , A61K47/6923
摘要： A triggerable delivery system for various functional compounds is disclosed. The delivery system incorporates a carrier composition containing alumina particles, silica particles or alumina coated particles. Various functional materials containing particular moieties may be adsorbed onto the particles and used as desired. The functional compounds can be, for instance, pharmaceuticals, xenobiotics, anti-microbial agents, anti-viral agents, fragrances, and the like.
摘要翻译：公开了用于各种功能性化合物的可触发递送系统。递送系统包含含有氧化铝颗粒，二氧化硅颗粒或氧化铝涂覆颗粒的载体组合物。包含特定部分的各种功能材料可以被吸附到颗粒上并根据需要使用。功能性化合物可以是例如药物，异生物，抗微生物剂，抗病毒剂，香料等。

225. 发明申请

US20040091421A1 Devices and methods for the treatment of cancer 有权
标题翻译：用于治疗癌症的装置和方法
公开(公告)号：US20040091421A1
公开(公告)日：2004-05-13
申请号：US10468742
申请日：2003-08-22
发明人： Roger Aston , Leigh T Canham
IPC分类号： A61K051/00 , A61M036/14
CPC分类号： A61K51/1244 , A61K41/009 , A61K47/6923 , A61K51/02
摘要： The invention relates to the treatment of cancer. In particular the invention relates to an internal therapeutic product comprising: (i) an anti-cancer component selected from one or both of: a radionucleotide, a cytotoxic drug; and (ii) a silicon component selected from one or more of: resorbable silicon, biocompatible silicon, bioactive silicon, porous silicon, polycrystalline silicon, amorphous silicon, and bulk crystalline silicon, the internal therapeutic product being for the treatment of cancer.
摘要翻译：本发明涉及癌症的治疗。特别地，本发明涉及内部治疗产品，其包含：（i）选自以下的一种或两种的抗癌成分：放射性核苷酸，细胞毒性药物; 和（ii）选自以下的一种或多种的硅成分：可再吸收硅，生物相容性硅，生物活性硅，多孔硅，多晶硅，非晶硅和体结晶硅，所述内部治疗产品用于治疗癌症。

226. 发明授权

US06720350B2 Therapeutic inhibitor of vascular smooth muscle cells 失效
标题翻译：血管平滑肌细胞治疗抑制剂
公开(公告)号：US06720350B2
公开(公告)日：2004-04-13
申请号：US10330834
申请日：2002-12-27
申请人： Lawrence L. Kunz , Richard A. Klein , John M. Reno
发明人： Lawrence L. Kunz , Richard A. Klein , John M. Reno
IPC分类号： A61K3140
CPC分类号： A61K9/0024 , A61K31/00 , A61K31/04 , A61K31/131 , A61K31/135 , A61K31/138 , A61K31/165 , A61K31/17 , A61K31/337 , A61K31/352 , A61K31/365 , A61K31/40 , A61K31/4025 , A61K31/4035 , A61K31/407 , A61K31/519 , A61K31/551 , A61K31/704 , A61K47/6803 , A61K47/6809 , A61K47/6817 , A61K47/6831 , A61K47/6843 , A61K47/6849 , A61K47/6923 , A61K47/6927 , A61L31/08 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/432 , A61L2300/602 , A61L2300/606 , A61L2300/622 , G01N2800/323 , Y10S977/906 , Y10S977/915 , Y10S977/92
摘要： Methods are provided for inhibiting stenosis or restenosis following vascular trauma in a mammalian host, comprising administering to the host a therapeutically effective dosage of a cytostatic agent and/or cytoskeletal inhibitor so as to biologically stent the traumatized vessel. Also provided is a method to inhibit or reduce vascular remodeling following vascular trauma, comprising administering an effective amount of a cytoskeletal inhibitor. Further provided are pharmaceutical compositions and kits comprising the therapeutic agents of the invention.
摘要翻译：提供用于抑制哺乳动物宿主血管创伤后的狭窄或再狭窄的方法，包括向宿主施用治疗有效剂量的细胞生长抑制剂和/或细胞骨架抑制剂，以便对创伤血管进行生物支架。还提供了抑制或减少血管创伤后血管重塑的方法，包括施用有效量的细胞骨架抑制剂。还提供了包含本发明治疗剂的药物组合物和试剂盒。

227. 发明授权

US06706394B2 Method and apparatus for manufacture of magnetizable microparticles 失效
标题翻译：用于制造可磁化微粒的方法和装置
公开(公告)号：US06706394B2
公开(公告)日：2004-03-16
申请号：US09847965
申请日：2001-05-02
申请人： Manfred R. Kuehnle , Adelheid Kuehnle
发明人： Manfred R. Kuehnle , Adelheid Kuehnle
IPC分类号： G11B566
CPC分类号： H01F1/143 , A61K9/5094 , A61K47/6923 , A61K48/0008 , C12N15/87 , H01F1/20 , Y10S428/90 , Y10T428/257 , Y10T428/2982 , Y10T428/2991 , Y10T428/2993 , Y10T428/2998
摘要： The subject invention related to methods and apparatuses for the manufacture of magnetizable carrier particles. In addition the subject invention pertains to particles having one or more of a variety of particle configurations and/or functional features. These geometric particle configurations and/or functional features such as delivering or removing a pay load can be tailored to achieve one or more desired missions. The subject invention also pertains to a method and apparatus for the delivery of particles to target materials, in order to accomplish one or more of a variety of missions. In a specific embodiment of the subject invention, acicular and other particles with a lengthwise dimension that are substantially uniform and homogenous in their geometry are manufactured and provided with magnetizations. In this way, predictable mechanical force responsivity can be achieved when these particles are subjected to an external magnetic field gradient.
摘要翻译：本发明涉及制造可磁化载体颗粒的方法和装置。此外，本发明涉及具有多种颗粒构型和/或功能特征中的一种或多种的颗粒。可以调整这些几何颗粒配置和/或诸如递送或去除工作负载的功能特征以实现一个或多个期望的任务。本发明还涉及用于将颗粒递送到目标材料的方法和装置，以便完成各种任务中的一种或多种。在本发明的一个具体实施方案中，制造具有在其几何形状上基本均匀和均匀的纵向尺寸的针状和其它颗粒并提供磁化。以这种方式，当这些颗粒经受外部磁场梯度时，可以实现可预测的机械力响应性。

228. 发明申请

US20030225033A1 Heat stable colloidal iron oxides coated with reduced carbohydrates and uses thereof 有权
公开(公告)号：US20030225033A1
公开(公告)日：2003-12-04
申请号：US10386394
申请日：2003-03-11
发明人： Ernest V. Groman , Kenneth G. Paul , Timothy B. Frigo , Howard Bengele , Jerome M. Lewis
IPC分类号： A61K031/721
CPC分类号： B82Y5/00 , A61K33/26 , A61K47/61 , A61K47/6923 , A61K49/1863
摘要： Compositions, methods of making the compositions, and methods of using the compositions are provided for an enhanced magnetic resonance imaging agent and a hematinic agent, the agents comprising carboxyalkylated reduced polysaccharides coated ultrasmall superparamagnetic iron oxides. Methods of use of the carboxymethyl reduced dextran as a plasma extender are provided.

229. 发明申请

US20030053983A1 Colloidal metal compositions and methods 失效
公开(公告)号：US20030053983A1
公开(公告)日：2003-03-20
申请号：US10135886
申请日：2002-04-30
发明人： Lawrence Tamarkin , Giulio F. Paciotti
IPC分类号： A61K048/00 , A61K038/19
CPC分类号： C07K14/525 , A61K38/191 , A61K38/39 , A61K39/39 , A61K47/60 , A61K47/6923 , A61K49/0013 , A61K49/0017 , A61K49/0056 , A61K49/0065 , A61K51/1244 , A61K2039/55505 , A61K2039/55516 , A61K2039/55522 , C07K16/241
摘要： The present invention comprises compositions and methods for delivery systems of agents, including therapeutic compounds, pharmaceutical agents, drugs, detection agents, nucleic acid sequences and biological factors. In general, these vector compositions comprise a colloidal metal, derivatized PEG (polyethylene glycol) and an agent. The invention also comprises methods and compositions for making such colloidal metal compositions and for treatment of cancer.

230. 发明授权

US06514481B1 Magnetic nanoparticles for selective therapy 有权
标题翻译：用于选择性治疗的磁性纳米颗粒
公开(公告)号：US06514481B1
公开(公告)日：2003-02-04
申请号：US09718825
申请日：2000-11-22
申请人： Paras N. Prasad , Earl J. Bergey , Charles Liebow , Laurent Levy
发明人： Paras N. Prasad , Earl J. Bergey , Charles Liebow , Laurent Levy
IPC分类号： A61B5055
CPC分类号： B82Y5/00 , A61K47/64 , A61K47/6923 , A61N1/406 , A61N2/00 , Y10T436/24
摘要： The present invention provides novel nanosized particles termed as “nanoclinics” for therapeutic and/or diagnostic use. The particles have a core made of a therapeutic or diagnostic material surrounded by a shell. Further, the particles contain a targeting agent on the surface of the shell for specific recognition of targeted cells. A method is also provided for lysis of cells using DC magnetic field. Further, the present invention also provides a method for fabrication of nanoclinics that can target and lyse specific cells such as cancer cells.
摘要翻译：本发明提供用于治疗和/或诊断用途的称为“纳米细胞学”的新型纳米尺寸颗粒。颗粒具有由壳包围的治疗或诊断材料制成的芯。此外，颗粒在壳的表面上含有靶向剂，用于特异性识别靶细胞。还提供了使用DC磁场裂解细胞的方法。此外，本发明还提供了可以靶向和裂解诸如癌细胞的特定细胞的纳米抗生素的制造方法。

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